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Type-B monoamine oxidase inhibitors in neurological diseases:clinical applications based on preclinical findings

Neural Regeneration Research 2024年第1期19卷 16-21页

作者： marika alb.rghetti Edoardo Bianchini Lanfranco De Carolis Silvia Galli Francesco E.Pontieri Domiziana Rinaldi Neurology Unit NESMOS DepartmentFaculty of Medicine&PsychologySapienza-University of RomeSant’Andrea University HospitalRomeItaly Department of Clinical and Behavioral Neurology IRCCS-Fondazione Santa LuciaRomeItaly

Type-B monoamine oxidase inhibitors,encompassing selegiline,rasagiline,and safinamide,are available to treat Parkinson's *** drugs ameliorate motor symptoms and improve motor fluctuation in the advanced stages of the *** is also evidence suppo rting the benefit of type-B monoamine oxidase inhibitors on non-motor symptoms of Parkinson's disease,such as mood deflection,cognitive impairment,sleep disturbances,and *** studies indicate that type-B monoamine oxidase inhibitors hold a strong neuroprotective potential in Parkinson's disease and other neurodegenerative diseases for reducing oxidative stress and stimulating the production and release of neurotrophic factors,particularly glial cell line-derived neurotrophic factor,which suppo rt dopaminergic ***,safinamide may interfere with neurodegenerative mechanisms,countera cting excessive glutamate overdrive in basal ganglia motor circuit and reducing death from *** to the dual mechanism of action,the new generation of type-B monoamine oxidase inhibitors,including safinamide,is gaining interest in other neurological pathologies,and many supporting preclinical studies are now *** potential fields of application concern epilepsy,Duchenne muscular dystrophy,multiple scle rosis,and above all,ischemic brain *** purpose of this review is to investigate the preclinical and clinical pharmacology of selegiline,rasagiline,and safinamide in Parkinson's disease and beyond,focusing on possible future therapeutic applications.

关键词： glial cell line-derived neurotrophic factor(GDNF) glutamate neurological disorders neuroprotection Parkinson's disease preclinical studies rasagiline safinamide selegiline type-B monoamine oxidase(MAO_(B))inhibitors

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Protein-S-100-beta is increased in patients with decompensated cirrhosis admitted to ICU

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Journal of Intensive Medicine 2024年第2期4卷 222-230页

作者： Nicolas Weiss Simona Tripon Maxime Mallet Françoise Imbert-Bismut Mehdi Sakka Dominique Bonnefont-Rousselot Philippe Sultanik Sarah Mouri marika Rudler Dominique Thabut Sorbonne Université AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreDépartement de NeurologieUnitéde Médecine Intensive RéanimationàOrientation NeurologiqueParisFrance Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et Fibro-Inflammatoire du FoieInstitute of Cardiometabolism and Nutrition(ICAN)ParisFrance Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université ParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreService d'hépato-GastroentérologieUnitéde Soins Intensifs d'HépatologieParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéService de Biochimie MétaboliqueHôpitaux Universitaires Pitié-Salpêtrière-Charles FoixDMU BioGeMParis F-75013France UniversitéParis Cité UFR de PharmacieCNRSInsermUTCBSParisFrance

Background Hepatic encephalopathy(HE)is highly prevalent in patients with liver *** pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic ***,some data suggest altered functioning of the blood–brain barrier(BBB).Assessing BBB function is challenging in clinical practice and at the ***-S-100 Beta(PS100-Beta)could be a useful peripheral marker of BBB permeability in *** study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit(ICU)with decompensated cirrhosis with and without overt *** We retrospectively evaluated a prospective cohort of cirrhotic patients admitted to the ICU from October 2013 to September 2015 that had an available plasmatic PS100-Beta *** with previous neurological impairment or limitation of intensive or resuscitative measures were *** HE was defined as West-Haven grades 2 to *** patients were compared to a control cohort of outpatient clinic cirrhotic and non-cirrhotic patients explored for isolated elevation of liver *** ICU discharge,the patients were followed for at least 3 months for the occurrence of overt *** outcomes(liver transplantation or death)were *** ability of PS100-Beta–in combination with other factors–to predict overt HE was evaluated in a multivariate analysis using logistic *** ratios were used to determine the effects and calculate odds ratios(OR).Survival analysis was performed by using the Kaplan–Meier method and survival between groups was compared using a Log-rank *** A total of 194 ICU patients and 207 outpatients were included in the *** levels of plasmatic PS100-Beta were detected in the ICU decompensated cirrhotic patients compared with the outpatients([0.15±0.01]mg/L vs.[0.08±0]mg/L,P<0.001).ICU patients with overt HE had higher levels of PS100-Beta([0.19±0.03]mg/L)compared with the

关键词： Cirrhosis Hepatic encephalopathy Blood-brain barrier PS100-Beta Liver disease

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Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies

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Neural Regeneration Research 2021年第6期16卷 1158-1167页

作者： marika Premoli Maurizio Memo Sara Anna Bonini Department of Molecular and Translational Medicine University of BresciaViale Europa 11BresciaItaly

Mice use ultrasonic vocalizations(USVs)to communicate each other and to convey their emotional *** have been greatly characterized in specific life phases and contexts,such as mother isolation-induced USVs for pups or female-induced USVs for male mice during *** can be acquired by means of specific tools and later analyzed on the base of both quantitative and qualitative ***,different ultrasonic call categories exist and have already been *** understanding of different calls meaning is still missing,and it will represent an essential step forward in the field of *** have long been studied in the ethological context,but recently they emerged as a precious instrument to study pathologies characterized by deficits in communication,in particular neurodevelopmental disorders(NDDs),such as autism spectrum *** review covers the topics of USVs characteristics in mice,contexts for USVs emission and factors that modulate their expression.A particular focus will be devoted to mouse USVs in the context of ***,several NDDs murine models exist and an intense study of USVs is currently in progress,with the aim of both performing an early diagnosis and to find a pharmacological/behavioral intervention to improve patients’quality of life.

关键词： autism spectrum disorders behavioral phenotyping emotional state environmental modulation maternal immune activation mouse models neurodevelopmental disorders social context ultrasonic communication vocalizations classification

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Variceal bleeding in cirrhotic patients

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Gastroenterology Report 2017年第3期5卷 185-192,I0001页

作者： Maxime Mallet marika Rudler Dominique Thabut Unitede Soins Intensifs d’Hepatologie Service d’Hepato-GastroenterologieGroupe Hospitalier Pitie-Salpetriere Charles FoixAssistance Publique-Hopitaux de ParisParisFrance

Variceal bleeding is one of the major causes of death in cirrhotic *** management during the acute phase and the secondary prophylaxis is well *** recommendations(2015 Baveno VI expert consensus)are available and should be followed for an optimal management,which must be performed as an emergency in a liver or general intensive-care *** is based on the early administration of a vasoactive drug(before endoscopy),an antibiotic prophylaxis and a restrictive transfusion strategy(hemoglobin target of 7 g/dL).The endoscopic treatment is based on band *** should be *** the most severe patients(Child Pugh C or B with active bleeding during initial endoscopy),transjugular intrahepatic portosystemic shunt(TIPS)should be performed within 72 hours after admission to minimize the risk of *** prophylaxis is based on the association of non-selective beta-blockers(NSBBs)and repeated band *** should be considered when bleeding reoccurs in spite of a well-conducted secondary prophylaxis or when NSBBs are poorly *** should also be considered when bleeding is *** transplantation should be discussed when bleeding is not controlled after TIPS insertion and in all cases when liver function is deteriorated.

关键词： variceal bleeding cirrhosis endoscopic treatment non-selective beta-blockers transjugular intrahepatic portosystemic shunt liver transplantation

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New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment

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Cellular & Molecular Immunology 2017年第12期14卷 951-953页

作者： Chiara Sorini Ilaria Cosorich marika Falcone Immunology and Allergy Unit Department of MedicineKarolinska InstitutetStockholmSweden Experimental Diabetes Unit-DRI Division of ImmunologyTransplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly

The gut microbiota plays a key role in the pathogenesis of autoimmune diseases such as Type 1 Diabetes(T1D),but the mechanism underlying this modulation is yet to be *** paper highlights the crucial role of the microbiota-induced gut metabolic profile,rather than the presence of single bacterial strains,in T1D *** importantly,it provides the first evidence that dietary interventions can modulate the autoimmune pathogenesis of T1D by altering the gut metabolic environment.

关键词： Diabetes autoimmune pathogenesis

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A machine learning approach to predict response to immunotherapy in type 1 diabetes

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Cellular & Molecular Immunology 2021年第3期18卷 515-517页

作者： Georgia Fousteri Ely Montee Rodrigues Gian Maria Giamporcaro marika Falcone Regulation of Adaptive immunity Unit Transplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Experimental Diabetes Unit Division of ImmunologyTransplantation and Infectious DiseasesDiabetes Research Institute(DRI)IRCCS San Raffaele Scientific InstituteMilanItaly

Type 1 diabetes(T1D)is an autoimmune disease mediated by selfreactive T cells that destroy insulin-producing β cells of the pancreatic islets.1 The disease is a complex multifactorial disorder resulting from a poorly defined interaction between genetic and environmental *** 40-50% of the disease risk is linked to genes,with the remaining risk arising from environmental factors.

关键词： diabetes immunotherapy autoimmune

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Ahmed glaucoma implant and augmented MicroPulse transscleral cyclophotocoagulation in a monocular Axenfeld-Rieger syndrome patient with glaucoma

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1714-1716页

作者： Sanchay Gupta Amy Yuan marika Chachanidze David A.Solá-Del Valle Harvard Medical School BostonMA 02115USA Glaucoma Service Massachusetts Eye and Ear InfirmaryBostonMA 02114USA

Dear Editor,We report the case of severe mixed-mechanism glaucoma observed in a monocular Axenfeld-Rieger syndrome(ARS) patient who was successfully managed with an ahmed glaucoma implant(AGI) followed by a novel technique described as augmented Micro Pulse transscleral cyclophotocoagulation(MP-TSCPC)[1]. ARS encompasses a heterogeneous spectrum of diseases involving anterior segment dysgenesis and systemic developmental anomalies[2].

关键词： glaucoma patient implant

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Glycated haemoglobin (HbA1c) for postmortem diagnosis of diabetes

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Forensic Sciences Research 2018年第2期3卷 170-177页

作者： Delia Lepik Mailis Tonisson Anne Kuudeberg marika Vali Department of Pathological Anatomy and Forensic Medicine Faculty of MedicineInstitute of Biomedicine and Translational MedicineUniversity of TartuTartuEstonia Department of Internal Medicine Faculty of MedicineInstitute of Clinical MedicineUniversity of TartuTartuEstonia Southern Estonian Forensic Medical Examination Department Estonian Forensic Science InstituteTallinnEstonia Management Board Estonian Forensic Science InstituteTallinnEstonia

The study was conducted at the Estonian Forensic Science Institute in 2008-2014 as continuous part of our previous study of alcohol and premature death in Estonian *** data from 504 cases of male deaths (ages 19-79) were collected and blood and urine samples for glycated haemoglobin (HbA1c),liver enzymes and alcohol concentration were *** aim of our research was to find undiagnosed diabetes and diabetes risk cases postmortem on the basis of increased values of ***1c was within the reference value 4.8%-5.9% (29-42 mmol/mol),in 88.1% (n =444) of cases,below reference value in 2.4% (n =12),in the risk group of diabetes,HbA1c 6.0%-6.4% (42-46 mmol/mol) was within 5.8% (n =29),and HbA1c result of ≥6.5% (48 mmol/mol) manifested in 3.8% (n =19) of *** higher the age,the more cases with HbA1c value ≥6.0% (42 mmol/mol) *** the group of external causes of death (n =348),the HbAlc value of ≥6.5% (48 mmol/mol) HbA1c occurred in four *** HbA1c value was ≥6.5% (48 mmol/mol) in 78.9% of 156 cases when the cause of death was disease,of which 58% were cardiovascular *** prevalence of diabetes and diabetes risk was found lower compared to population-based study,as majority of the deceased were young and middle-aged males and no females were *** the case of poisoning with narcotic substances,HbA1c was within the reference range.A negative correlation occurred between alcohol intoxication and HbA1c value.A positive correlation between ALT and HbA1c was found-the higher stage of liver damage correlated with the higher HbA1c level.

关键词： Forensic science forensic pathology postmortem diabetes glycated haemoglobin

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Pyrolysis of WEEE plastics using catalysts produced from fly ash of coal gasification

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Frontiers of Environmental Science & Engineering 2017年第5期11卷 113-123页

作者： marika Benedetti Lorenzo Cafiero Doina De Angelis Alessandro Dell'Era Mauro Pasquali Stefano Stendardo Riceardo Tuffi Stefano Veechio Ciprioti Department for Sustainability ENEA - Casaccia Research Center Via Anguillarese 301 S. Maria di Galeria Rome Italy Department of SBAI Sapienza University of Rome Via del Castro Laurenziano 7 00161 Rome Italy Department of Energy Technologies ENEA Casaccia Research Center Via Anguillarese 301 S. Mafia di Galeria Rome Italy

Catalytic pyrolysis of thermoplastics extracted from waste electrical and electronic equipment （WEEE） was investigated using various fly ash-derived catalysts. The catalysts were prepared from fly ash by a simple method that basically includes a mechanical treatment followed by an acid or a basic activation. The synthesized catalysts were characterized using various analytical techniques. The results showed that not treated fly ash （FA） is characterized by good crystallinity, which in turn is lowered by mechanical and chemical treatment （fly ash after mechanical and acid activation, FAMA） and suppressed almost entirely down to let fly ash become completely amorphous （fly ash al^er mechanical and basic activation FAMB）. Simultaneously, the surface area resulted increased. Subsequently, FA, FAMB and FAMA were used in the pyrolysis of a WEEE plastic sample at 400~C and their performance were compared with thermal pyrolysis at the same temperature. The catalysts principally improve the light oil yield： from 59 wt.% with thermal pyrolysis to 83 wt.% using FAMB. The formation of styrene in the oil is also increased： from 243 mg/g with thermal pyrolysis to 453 mg/g using FAMB. As a result, FAMB proved to be the best catalyst, thus producing also the lowest and the highest amount of char and gas, respectively.

关键词： Waste electrical and electronic equipment(WEEE) plastic mixture Pyrolysis Catalyst Fly asla Oil

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Reliability of R2R-printed, flexible electrodes for e-clothing applications

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npj Flexible Electronics 2020年第1期4卷 117-125页

作者： Rafal Sliz Olli-Heikki Huttunen Elina Jansson Juhani Kemppainen Jyrki Schroderus marika Kurkinen Tapio Fabritius OPEM Unit University of OuluErkki Koiso-Kanttilankatu 390570OuluFinland VTT Technical Research Center of Finland Kaitoväylä190570OuluFinland Polar Electro Oy Professorintie 590440KempeleFinland

Conformable electrodes are essential for the development of flexible electronics or functional clothing,regardless of their *** reliable ability to transfer electric signals or serve as sensing elements in various conditions is vital for the advancement of wearables that will enhance our everyday *** this research,we concentrate our efforts on the understanding of the influence of elongation and washing on roll-to-roll printed conductive electrodes of various shapes and materials.A large sample set provides data on the breaking mechanisms and how these affect the electrical properties of the *** addition,the physicochemical analysis offers insights into the electrodes’and materials’behavior in extreme conditions during elongation and washing *** achieved results indicate auspicious nanoparticle shapes and sizes as well as evidence regarding micro-scale breaking mechanisms responsible for electrodes *** of commercially available materials and roll-to-roll printing techniques allow the seamless application of achieved results and the creation of more reliable,flexible electronic devices.

关键词： breaking Reliability extreme

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