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Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2024年第13期30卷 1899-1910页

作者： Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males Josko Bozic Biology of Neoplasms University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia Department of Pharmacy University of Split School of MedicineSplit 21000Croatia Department of Medical Laboratory Diagnostics University Hospital of SplitSplit 21000Croatia Department of Health Studies University of SplitSplit 21000Croatia Department of Internal Medicine University of Split School of MedicineSplit 21000Croatia Department of Surgery University Hospital of SplitSplit 21000Croatia

BACKGROUND Population of patients with inflammatory bowel disease(IBD)is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and ***-differentiation factor-15(GDF-15)is often overexpressed under stress conditions,such as inflammation,malignancies,heart failure,myocardial ischemia,and many *** To explore the association between GDF-15 and IBD as serum concentrations of GDF-15 were shown to be an independent predictor of poor outcomes in multiple *** additional aim was to determine possible associations between GDF-15 and multiple clinical,anthropometric and laboratory parameters in patients with *** This cross-sectional study included 90 adult patients diagnosed with IBD,encompassing both Crohn’s disease(CD)and ulcerative colitis(UC),and 67 healthy age-and sex-matched *** patients underwent an extensive workup,including colonoscopy with subsequent histopathological *** activity was assessed by two independent gastroenterology consultants specialized in IBD,employing well-established clinical and endoscopic scoring ***-15 serum concentrations were determined following an overnight fasting,using electrochemiluminescence *** In patients with IBD,serum GDF-15 concentrations were significantly higher in comparison to the healthy controls[800(512-1154)pg/mL vs 412(407-424)pg/mL,P<0.001],whereas no difference in GDF-15 was found between patients with CD and UC[807(554-1451)pg/mL vs 790(509-956)pg/mL,P=0.324].Moreover,multiple linear regression analysis showed that GDF-15 levels predict CD and UC severity independent of age,sex,and C-reactive protein levels(P=0.016 and P=0.049,respectively).Finally,an association between GDF-15 and indices of anemia was ***,negative correlations were found between GDF-15 and serum iron levels(r=-0.248,P=0.021),as well as GDF-15 and hemoglobin(r=-0.351,P=0.021).Accordingly,in comparison to I

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Growth-differentiation factor-15 Anemia Extraintestinal manifestations

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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

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Diophantine Equations and the Freeness of Mobius Groups

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Applied Mathematics 2014年第10期5卷 1400-1411页

作者： marin.gutan Laboratoire de Mathématiques Universite Blaise-PascalClermont-FerrandFrance

Let p and q be two fixed non zero integers verifying the condition gcd(p,q) = 1. We check solutions in non zero integers a1,b1,a2,b2 and a3 for the following Diophantine equations: (B1) (B2) . The equations (B1) and (B2) were considered by R.C. Lyndon and J.L. Ullman in [1] and A.F. Beardon in [2] in connection with the freeness of the M?bius group generated by two matrices of namely and where .?They proved that if one of the equations (B1) or (B2) has solutions in non zero integers then the group is not free. We give algorithms to decide if these equations admit solutions. We obtain an arithmetical criteria on p and q for which (B1) admits solutions. We show that for all p and q the equations (B1) and (B2) have only a finite number of solutions.

关键词： Diophantine Equation Mobius Groups Free Group

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时间隔离——一种新的控制交尾模式

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中国蜂业 2024年第5期75卷 22-23页

作者： Aleksandar Uzunov marin Kovacic 陈超单金琼中国农业科学院蜜蜂研究所资源昆虫高效养殖与利用全国重点实验室北京100193 北马其顿圣基里尔·麦托迪大学农业科学与食品学院斯科普里1000 克罗地亚奥西耶克大学农业生物技术科学学院奥西耶克31000

控制交尾是蜜蜂育种项目中遗传改良和保护的关键因素。在上一期文章中,我们讨论了控制交尾的四种可选的模式及其相关性,即地理隔离、生物隔离、人工授精和时间隔离。实际上,最后一种模式在近几十年刚刚发展起来,可以作为传统模式的一种... 详细信息

控制交尾是蜜蜂育种项目中遗传改良和保护的关键因素。在上一期文章中,我们讨论了控制交尾的四种可选的模式及其相关性,即地理隔离、生物隔离、人工授精和时间隔离。实际上,最后一种模式在近几十年刚刚发展起来,可以作为传统模式的一种替代模式。在本文中,我们更加详细的介绍时间隔离的概念及其变体,这种模式吸引了蜜蜂育种人员和育王人员的高度关注。

关键词：地理隔离时间隔离育王遗传改良替代模式蜜蜂育种交尾人工授精

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时间隔离——控制交尾的替代方案及新发展

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中国蜂业 2024年第6期75卷 26-27页

作者： Aleksandar Uzunov marin Kovacic 段宇杰陈超中国农业科学院蜜蜂研究所资源昆虫高效养殖与利用全国重点实验室北京100193 北马其顿圣基里尔·麦托迪大学农业科学与食品学院斯科普里1000 克罗地亚奥西耶克大学农业生物技术科学学院奥西耶克31000

时间隔离的第二种方法被称为“迷宫”,这个装置可以将蜂王限制在交尾箱中或将其释放。该方法不需要黑暗和寒冷的环境,并且配备该装置的交尾箱可以始终放置在室外。这让蜂农的工作变得更简单,而且由于无需制冷设备,该装置的成本也会较低... 详细信息

时间隔离的第二种方法被称为“迷宫”,这个装置可以将蜂王限制在交尾箱中或将其释放。该方法不需要黑暗和寒冷的环境,并且配备该装置的交尾箱可以始终放置在室外。这让蜂农的工作变得更简单,而且由于无需制冷设备,该装置的成本也会较低。然而,交尾箱需要安装迷宫进行改装。下面简要介绍一下迷宫这种装置以及操作步骤。

关键词：交尾箱时间隔离制冷设备替代方案迷宫操作步骤蜂王蜂农

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New opportunities for light-based tumor treatment with an“iron fist”

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Light(Science & Applications) 2022年第4期11卷 457-459页

作者： Riccardo marin Erving Ximendes Daniel Jaque Nanomaterials for Bioimaging Group(NanoBIG) Departamento de Ffsica de MaterialesFacultad de CienciasUniversidad Aut6noma de MadridMadrid 28030Spain

The efficacy of photodynamic treatments of tumors can be significantly improved by using a new generation of nanoparticles that take advantage of the unique properties of the tumor microenvironment.

关键词： protective light treatment

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A Simple and Efficient Structural Topology Optimization Implementation Using Open-Source Software for All Steps of the Algorithm:Modeling, Sensitivity Analysis and Optimization

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1371-1397页

作者： Rafael marin Ferro Renato Pavanello Coordination of Mechanical Engineering Federal Institute of Science and Technology of ES-IFESAracruz-ES29192-733Brazil Department of Computational Mechanics Faculty of Mechanical EngineeringUnicampCampinas-SP13083-860Brazil

This work analyzes the implementation of a continuous method of structural topology optimization(STO)using open-source software for all stages of the topology optimization problem:modeling,sensitivity analysis and *** implementation involves three main components:numerical analysis using the Finite Element Method(FEM),sensitivity analysis using an Adjoint method and an optimization *** order to allow the automated numerical solution of Partial Differential Equations(PDEs)and perform a sensitivity analysis,FEniCS and Dolfin Adjoint software are used as tools,which are open-source *** the optimization process,Ipopt(Interior Point OPTimizer)is used,which is a software package for nonlinear optimization scale designed to find(local)solutions of mathematical optimization *** topological optimization method used is based on the SIMP-Solid IsotropicMaterial with Penalization *** considered problem is the minimization of compliance/maximization of stiffness,considering the examples of recurrent structures in the literature in 2D and 3D.A density filtering algorithm based on Helmholtz formulation is *** complete code involves 51 lines of programming and is presented and commented in detail in this article.

关键词： Structural topology optimization finite element method FEniCS Dolfin Adjoint

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How we have learned about the complexity of physiology,pathobiology and pharmacology of bile acids and biliary secretion

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World Journal of Gastroenterology 2008年第37期14卷 5617-5619页

作者： Jose JG marin Laboratory of Experimental Hepatology and Drug Targeting CIBERehd University of SalamancaSalamanca 37007 Spain

During the last decades the concept of bile secretion as merely a way to add detergent components to the intestinal mixture to facilitate fat digestion/absorption and to eliminate side products of heine metabolism has evolved considerably. In the series of mini-reviews that the World Journal of Gastroenterology is to publish in its section of ＂Highlight Topics＇; we will intend to give a brief but updated overview of our knowledge in this field. This introductory letter is intended to thank all scientists who have contributed to the development of this area of knowledge in gastroenterology.

关键词： Bile flow Cholestasis Hepatocyte Liver Transport

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Thickness-dependent wrinkling of PDMS films for programmable mechanochromic responses

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Nano Research 2020年第7期13卷 1882-1888页

作者： Zhiwei Li Yun Liu Melinda marin Yadong Yin Department of Chemistry University of CaliforniaRiversideCA 92521USA

We report a remarkable thickness-dependent wrinkling behavior of oxygen plasma-treated polydimethylsiloxane(PDMS)flms,in which an energy barrier separates the wrinkling mechanics into two *** thick films,the film wrinkles with a constant periodicity which can be precisely predicted by the classic nonlinear finite *** the film thickness below 1 mm leads to nonuniform wrinkles with an increasing periodicity which gives rise to random scattering and transparency changes under mechanical *** tuning the flm thickness,we were able to control both the quality and size of the periodic wrinkles and further design mechanochromic devices featuring briliant structural colors and programmable colorimetric *** work sheds light on the fundamental understanding of the wrinkling mechanics of bilayer systems and their intriguing mechanochromic applications.

关键词： wrinkle polydimethylsiloxane(PDMS) structural colors mechanochromic thickness-dependent

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Generating native user interfaces for multiple devices by means of model transformation

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Frontiers of Information Technology & Electronic Engineering 2015年第12期16卷 995-1017页

作者： Ignacio marin Francisco ORTIN German PEDROSA Javier RODRIGUEZ Department of Research and Development CTIC Foundation Department of Computer Science University of Oviedo

In the last years, the types of devices used to access information systems have notably increased using different operating systems, screen sizes, interaction mechanisms, and software features. This device fragmentation is an important issue to tackle when developing native mobile service front-end applications. To address this issue,we propose the generation of native user interfaces(UIs) by means of model transformations, following the modelbased user interface(MBUI) paradigm. The resulting MBUI framework, called LIZARD, generates applications for multiple target platforms. LIZARD allows the definition of applications at a high level of abstraction, and applies model transformations to generate the target native UI considering the specific features of target platforms. The generated applications follow the UI design guidelines and the architectural and design patterns specified by the corresponding operating system manufacturer. The objective is not to generate generic applications following the lowest-common-denominator approach, but to follow the particular guidelines specified for each target device. We present an example application modeled in LIZARD, generating different UIs for Windows Phone and two types of Android devices(smartphones and tablets).

关键词： Model-to-model transformation Native user interfaces Model-based user interfaces Model-driven engineering

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