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Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, france

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Asian Journal of Andrology 2012年第4期14卷 584-590页

作者： Cendrine Geoffroy-Siraudin Anderson Dieudone Loundou Fanny Romain Vincent Achard Blandine Courbibre marie-He1ene Perrard Philippe Durand marie-Roberte Guichaoua Reproduction Biology Laboratory Conception Hospital AP-HM Marseille 13005 France Aix-Marseille University UMR CNRS IMBE 7263 Faculty of medicine of Marseille Marseille 13005 France Department of medical information Conception Hospital AP-HM Marseille 147 Bd Baille Marseille 13005 France Health Laboratory Faculty of Medicine of Marseille Marseille 13005 France Centre of Assisted Reproductive Technique (CPMA) Conception Hospital AP-HM Marseille 13005 France Functional Genomic Institute of Lyon CNRS INRA ENS of Lyon Lyon 69007 France

Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille （france） between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration （〉~ 40 million per ejaculate）. The whole population demonstrated declining trends in sperm concentration （1.5% per year）, total sperm count （1.6% per year）, total motility （0.4% per year）, rapid motility （5.5% per year） and normal morphology （2.2% per year）. In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the auality of semen decreased in this population over the study period.

关键词： environment male infertility regional differences semen quality sperm parameters

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Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats

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World Journal of Gastroenterology 2023年第5期29卷 851-866页

作者： Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian Mourey Lena M'Ba Lucil Schneider marie Titecat Benoît Foligné Michaël Genin Christel Neut Philippe Zerbib Pierre Desreumaux Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France U1286-INFINITE-Institute for Translational Research in Inflammation Univ.LilleInsermCHU LilleLille 59000France Intestinal Biotech Development Lille 59045France Department of Research and Applications Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France ULR 2694-METRICS:Évaluation des Technologies de Santéet des Pratiques Médicales University of LilleLille University HospitalLille 59000France Department of Hepato-Gastroenterology Lille University HospitalLille 59037France

BACKGROUND Postoperative recurrence(POR)after ileocecal resection(ICR)affects most Crohn's disease patients within 3-5 years after ***-invasive Escherichia coli(AIEC)typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease *** cerevisiae CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the *** To evaluate the efficacy of CNCM I-3856 in preventing POR induced by LF82 in an HLA-B27 transgenic(TgB27)rat *** Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of ***27 rats were challenged daily with oral administration of LF82(109 colony forming units(CFUs)/day(d),n=8),PBS(n=5),CNCM I-3856(109 CFUs/d,n=7)or a combination of LF82 and CNCM I-3856(n=18).nTg rats receiving LF82(n=5),PBS(n=5),CNCM I-3856(n=7)or CNCM I-3856 and LF82(n=9)under the same conditions were used as *** was analyzed using macroscopic(from 0 to 4)and histologic(from 0 to 6)*** LF82 quantifications were performed weekly for each *** LF82 and inflammatory/regulatory cytokines were quantified in biopsies at W12 and *** are expressed as the median with the interquartile *** nTg animals did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving LF82 alone had POR(macroscopic score≥2),which was significantly prevented by CNCM I-3856 administration[6/18(33%)TgB27 rats,P=0.01].Macroscopic lesions were located 2 cm above the anastomosis in the TgB27 rats receiving LF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCM I-3856 and LF82 had no macroscopic *** to untreated TgB27 animals receiving LF82 alone,coadministration of CNCM I-3856 and LF82 significantly red

关键词： Crohn's disease Recurrence Escherichia coli Probiotic Saccharomyces cerevisiae Colorectal surgery

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Allogeneic stem cell transplantation-A curative treatment for paroxysmal nocturnal hemoglobinuria with PIGT mutation:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5702-5707页

作者： Laurence Schenone Anne-Béatrice Notarantonio Véronique Latger-Cannard Veronique Fremeaux-Bacchi Marcelo De Carvalho-Bittencourt marie-Thérèse Rubio Marc Muller Maud D'Aveni Department of Hematology CHRU de NancyNancy F-54000France Genetic Laboratory CHRU de NancyNancy F-54000France IMoPA CNRS 7365University of LorraineNancy F-54000France Hematology Laboratory Cytometry PlatformCHRU de NancyNancy F-54000France Immunology Laboratory Hôpital Européen George PompidouParis 75015France Immunology Laboratory CHRU de NancyNancy F-54000France

BACKGROUND Patients with paroxysmal nocturnal hemoglobinuria(PNH)have a clonal population of blood cells deficient in glycosylphosphatidylinositol-anchored(GPIanchored)proteins,most of the time resulting from a mutation in the X-linked gene *** report a patient with PNH resulting from a rare biallelic PIGT mutation on chromosome *** SUMMARY A 47-year-old man was referred to our hospital for febrile *** patient reported a history of recurrent urticaria and arthralgia and he presented during 3 mo recurrent acute dermo-hypodermitis and aseptic *** on clinical cases published with PIGT-PNH,with clinically typical PNH and autoinflammatory symptoms,we treated our patients with repeated infusions of eculizumab to decrease autoinflammatory symptoms and then we performed an allogeneic stem cell transplantation(allo-SCT)with a mismatched unrelated *** patient experienced no acute Graft vs Host disease(GvHD)and a moderate chronic GvHD and is now considered cured at 24 mo after *** This case report suggests that allo-SCT should be considered to cure PIGT-PNH patients.

关键词： Paroxysmal nocturnal hemoglobinuria Allogeneic stem cell transplantation PIGT mutation Recurrent meningitidis Autoinflammatory symptoms Case report

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Effect of Dietary Incorporation of <i>Curcuma longa</i>Powder on Haematology and Serological Properties of Guinea Pigs (<i>Cavia porcellus</i>)

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Open Journal of Animal Sciences 2020年第4期10卷 750-760页

作者： france Gina Djoumessi Tobou Fernand Tendonkeng Emile Miégoué Bertine marie Noel Noumbissi David Fokom Wauffo Hervé Mube Kuitche Dayan Ebile Agwah Department of Zootechnic Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon

The reduced efficiency of antibiotic growth promoters in livestock, and the unavoidable residual effects on livestock products such as egg, meat and milk have pushed researchers to rush towards the use of phytobiotics in animal feed. This study was conducted at the Teaching and Research Farm of the University of Dschang to evaluate the Effect of Cucurma longa powder as feed additive on hemato-serological parameters in Guinea pigs. A total of 120 three weeks old Guinea pigs (60 males and 60 females), with an average weight of 150 ± 20 g were used. The animals were randomly distributed into four treatments in a completely randomized design with 30 animals per treatment (15 males and 15 females). Four experimental treatments were used by adding 0%, 0.25%, 0.5% and 1% C. longa in the diet corresponding to R0, R0.25%, R0.5% and R1% respectively. At the 8th week of age, 12 Guinea pigs (6 males and 6 females) per treatment were fasted for 12 hours and sacrificed by cervical dislocation. Blood was rapidly collected from the jugular vein for the evaluation of haematological and biochemical parameters. Results revealed that the inclusion of Curcuma longa at 0.25% significantly (p Curcuma longa powder at 0.25% as feed additive positively regulates blood serum parameters of Guinea pigs.

关键词： Cavia porcellus Cucurma longa Haematology and Serological Parameters

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Relationships between mucinous gastric carcinoma, MUC2 expression and survival

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World Journal of Gastroenterology 2006年第21期12卷 3324-3331页

作者： Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy marie-Christine Copin Christophe mariette Jean-Pierre Aubert Nicole Porchet marie-Pierre Buisine INSERM U560 59045Lille cedexFrance Service d'Anatomie et Cytologie Pabologiques Pôle Biologie-Pathogie Pac Eurasanté.CHR-U de Lille59037 Lille cedexFrance Service de Biochimie et Biologie Moléculaire CHR-U de Lille59037 Lille cedexFrance Facultéde Médecine H.Warembourg 59045 Lille cedexFrance Service.de Chirurgie Digetive et Générale CAEB CHR-U de Lille59045 Lille cedexFrance

AIM:To investigate the expression of the four secreted gel-forming mucins(MUC2,MUCSAC,MUCSB and MUC6)in a series of gastric carcinomas,classified according Laurén's,Mulligan's,WHO and Goseki's classifications,with special attention to all the different components(major and minor)present in tumors and to follow up clinical ***:Expression of MUC2,MUC5AC,MUC5B and MUC6 was investigated using immunohistochemistry and in situ ***:Expression of secreted gel-forming mucins in gastric carcinoma was particularly complex,each mucin being not restricted to any histopathological type even considering all components(major and minor)present in a given *** was a worst survival in patients with a higher content of mucus(GosekiⅡorⅣ)and high positive MUC2 ***:Complexity of mucin gene expression patterns in gastric cancer may reflect a precise state of differentiation at the cell level not recognized in used morphologic classification *** expression of MUC2 was nevertheless associated with mucinous subtype of the WHO classification and with groupⅡof Goseki's classification identified by the major component of a particular *** quantity and quality of mucus were related to survival.

关键词： Gastric cancer Secreted gel-forming mucin MUC Immunohistochemistry in situ hybridization Survival

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Tuning Intermolecular Interaction Between Lignin and Carbon Nanotubes in Fiber Composites–A Combined Experimental and Ab-Initio Modeling Study

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Journal of Renewable Materials 2018年第3期6卷 325-335页

作者： Jan Badorrek Michael Walter marie-Pierre Laborie Freiburger Materialforschungszentrum Stefan-Meier-Straße 21D-79104 Freiburg im BreisgauGermany Chair of Forest Biomaterials Werthmannstraße 6D-79085 Freiburg im BreisgauGermany Freiburg Center for Interactive Materials and Bioinspired Technologies(FIT) Georges-Köhler-Allee 105D-79110 Freiburg im BreisgauGermany Fraunhofer Institute for Mechanics of Materials(IWM) Wöhlerstraße 11D-79108 Freiburg im BreisgauGermany

Doping lignin with carbon nanotubes is a promising strategy for cost-effective high-performance carbon *** investigate the intermolecular interaction potential of CNT and organosolv lignin with two main ***,oxidized purified multiwalled carbon nanotubes(MWCNTs)and beech organosolv lignins and derivatives are analyzed with their Hansen solubility parameters(HSPs)to assess their mutual ***,dispersion-corrected density functional theory simulations of the interaction between model molecules and single-walled carbon nanotubes reveal the source of *** find that oxidation enables and enhances the interaction between carbon nanotubes and organosolv lignin experimentally,which is in agreement with the enhanced polar interaction found in the simulations.

关键词： CNT DFT Hansen solubility parameters lignin oxidation

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Effect of Substrate Type on Deposition Behavior and Wear Performance of Ni-Coated Graphite/Al Composite Coatings Deposited by Cold Spraying

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Journal of Materials Science & Technology 2017年第4期33卷 338-346页

作者： Chunjie Huang Wenya Li Yingchun Xie marie-Pierre Planche Hanlin Liao Ghislain Montavon ICB UMR 6303 CNRSUniversite Bourgogne Franche-ComteUTBMF-90100 BelfortFrance State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi'an 710072China

This work focused on the deposition characteristics and wear behavior of Ni-coated graphite mixed with40 vol.% Al（Ni-Gr/Al） composite coatings sprayed on an Al alloy and a steel substrate by cold spraying（CS）. The morphology of the flattened Ni-Gr particles was examined by single-impact tests. Crosssectional microstructure and wear performance of the Ni-Gr/Al composite coatings were studied. Results showed that a larger number of Ni-Gr particles were finally bonded with the steel substrate, whereas many craters existed on the Al alloy substrate after the single-impact tests. The coating on the steel substrate had a high thickness, high graphite content and low coeficient of friction（COF） compared to those on the Al alloy substrate. In addition, the CS coatings presented a homogeneous distribution and uniform morphology of graphite, and a comparative COF to that of conventional thermal sprayed coatings. It was shown that CS could avoid the decomposition and transformation of graphite phase.

关键词： Cold spraying Ni-coated graphite Deposition behavior Microstructure Wear performance

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Impact of nanocrystallinity segregation on the growth and morphology of nanocrystal superlattices

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Nano Research 2013年第8期6卷 611-618页

作者： Yanfen Wan Herve Portals Nicolas Goubet Alain Mermet marie-Paule Pileni Université Pierre et marie Curie Paris 6 UMR 7070 LM2N 8P 52 4 place Jussieu 75005 Paris France Centre National de la Recherche Scientifique Unitd Mixte de Recherche 7070 LM2N 4 place Jussieu 75005 Paris France Université Lyon I Institut Lumiére Matiére Unité Mixte de Recherche 5306 CNRS Bāt. A. Kastler 10 rueAda Byron 69622 Villeurbanne France

5 nm Au tetradecanethiol 涂的 nanoparticles 的一个胶体的答案被综合。在一落下的快蒸发以后，订了两个都由单个领域组成的单层，多晶的 nanocrystals 被获得。在增加材料和蒸发时间的数量以后，有不规则的轮廓的 nanocrystal 电影... 详细信息

5 nm Au tetradecanethiol 涂的 nanoparticles 的一个胶体的答案被综合。在一落下的快蒸发以后，订了两个都由单个领域组成的单层，多晶的 nanocrystals 被获得。在增加材料和蒸发时间的数量以后，有不规则的轮廓的 nanocrystal 电影和展出截断有四面的形状的拥挤不堪的 3D 超点阵被生产。用散布光谱学和电子显微镜学的低频率的 micro-Raman，积木 nanocrystallinity 被描绘。自发的 nanocrystallinity 分离被揭示：当 supracrystalline 电影由单个领域和多晶的 nanocrystals 的混合物组成时，截断有四面的 supracrystals 被显示主要包含单个领域积木。这观察指出在涉及 nanocrystal 超点阵和他们的形态学的生长的 nanocrystallinity 分离之间的关联。

关键词：纳米晶体超晶格结晶分离形态生长纳米结晶拉曼散射光谱晶体薄膜

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Anion Channel Blockage by ATP as a Means for Membranes to Perceive the Energy Status of the Cell

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Molecular Plant 2016年第3期9卷 320-322页

作者： Alexis De Angeli Sebastien Thomine Jean-marie Frachisse nstitute for Integrative Biology of the Cell (12BC) CEA CNRS Univ. Paris-Sud Universite Paris-Saclay 91198 Gif-sur-Yvette cedex France

ATP harbors three phosphoric groups linked by two highly energetic phospho-anhydride *** exergonic hydrolysis of the phospho-anhydride bonds of ATP can be used in biochemical reactions to couple the released energy to another endergonic ***,ATP is a timing belt of cellular metabolism and energy distribution in *** cytosolic concentration of ATP and of its hydrolysis products,ADP,AMP,and PPi,is a function of the metabolic activity and defines the energetic status of cells.

关键词： phospho couple products

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Genetic identification and reiterated captures suggest that the Astyanax mexicanus El Pachón cavefish population is closed and declining

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Zoological Research 2023年第4期44卷 701-711页

作者： Laurent Legendre Julie Rode Isabelle Germon marie Pavie Carla Quiviger Maxime Policarpo Julien Leclercq Stéphane Père Julien Fumey Carole Hyacinthe Patricia Ornelas-García Luis Espinasa Sylvie Rétaux Didier Casane UniversitéParis-Saclay CNRSIRDUMRÉvolutionGénomesComportement etÉcologieGif-sur-Yvette 91190France Objectif Sciences International NGO OSI-Panthera ProgramGeneva 99140Switzerland Institut de Neuroscience Paris-Saclay UniversitéParis-Saclay and CNRSSaclay 91400France Institut Pasteur UniversitéParis CitéCNRS UMR 2000Microbial Paleogenomics UnitParis 75015France Institut Pasteur UniversitéParis CitéBioinformatics and Biostatistics HubParis 75015France Department of Genetics Harvard Medical SchoolBlavatnik InstituteBoston MA 02115USA Colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico DF CP 04510México School of Science Marist CollegePoughkeepsieNew York 12601USA UniversitéParis Cité UFR Sciences du VivantParis 75013France Zoological Institute Department of Environmental SciencesUniversity of BaselBaselSwitzerland

The sizes of Astyanax mexicanus blind cavefish populations of North-East Mexico are demographic parameters of great importance for investigating a variety of ecological,evolutionary,and conservation ***,few estimates have been *** these mobile animals living in an environment difficult to explore as a whole,methods based on capture-mark-recapture are appropriate,but their feasibility and interpretation of results depend on several assumptions that must be carefully ***,we provide evidence that minimally invasive genetic identification from captures at different time intervals(three days and three years)can give insights into cavefish population size dynamics as well as other important demographic parameters of *** also provide tools to calibrate sampling and genotyping efforts necessary to reach a given level of *** results suggest that the El Pachón cave population is currently very small,of an order of magnitude of a few hundreds of individuals,and is distributed in a relatively isolated *** probable decline in population size in the El Pachón cave since the last census in 1971 raises serious conservation issues.

关键词： Cavefish Population size Conservation Swabbing Genetic identification

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