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Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer

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World Journal of Gastroenterology 2019年第34期25卷 5082-5096页

作者： diane Lorenzo Vinciane Rebours frédérique Maire Maxime Palazzo Jean-Michel Gonzalez marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier Pancreatology department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 75013France INSERM UMR1149Paris 92110France departement of Gastroenterology Aix Marseille university-APHM-Hopital NordMarseille 13000France Radiology department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France Oncology department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France

Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and ***-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo *** appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic *** can also be used to obtain tissue ***,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to *** cost-effectiveness of screening is also *** new EUS-related techniques,such as searching for dNA abnormalities or protein markers in pancreatic fluid,appear to be promising.

关键词： Endoscopic ultrasound Familial pancreatic cancer Fine-needle aspiration Intraductal papillary mucinous neoplasm Pancreatic cancer Pancreatic intraepithelial neoplasia Pancreatic cancer screening guidelines

Modification of the adsorption and catalytic properties of micro-and mesoporous materials by reactions with organometallic complexes

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Science China Chemistry 2010年第9期53卷 1862-1869页

作者： LEFEBVRE frédéric PUTAJ Piotr BASSET Jean-marie Université de Lyon ICL C2P2 UMR 5265(CNRS-CPE-Université Lyon 1) LCOMS-CPE Lyon

This review describes the work of two laboratories in the field of the modification of micro-and mesoporous molecular sieves through reactions with organometallic *** modification of zeolites can occur inside the pore channels or on the external surface,depending on the size of the organometallic *** the modification occurs on the external surface,it results in a decrease of the pore entrance,which will lead in turn to a modification of the sorption properties of the zeolite,by decreasing the rate of the adsorption(mainly by a kinetic control).Such a material can be also used in catalysis,because the external acid sites,which are responsible for side-reactions,have been removed upon *** small organometallic complexes are used,they can fill the channels and cages of the zeolite and react with internal hydroxyl *** to the high acidity of zeolites,the reaction occurs very easily(for example at-100℃ on faujasite),in contrast to what is observed on the external surface,therefore leading to high metal *** that case,the modification of the sorption properties will be mainly related to a thermodynamic *** resulting materials can be useful in catalysis,by combining the activity of the organometallic complex and properties(for example shape-selectivity) of the *** of mesoporous molecular sieves occurs always in the pores and results in altering of the sorption properties of the solid,by changing the interaction type between the sorbent and the *** example the sorption isotherm of alkanes is changed from type II to type III according to the IUPAC nomenclature.

关键词： zeolites transition metals organometallic compounds adsorption properties

A double Swath Configuration for Improving Throughput and Accuracy of Trait Estimate from UAV Images

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Plant Phenomics 2021年第1期3卷 378-388页

作者： Wenjuan Li Alexis Comar marie Weiss Sylvain Jay Gallian Colombeau Raul Lopez-Lozano Simon Madec frédéric Baret HIPHEN 228 Route de l’Aérodrome84000 AvignonFrance INRAE Avignon UniversitéUMR EMMAH84000 AvignonFrance ARVALIS Institut du Végétal 3 Rue Joseph et Marie Hackin75116 ParisFrance

Multispectral observations from unmanned aerial vehicles(UAVs)are currently used for precision agriculture and crop phenotyping applications to monitor a series of traits allowing the characterization of the vegetation ***,the limited autonomy of UAVs makes the completion of flights difficult when sampling large *** the throughput of data acquisition while not degrading the ground sample distance(GSd)is,therefore,a critical issue to be *** propose here a new image acquisition configuration based on the combination of two focal length(f)optics:an optics with f=4:2 mm is added to the standard f=8 mm(SS:single swath)of the multispectral camera(dS:double swath,double of the standard one).Two flights were completed consecutively in 2018 over a maize field using the AIRPHEN multispectral camera at 52 m *** dS flight plan was designed to get 80%overlap with the 4.2 mm optics,while the SS one was designed to get 80%overlap with the 8 mm *** a result,the time required to cover the same area is halved for the dS as compared to the *** georeferencing accuracy was improved for the dS configuration,particularly for the Z dimension due to the larger view angles available with the small focal length *** to plant height estimates demonstrates that the dS configuration provides similar results as the SS ***,for both the dS and SS configurations,degrading the quality level used to generate the 3d point cloud significantly decreases the plant height estimates.

关键词： optics overlap altitude

EXISTENCE OF MINIMIZING SOLUTIONSAROUNd“EXTENdEd STATES”FOR A NONLINEARLY ELASTICCLAMPEd PLANE MEMBRANE

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Chinese Annals of Mathematics,Series B 1999年第3期20卷 279-296页

作者： d. COUTANd(University of Pierre et marie Curie, Laboratoire d’Analyse Numerique, 4, Place Jussieu, 75005 Paris,france. E-mail: coutand@ann.jussieu.fr) Univ Paris 06 Anal Numer Lab F-75005 Paris France

The formal asymptotic analysis of d. Fox, A. Raoult & J.C. Simo[10] has justified the twodimensional nonlinear "membrane" equations for a plate made of a Saint Venant-Kirchhoff *** model, which retains the material-frame indifference of the original three dimensional problem in the sense that its energy density is invariant under the rotations of R3, is equivalent to finding the critical points of a functional whose nonlinear part depends on the first fundamental form of the unknown deformed *** author establishes here, by the inverse function theorem, the existence of an injective solution to the clamped membrane problem around particular forces corresponding physically to an "extension" of the membrane. Furthermore, it is proved that the solution found in this fashion is also the unique minimizer to the nonlinear membrane functional, which is not sequentially weakly lower semi-continuous.

关键词： Minimizing solution Nonlinearly elastic clamped plane membrane Injective Solution

Elaboration of Materials with Functionality Gradients by Assembly of Chitosan-Collagen Microspheres Produced by Microfluidics

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Journal of Renewable Materials 2018年第3期6卷 314-324页

作者： david Azria Raluca Guermache Sophie Raisin Sébastien Blanquer frédéric Gobeaux marie Morille Emmanuel Belamie ICGM-MACS UMR 5253 CNRS-ENSCM-UMCharles Gerhardt Institute Montpellier8 rue de l’Ecole normale34296 Montpellier cedex 5France Ecole Pratique des Hautes Etudes PSL Research University75014 ParisFrance LIONS-NIMBE CEA CNRSUniversity of Paris-SaclayCEA Saclay91191 Gif-sur-YvetteFrance

Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilicity,biocompatibility and *** many cases,functional recovery of an injured tissue or organ requires oriented cell outgrowth,which is particularly critical for nerve ***,there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide ***,we explore an original way of elaborating such gradients by assembling particles from a library of functionalized *** propose a simple process to prepare chitosan-collagen hybrid microspheres by micro-and milli-fluidics,with adaptable dimensions and narrow size *** adhesion and survival rate of PC12 cells on hybrid microspheres were compared to those on pure chitosan ***,functionalized microspheres were assembled into membranes exhibiting a functionalization gradient.

关键词： Hybrid microspheres biomaterials chitosan collagen functionality gradient nerve regeneration microfluidics

Analysis of a Prototypical Multiscale Method Coupling Atomistic and Continuum Mechanics:the Convex Case

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 209-216页

作者： Xavier Blanc Claude Le Bris frédéricLegoll Laboratoire J.L.-Lions Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance CERMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance CERMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In order to describe a solid which deforms smoothly in some region, but non smoothly in some other region, many multiscale methods have been recently proposed that aim at coupling an atomistic model （discrete mechanics） with a macroscopic model （continuum mechanics）. We provide here a theoretical basis for such a coupling in a one-dimensional setting, in the case of convex energy.

关键词： Multiscale methods variational problems continuum mechanics discrete mechanics

An adaptive microscope for the imaging of biological surfaces

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Light(Science & Applications) 2021年第11期10卷 2195-2206页

作者： Faris Abouakil Huicheng Meng marie-Anne Burcklen Herve Rigneault frederic Galland Loïc LeGoff Aix Marseille Univ CNRSCentrale MarseilleInstitut FresnelTuring Center for Living SystemsMarseilleFrance

Scanning fluorescence microscopes are now able to image large biological samples at high spatial and temporal *** comes at the expense of an increased light dose which is detrimental to fluorophore stability and cell *** highly reduce the light dose,we designed an adaptive scanning fluorescence microscope with a scanning scheme optimized for the unsupervised imaging of cell sheets,which underly the shape of many embryos and *** surface of the tissue is first delineated from the acquisition of a very small subset(~0.1%)of sample space,using a robust estimation *** alternative scanning strategies are then proposed to image the tissue with an improved photon budget,without loss in *** first strategy consists in scanning only a thin shell around the estimated surface of interest,allowing high reduction of light dose when the tissue is *** second strategy applies when structures of interest lie at the cell periphery(*** junctions).An iterative approach is then used to propagate scanning along cell *** demonstrate the benefit of our approach imaging live epithelia from drosophila *** the examples shown,both approaches yield more than a 20-fold reduction in light dose-and up to more than 80-fold-compared to a full scan of the *** smart-scanning strategies can be easily implemented on most scanning fluorescent imaging *** dramatic reduction in light exposure of the sample should allow prolonged imaging of the live processes under investigation.

关键词： image curved smart

Influence of Some Physicochemical Exposure Factors on the Metronidazole Content of a Pharmaceutical Product: Flagyl®250 mg Tablet

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Open Journal of Physical Chemistry 2022年第3期12卷 31-45页

作者： mariette desiree Yehe frédérique Yah marie-Pierre Nikiema Linda Hé Vincent de Paul Ovi Jean-Kisito Kouame Patrick Grah Atheba Gildas Komenan Gbassi department of Analytical Sciences and Public Health UFR of Pharmaceutical and Biological Sciences (UFR SPB) Félix Houphou&#235 t Boigny University Abidjan Ivory Coast National Public Health Laboratory Food Control Service Abidjan Ivory Coast Félix Houphouë t Boigny University Laboratory of Analytical Chemistry Bromatology General Chemistry and Inorganic Chemistry Abidjan Ivory Coast

The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on the content of Metronidazole (MTZ) contained in the reference substance (SR) and in a pharmaceutical specialty Flagyl® 250 mg tablet (FLG). The method developed was linear and accurate in accordance with USP 38 and the MTZ contents were obtained by UV-visible spectrophotometry at 278 nm. These contents ranged from 225 mg to 275 mg and were thus consistent with the concentration present in the proprietary medicines (250 mg). The study of the influence of physicochemical parameters on the MTZ content in SR and FLG showed that MTZ contents are unstable in the presence of Ethanol at 96˚, KOH at 0.1N and bile salts but also when the temperature is higher than 25˚C. However, they remain stable in the presence of light and H2O2 and undergo degradation in an acidic environment.

关键词： Metronidazole Influence Physicochemistry Content Stability

沸石表面有机金属化学──ZSM-5外表面上—Ge(n-C_4H_9)_x基团的接枝及其性质研究

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高等学校化学学报 2001年第2期22卷 285-288页

作者：王绪绪赵慧霞付贤智 frédéric LEFEBVRE Jean-marie BASSET 福州大学光催化研究所福州350002 Laboratoire de Chimie Organo métalliquede Surface

用气体分析及IR ,NMR和元素分析等方法研究了真空系统中 2 30和 2 80℃下四丁基锗在ZSM 5沸石表面上的接枝反应 ,并对所得沸石的热稳定性和吸附性质进行了表征 .与作者曾报道的在硅胶及丝光沸石上的反应类似 ,四丁基锗也能与ZSM 5沸石... 详细信息

用气体分析及IR ,NMR和元素分析等方法研究了真空系统中 2 30和 2 80℃下四丁基锗在ZSM 5沸石表面上的接枝反应 ,并对所得沸石的热稳定性和吸附性质进行了表征 .与作者曾报道的在硅胶及丝光沸石上的反应类似 ,四丁基锗也能与ZSM 5沸石表面上的硅羟基发生缩合反应 ,在其外表面或孔口生成组成为 (≡Si—O) xGe(n C4 H9) 4-x(x =13)的表面有机锗化合物 .在 2 30℃接枝丁基锗基团不影响沸石的结构和表面积 ,仅改变它的孔口大小 .在改性后的沸石上 ,N2 的吸附性质没有改变 ,而不同分子尺寸的烃 ,如正己烷、2 甲基戊烷、2 ,3 二甲基丁烷却呈现出完全不同于起始ZSM 5沸石的择形吸附效应 .

关键词： ZSM-5 四丁基锗表面修饰有机金属化合物表面接枝反应沸石