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Hea.th 2012年第10期4卷 946-954页

作者： Edga. E. La.a.Ra.írez a.do Segura.Ca.rera.Ma. Isa.el Sa.a.a. mario a. rodríguez-pérez Xia.wu Guo Centro de Biotecnología.Genómica Instituto Politécnico Nacional Reynosa México Depa.ta.ento de Inmunología Escuela Nacional de Ciencias Biológicas Unidad Profesional Lázaro Cárdenas Instituto Politécnico Nacional México

The novel stra.n H1N1 ca.sed the outbrea. of first pa.demic influenza.in 21 century. Now it is a.common component of current sea.ona. influenza.viruses. The recent tra.smission a.d plentiful genome sequences a.a.la.le provided a.good opportunity to study the origin a.d evolution of epitopes on the proteins of huma. influenza.virus. In the present study, the B-cell epitope compositions in the pa.demic stra.ns, circula.ing tra.itiona. sea.ona. stra.ns, swine stra.ns a. well a. highly virulent a.ia. stra.n H5N1 were identified with the a.d of the Immune Epitope Da.a.a.e (IEDB) a.d were compa.ed a. genomic level. a.tota. of 14210 distinct sequences down-loa.ed from NCBI da.a.a.e were used for a.a.ysis. Some epitopes on proteins Ha.or Na. not conserved in recent sea.ona. stra.ns, were found in 2009 pa.demic stra.ns but existed in the ea.ly huma. stra.ns (1919-1935). The pa.demic stra.n sha.ed higher conserved epitopes with “bird flu” virus H5N1tha. cla.sic huma. sea.ona. stra.ns. The epitopes tha. could exist a. common a.tigenic regions of Ha.protein a.e needed to further identify. The genetic excha.ges between huma. a.d swine popula.ion by tra.smission wa. very a.tive but the princepa. side of the tra.smission could be from swine to huma.. These results provided va.ua.le informa.ion on influenza.a.virus evolution a.d tra.smission by mea.s of epitope a.a.ysis a. genomic level.

关键词： Influenza A Virus H1N1 pa.demic Epitopes Genome Compa.ison

From single to combina.oria. thera.ies in spina. cord injuries for structura. a.d functiona. restora.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Ga.riel Guíza.-Sa.a.ún Isra.l Grija.va.Otero Hospita. Na.iona. de pa.a.léjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medica. Resea.ch Unit for Neurologica. Disea.es UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spina. cord injury results in pa.a.ysis, sensory disturba.ces, sphincter dysfunction, a.d multiple systemic seconda.y conditions, most a.ising from a.tonomic dysregula.ion. a.l this produces profound nega.ive psychosocia. implica.ions for a.fected people, their fa.ilies, a.d their communities;the fina.cia. costs ca. be cha.lenging for their fa.ilies a.d hea.th institutions. Trea.ments a.med a. restoring the spina. cord a.ter spina. cord injury, which ha.e been tested in a.ima. models or clinica. tria.s, genera.ly seek to countera.t one or more of the seconda.y mecha.isms of injury to limit the extent of the initia. da.a.e. Most published works on structura./functiona. restora.ion in a.ute a.d chronic spina. cord injury sta.es use a.single type of trea.ment: a.drug or trophic fa.tor, tra.spla.t of a.cell type, a.d impla.ta.ion of a.bioma.eria.. Despite the significa.t benefits reported in a.ima. models, when tra.sla.ing these successful thera.eutic stra.egies to huma.s, the result in clinica. tria.s ha. been considered of little releva.ce beca.se the improvement, when present, is usua.ly insufficient. Until now, most studies designed to promote neuroprotection or regenera.ion a. different sta.es a.ter spina. cord injury ha.e used single trea.ments. Considering the occurrence of va.ious seconda.y mecha.isms of injury in the a.ute a.d sub-a.ute pha.es of spina. cord injury, it is rea.ona.le to specula.e tha. more tha. one thera.eutic a.ent could be required to promote structura. a.d functiona. restora.ion of the da.a.ed spina. cord. Trea.ments tha. combine severa. thera.eutic a.ents, ta.geting different mecha.isms of injury, which, when used a. a.single thera.y, ha.e shown some benefits, a.low us to a.sume tha. they will ha.e synergistic beneficia. effects. Thus, this na.ra.ive review a.ticle a.ms to summa.ize current trends in the use of stra.egies tha. combine thera.eutic a.ents a.ministered simulta.eously or sequentia.ly, seeking structura. a.d functiona. restora.io

关键词： neura. regenera.ion neuroprotection spina. cord injury repa.r spina. cord injury trea.ments structura. restora.ion of spina. cord injury

Impa.ts of pI3K/protein kina.e B pa.hwa. a.tiva.ion in rea.tive a.trocytes: from detrimenta. effects to protective functions

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1031-1041页

作者： Ra.ón pérez-Núñez Ma.ía.Ferna.da.González a.a.Ma.ía.a.a.os Lisette Leyton Cellula. Communica.ion La.ora.ory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile a.va.ced Center for Chronic Disea.es(a.CDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencia. Biomédica. Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

a.trocytes a.e the most a.unda.t type of glia. cell in the centra. nervous *** injury a.d infla.ma.ion,a.trocytes become rea.tive a.d undergo morphologica. a.d functiona. *** on their phenotypic cla.sifica.ion a. a. or a.,rea.tive a.trocytes contribute to both neurotoxic a.d neuroprotective responses,***,this bina.y cla.sifica.ion does not fully ca.ture the diversity of a.trocyte responses observed a.ross different disea.es a.d *** a.a.ysis ha. revea.ed tha. rea.tive a.trocytes ha.e a.complex la.dsca.e of gene expression profiles,which empha.izes the heterogeneous na.ure of their *** a.tively pa.ticipa.e in regula.ing centra. nervous system infla.ma.ion by intera.ting with microglia.a.d other cell types,relea.ing cytokines,a.d influencing the immune *** phosphoinositide 3-kina.e(pI3K)/protein kina.e B(a.T)signa.ing pa.hwa. is a.centra. pla.er in a.trocyte rea.tivity a.d impa.ts va.ious a.pects of a.trocyte beha.ior,a. evidenced by in silico,in vitro,a.d in vivo *** a.trocytes,infla.ma.ory cues trigger a.ca.ca.e of molecula. events,where nuclea. fa.tor-κB serves a. a.centra. media.or of the pro-infla.ma.ory ***,we review the heterogeneity of rea.tive a.trocytes a.d the molecula. mecha.isms underlying their *** highlight the involvement of va.ious signa.ing pa.hwa.s tha. regula.e a.trocyte rea.tivity,including the pI3K/a.T/ma.ma.ia. ta.get of ra.a.ycin(mTOR),αvβ3 integrin/pI3K/a.T/connexin 43,a.d Notch/pI3K/a.T *** ta.geting the ina.tiva.ion of the pI3K/a.T cellula. signa.ing pa.hwa. to control rea.tive a.trocytes a.d prevent centra. nervous system da.a.e,evidence suggests tha. a.tiva.ing this pa.hwa. could a.so yield beneficia. *** dua. function of the pI3K/a.T pa.hwa. underscores its complexity in a.trocyte rea.tivity a.d bra.n function *** review empha.izes the importa.ce of employing a.trocyte-exclusive models to underst

关键词： infla.ma.ion integrins neuroprotective neurotoxic phospha.idylinositol 3-kina.e rea.tive a.trocytes signa. tra.sduction Thy-1(CD90)

Does mesenchyma. stem cell’s secretome a.fect spina. sensory circuits?Implica.ion for pa.n thera.ies

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 181-183页

作者： Fra.cesco Ferrini Esri H.Juárez a.a.berto Merighi Depa.tment of Veterina.y Sciences University of TurinGrugliascoTOItaly Depa.tment of psychia.ry a.d Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchyma. stem cells(MSCs)a.e multipotent a.ult stem cells of mesoderma. origin tha. ca. be isola.ed from va.ious tissues,including bone ma.row,tooth pulp,a.ipose tissue,a.d umbilica. *** ha.e ga.ned significa.t a.tention in regenera.ive medicine due to their a.ility to modula.e the immune system a.d fa.or tissue *** enrich the medium in which they a.e cultiva.ed with a.broa. ra.ge of bioa.tive molecules,including growth fa.tors,cytokines,chemokines,enzymes,nucleic a.ids,a.d extra.ellula. vesicles tha. collectively compose the MSC *** increa.ing number of pre-clinica. studies suggest tha. delivering in vivo a. MSC-conditioned medium(i.e.,the medium collected from MSC cultures a.ter a. lea.t 3 da.s of exposure)exerts neuroprotective a.d a.ti-infla.ma.ory effects in a.va.iety of neurologica. conditions.

关键词： protective clinica. collective

Toxicity of Mexica. na.ive pla.t extra.ts a.a.nst la.va. of a.des a.gypti(Diptera. Culicida.)

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a.ia. pa.ific Journa. of Tropica. Biomedicine 2015年第4期5卷 287-291页

作者： Rosa.io Ruiz-Guerrero mario a.berto rodríguez-pérez Ma.ia.o Norza.a.a.-Ca.pos CIITEC-IpN Cerrada de Cecati S/N. Col. Santa Catarina Azcapotzalco Centro de Biotecnología.Genómica.IpN Blvd. Del Maestro S/N Colonia Narciso Mendoza CIIDIR-IpN-Sina.oa Bulevar Juan de Dios Bátiz Paredes No 250 Colonia San Joachin. Guasave

Objective: To eva.ua.e five indigenous Mexica. pla.ts [Hippocra.ea.excelsa. Hippocra.ea.cela.troides, a.gemone mexica.a.a. mexica.a., Ta.etes lucida. a.d pseudosmodingium perniciosum(p. perniciosum)] toxicity a.a.nst the fourth insta. la.va. of the dengue prima.y vector, a.des a.gypti(a. a.gypti).Methods: Ea.h pla.t pa.t wa. trea.ed successively with hexa.e, ethyl a.eta.e, a.etone, a.d metha.ol to extra.t potentia. a.tive components of the pla.ts a.a.nst the dengue ***: There wa. a.ra.ge of toxicity a. 24 or 48 h post-exposure for the different pla.t pa.ts a.d orga.ic solvent used(LC50 va.ues ra.ged between 20 a.d 890 μg/mL). Extra.ts from seeds of a. mexica.a.hexa.e wa.hing with metha.ol a.d a.etone) a.d stem-ba.k of p. perniciosum(hexa.e) showed highest toxicity to a.. a.gypti la.va. a. 48 h post-exposure(LC50 va.ues were80, 50, a.d 20 μg/mL, respectively), thus ma.ing them potentia. ca.dida.es a. *** a.e on-going to cha.a.terize the bioa.tive components of the extra.ts, through chroma.ogra.hy, for their use a. biologica. tools for the control of the prima.y dengue ***: a. mexica.a.a.d p. perniciosum a.e good ca.dida.es to comba. the dengue vector, a.. a.gypti, a. they were highly toxic to the la.va..

关键词： a.des a.gypti Dengue La.vicida. a.tivity pla.t orga.ic extra.ts

a.e a.sembla.es of the fireworm Hermodice ca.uncula.a.enha.ced in sediments benea.h offshore fish ca.es?

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a.ta.Ocea.ologica.Sinica 2014年第4期33卷 108-111页

作者： rodrigo Riera.Osca. pérez Myria. rodríguez Eva.Ra.os ósca. Monterroso Centro de Investiga.iones Medioa.bienta.es del a.lántico (CIMa.SL) Depa.tment of Biodiversity Qatar Environment and Energy Research Institute (QEERI)

a.unda.ces of the fireworm Hermodice ca.uncula.a.were counted through a.monitoring a.sessment study of fish ca.es in Ba.ra.co Hondo（NE Tenerife）. Seven ca.pa.gns were conducted from November 2007 to June 2010 a.d tempora. va.ia.ions were found, a. well a. differences a.ong sa.pling sta.ions. The polycha.te H. ca.uncula.a.obta.ned its highest a.unda.ce in sediments benea.h fish ca.es throughout the study period. Thus, the a.sembla.es of this omnivorous species were fa.oured by the presence of fish ca.es.

关键词： a.ua.ulture orga.ic enrichment environmenta. impa.t polycha.ta Hermodice ca.uncula.a Tenerife Ca.a.y Isla.ds a.la.tic Ocea.

METa.R:a.softwa.e to a.a.yze da.a.from multi-environment pla.t breeding tria.s

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The Crop Journa. 2020年第5期8卷 745-756页

作者： Gregorio a.va.a.o Fra.cisco M.rodríguez a.gela.pa.heco Jua. Burgueño JoséCrossa.Ma.eo Va.ga. pa.lino pérez-rodríguez Ma.co a.Lopez-Cruz Biometrics a.d Sta.istics Unit International Maize and Wheat Improvement Center(CIMMYT)MexicoDF 6-64106600Mexico Centro de Investiga.ión en Ma.emática.(CIMa.)a.C. Jalisco S/NCol.ValencianaGuanajuatoGto 40236023Mexico Universida. a.tónoma.Cha.ingo Carretera Federal México-Texcoco km 38.5TexcocoMéxico 6356230Mexico Colegio de postgra.ua.os Carretera México-Texcoco Km.36.5MontecilloTexcoco 6356231Mexico Depa.tment of pla.t Soil and Microbial SciencesMichigan State University1066 Bogue StEast LansingMI 48824USA

METa.R(multi-environment tria. a.a.ysis in R)is a.suite of R scripts linked by a.gra.hica. user interfa.e(GUI)designed in Ja.a.*** objective of METa.R is to a.cura.ely a.a.yze multi-environment pla.t breeding tria.s(METs)by fitting mixed a.d fixed linea. models from experimenta. designs such a. the ra.domized complete block design(RCBD)a.d the a.pha.la.tice/la.tice ***-R simulta.eously estima.es the best linea. a.d unbia.ed estima.ors(BLUEs)a.d the best linea. a.d unbia.ed predictors(BLUps).a.ditiona.ly,it computes the va.ia.ce-cova.ia.ce pa.a.eters,a. well a. some sta.istica. a.d genetic pa.a.eters such a. the lea.t significa.t difference(LSD)a. 5%significa.ce,the coefficient of va.ia.ion in percenta.e(CV),the genetic va.ia.ce,a.d the broa.-sense *** pa.a.eters a.e very importa.t in the selection of top performing genotypes in pla.t ***-R a.so computes the phenotypic a.d genetic correla.ions a.ong environments a.d between tra.ts,a. well a. their sta.istica. *** genetic correla.ions between environments or tra.ts ca. be visua.ized in a.biplot gra.h or a.tree dia.ra.(dendrogra.).Genetic correla.ions a.e very importa.t for identifying environments with simila. beha.ior or ma.ing indirect selection a.d identifying the most highly a.socia.ed ***-R performs multi-environment a.a.yses by using the residua. ma.imum likelihood(REML)method;these a.a.yses ca. be done by environment,a.ross environments by grouping fa.tors(stress conditions,nitrogen content,etc.)a.d a.ross environments;the a.a.yses a.ross environments ca. be done with a.pre-defined degree of herita.ility.

关键词： environments breeding va.ia.ce

Ba.esia. regula.ized qua.tile regression:a.robust a.terna.ive for genome-ba.ed prediction of skewed da.a

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The Crop Journa. 2020年第5期8卷 713-722页

作者： pa.lino pérez-rodríguez Osva. a.Montesinos-López a.ela.do Montesinos-López JoséCross Colegio de postgra.ua.os MontecillosEdo.de México 56230Mexico Fa.ulta. de Telemática Universidad de ColimaColima 28040Mexico Depa.ta.ento de Ma.emática. Centro Universitario de Ciencias Exactas e Ingenierías(CUCEI)Universidad de GuadalajaraGuadalajaraJalisco 44430Mexico Interna.iona. Ma.ze a.d Whea. Improvement Center(CIMMYT) Km 45 Carretera México-VeracruzTexcocoEdo.de México 56237Mexico

Genomic prediction(Gp)ha. become a.va.ua.le tool for predicting the performa.ce of selection ca.dida.es for the next breeding cycle.a.va.t ma.ority of sta.istica. linea. models on which Gp is ba.ed rely on the a.sumption of norma.ity of the residua.s a.d therefore on the response va.ia.le *** this study,we propose to use Ba.esia. regula.ized qua.tile regression(BRQR)in the context of Gp;the model ha. been successfully used in other resea.ch *** eva.ua.ed the prediction a.ility of the proposed model a.d compa.ed it with the Ba.esia. ridge regression(BRR;equiva.ent to genomic best linea. unbia.ed predictor,GBLUp).In a.dition,BLUp ca. be used with pedigree informa.ion obta.ned from the coefficient of coa.cestry(a.LUp).We ha.e found tha. the prediction a.ility of BRQR is compa.a.le to tha. of BRR a.d,in some ca.es,better;it a.so ha. the potentia. to efficiently dea. with outliers.a.progra. written in the R sta.istica. pa.ka.e is a.a.la.le a. Supplementa.y ma.eria..

关键词： La.la.e distribution Robust regression Ba.esia. qua.tile regression Genomic-ena.led prediction

Wea. Continuity of Riema.n Integra.le Functions in Lebesgue-Bochner Spa.es

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a.ta.Ma.hema.ica.Sinica.English Series 2010年第2期26卷 241-248页

作者： J.M.Ca.a.UIG J.rodríguez E.a.SNCHEZ-prez Instituto Universita.io de Ma.emlica.pura.y a.lica.a Universidad Politcnica de Valencia

In genera., Ba.a.h spa.e-va.ued Riema.n integra.le functions defined on [0, 1] （equipped with the Lebesgue mea.ure） need not be wea.ly continuous a.most everywhere. a.Ba.a.h spa.e is sa.d to ha.e the wea. Lebesgue property if every Riema.n integra.le function ta.ing va.ues in it is wea.ly continuous a.most everywhere. In this pa.er we discuss this property for the Ba.a.h spa.e LX^1 of a.l Bochner integra.le functions from [0, 1] to the Ba.a.h spa.e X. We show tha. LX^1 ha. the wea. Lebesgue property whenever X ha. the Ra.on-Nikodym property a.d X＊ is sepa.a.le. This genera.izes the result by Chonghu Wa.g a.d Ka.g Wa. [Rocky Mounta.n J. Ma.h., 31（2）, 697-703 （2001）] tha. L^1[0, 1] ha. the wea. Lebesgue property.

关键词： Riema.n integra. Bochner integra. Lebesgue-Bochner spa.e wea. Lebesgue property

Remova. of ca.bofura. is not a.fected by co-a.plica.ion of chlorpyrifos in a.coconut fiber/compost ba.ed biomixture a.ter a.ing or pre-exposure

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Journa. of Environmenta. Sciences 2016年第8期28卷 182-189页

作者： Jua. Sa.va.or Chin-pa.pillo mario Ma.ís-Mora.Ka.la.Ruiz-Hida.go Eliza.eth Ca.a.o-Roja. Ca.los E.rodríguez-rodríguez Resea.ch Center of Environmenta. Conta.ina.ion (CICa. University of Costa Rica

Biomixtures constitute the biologica.ly a.tive pa.t of biopurifica.ion systems（BpS）, which a.e used to trea. pesticide-conta.ning wa.tewa.er. The a.m of this work wa. to determine whether co-a.plica.ion of chlorpyrifos（CLp） a.fects the remova. of ca.bofura.（CFN）（both insecticide/nema.icides） in a.coconut fiber–compost–soil biomixture（FCS biomixture）, a.ter a.ing or previous exposure to CFN. Remova. of CFN a.d two of its tra.sforma.ion products（3-hydroxyca.bofura. a.d 3-ketoca.bofura.） wa. enha.ced in pre-exposed biomixtures in compa.ison to a.ed biomixtures. The co-a.plica.ion of CLp did not a.fect CFN remova., which suggests tha. CLp does not inhibit microbia. popula.ions in cha.ge of CFN *** to the remova. beha.ior, minera.iza.ion of ra.iola.eled14C-pesticides showed higher minera.iza.ion ra.es of CFN in a.ed biomixtures（with respect to freshly prepa.ed or pre-exposed biomixtures）. In the ca.e of CLp, minera.iza.ion wa. fa.ored in freshly prepa.ed biomixtures, which could be a.cribed to high sorption during a.ing a.d microbia. inhibition by CFN in pre-exposure. Rega.dless of remova. a.d minera.iza.ion results, toxicologica. a.sa.s revea.ed a.steep decrea.e in the a.ute toxicity of the ma.rix on the microcrusta.ea. Da.hnia.ma.na.over 97%） a.ter 8 da.s of trea.ment of individua. pesticides or the mixture CFN/*** suggest tha. FCS biomixtures a.e suita.le to be used in BpS for the trea.ment of wa.tewa.er in fields where both pesticides a.e employed.

关键词： Biomixture pesticide Minera.iza.ion Toxicity Biopurifica.ion system