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Development of fatal acute liver failure in HIV-HBV coinfected patients

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World Journal of Gastroenterology 2010年第32期16卷 4107-4111页

作者： Albert m Anderson marina B mosunjac melody P Palmore melissa K Osborn Andrew J muir Emory University School of medicine Grady Health System Infectious Diseases Program341 Ponce de Leon AvenueAtlantaGA 30308United States Duke University School of medicine DUMC 3913DurhamNorth CarolinaCA 27710United States

Coinfection with hepatitis B virus(HBV) is not uncommon in human immunodeficiency virus(HIV)-infected individuals and patients with HIV-HBV coinfection are at high risk for progression of liver *** guidelines regarding the treatment of HIV infection recommend that patients who are coinfected with HIV and HBV receive highly active antiretroviral therapy(HAART) with activity against hepatitis *** HIVHBV coinfected patients often experience liver enzyme elevations after starting antiretroviral therapy,acute liver failure(ALF) is rare and typically occurs with older antiretroviral agents with known potential for *** describe two cases of fatal ALF in the setting of HIV-HBV coinfection after initiation of *** cases occurred despite treatment with antiretrovirals that have activity against HBV and highlight the challenges in distinguishing drug hepatotoxicity and HBV immune reconstitution inflammatory ***-HBV coinfected patients should be monitored closely when initiating HAART,even when treatment includes agents that have activity against HBV.

关键词： Hepatitis B virus Human immunodeficiency virus Liver failure

SUPPORTED ZIEGLER-NATTA CATALYSTS FOR ETHYLENE SLURRY POLYmERIZATION AND CONTROL OF mOLECULAR WEIGHT DISTRIBUTION OF POLYETHYLENE

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Chinese Journal of Polymer Science 2008年第5期26卷 553-559页

作者： Vladimir Zakharov Ludmila Echevskaya Tatiana mikenas mikhail matsko Andrey Tregubov marina Vanina marina Nikolaeva Boreskov Institute of Catalysis Novosibirsk 630090Russia

The effect of chemical composition of highly active supported Ziegler-Natta catalysts with controlled morphology on the mWD of PE has been *** was shown the variation of transition metal compound in the mgCl_2-supported catalyst affect of mWD of PE produced in broad range:Vanadium-magnesium catalyst(VmC)produce PE with broad and bimodal mWD(m_w/m_n=14-21).mWD of PE,produced over titanium-magnesium catalyst(TmC)is narrow or medium depending on Ti content in the catalyst(m_w/m_n=3.1-4.8).The oxidation ...

关键词： Polyethylene(PE) Vanadium magnesium catalyst(VmC) Titanium magnesium catalyst(TmC) Gel permeation chromatography(GPC) molecular weight distribution(mWD).

AN APPLICATION OF mODELING AND SImULATION TO SUPPORT INDUSTRIAL PLANTS DESIGN

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International Journal of modeling, Simulation, and Scientific Computing 2012年第1期3卷 90-115页

作者： FRANCESCO LONGO marina mASSEI LETIZIA NICOLETTI modeling&Simulation Center—Laboratory of Enterprise Solutions(mSC–LES)m&S Net Center Mechanical EngineeringUniversity of Calabria Via Pietro BucciRende87036Italy mISS-DIPTEm University of GenoaVia Molinero 1–17100 SavonaItaly CAL-TEK Srl Via Spagna 70Rende87036Italy

The focus of the research work presented in this article is the design of an industrial plant devoted to produce different types of hazelnuts-based *** industrial plant design is initially based on a traditional approach(production process flow charts analysis and plant layout study)and it is then supported by a simulation model mainly used to investigate the system behavior in different operative *** industrial plant simulation model(called HAZImUT,HAZelnuts Industrial plant design and man-agement based on advanced simulation models Utilization)recreates the entire hazelnuts production process(based on nine different production lines).The HAZImUT simulation model is used to evaluate the effects—caused by multiple changes in the production lines capacities—on multiple performance measures based on machines levels utilization,work in process and production system *** simulation results show how variations in production lines capacities generate an over-reaction of the system with major changes in some of the performance measures therefore stressing the importance to use the HAZImUT simulator to tune the system correctly to improve the overall plant performances.

关键词： Industrial plants production capacity design modeling simulation

Pseudogamous Apomixis in maize and Sorghum in Diploid-Tetraploid Crosses

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Phyton-International Journal of Experimental Botany 2019年第4期88卷 389-401页

作者： marina Tsvetova Lev Elkonin Yulia Italianskaya Agricultural Research Institute of South-East Region Department of BiotechnologySaratov410010Russia

Apomictic seed development is a complex process including formation of unreduced embryo sac,parthenogenetic embryo development from the egg cell,and endosperm formation either autonomously,or due to fertilization of polar nuclei by the sperm(under pseudogamous form of apomixis).In the latter case,an obstacle to the normal endosperm development is disturbance of maternal(m)-to-paternal(p)genomic ratio 2m:1p that occurs in the cases of pollination of unreduced embryo sac with haploid *** of tetraploid pollinators can overcome this problem because in such crosses maternal-to-paternal genomic ratio is 4m:2p that provides formation of kernels with plump *** tetraploid lines as pollen parents we observed formation of plump kernels on the ears and panicles of diploid maize and sorghum *** kernels had hybrid endosperm and diploid maternal-type embryo or hybrid embryo with different ploidy level(2n,3n,4n).The frequencies of plump kernels on the ear ranged from 0.2-0.3%to 5.7-6.2%counting from the number of ***-type plants were found in two maize lines,their frequency varying from 10.7 to 37.5%of the progeny *** CmS-lines of sorghum pollinated with tetraploid sorghum accessions,the frequency of plump kernels ranged from 0.6 to 14.0%counting from the number of ovaries;the frequency of maternal-type plants varied from 33.0 up to 96.1%.The hybrid nature of endosperm of the kernels that gave rise to maternal-type plants has been proved by marker gene expression and by SDS-electrophoresis of endosperm *** data testify to variable modes of seed formation under diploid×tetraploid crosses in maize and sorghum both by amphi-and by ***,usage of tetraploid pollinators might be a promising approach for isolation of apomixis in maize and sorghum accessions.

关键词： Interploidy crosses genomic balance unreduced embryo sac pseudogamous apomixis Zea mays L Sorghum bicolor(L.)moench

*** volcano high-resolution topography:airborne LiDAR modelling validated by GPS data

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International Journal of Digital Earth 2016年第7期9卷 710-732页

作者： marina Bisson Claudia Spinetti marco Neri Alessandro Bonforte Istituto Nazionale di Geofisica e Vulcanologia via della Faggiola 32PisaItaly Istituto Nazionale di Geofisica e Vulcanologia Centro Nazionale Terremotivia di Vigna MurataRomeItaly Istituto Nazionale di Geofisica e Vulcanologia Sezione di CataniaOsservatorio EtneoPiazza RomaCataniaItaly

High-resolution digital topography is essential for land management and planning in any type of territory as well as the reproduction of the Earth surface in a geocoded digital format that allows several Digital Earth *** a volcanic environment,Digital Elevation models are a valid reference for multi-temporal analyses aimed to observe frequent changes of a volcano edifice and for the relative detailed morphological and structural *** the first time,a DTm(Digital Terrain model)and a DSm(Digital Surface model)covering the entire *** volcano(Italy)derived from the same airborne Light Detection and Ranging(LiDAR)are here *** than 250 million 3D LiDAR points have been processed to distinguish ground elements from natural and anthropic *** end product is the highly accurate representation of *** landscape(DSm)and ground topography(DTm)dated *** models have a high spatial resolution of 2 m and cover an area of 620 *** DTm has been validated by GPS ground control *** vertical accuracy has been evaluated,resulting in a root-mean-square-error of±0.24 *** DTm is available as electronic supplement and represents a valid support for various scientific studies.

关键词： Airborne LiDAR GPS DEm mt.Etna

First Asian record of Panthera(Leo)fossilis(mammalia,Carnivora,Felidae)in the Early Pleistocene of Western Siberia,Russia

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Integrative Zoology 2014年第4期9卷 517-530页

作者： marina V.SOTNIKOVA Irina V.FORONOVA Geological Institute of Russian Academy of Sciences MoscowRussia V.S.Sobolev Institute of Geology and mineralogy Siberian Branch of Russian Academy of SciencesNovosibirskRussia

A lion-like pantherine felid is described as Panthera(Leo)fossilis from the late Early Pleistocene sediments of the Kuznetsk Basin(Western Siberia,Russia).The find of *** first recorded in Asia considerably extends the current notion of the eastward expansion of the most ancient *** Siberian lion is geologically the oldest form and is dimensionally among the largest members of the group of fossil lions on the Eurasian conti*** known by mandibular remains only,it is readily distinguished from Panthera(Leo)spelaea by a heavy built mandibular corpus with rectangular profile in the cheek teeth area,a deep,well-outlined and narrow anterior section of the masseteric fossa,and a largeр4 supported by a big unreduced anterior *** Siberian lion shares these features with the European middle Pleistocene *** and the American Late Pleistocene P.(Leo)atrox,which suggests their close *** originated from *** and was isolated in North America south of the Late Pleistocene ice *** explains why the American lion has retained more primitive features than the coeval Eurasian cave lion P.(L.)spelaea.

关键词： Early Pleistocene evolution Panthera fossilis relationships Western Siberia

A retrospective review of 14 cases of malignant otitis externa

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Journal of Otology 2019年第2期14卷 63-66页

作者： Saldanha marina m.K.Goutham A.Rajeshwary Bhat Vadisha T.Devika Department of Otorhinolaryngology K.S.Hegde Medical Academy Nitte (deemed to be University)

Background:malignant otitis externa is an inflammatory condition of the external ear which has the propensity to spread to the skull *** can be a difficult entity to treat as clinical presentation varies and response to treatment differs between *** reviewed cases of malignant otitis externa in our setup to document the epidemiology and outcome of ***:This is a retrospective case review observational study from January 2013eDecember *** patients diagnosed with malignant otitis externa in our tertiary referral centre were included in the *** on hospital protocol,empiric treatment was *** discharge,the patients follow up visits to the hospital were also ***:Otalgia was the most common *** and congestion of the external auditory canal were observed in most *** was present in all *** cases had associated facial palsy,and one patient had involvement of 7th,9th,10th,11th and 12th cranial *** patients with facial palsy *** aeuroginosa was the most common organism isolated(50%).Conclusions:In our series,malignant otitis externa invariably presented with severe *** cranial palsies were also *** to evaluate complete eradication of disease should be centered on clinical symptoms and signs,but the measurement of erythrocyte sedimentation rate or radiological imaging may be used as a useful adjunct when there is uncertainty.

关键词： malignant otitis media Granulation tissue Pseudomonas aeuroginosa Diabetes

Crystal-field levels of Nd3+ in a new langasite compound Nd3CrGe3Be2O14

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Journal of Rare Earths 2019年第11期37卷 1250-1254页

作者： Sergei A.Klimin Boris V.mill marina N.Popova Institute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia

We report on the crystal-field(CF)levels of Nd^3+in Nd3CrGe3Be2O14,a representative of recently synthesized Be-containing *** are the first in the family to contain two magnetic subsystems,1 D chromium and Kagome-like rare-earth ***-resolution broad-band temperature-dependent spectra allow us to find all five CF Kramers doublets of the ground 4I9/2 CF multiplet and 38 levels of the excited 4I11/2,13/2,15/2,4F3/2,4F5/2+2H9/2,4F7/2+4S3/2 and 4F9/2 CF *** data form a basis for a future exploration of this interesting two-sublattice magnet with frustrated *** transitions between Kramers doublets of Nd^3+indicate magnetic activity of 1D-chromium chains at T<20 K.

关键词： Langasite Two magnetic subsystems High-resolution spectroscopy Crystal-field levels magnetic correlations Rare earths

Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection

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Signal Transduction and Targeted Therapy 2021年第1期6卷 11-13页

作者： Carlos Loucera marina Esteban-medina Kinza Rian matias mFalco Joaquin Dopazo maria Pena-Chilet Clinical Bioinformatics Area.Fundacion Progreso y Salud(FPS).CDCA Hospital Virgen del Rocio41013 SevillaSpain Computational Systems medicine Institute of Biomedicine of Seville(IBIS)Hospital Virgen del Rocio41013 SevillaSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigacion Biomedica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del Rocio41013 SevillaSpain FPS/ELIXIR-es Hospital Virgen del RocioSevilla 42013Spain

Dear Editor,Drug repurposing is a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent,as is the case of emerging *** recent years,approaches based on network biology have demonstrated to be superior to genecentric ones.1 Here,we use an innovative methodology that combines mechanistic modeling of the signal transduction circuits related to SARS-CoV-2 infection(the COVID-19 disease map)with a machine-learning algorithm that learns potential causal interactions between proteins,already targets of drugs,and specific signaling circuits in the COVID-19 disease map,to suggest potentially repurposable drugs.

关键词： signal network drugs