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Complexation Properties and Synthesis of 1,2-Bis(2 ,2' -bipyridinyl)ethylene and 1,2-Bis(2,2' -bipyridinyl)ethane Ligands with Cu(I)

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Chemical Research in Chinese Universities 1990年第3期6卷 183-187页

作者： He Yongbing and Lehn Jean-marie (Institut Le Bel,Universite Louis Pasleur, A, rue Blaise Pascal, 67000 Strasbourg, france) Department of Chemistry, Wuhan University, Wuhan.

l,2-Bis(2,2'-bipyridinyl)ethylene(1) ligand was synthesized by Wittig-Horner reaction and 1, 2-Bis(2, 2'-bipyridinyl)ethane(2) ligand(which can be obtained via another route ) was prepared by hydrogenation of (1). The formation of complexes of (1) and (2) with copper (I) has been studied. The influence of the different bridge chains (CH =CH, CH2CH2) on complexation is discussed on the basis of 1H NMR spectra. Keywords Dipyridine aldehyde, Dipyridine derivative, Copper complex

关键词： BP Complexation Properties and Synthesis of 1,2-Bis bipyridinyl)ethylene and 1,2-Bis bipyridinyl)ethane Ligands with Cu

Circadian rhythms in the pathogenesis of gastrointestinal diseases

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World Journal of Gastroenterology 2018年第38期24卷 4297-4303页

作者： Pilar Codonr-Franch marie Gombert Department of Pediatrics Obstetrics and GinecologyUniversity of ValenciaValencia 46010Spain Department of Pediatrics Dr.Peset University HospitalValencia 46017Spain Department of Biotechnology University of La RochelleLa Rochelle 17000France

The etiology of digestive pathologies such as irritable bowel syndrome(IBS), inflammatory bowel diseases(IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved in digestive health. In situations of disturbed circadian rhythms(chronodisruption) where the central clock and the peripheral clocks receive incoherent signals, the synchronicity is lost producing implications for health. This lack of coordination could alter the tissue function and cause long term damage to the organs. Life habits such as sleep, physical exercise, social interaction, and feeding times are determinants for stability and integrity of circadian rhythms. In recent years, experimental and clinical studies have consistently evidenced that the alteration of circadian rhythms is associated with the development of digestive pathologies mainly linked to dismotility or changes in microbiota composition. Likewise, it seems reasonable to deep into the importance of chronodisruption as a factor that may participate in the development of pathologies such as IBS, IBD and digestive cancers. Moreover, life habits respecting circadian rhythms should be promoted for the prevention of these diseases. Further studies will allow us a better understanding of the mechanisms acting at molecular level, and the development of new therapeutic targets.

关键词： Circadian rhythms Gastrointestinal diseases Irritable bowel syndrome Inflammatory bowel disease Digestive cancers

Maintenance of radiation-induced intestinal fibrosis:Cellular and molecular features

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World Journal of Gastroenterology 2007年第19期13卷 2675-2683页

作者： Valérie Haydont marie-Catherine Vozenin-Brotons UPRES EA 27-10 "Radiosensibilité des tumeurs et tissus sains" Institut de Radioprotection et de Sreté Nucléaire/Institut Gustave Roussy. Villejuif Laboratoire de Radiopathologie. SRBE/DRPH. Institut de Radioprotection et de Sreté Nucléaire Fontenay-aux-Roses France

Recent advances in cell and molecular radiobiology clearly showed that tissue response to radiation injury cannot be restricted to a simple cell-killing process, but depends upon continuous and integrated pathogenic processes, involving cell differentiation and crosstalk between the various cellular components of the tissue within the extracellular matrix. Thus, the prior concept of primary cell target in which a single-cell type （whatever it＇s epithelial or endothelial cells） dictates the whole tissue response to radiation injury has to be replaced by the occurrence of coordinated multicellular response that may either lead to tissue recovery or to sequel development. In this context, the present review will focus on the maintenance of the radiation-induced wound healing and fibrogenic signals triggered by and through the microenvironment toward the mesenchymal cell compartment, and will highlight how sequential and sustained modifications in cell phenotypes will in cascade modify ceU-to-ceU interactions and tissue composition.

关键词： Radiotherapy Fibrosis Fibrogenic differentiation TGF-131 CCN2 Smad Rho ROCK Actincytoskeleton

Synthesis of a novel macrocyclic ligand containing bipyridine units

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Chinese Journal of Chemistry 2000年第3期18卷 384-387页

作者：何永炳 LEHN Jean-marie Department of Chemistry Wuhan University Wuhan Hubei 430072 China

The 6-hydroxymethyl-6'-tetrahydropyranyloxymethyl-2, 2'-bipyridine (2) was synthesized by the reaction of 6,6'-dihydroxymethyl-2, 2'-bipyridine (1) with 3, 4-dihydroxypyran (DHP). ***-6'-iodomethyl-2, 2'-bipyridine (5) was obtained from mesylate and iodizating reaction of compound 2. The coupling of 2 and 5 followed by hydrolysis gave bis(6'-hydroxymethyl-2, 2'-bipyridine-6-methyl) ether (7). The macrocyclic ligand 8 was obtained by treating 7 and 6, 6'-dibromethyl-2, 2'-bipyridine. The synthetic conditions of the intermediate 2 and macocyclic ligand 8 were discussed.

关键词： azacrown ether bipyridine derivative macrocyclic ligand

Displacement manifold method for type synthesis of lower-mobility parallel mechanisms

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Science China(Technological Sciences) 2004年第6期47卷 641-650页

作者： LI Qinchuan HUANG Zhen Jacques marie Hervé Center of Integration Engineering Zhejiang University of SciencesHangzhou 310033China Robotics Research Center Yanshan UniversityQinhuangdao 066004China Ecole Centrale Paris France

Type synthesis of lower-mobility parallel mechanisms is a hot and frontier topic in international academic and industrial field. Based on the Lie group theory, a displacement manifold synthesis method is proposed. For all the nine kinds of lower-mobility parallel mechanisms, the mechanism displacement manifold, limb displacement manifold and the geometrical conditions which guarantee that the intersection of the limb displacement manifold is the desired mechanism displacement manifold are enumerated. Various limb kinematic chains can be obtained using the product closure of displacement subgroup. Parallel mechanisms can be constructed with these limbs while obeying the geometrical conditions. Hence, all the nine kinds of lower-mobility parallel mechanisms can be synthesized using this method. Since displacement manifold deals with finite motion, the result mechanism of synthesis have full-cycle mobility. Novel architectures of lower-mobility parallel mechanisms can be obtained using this method.

关键词： lower-mobility parallel mechanisms Lie group displacement manifold type synthesis

A formal approach using SysML for capturing functional requirements in avionics domain

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Chinese Journal of Aeronautics 2019年第12期32卷 2717-2726页

作者： Shaofan ZHU Jian TANG Jean-marie GAUTHIER Raphael FAUDOU Beijing Aeronautical Science and Technology Research Institute COMACBeijing 102211China Samares-Engineering Blagnac 31700France

In this work,a Model-Based Systems Engineering approach based on Sys ML is *** approach is used for the capture and the definition of functional requirements in avionics *** motivation of this work is triple:guide the capture of functional requirements,validate these functional requirements through functional simulation,and verify efficiently the consistency of these functional *** proposed approach is decomposed into several steps that are detailed to go from conceptual model of avionics domain to a formal functional model that can be simulated in its operating *** achieve this work,a subset of Sys ML has been used as an intermediate modelling language to ensure progressive transformation that can be understood and agreed by system *** concepts are introduced to ensure theoretical consistency of the *** addition,transformation rules are defined and the mappings between concepts of ARP4754 A civil aircraft guidelines and Sys ML are formalized through *** resulting formalization enables engineers to perform functional simulation of the top-level functional architecture extracted from operational ***,the approach has been tested on an industrial avionics system called the Onboard Maintenance System.

关键词： Avionics systems Conceptual model Functional simulation Model-Based Systems Engineering

A REMARK ON FORMAL MODELS FOR NONLINEARLY ELASTIC MEMBRANE SHELLS

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Chinese Annals of Mathematics,Series B 2001年第3期22卷 307-324页

作者： C. COLLARD Laboratoire d’Analyse Numerique, Tour n°55, Universite Pierre et marie Curie, 4, place Jussieu, 75005 Paris, france. Laboratoire de Mathematiques Appliquees au Calcul Scientifique, Universite de Valenciennes et du Hainaut-Cambresis, Le Mont H Labiratoire d'Analyse Numérique Tour n°55 Université Pierre et Marie Curie 4 place Jussieu 75005 Paris France Laboratoire de Mathématiques Appliquées au Calcul Scientifique Université de Valenciennes et du Hainaut-Cambresis Le Mont Houy - B.P. 311 - F 59304 Valenciennes cedex France

This paper gives all the two-dimensional membrane models obtained from formal asymptotic analysis of the three-dimensional geometrically exact nonlinear model of a thin elastic shell made with a Saint Venant-Kirchhoff material. Therefore, the other models can be quoted as flexural nonlinear ones. The author also gives the formal equations solved by the associated stress tensor and points out that only one of those models leads, by linearization, to the "classical" linear limiting membrane model, whose justification has already been established by a convergence theorem.

关键词： Nonlinear elastic shell Convergence theorem Asymptotic analysis

IL-6对小鼠(B-杂交瘤)7TD1细胞凋亡的调控作用

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中华微生物学和免疫学杂志 1995年第6期15卷 382-385页

作者：刘佳李宏 marie-franceHamou Nicolas de Tribolet 沈阳医学院分子生物学研究室 110031 瑞士洛桑大学神经肿瘤生物及遗传学实验室

小鼠B—杂交瘤7TD1细胞的生长依赖于IL—6的存在。本研究对有或无IL-6条件下,对7TD1细胞的生物学行为加以分析。结果发现:1.细胞在缺乏IL—6时,生长停滞并出现细胞凋亡的典型特征;***核酸酶抑制剂ATA可有效防止因IL—6缺乏所致的凋亡;**... 详细信息

小鼠B—杂交瘤7TD1细胞的生长依赖于IL—6的存在。本研究对有或无IL-6条件下,对7TD1细胞的生物学行为加以分析。结果发现:1.细胞在缺乏IL—6时,生长停滞并出现细胞凋亡的典型特征;***核酸酶抑制剂ATA可有效防止因IL—6缺乏所致的凋亡;***合成抑制剂CHX能充分抑制IL—6对7TD1的生物效应,从而使细胞步入凋亡。本研究提示,IL—6通过抑制7TD1内部持续存在的细胞死亡程序来促进细胞存活和生长;而这种抑制作用需要新的蛋白质合成。

关键词： IL-6 杂交瘤细胞凋亡调控作用

Optimal Low-voltage Distribution Topology with Integration of PV and Storage for Rural Electrification in Developing Countries:A Case Study of Cambodia

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Journal of Modern Power Systems and Clean Energy 2020年第3期8卷 531-539页

作者： Vannak Vai marie-Cecile Alvarez-Herault Bertrand Raison Long Bun Department of Electrical and Energy Engineering(GEE) Institute of Technology of Cambodia(ITC)Phnom Penh 12150Cambodia Institute of Engineering UniversitéGrenoble Alpes38000 GrenobleFrance

This paper addresses an optimal design of low-voltage(LV)distribution network for rural electrification considering photovoltaic(PV)and battery energy storage(BES).It aims at searching for an optimal topology of an LV distribution system as well as the siting and sizing of PV and storage over a time horizon of 30 ***,the shortest-path algorithm(SPA)and first-fit bin-packing algorithm(FFBPA)are used to search for the optimal radial topology that minimizes the total length of the distribution line and improves the load ***,the optimal siting of decentralized BES(DeBES)is determined using a genetic algorithm(GA)to eliminate the undervoltage constraints due to the load *** iterative techniques are elaborated to size the maximum peak power of PV and the minimum number of DeBES that can be connected to an LV network without violating the voltage and current ***,the sizing strategy of centralized BES(CeBES)is developed to avoid reverse power flows into the medium-voltage(MV)***,a Monte Carlo approach is used to study the impact of load profile uncertainties on the topology.A non-electrified village in Cambodia has been chosen as a case study.

关键词： Battery energy storage(BES) low-voltage(LV)distribution network Monte Carlo photovoltaic(PV) electrification planning