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Using data from‘visible’populations to estimate the size and importance of‘hidden’populations in an epidemic:A modelling technique

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Infectious Disease Modelling 2020年第1期5卷 798-813页

作者： Anna M.Foss Holly J.Prudden Kate M.Mitchell Michael Pickles Reynold Washington Anna E.Phillips Michel Alary marie-Claude Boily Stephen Moses Charlotte H.Watts Peter T.Vickerman Department of Global Health and Development and Centre for Mathematical Modelling of Infectious Diseases London School of Hygiene and Tropical Medicine15-17 Tavistock PlaceLondonWC1H 9SHUK Department of Infectious Disease Epidemiology School of Public HealthImperial College LondonMedical School BuildingSt Mary’s CampusNorfolk PlaceLondonW21PGUK St John’s Research Institute 100 Feet RoadJohn NagarKoramangalaBangalore560034KarnatakaIndia Department of Community Health Sciences Max Rady College of MedicineRady Faculty of Health SciencesUniversity of ManitobaS113-750 Bannatyne AvenueWinnipegManitobaR3E 0W3Canada Centre de recherche du CHU de Québec-UniversitéLaval 1050 Chemin Ste-FoyQuébec(Qc)G1S 4L8Canada Département de médecine sociale et préventive Facultéde médecineUniversitéLaval1050avenue de la MédecineQuébec(Qc)G1V 0A6Canada

We used reported behavioural data from cisgender men who have sex with men and transgender women(MSM/TGW)in Bangalore,mainly collected from‘hot-spot’locations that attract MSM/TGW,to illustrate a technique to deal with potential issues with the representativeness of this sample.A deterministic dynamic model of HIV transmission was developed,incorporating three subgroups of MSM/TGW,grouped according to their reported predominant sexual role(insertive,receptive or versatile).Using mathematical modelling and data triangulation for‘balancing’numbers of partners and role preferences,we compared three different approaches to determine if our technique could be useful for inferring characteristics of a more‘hidden’insertive MSM subpopulation,and explored their potential importance for the HIV *** for 2009 across all three approaches suggest that HIV prevalence among insertive MSM was likely to be less than half that recorded in the surveys(4.5e6.5%versus 13.1%),but that the relative size of this subgroup was over four times larger(61e69%of all MSM/TGW versus 15%).We infer that the insertive MSM accounted for 10e20%of all prevalent HIV infections among urban males aged *** modelling can be used with data on‘visible’MSM/TGW to provide insights into the characteristics of‘hidden’MSM.A greater understanding of the sexual behaviour of all MSM/TGW is important for effective HIV *** broadly,a hidden subgroup with a lower infectious disease prevalence than more visible subgroups,has the potential to contain more infections,if the hidden subgroup is considerably larger in size.

关键词： HIV Infectious diseases Mathematical modelling Men who have sex with men Transgender women India

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千禧一代、z世代在关心什么?

国际品牌观察 2020年第5期 33-36页

作者： Kathryn Lundstrom Monica marie zorrilla 岳璐(译) 不详

电通安吉斯的调研结果清晰地展示了消费者的期望与需求:消费者希望品牌关注危机,并见证品牌如何力挽狂澜。而数据情报公司Morning Consult的一份报告评估了企业如何在保持敏感的同时推动自身增长。

关键词：电通千禧一代品牌调研结果消费者

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跨媒介叙事

The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases

丛书名：符号学译丛

2019年

作者：（美）玛丽-劳尔·瑞安（marie-Laure Ryan）

这部论文集探讨的问题是，在跨越各种媒介的表达过程中，叙事如何迁移、变异并创造意义。探讨分五个方面：面对面叙事、静止画面、活动画面、音乐、数字媒介。《跨媒介叙事》考察支撑媒介的内在属性如何塑造了叙事的形式并影响叙事体验... 详细信息

ISBN: (纸本)9787569015164

这部论文集探讨的问题是，在跨越各种媒介的表达过程中，叙事如何迁移、变异并创造意义。探讨分五个方面：面对面叙事、静止画面、活动画面、音乐、数字媒介。《跨媒介叙事》考察支撑媒介的内在属性如何塑造了叙事的形式并影响叙事体验。这本文集的独特之处在于恰逢其时地分析了视觉、体态、电子、音乐表达手段中的叙事运作，还重新界定了讲故事行为。

关键词：文化、科学、教育、体育信息与知识传播

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Cellular & Molecular Immunology 2011年第2期8卷 110-120页

作者： Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka zuzana zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova zdenek zıdek Martin Schwarzer Pavel Drastich David P Funda Institute of Microbiology Academy of Sciences of the Czech Republicv.v.i.PragueCzech Republic Institute of Dental Research General Faculty Hospital and 1st Faculty of MedicineCharles UniversityPragueCzech Republic Ear Nose and Throat DepartmentCentral Military HospitalPragueCzech Republic Institute of Experimental Medicine Academy of Science of the Czech RepublicPragueCzech Republic Institute of Clinical and Experimental Medicine PragueCzech Republic

Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the *** methods are an indispensable tool for studying the consequences of bacterial *** used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these *** this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)***,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared *** induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of *** of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment.

关键词： allergy hygiene hypothesis intestinal permeability leaky gut probiotics

First Use of Bedaquiline in Democratic Republic of Congo: Two Case Series of Pre Extensively Drug Resistant Tuberculosis

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Journal of Tuberculosis Research 2018年第2期6卷 125-134页

作者： Murhula Innocent Kashongwe Leopoldine Mbulula Brian Bakoko Pamphile Lubamba Murielle Aloni Simon Kutoluka Pierre Umba Luc Lukaso Michel Kaswa Jean marie Ntumba Kayembe zacharie Munogolo Kashongwe Kinshasa University Hospital Kinshasa Democratic Republic of Congo Action Damien Centre d’Excellence Damien Kinshasa Democratic Republic of Congo Coordination Provinciale de Lutte contre la Tuberculose Kinshasa Democratic Republic of Congo National Tuberculosis Program Kinshasa Democratic Republic of Congo

In this manuscript the authors have studied the first two patients who were successfully treated with the treatment regimen containing Bedaquiline as second-line drug. The patients were diagnosed with pre-extensively drug-resistant tuberculosis (preXDR TB) whose prognosis was fatal in Democratic Republic of Congo (DRC). Bedaquiline is arguably one of the molecules of the future in the management of ultra-resistant tuberculosis. However, a larger cohort study may help to establish its effectiveness. Case report: Patients 1, 29 years old, with a history of multidrug-resistant TB (MDR-TB) one year previously. He showed signs of TB impregnation again 6 months after the last treatment. Bascilloscopy was positive again. The pre-extensively tuberculosis (pre-XDR TB) diagnosis was made by the Hain test (GenoType®MTBDRsl, Hain Lifescience). Patient 2, brother of the first patient, with a history of MDR TB a year before. He had low back pain with right parietal dorso swelling four months after the last treatment. The x-ray of the column showed L4-L5 disc disease. Parietal ultrasound showed a parietal abscess to the right of thoracic vertebrae with fistulization. Surgical biopsy and pus culture confirmed the diagnosis of Pre-XDR Extrapulmonary TB. The treatment regimen was the same for both patients: 6 months with Amikacin (Am) Bedaquiline (Bdq) Prothionamide (Pto) Paraamino Salicylic acid (PAS) Linezolid (Lzd) Cycloserine (Cs) Pyrazinamide (z) and 14 months with PAS Lzd Cs z. The side effects were minor. Bacteriological controls (smears and cultures) after 20 months of treatment are negative to date.

关键词： Pre-XDR TB Pott’s Disease Bedaquiline Molecular Technique Loweinstein Culture

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古代斯拉夫文化

Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse

丛书名：史地小丛书

1936年

作者：（法）来瑞（Louis Paul marie Leger）万良炯译

书名原文:Les anciennes civilisations,slaves:共17章。介绍古代斯拉夫人的社会风俗、家庭与部落、战争、政治组织、语言、艺术等情况。卷首有译者序和作者小传。

ISBN: (纸本)M01523

关键词：古代民族斯拉夫人民族文化

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World Journal of Gastroenterology 2007年第22期13卷 3071-3079页

作者： Juan Enrique Tichauer María Gabriela Morales Ludwig Amigo Leopoldo Galdames Andrés Klein Verónica Quiones Carla Ferrada Alejandra Alvarez R marie-Christine Rio Juan Francisco Miquel Attilio Rigotti Silvana zanlungo Departamento de Gastroenterología Facultad de Medicina Pontifi cia Universidad Católica Santiago Chile Departamento de Biología Celular y Molecular Facultad de Ciencias Biológicas Pontificia Universidad Católica Santiago Chile Institut de Génétique et de Biologie Moléculaire et Cellulaire INSERM U596 67404 Illkirch France

AIM: To examine the in vivo phenotype associated with hepatic metastatic lymph node 64 (MLN64) over-expression. METHODS: Recombinant-adenovirus-mediated MLN64 gene transfer was used to overexpress MLN64 in the livers of C57BL/6 mice. We measured the effects of MLN64 overexpression on hepatic cholesterol content, bile flow, biliary lipid secretion and apoptosis markers. For in vitro studies cultured CHO cells with transient MLN64 overexpression were utilized and apoptosis by TUNEL assay was measured. RESULTS: Livers from ***64-infected mice exhibited early onset of liver damage and apoptosis. This response correlated with increases in liver cholesterol content and biliary bile acid concentration, and impaired bile flow. We investigated whether liver MLN64 expression could be modulated in a murine model of hepatic injury. We found increased hepatic MLN64 mRNA and protein levels in mice with chenodeoxycholic acid-induced liver damage. In addition, cultured CHO cells with transient MLN64 overexpression showed increased apoptosis. CONCLUSION: In summary, hepatic MLN64 over- expression induced damage and apoptosis in murinelivers and altered cholesterol metabolism. Further studies are required to elucidate the relevance of these fi ndings under physiologic and disease conditions.

关键词：胆固醇基因表达过表达肝损伤鼠细胞凋亡

Effect of WeiJia on carbon tetrachloride induced chronic liver injury

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World Journal of Gastroenterology 2006年第12期12卷 1912-1917页

作者： Pik-Yuen Cheung Qizhang Gan-Rong Bai Chi-Chun Fong Lin Shi Yue-Feng Shi Meng-SuYang DepartmentofBiology Ya-Ou zhang marie Chia-Mi Lin Bernard Chan Jay Chun Hsiang-Fu Kung Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee AvenuKowloonHong Kong SARChina Life Science Division Tsinghua University Graduate School at ShenzhenTsinghua CampusUniversity TownShenzhenChina Institute of Molecular Biology The University of Hong KongPokfulamHong KongSARChina Life Tec Enterprise Limited CentralHong KongSARChina The Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongShatinN.T.Hong Kong SARChina

瞄准：为了在长期的肝损伤使用上学习 WeiJia 的效果，四氯化碳(CCl (4 )) 劝诱了肝损伤动物模型。方法: 称 180-220g 的 Wistar 老鼠随机被划分成三个组：正常控制组(组 A ) ，导致的肝损伤控制组织的 CCl (4 )( 组 B ) 和有 WeiJia ... 详细信息

瞄准：为了在长期的肝损伤使用上学习 WeiJia 的效果，四氯化碳(CCl (4 )) 劝诱了肝损伤动物模型。方法: 称 180-220g 的 Wistar 老鼠随机被划分成三个组：正常控制组(组 A ) ，导致的肝损伤控制组织的 CCl (4 )( 组 B ) 和有 WeiJia 处理的正式就职组织的 CCl (4 )( 组 C ) 。每个组由 14 只老鼠组成了。肝损坏和纤维变性被皮下注射在 3 mL/kg 体重在齐墩果油与 40% CCl (4 ) 导致两次为为组 B 和 C 老鼠的八个星期的一个星期而齐墩果油被用于组 A 老鼠。从第三个星期开始，组 C 老鼠也在 1.25 microg/kg 体重的剂量收到了 WeiJia 的每日的腹膜内注射。动物在第五个星期被牺牲(4 男性， 3 女性) ，并且第八个星期(4 男性， 3 女性) 分别地。纤维变性的度被测量并且为肝纤维变性和功能包括透明质酸的血清学的标记(哈) ，类型 IV 骨胶原(CIV ) ， gamma-glutamyl 转移酶(gamma-GT ) ，丙氨酸 aminotransferase (中高音) 和 aspartate aminotransferase (著名计算机生产厂商) 被决定。α平滑肌肌动朊(alpha-SMA ) 和原子抗原(PCNA ) 免疫组织化学也是的增殖的房间表现了。结果：当时， CCl (4 ) 正式就职在组 B 和组 C 老鼠导致了肝的损坏和纤维变性的开发与组 A 相比老鼠。在组 C 老鼠的 WeiJia 的处理能与组 B 老鼠相比显著地减少纤维变性条件。效果能在三星期处理以后被观察并且在八星期处理以后是更明显的。浆液哈，在八星期为组 C 老鼠的处理以后的 CIV ，中高音，著名计算机生产厂商和 gamma-GT 层次是 58+/-22 microg/L ( P0.05 )分别地，从导致的肝损伤控制组织的 CCl ( 4 )(组 B )类似于正常控制组(组 A )，却显著地不同。PCNA 的增加和在 alpha-SMA 表示水平的减少也被观察。结论：WeiJia 能改进肝功能和可能通过星形的房间活动的抑制的还原剂肝纤维变性。

关键词：慢性肝损伤四氯化碳感应反应病理机制

Observation of the Y(4230)and a new structure in e^(+)e^(-)→K^(+)K^(-)J/Ψ

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Chinese Physics C 2022年第11期46卷 7-21页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina R.Baldini Ferroli I.Balossino 班勇 V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈刚陈和生陈玛丽陈申见 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.Ede Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K.Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 顾旻皓关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold M.Himmelreich T.Holtmann 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍 z.Huang T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv Q.Ji 姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李聪李翠李春花李澄李德民李飞李刚李贺 H.Li 李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李紫源梁浩梁昊梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat C.X.Lin 林德旭 T.Lin 刘北江刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 FEMaas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi H.Muramatsu Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥 Y.Pan A.Pathak A.Pathak M.Pelizaeus 彭海平 K.Peters J.Pettersson 平加伦平荣刚 S.Plura S.Pogodin R.Poling V.Prasad 齐法制齐航漆红荣祈鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 S.Q.Qu Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

The cross sections of e^(+)e^(-)→K^(+)K^(-)J/Ψat center-of-mass energies from 4.127 to 4.600 GeV are measured based on 15.6 fb-1data collected with the BESⅢ detector operating at the BEPCⅡ storage *** resonant structures are observed in the line shape of the cross *** mass and width of the first structure are measured to be(4225.3±2.3±21.5)MeV and(72.9±6.1±30.8)MeV,*** are consistent with those of the established Y(4230).The second structure is observed for the first time with a statistical significance greater than 8σ,denoted as Y(4500).Its mass and width are determined to be(4484.7±13.3±24.1)MeV and(111.1±30.1±15.2)MeV,*** first presented uncertainties are statistical and the second ones are *** product of the electronic partial width with the decay branching fractionΓ(Y(4230)→e^(+)e^(−))B(Y(4230)→K^(+)K^(−)J/Ψ)is reported.

关键词： Y states charmonium-like states BESⅢ