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Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157,L-NAME and L-arginine

World Journal of Gastroenterology 2018年第48期24卷 5462-5476页

作者： Domagoj Drmic Mariam Samara Tinka Vidovic Dominik Malekinusic Marko Antunovic Borna Vrdoljak Jelena Ruzman marija milkovic perisa Katarina Horvat Pavlov Jerusha Jeyakumar Sven Seiwerth Predrag Sikiric Departments of Pharmacology and Pathology Medical Faculty University of Zagreb

AIM To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide(NO) system *** Alongside with the agents' application(after 1 min, medication(/kg, 10 ml/2 min bath/rat) includes: BPC 157(10 μg), L-NAME(5 mg), L-arginine(100mg) alone or combined, and saline baths(controls)) on the rat perforate cecum injury, we continuously assessed the gross reappearance of the vessels(USB microcamera) quickly propagating toward the defect at the cecum surface, defect contraction, bleeding attenuation, MDA-and NO-levels in cecum tissue at 15 min, and severity of cecum lesions and adhesions at 1 and 7 d. RESULTS Post-injury, during/after a saline bath, the number of vessels was significantly reduced, the defect was slightly narrowed, bleeding was significant and MDA-levels increased and NO-levels decreased. BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA-and NO-levels remained normal. L-NAME: reduced vessel presentation but not more than the control, did not change defect and shortened bleeding. L-arginine: exhibited less vessel reduction, did not change the defect and prolonged bleeding. In combination, mutual counteraction occurred(L-NAME + L-arginine) or the presentation was similar to that of BPC 157 rats(BPC 157 + L-NAME; BPC 157 + L-arginine; BPC 157 + L-NAME + L-arginine), except the defect did not change. Thereby at day 1 and 7, saline, L-NAME, L-arginine and L-NAME + L-arginine failed(defect was still open and large adhesions present). CONCLUSION The therapeutic effect was achieved with BPC 157 alone or in combination with L-NAME and L-arginine as it was able to consolidate the stimulating and inhibiting effects of the NO-system towards more effective healing recruiting vessels.

关键词： BPC 157 perforated cecum L-arginine L-NAME vessels rats

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Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine

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World Journal of Gastroenterology 2018年第47期24卷 5366-5378页

作者： Fedor Amic Domagoj Drmic Zdenko Bilic Ivan Krezic Helena Zizek Marina Peklic Robert Klicek Alen Pajtak Enio Amic Tinka Vidovic Mislav Rakic marija milkovic perisa Katarina Horvat Pavlov Antonio Kokot Ante Tvrdeic Alenka Boban Blagaic Mario Zovak Sven Seiwerth Predrag Sikiric Department of Pharmacology Medical Faculty University of Zagreb Department of Pathology Medical Faculty University of Zagreb

AIM To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide(NO) system *** Male Wistar rats underwent superior anterior pancreaticoduodenal vein(SAPDV)-ligation and were treated with a bath at the ligated SAPDV site(BPC 157 10 μg, 10 ng/kg per 1 mL bath/rat; L-NAME 5 mg/kg per 1 m L bath/rat; L-arginine 100 mg/kg per 1 mL bath/rat, alone and/or together; or BPC 157 10 μg/kg instilled into the rat stomach, at 1 min ligation-time). We recorded the vessel presentation(filled/appearance or emptied/disappearance) between the 5 arcade vessels arising from the SAPDV on the ventral duodenum side, the inferior anterior pancreaticoduodenal vein(IAPDV) and superior mesenteric vein(SMV) as bypassing vascular pathway to document the duodenal lesions presentation; increased NO-and oxidative stress [malondialdehyde(MDA)]-levels in *** Unlike the severe course in the SAPDV-ligated controls, after BPC 157 application, the rats exhibited strong attenuation of the mucosal lesions and serosal congestion, improved vessel presentation, increased interconnections, increased branching by more than 60% from the initial value, the IAPDV and SMV were not congested. Interestingly, after 5 min and 30 min of L-NAME and L-arginine treatment alone, decreased mucosal and serosal duodenal lesions were observed; their effect was worsened at 24 h, and no effect on the collateral vessels and branching was seen. Together, L-NAME+L-arginine antagonized each other's response, and thus, there was an NO-related effect. With BPC 157, all SAPDV-ligated rats receiving L-NAME and/or L-arginine appeared similar to the rats treated with BPC 157 alone. Also, BPC 157 in SAPDV-ligated rats normalized levels of NO and MDA, two oxidative stress markers, in duodenal *** BPC 157, rapidly bypassing occlusion, rescued the original duodenal flow through IAPDV to SMV flow, aneffect related to the NO system and

关键词： Major venous occlusion Duodenal lesions BPC 157 L-NAME Bypassing L-arginine Reduction of free radical formation Rats

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Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions

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Neural Regeneration Research 2022年第11期17卷 2325-2334页

作者： Milena Stevanovic Danijela Stanisavljevic Ninkovic marija Mojsin Danijela Drakulic marija Schwirtlich Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeBelgradeSerbia University of Belgrade Faculty of BiologyBelgradeSerbia Serbian Academy of Sciences and Arts BelgradeSerbia

Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain *** SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial *** represent a class of small non-coding RNAs that play important roles in the regulation of gene *** with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for *** emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult *** SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and *** strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of *** in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological *** focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.

关键词： dysregulation of miRNA expression glioblastoma gliogenesis glioma stem cells ischemic stroke neural stem cells neural tissue regeneration neurodegenerative diseases neurodevelopment neurogenesis SOX/miRNA interplay traumatic brain injury

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Removal of humic substances by biosorption

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Journal of Environmental Sciences 2008年第12期20卷 1423-1428页

作者： VUKOVI marija DOMANOVAC Tomislav BRIKI Felicita Division of Industrial Ecology Faculty of Chemical Engineering and TechnologyUniversity of ZagrebMaruliev trg 19HR 10000 ZagrebCroatia IPZ Uniprojekt Terra Babonieva 32HR 10000 ZagrebCroatia

Fungal pellets of Aspergillus niger 405,Aspergillus ustus 326,and Stachybotrys sp.1103 were used for the removal of humic substances from aqueous *** biosorption,carried out at pH 6 and 25°C,was monitored spectrophotometrically and the process described with Freundlich’s *** sorption coeffcients Kf and n showed that *** exhibited the highest effciency.A good match between the model and experimental data and a high correlation coeffcient(R2)pointed out to judicious choice of ...

关键词： biosorption humic substances fungal pellets aqueous solution desorption

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Short-circuit Analysis in Large-scale Distribution Systems With High Penetration of Distributed Generators

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IEEE/CAA Journal of Automatica Sinica 2017年第2期4卷 243-251页

作者： Luka V.Strezoski marija D.Prica IEEE Case School of Engineering Case Western Reserve University

In this paper a short-circuit computation(SCC) procedure for large-scale distribution systems with high penetration of distributed generators based on contemporary technologies is proposed. The procedure is suitable for real-time *** of modern distributed generators differs from the modeling of traditional synchronous and induction ***, SCC procedures found on the presumption of distribution systems with only traditional generators are not suitable in nowadays systems. In the work presented in this paper, for computation of the state of the system with short-circuit, the improved backward/forward sweep(IBFS) procedure is *** results show that the IBFS procedure is much more robust than previous SCC procedures, as it takes into account all distribution system elements, including modern distributed generators.

关键词： Distributed generation(DG) distribution system distribution management system(DMS) short-circuit computation

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On cancer,stemness,and deep evolutionary homologies

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Genes & Diseases 2023年第4期10卷 1143-1144页

作者： Zoran Ivanovic marija Vlaski-Lafarge Research Department New Aquitaine Branch of French Blood Institute(EFS)BordeauxCS***France

Recently,Niculescu published an interesting paper^(1)con-cerning“deep homologies”between the formation of cancer stem cells by polyploidization and reproductive polyploidization of *** life cycle of both sys-tems shares the same genetic machinery inherited from the Last Eukaryote Common Ancestor(LECA).This theory claims that cancer is nothing more than the expression of a pre-existing life cycle that was reactivated in“sick and weakened metazoan cell that cannot continue its multi-cellular life and finds itself in the same dead-end situation”.

关键词： cancer homolog nothing

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EFFECTS OF SPECTRAL DEPENDENCE IN PASS-THROUGH PHOTON-BASED BIOMEDICAL TRANSILLUMINATION

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 235-244页

作者： PAULINO VACAS-JACQUES marija STROJNIK GONZALO PAEZ Centro de Investigaciones en Optica Apartado Postal 1-94837000LeonGuanajuatoMexico

We have proposed an interferometric setup for biomedical analysis in transillumination *** dependence of optical properties must be considered for selecting source and sam*** expansion of the sample optical properties,around the central wavelength of emission,serves to account for spectral *** spectral values depend on the central moments of the source,and specific constants associated to the optical properties of the *** matching wavelength characteristics of source and sample,a first-order approximation is *** such case,the expected values are exactly the optical properties evaluated at the central ***,in the first-order approximation,the transillumination interferometer yields the integrated attenuation of the sample at the central wavelength of *** verify the latter assertion by performing a wavelength-dependent Monte Carlo analysis to calculate the response of the transillumination *** attenuation coefficients,for imaging and characterization scenarios,are in agreement with the value computed at the central wavelength of the source.

关键词： Transillumination wavelength-dependent Monte Carlo tissue characterization tissue imaging.

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Sustainable tourism development in mountain areas in Sumadija and Western Serbia

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Journal of Mountain Science 2021年第3期18卷 735-748页

作者： MILICEVIC Snezana BOSKOVIC Nikola LAKICEVIC marija University of Kragujevac Faculty of Hotel Management and Tourism in Vrnjadka BanjaVojvodanska 5AVrnjadka Banja 36210Serbia University of Kragujevac Faculty of EconomicsLiceja Knezevine Srbije 3Kragujevac 34000Serbia

Sustainable tourism,as an integral part of sustainable development,emerged as a logical outcome of preventing the uncontrolled and excessive use of tourism resources and *** study analyzes whether mountain tourism development in Serbia can be sustainable and feasible in the long *** the heterogeneity of mountains in Serbia in terms of tourism development,the subject of this research is the achieved level of sustainable tourism development in mountains in the most developed and most visited region in Serbia-sumadija and Western Serbia:Zlatibor,Kopaonik,Tara,Zlatar,Mokra Gora and Go?.The sustainable tourism development level was analyzed by using five groups of the EU’s comparative indicators:economic,social,cultural,environmental and tourist satisfaction *** results showed that the development of tourism in the examined mountains is not fully aligned with sustainable *** tourist satisfaction indicator has the most acceptable values,which is a good basis for further harmonization of tourism development on the principles of *** indicators,especially the ratio of overnight stays and accommodation capacities,show the most unacceptable values,which indicate the need for implementing changes in the process of tourism development in the coming *** analysis of sustainable tourism in mountain areas in sumadija and the Western Serbia undoubtfully points out that it is necessary to significantly change the current tourism product portfolio,which implies harmonizing mountain tourism development with global ***,a comparative analysis that looks at the degree of sustainability of mountain tourism in some countries of the Alpine region,such as Switzerland,Austria and Slovenia,contributes to *** more intensive development of tourism throughout the year would significantly improve indicators of sustainable tourism in all analyzed mountain areas of Sumadija and Western *** would improve the

关键词： Sustainable tourism development Mountains Tourism effects Sustainability indicators Sumadija and Western Serbia

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Prediction of the surface roughness of wood for machining

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Journal of Forestry Research 2017年第6期28卷 1271-1273页

作者： Damjan Stanojevic marija Mandic Gradimir Danon Srdjan Svrzic High School Applied Professional Studies Filipa Filipovica 20 Vranje 17500 Serbia Faculty of Forestry University of Belgrade Kneza Viseslava 1 Belgrade 11000 Serbia

The surface quality of solid wood is very important for its effective response in manufacturing processes. The effects of feed rate, cutting depth and rake angle on surface roughness and power consumption were investigated and modeled. Neuro-fuzzy methodology was applied and shown that it could be useful, reliable and an effective tool for modeling the surface roughness of ***, the results of the present research can be successfully applied in the wood industry to reduce time, energy and high experimental costs.

关键词： Neuro-fuzzy Forecasting Surface roughness Wood Prediction

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Prevalence and Factors Associated with Depression, Anxiety and Stress in IBD Patients Undergoing Intravenous Biological Therapy during the COVID-19 Pandemic-Montenegro Experience

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International Journal of Mental Health Promotion 2022年第4期24卷 551-564页

作者： Brigita Smolović marijaĐurović MilošLukić marija Abramović Damir Muhović Department of Gastroenterohepatology Clinic for Internal MedicineClinical Center of MontenegroPodgorica81000Montenegro Faculty of Medicine University of MontenegroPodgorica81000Montenegro Clinic of Radiology Clinical Center of MontenegroPodgorica81000Montenegro

Throughout its duration,the coronavirus disease 2019(COVID-19)pandemic has been affecting lives worldwide and has had a sizeable impact on mental health,particularly for those who already suffer from a chronic ***,Anxiety and Stress(DAS)are common psychiatric comorbidities in inﬂammatory bowel disease(IBD)*** study aims to determine the prevalence and risk factors for moderate and severe symptoms of DAS in IBD patients have been undergoing intravenous biological therapy(IvBTh)during the COVID-19 *** study was conducted between September 1st and November 30th,2020 at the Clinical Center of Mon-tenegro-IBD unit,where all patients from Montenegro received the registered *** case control study consists of 94 IBD patients that completed a validated questionnaire Depression,Anxiety and Stress Score-21(DASS-21).A total of 59 patients received tumor necrosis factor alpha inhibitors(anti-TNF therapy),while 35 received anti-integrin *** we calculated the DASS-21 score,we divided the patients into two groups:those who had moderate and severe symptoms(if they had any of the mentioned DASS-21 subscale score above limit for moderate or more severe symptoms:DASS-21 Depression,higher than 14;DASS-21 Anxiety,higher than 10 and DASS-21 Stress,higher than 19)and those who did not have signiﬁcant symptoms(DASS-21 subscale score did not exceed the limit).We also examined demographic data,data on IBD characteristics and COVID-19 data and their impact on mental *** statistical processing tests were used to identify risk factors for examined mental *** the DASS-21 criteria,we diagnosed the least moderate depression in 19.1%,anxiety in 14.9%and stress in 20.2%*** multivariate analysis indicated there to be a statistically signiﬁcant relation of being higher at risk of developing depression,anxiety and stress when suffering from an active form of IBD(OR 6.487;95%Cl 1.220–34.500,P=0.028).Almost one t

关键词： Inflammatory bowel disease depression anxiety stress COVID-19

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