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Antihypertensive Effect of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-like Peptide 1 Receptor Agonists

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Cardiology Discovery 2024年第1期4卷 38-42页

作者： marijana Tadic Cesare Cuspidi Klinik für Innere Medizin II Universitätsklinikum UlmUlm 89081Germany Department of Medicine and Surgery University of Milano-BicoccaMilano 20126Italy

An increasing body of evidence shows that new antidiabetic drugs—particularly sodium-glucose cotransporter 2(SGLT2)inhibitors and glucagon-like peptide 1(GLP-1)receptor agonists—have a beneficial effect on cardiovascular *** majority of these studies have been performed in patients with heart failure and the results have shown first positive effect on blood pressure(BP)*** effects are more pronounced with SGLT2 inhibitors than with GLP-1 receptor ***,the reasons and mechanisms of action inducing BP reduction are still not sufficiently *** mechanisms of SGLT2 inhibitors involve the natriuretic effect,modification of the renin-angiotensin-aldosterone system,and/or the reduction in the sympathetic nervous ***-1 receptor agonists have several mechanisms that are related to glycemic,weight,and BP *** data show that SGLT2 inhibitors have a stronger antihypertensive effect than GLP-1 receptor agonists,which is mainly related to their renal ***,SGLT2 inhibitors increase the response to diuretics and decrease the meal-related antinatriuretic pressure by lowering post-prandial hyperglycemia and hyperinsulinemia and prevent proximal sodium ***2 inhibitors can be used as second-line therapy in patients with diabetes mellitus or heart disease and concomitant *** article aims to summarize current knowledge regarding the antihypertensive effect of SGLT2 inhibitors and GLP-1 receptor agonists.

关键词： Hypertension Sodium-glucose cotransporter 2 inhibitors Glucagon-like peptide 1 receptor agonists Blood pressure

Pharmacological methods for ovarian function and fertility preservation in women with cancer:A literature review

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Oncology Research 2024年第8期32卷 1309-1322页

作者： ANA S.CVETANOVIC MATTEO LAMBERTINI KEVIN PUNIE GORANA G.MATOVINA BRKO NIKOLA D.ZIVKOVIC MAJA J.POPOVIC marijana M.MILOVIC KOVACEVIC LAZAR S.POPOVIC Department for Oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of Oncology University Clinical Centre NisNis18000Serbia Department of Internal Medicine and Medical Sciences(DiMI) School of MedicineUniversity of GenovaGenova16100Italy Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy Department of General Medical Oncology and Multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium Department of Medical Oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia Department for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of Medicine University of Novi SadNovi Sad21000Serbia Department of Medical Oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is an extremely signiﬁcant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but signiﬁcantly contributes to preserving life *** effect of chemotherapy can range from minimal effects to complete ovarian *** data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and *** ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufﬁciency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian ***,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological ***,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor *** addition,studies on hematological malignancies have yielded negative results;nevertheless,theﬁndings must be interpreted with caution owing to numerous *** guidelines from the American Society of Clinical Oncology and ESMO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not *** this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisﬁeld

关键词： Gonadotropin-releasing hormone agonists(GnRHa) Fertility preservation Premature ovarian insufficiency(POI) Premenopausal patients

Global warming scenarios for the Eastern Adriatic Sea indicate a higher risk of invasiveness of non-native marine organisms relative to current climate conditions

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Marine Life Science & Technology 2024年第1期6卷 143-154页

作者： Branko Glamuzina Lorenzo Vilizzi Marina Piria Ante Zuljevic Ana Bratos Cetinic Ana Pesic Branko Dragicevic Lovrenc Lipej marijana Pecarevic Vlasta Bartulovic Sanja Grđan Ivan Cvitkovic Tatjana Dobroslavic Ana Fortic Luka Glamuzina Borut Mavric Jovana Tomanic Marija Despalatovic Domen Trkov Marina Brailo Scepanovic Zoran Vidovic Predrag Simonovic Sanja Matic-Skoko Pero Tutman Department of Applied Ecology University of DubrovnikDubrovnikCroatia Department of Ecology and Vertebrate Zoology Faculty of Biology and Environmental ProtectionUniversity of LodzLodzPoland Faculty of Agriculture Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebZagrebCroatia Institute of Oceanography and Fisheries SplitCroatia Institute of Marine Biology University of MontenegroKotorMontenegro National Institute of Biology Marine Biology Station PiranPiranSlovenia Teacher Education Faculty University of BelgradeBelgradeSerbia Faculty of Biology University of BelgradeBelgradeSerbia

Globally,marine bioinvasions threaten marine ecosystem structure and function,with the Mediterranean Sea being one of the most affected *** invasions are expected to increase due to climate *** conducted a risk screening of marine organisms(37 fishes,38 invertebrates,and 9 plants),both extant and‘horizon’(i.e.,not present in the area but likely to enter it).Based on expert knowledge for the Eastern Adriatic Sea coasts of Slovenia,Croatia,and Montenegro,screenings were conducted under both current and predicted climate conditions indicating with an increase in sea surface temperature and salinity of the Adriatic Sea together with changes in precipitation *** aims were to:(1)identify non-native extant and horizon marine species that may pose threats to native biodiversity and(2)evaluate the risk of invasiveness of the selected species under current and predicted climate *** the 84 species screened,there was an increase in those ranked as‘high risk’from 33(39.3%)under current climate conditions and to 47(56.0%)under global warming *** those ranked as‘very high’risk,the increase was from 6(7.1%)to 21(25.0%).Amongst the screened species,the already established high-risk species Pacific oyster Magallana gigas and Atlantic blue crab Callinectes sapidus represent a threat to ecosystem *** the under-representation of marine species in the current European Union List,the species we have ranked as high to very high risk should be included.

关键词： AS-ISK Early detection Introduction vectors/pathways Invasive species Rapid response

Update on biomarkers of glycemic control

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World Journal of Diabetes 2019年第1期10卷 1-15页

作者： Maja Krhac marijana Vucic Lovrencic Division of Laboratory Medicine Department of Medical Biochemistry and Laboratory Medicine Merkur University Hospital

Attaining and maintaining good glycemic control is a cornerstone of diabetes care. The monitoring of glycemic control is currently based on the self-monitoring of blood glucose(SMBG) and laboratory testing for hemoglobin A1 c(HbA1 c),which is a surrogate biochemical marker of the average glycemia level over the previous 2-3 mo period. Although hyperglycemia is a key biochemical feature of diabetes, both the level of and exposure to high glucose, as well as glycemic variability, contribute to the pathogenesis of diabetic complications and follow different patterns in type 1 and type 2 diabetes. HbA1 c provides a valuable,standardized and evidence-based parameter that is relevant for clinical decision making, but several biological and analytical confounders limit its accuracy in reflecting true glycemia. It has become apparent in recent years that other glycated proteins such as fructosamine, glycated albumin, and the nutritional monosaccharide 1,5-anhydroglucitol, as well as integrated measures from direct glucose testing by an SMBG/continuous glucose monitoring system, may provide valuable complementary data, particularly in circumstances when HbA1 c results may be unreliable or are insufficient to assess the risk of adverse outcomes. Long-term associations of these alternative biomarkers of glycemia with the risk of complications need to be investigated in order to provide clinically relevant cut-off values and to validate their utility in diverse populations of diabetes patients.

关键词： Diabetes mellitus Hemoglobin A1c Fructosamine Glycated albumin 1,5anhydroglucitol Plasma glucose Glucose variability Diabetic complications

Cardiac Lymphoma： After the Hurricane

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Chinese Medical Journal 2017年第19期130卷 2391-2392页

作者： marijana Tadic Sabine HaSleld Burket Pieske Martin Genger Department of Cardiology Charite-University-Medicine Berlin 13353 Germany Deutsches Zentrum for Herz-Kreislauf-Forschung Berlin 13353 Germany Department of Cardiology Deutsches Herzzentrum Berlin Berlin 13353 Germany

A71-year-old male patient with symptoms and signs of right heart failure was presented. Echocardiographic examination revealed a large tumor mass infiltrating predominantly the right atrium （RA）, tricuspid valve, an... 详细信息

关键词： CELL LYMPHOMA BLOCK

Atypical Cogan＇s syndrome associated with coronary disease

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Chinese Medical Journal 2011年第19期124卷 3192-3194页

作者： Ivanovic Branislava Tadic marijana Damjanov Nemanja Simic Dragan Zlatanovic Maja Clinic for Cardiology Clinical Centre of Serbia Belgrade 11000 Serbia Institute of Rheumatology Belgrade 11000 Serbia

Cogan＇s syndrome （CS） is a rare inflammatory disorder characterized by interstitial keratitis and vestibuloauditory abnormalities often associated with various systemic manifestations. Involvement of cardiovascular system resembling systemic vasculitis may lead to severe complications and death. The present report describes a case of a female patient with atypical Cogan＇s syndrome presented with systemic manifestations and severe coronary and femoral artery stenosis Despite the clinical improvement after glucocorticoids and cyclophosphamide, the patient required double aortocoronal bypass grafting one year letter. During three years follow-up, she was in stable condition, without stenocardial symptoms and claudication and her inflammatory parameters remain normal. This case highlights the rare involvement of coronary arteries without associated large-vessel vasculitis of the aortic arch in CS.

关键词： Cogan's syndrome hearing loss coronary artery disease

Investigation of chlorinated phenols sorption mechanisms on different layers of the Danube alluvial sediment

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Journal of Environmental Sciences 2020年第12期32卷 134-142页

作者： Tamara Apostolovic Jelena Trickovic marijana Kragulj Isakovski Branislav Jovic Snežana Maletic Aleksandra Tubic Jasmina Agbaba University of Novi Sad Faculty of SciencesDepartment of ChemistryBiochemistry and Environmental ProtectionTrg Dositeja Obradovica 3Novi SadSerbia

The characteristics of the Danube river alluvial sediment are of great importance in assessing the risk for transport of pollutants to drinking water sources. Characterization of the sediment column layers has shown that the alluvial sediment, sampled near the city of Novi Sad, is a mesoporous sandy material with certain differences in the properties of individual layers. In order to investigate the sorption mechanisms of four chlorinated phenols(CPs) on the alluvial deposit, static sorption experiments were performed at pH 4, 7 and 10. The results of sorption experiments, confirmed by principal components analysis sugest different mechanisms govern the sorption process at different p H conditions. This can be attributed to the molecular characteristics of CPs, geosorbent properties and to variations in the surface charge of the sorbent at different p H conditions.

关键词： Sorption mechanisms Chlorinated phenols Alluvial sediment Principal component analysis

Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics

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Cancer Biology & Medicine 2019年第2期16卷 247-263页

作者： Jelena Grahovac Tatjana Srdic-Rajic Juan Francisco Santibanez marijana Pavlovic Milena Cavic Sinisa Radulovic1 Laboratory for Experimental Pharmacology Institute for Oncology and Radiology of Serbia Belgrade 11000 Serbia Department of Molecular Oncology Institute for Medical Research University of Belgrade Belgrade 11000 Serbia Integrative Center for Biology and Applied Chemistry (CIBQA) Bernardo O'Higgins University Santiago 8370854 Chile

Objective: Despite recent advancements in targeted therapy and immunotherapies, prognosis for metastatic melanoma patients remains extremely poor. Development of resistance to previously effective treatments presents a serious challenge and new approaches for melanoma treatment are urgently needed. The objective of this study was to examine the effects of telmisartan, an AGTR1 inhibitor and a partial agonist of PPARγ, on melanoma cells as a potential agent for repurposing in melanoma ***: Expression of AGTR1 and PPARγ m RNA in melanoma patient tumor samples was examined in publicly available datasets and confirmed in melanoma cell lines by qRT-PCR. A panel of melanoma cell lines was tested in viability, apoptosis and metabolic assays in presence of telmisartan by flow cytometry and immunocytochemistry. A cytotoxic effect of combinations of telmisartan and targeted therapy vemurafenib was examined using the Chou-Talalay combination index ***: Both AGTR1 and PPARγ mRNA were expressed in melanoma patient tumor samples and decreased compared to the expression in the healthy skin. In vitro, we found that telmisartan decreased melanoma cell viability by inducing cell *** glucose uptake, but not utilization, in the presence of telmisartan caused the fission of mitochondria and release of reactive oxygen species. Telmisartan altered the cell bioenergetics, thereby synergizing with vemurafenib in vitro, and even sensitized vemurafenib-resistant cells to the ***: Given that the effective doses of telmisartan examined in our study can be administered to patients and that telmisartan is a widely used and safe antihypertensive drug, our findings provide the scientific rationale for testing its efficacy in treatment of melanoma progression.

关键词： Melanoma telmisartan apoptosis mitochondria reactive oxygen species targeted therapy

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微生物对混凝土的侵蚀(英文)

硅酸盐学报 2010年第9期38卷 1741-1745页

作者： DUBRAVKA Bjegovic marijana Serdar IGOR Cigrovski Faculty of Civil Engineering University of Zagreb Zagreb 10000 Croatia Institut IGH Zagreb 10000 Croatia

微生物侵蚀会导致混凝土的严重破坏,尤其导致了城市污水收集和处理系统的过早破坏,使其需要提前修复。世界范围内的研究结果表明:处于污水和下水道污泥中的混凝土会遭受由硫酸盐、酸、CO2等导致的严重破坏。评述了混凝土处于利于细菌生... 详细信息

微生物侵蚀会导致混凝土的严重破坏,尤其导致了城市污水收集和处理系统的过早破坏,使其需要提前修复。世界范围内的研究结果表明:处于污水和下水道污泥中的混凝土会遭受由硫酸盐、酸、CO2等导致的严重破坏。评述了混凝土处于利于细菌生长和生物降解环境中时的细菌、微生物侵蚀破坏过程。此外还分析了硫酸产生的机理(硫循环)、用于污水管道系统和农用工业的混凝土的受侵蚀破坏机理以及评价混凝土抵抗微生物侵蚀的方法。

关键词：混凝土的微生物侵蚀混凝土的破坏微生物细菌废水硫酸盐