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Building Information Modeling for Environmental Impact Assessment in Early Design Phases: A Literature Review

Open Journal of Applied Sciences 2022年第1期12卷 59-81页

作者： marie-france stendahl marie-Claude Dubois Daniel Forgues Eilif Hjelseth Architecture and the Built Environment Division of Energy and Building Design Lund University (LTH) Lund Sweden Department of Construction University of Quebec école de Technologie Supérieure (éTS) Montréal Canada Department of Civil and Environmental Engineering Faculty of Engineering Norwegian University of Science and Technology (NTNU) Trondheim Norway

The building sector is the largest consumer of energy in industrial countries. Saving energy in new buildings or building renovations can thus lead to significant global environmental impacts. In this endeavor, building information modeling (BIM) and building energy modeling (BEM) are two important tools to make the transition to net-zero energy buildings (NZEB). So far, little attention has been devoted, in the literature, to discuss the connection between BIM, BEM, and Life-cycle assessment (LCA), which is the main topic of this article. A literature review of 157 journal articles and conference proceedings published between 1990 and 2020 is presented. This review outlines knowledge gaps concerning BIM, BEM, and environmental impact assessment. It suggests that defining the process with the right technology (at the right time) would result in a more integrated design process (IDP) and bridge current gaps. The most efficient way to improve process and technology is related to the competences of the architects, engineers and constructors (AEC). The review also indicates that the IDP in the early design phases (EDP) is in need of improvement for architects and engineers, where a better connection between design phases, specific levels of development (LOD) and BIM tools is needed. Competences, process and technology are the three main themes addressed in the review. Their relation to design phases and LOD is discussed. The aim is to propose possible solutions to the current hinders in BIM-to-BEM (BIM2BEM) and BIM-for-LCA (BIM4LCA) integration.

关键词： Building Information Modeling (BIM) Building Energy Modeling (BEM) Life Cycle Assessment (LCA) Simulations Energy Carbon Design Process Design Phases Level of Development

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Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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Neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel Fleury Imane Boukhatem marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance Service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia

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A Review on Sources,Extractions and Analysis Methods of a Sustainable Biomaterial:Tannins

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Journal of Renewable Materials 2024年第3期12卷 397-425页

作者： Antonio Pizzi marie-Pierre Laborie Zeki Candan LERMAB University of LorraineFaculty of SciencesBlvd des AiguillettesNancy54000France Chair of Forest Biomaterials Institute of Earth and Environmental SciencesUniversity of FreiburgFreiburgGermany Freiburg Materials Research Center Alberst Ludwig University of FreiburgFreiburg79104Germany Department of Forest Products Engineering Faculty of ForestryIstanbul UniversitySariyerIstanbul34473Turkey

Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based *** are a definite class of sustainable materials of the forestry *** have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries,such as wood adhesives,metal coating,pharmaceutical/medical applications and several *** review presents the main sources,either already or potentially commercial of this forestry by-materials,their industrial and laboratory extraction systems,their systems of analysis with their advantages and drawbacks,be these methods so simple to even appear primitive but nonetheless of proven effectiveness,or very modern and *** constitutes a basic but essential summary of what is necessary to know of these sustainable *** doing so,the review highlights some of the main challenges that remain to be addressed to deliver the quality and economics of tannin supply necessary to fulfill the industrial production requirements for some materials-based uses.

关键词： Tannins flavonoids sources extraction methods analysis methods

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Analysis of mid-spatial frequency wavefront distortions from a liquid-cooled flash-lamp pumped Nd:phosphate laser amplifier

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High Power Laser Science and Engineering 2024年第1期12卷 24-29页

作者： Pierre-marie Dalbies Sandy Cavaro Edouard Bordenave Nathalie Blanchot Julien G.Moreau Jérôme Neauport CEA CESTA Le BarpFrance

Mid-spatial frequency wavefront deformation can be deleterious for the operation of high-energy laser systems. When fluid cooled high-repetition-rate amplifiers are used, the coolant flow is likely to induce such detrimental mid-spatial frequency wavefront deformations. Here, we describe the design and performance of a 90 mm × 90 mm aperture, liquid-cooled Nd:phosphate split-slab laser amplifier pumped by flash-lamps. The performance of the system is evaluated in terms of wavefront aberration and gain at repetition rates down to 1 shot per minute. The results show that this single cooled split-slab system exhibits low wavefront distortions in the medium to large period range, compatible with a focus on target, and despite the use of liquid coolant traversed by both pump and amplified wavelengths. This makes it a potential candidate for applications in large high-energy laser facilities.

关键词： flash-lamp pumping high-power laser laser cooling neodymium glass wavefront error

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Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR-Cas endonucleases

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Molecular Plant 2024年第5期17卷 824-837页

作者： Tom Schreiber Anja Prange Petra Schafer Thomas Iwen Ramona Grutzner Sylvestre Marillonnet Aurelie Lepage marie Javelle Wyatt Paul Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Limagrain Centre de RechercheRoute d’EnnezatCS 9012663720 ChappesFrance

In plants and mammals,non-homologous end-joining is the dominant pathway to repair DNA doublestrand breaks,making it challenging to generate knock-in *** this study,we identified two groups of exonucleases from the herpes virus and the bacteriophage T7 families that conferred an up to 38-fold increase in homology-directed repair frequencies when fused to Cas9/Cas12a in a tobacco mosaic virus-based transient assay in Nicotiana *** achieved precise and scar-free insertion of several kilobases of DNA both in transient and stable transformation *** Arabidopsis thaliana,fusion of Cas9 to a herpes virus family exonuclease led to 10-fold higher frequencies of knock-ins in the first generation of *** addition,we demonstrated stable and heritable knock-ins in wheat in 1%of the primary *** together,our results open perspectives for the routine production of heritable knock-in and gene replacement events in plants.

关键词： homology-directed repair knockin gene replacement CRISPR-Cas 50 exonuclease plants

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Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type II,among others.

关键词： diseases den rigidity

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Prevalence and Factors Associated with Anemia among People Living with Human Immunodeficiency Virus Followed at the Outpatient Treatment Centre of Panzi General Referral Hospital in Eastern Democratic Republic of Congo

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Journal of Biosciences and Medicines 2024年第3期12卷 259-274页

作者： Marlene Abedi Zalufa Jean-Paulin Mbo Mukonkole Aline Byabene Kusinza Nicolas Vignier Dieudonné Bihehe Masemo David Willy Shamputi Omari Mukanga Lampard marie Hatem Department of Internal Medicine Panzi General Referral Hospital Bukavu Democratic Republic of Congo Evangelical University in Africa Bukavu Democratic Republic of Congo Statistics Department Panzi General Referral Hospital Bukavu Democratic Republic of Congo International Centre for The Advanced Research and Training-ICART Panzi Foundation Bukavu Democratic Republic of Congo Faculty of Medicine University of Kisangani Kisangani Democratic Republic of Congo Service des Maladies Infectieuses et Tropicales CHU Avicenne Bobigny France Sorbonne University Paris France School of Public Health Department of Social and Preventive Medicine Université de Montréal Montréal Canada

Introduction: Anemia in people living with human immunodeficiency virus (PLHIV) is a major health problem. Although anemia often responds to combination antiretroviral therapy, many patients remain anemic despite treatment, and such persistent anemia continues to adversely affect prognosis, regardless of drug response. Scientists have identified some of the factors involved. However, the mechanisms put in place have not been effective in overcoming them. Examples include the withdrawal of zidovudine from antiretroviral treatment lines, iron and folate supplementation, etc. Anemia is still a major concern in HIV-positive patients. The aim of this study is to assess the prevalence of anemia and its associated factors among PLHIV followed up at the outpatient treatment centre (CTA) of the Panzi General Reference Hospital (HGR) in South Kivu, Democratic Republic of Congo (DRC). Method: We conducted a cross-sectional, comparative study of 276 HIV-infected adults on antiretroviral therapy (ART) followed up at the CTA of Panzi HGR. Socio-demographic and nutritional parameters were collected using a survey questionnaire, and clinical assessment and nutritional status were performed at the centre. Hemoglobin, seric albumin and viral load determinations were performed at the HGRP laboratory. We constructed univariate and multivariate logistic regression models to assess factors associated with anemia in people living with HIV/AIDS. Results: We found a prevalence of anemia of 39.4%, including 4.1% severe anemia, 17.7% moderate anemia and 17.5% mild anemia. After multivariate adjustment, the factors associated with anemia in our PLHIV were: moderate undernutrition (aOR = 1.26;95% CI: 1.50 - 4.20;p = 0.001), severe undernutrition (aOR = 115.4;95% CI: 2.04 - 164.52;p = 0.021), hypoalbuminemia (aOR = 2.11;95% CI: 1.87 - 5.10;p = 0.004) and the lower degree of dietary diversity (aOR = 1.56;95% CI: 1.10 - 4.32;p = 0.034). Conclusion: The prevalence of anemia in PLHIV on ART is high.

关键词： Anemia HIV/AIDS Undernutrition PANZI Hospital

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Density Results in Sobolev Spaces Whose Elements Vanish on a Part of the Boundary

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Chinese Annals of Mathematics,Series B 2011年第6期32卷 823-846页

作者： Jean-marie Emmanuel BERNARD Laboratoire Analyse et Probabitilités Université d'Evry val d'Essonne23 Boulevard de France91037 EVRYFrance

This paper is devoted to the study of the subspace of W m,r of functions that vanish on a part γ 0 of the *** author gives a crucial estimate of the Poincar'e constant in balls centered on the boundary of γ ***,the convolution-translation method,a variant of the standard mollifier technique,can be used to prove the density of smooth functions that vanish in a neighborhood of γ 0,in this *** result is first proved for m=1,then generalized to the case where m ≥ 1,in any dimension,in the framework of Lipschitz-continuous ***,as may be expected,it is needed to make additional assumptions on the boundary of γ 0,namely that it is locally the graph of some Lipschitz-continuous function.

关键词： Sobolev空间边界密度元素光滑函数连续函数子空间彭加勒

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Early local intracoronary platelet activation after drug-eluting stent placement

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Chinese Medical Journal 2007年第22期120卷 1986-1991页

作者： Ailiman Mahemuti Nicolas Meneveau marie-france Seronde FrancoisSchiele mariette Mercier Evelyne Racadotand Jean-Pierre Bassand Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Biostatistics and Epidemiology Faculty of Medecine and PharmacyUniversity of Franche-Comte Medical SchoolBesanconFrance Hemostasis Laboratory French Blood Products InstitutionBesanconFrance

Background Early local platelet activation after coronary intervention identifies patients at increased risk of acute stent thrombosis （AST）. However, early changes in platelet activation in coronary circulation following drug-eluting stent （DES） implantation have never been reported. Methods In a prospective study of 26 consecutive elective stable angina patients, platelet activation was analyzed by measuring soluble glycoprotein V （sGPV） and P-selectin （CD62P） before and after implantation of either DES or bare metal stent （BMS）. All patients were pretreated with clopidogrel （300 mg loading dose） and aspirin （75 mg orally） the day before the procedure. Blood samples were drawn from the coronary ostium and 10 - 20 mm distal to the lesion site. Results Consistent with the lower baseline clinical risk, the levels of CD62P and sGPV were within normal reference range, both in the coronary ostium and distal to the lesion before percutaneous coronary intervention （PCI） procedure. The levels of CD62P and sGPV did not change significantly （CD62P：（31.1 ± 9.86） ng/ml vs （29.5 ± 9.02） ng/ml, P=0.319 and sGPV：（52.4 ± 13.5） ng/ml vs （51.8 ± 11.7） ng/ml, P=0.674, respectively） after stent implantation when compared with baseline. Changes in these platelet activation markers did not differ between stent types. Conclusions Intracoronary local platelet activation does not occur in stable angina patients before and immediately followina DES implantation when dual anti-Dlatelet is administered.

关键词： stents platelet activation thrombosis P-selectin soluble glycoprotein V

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Influence of Water and Humidity on Wood Modification with Lactic Acid

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Journal of Renewable Materials 2018年第3期6卷 259-269页

作者： Charlotte Grosse Marion Noel marie-france Thevenon Lauri Rautkari Philippe Gerardin Department of Architecture Wood and Civil EngineeringBern University of Applied SciencesSolothurnstrasse 102Postfach 6096CH-2500BielSwitzerland LERMaB EA 4370University of LorraineFaculty of Science and TechnologyBP 70239F-54506 Vandoeuvre-lès-NancyFrance CIRAD UR BIOWooEBTA B 114/1673 rue Jean Francois Breton34398 Montpellier cedex 5France Department of Bioproducts and Biosystems Aalto UniversityVuorimiehentie 116300EspooFinland

Impregnation of dry wood with pure lactic acid oligomers(OLAs)followed by heat treatment confers promising properties to wood because of OLA’s good diffusion,in-situ polymerization and persistence in cell *** provides drastic reduction of the equilibrium moisture content,high dimensional stability and good *** presence of water during treatment has been *** of OLA impregnated dry wood in humid atmosphere leads to a strong and global degradation of the *** treatment of wet wood only impacts the water leaching rate *** of dry wood with OLA diluted in water additionally decreases the biological resistance and is not efficient for decreasing *** of dry wood with lactic acid solution leads to a lower polymerization level but confers good properties.

关键词： Wood modification lactic acid wood impregnation heat treatment

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