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Neural Regeneration Research 2019年第9期14卷 1544-1555页

作者： Laia Farras-Permanyer Nuria Mancho-Fora Marc Montala-Flaquer David Bartres-Faz Lidia Vaque-Alcazar maribel pero-cebollero Joan Guardia-Olmos Quantitative Psychology Section Faculty of PsychologyUniversity of BarcelonaBarcelonaSpain Department of Medicine Faculty of Medicine and Healthy SciencesUniversity of BarcelonaBarcelonaSpain Institute of Neuroscience UB Institute of Complex SystemsUniversity of BarcelonaBarcelonaSpain Institut d’Investigacions Biomediques August Pi i Sunyer BarcelonaSpain

Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained *** of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and ***,these studies compared young individuals with older subjects,but few studies compared different age groups only in older *** purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(<60,60–64,65–69,70–74,75–79,≥80 years old).A partial correlation analysis,a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were *** results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years *** oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other *** occurred possibly because of compensatory mechanism in brain *** study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity *** for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval ***2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively.

关键词： brain connectivity resting state default mode network aging healthy functional connectivity resting state network age groups

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Resistance risk assessment of six pyrethroids and acephate toward the resistant adult tarnished plant bug,Lygus lineolaris

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Insect Science 2024年第3期31卷 792-802页

作者： Yuzhe Du Shane Scheibener Yucheng Zhu maribel Portilla Mingling Zhang USDA-ARS Southern Insect Management Research UnitStonevilleUSA USDA-ARS Pollinator Health in Southern Crop Ecosystem Research UnitStonevilleUSA

Due to rapidly developed resistance,pest management relies less on pyrethroids to control economically damaging infestations of the tarnished plant bug(TPB),Lygus lineolaris(Palisot de Beauvois)in cotton fields of ***,pyrethroid resistance remains prevalent in TPB *** study assessed the resistance levels in adult TPB to six common pyrethroids and *** TBPs were collected from wild host plants in late October after harvest in the Mississippi Delta region of the United *** on LCso values,the field-resistant TPBs displayed higher resistance to permethrin,esfenvalerate,and bifenthrin(approximately 30 fold)and moderate resistance toα-cyhalothrin,β-cyfluthrin,5-cypermethrin,and acephate(approximately 15 fold).Further investigations showed that the inhibitors of three detoxification enzyme,triphenyl phosphate(TPP),diethyl maleate(DEM),and piperonyl butoxide(PBO)had synergistic effects on permethrin,γ-cyhalothrin,and bifenthrin in resistant ***,elevated esterase,GST,and P450 activities were significantly expressed in fieldresistant ***,GST and esterase were reduced after 48 h exposure to certain pyrethroids at LCso *** synergistic and biochemical assays consistently indicated that P450 and esterase were involved in pyrethroid detoxification in *** study provides valuable information for the continued use of pyrethroids and acephate in controlling TPBs in cotton fields in the Mississippi Delta region of the United States.

关键词： cytochrome P450-monooxygenases(P450) detoxification enzyme activities esterase Lygus lineolaris pyrethroids and organophosphate resistance tarnished plant bug

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A Systematic Literature Review on Task Allocation and Performance Management Techniques in Cloud Data Center

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Computer Systems Science & Engineering 2024年第3期48卷 571-608页

作者： Nidhika Chauhan Navneet Kaur Kamaljit Singh Saini Sahil Verma Abdulatif Alabdulatif Ruba Abu Khurma maribel Garcia-Arenas Pedro A.Castillo University Institute of Computing Chandigarh UniversityPunjab143001India Department of Computer Science and Engineering Chandigarh UniversityPunjab143001India Department of Computer Science and Engineering Uttaranchal UniversityUttarakhand248007India Department of Computer Science College of Computer Qassim UniversityBuraydah52571Saudi Arabia MEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Department of Computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain Applied Science Research Center Applied Science Private UniversityAmman11931Jordan

As cloud computing usage grows,cloud data centers play an increasingly important *** maximize resource utilization,ensure service quality,and enhance system performance,it is crucial to allocate tasks and manage performance *** purpose of this study is to provide an extensive analysis of task allocation and performance management techniques employed in cloud data *** aim is to systematically categorize and organize previous research by identifying the cloud computing methodologies,categories,and gaps.A literature review was conducted,which included the analysis of 463 task allocations and 480 performance management *** review revealed three task allocation research topics and seven performance management *** allocation research areas are resource allocation,load-Balancing,and *** management includes monitoring and control,power and energy management,resource utilization optimization,quality of service management,fault management,virtual machine management,and network *** study proposes new techniques to enhance cloud computing work allocation and performance ***-comings in each approach can guide future *** research’s findings on cloud data center task allocation and performance management can assist academics,practitioners,and cloud service providers in optimizing their systems for dependability,cost-effectiveness,and *** methodologies can steer future research to fill gaps in the literature.

关键词： Cloud computing data centre task allocation performance management resource utilization

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Targeting collective behaviors of transplanted retinal cells as a strategy to improve cellular integration

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Neural Regeneration Research 2022年第6期17卷 1271-1272页

作者： Miles Markey maribel Vazquez Department of Biomedical Engineering RutgersThe State University of New JerseyPiscatawayNJUSA

Introduction:The rapidly growing field of regenerative medicine incorporates fundamental principles of stem cell biology and biomedical engineering to repair tissues damaged by genetic disorder,degeneration,or traumatic *** global market for stem cell therapies is expanding at an accelerating rate and projected to triple to over 100 Billion USD by the end of the decade(No author listed,2019),as per Figure 1A.

关键词： degeneration collective traumatic

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Opportunities for agent based modeling of retinal stem cell transplantation

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Neural Regeneration Research 2022年第9期17卷 1978-1980页

作者： Larissa M.DePamphilis Troy Shinbrot maribel Vazquez Department of Biomedical Engineering RutgersThe State University of New JerseyPiscatawayNJUSA

Late stage blindness and visual impairment(BVI)affects over 400 mi l l ion adul ts *** disabilities severely impact the ability of adults to function independently,reduce their quality of life,and worsen socio-economic burdens on health care ***,the World Health Organization projects worldwide BVI from degenerated retina to more than double by the year 2050(Bourne et al.,2021).To understand the clinical problem,consider Figure 1A depicting the retina’s seven neuronal cell types that interconnect across three nuclear *** photoreceptors of the outer nuclear layer(ONL)are light sensitive neurons that absorb and convert photons into bioelectrical signals.

关键词： Figure outer convert

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Electro-chemotactic stimuli for cell replacement therapy in neurosensory retina

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Neural Regeneration Research 2020年第3期15卷 450-452页

作者： maribel Vazquez Department of Biomedical Engineering Rutgers University:The State University of New Jersey

Focus of perspective:Numbers of visually-impaired adults are rising rapidly around the *** transplantation therapies show great promise to restore vision,but have been severely impeded by poor synaptic positioning within retinal *** perspectives article highlights our group’s abilities to remarkably direct the migration of transplantable cells by applying electro-chemical fields within retina-customized *** of our in vitro results with current ex vivo and in vivo studies has the potential to transformatively impact outcomes of cell replacement therapy.

关键词： Focus impaired vivo

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Prospective observational study to assess the validity of the functional disability score in patients with blepharospasm,hemifacial spasm and synkinesis treated with botulinum toxin injection

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Annals of Eye Science 2023年第3期8卷 41-47页

作者： Linda O.Okafor Aaron Jamison maribel Favor Raman Malhotra Corneoplastic Unit Queen Victoria HospitalEast GrinsteadUK

Background:Benign essential blepharospasm(BEB),aberrant facial nerve degeneration and hemifacial spasm(HFS)are all examples dystonia which,though not life-threatening,can have a significant impact on patient quality of *** need for reliable self-rating surveys to monitor functional disability is *** Blepharospasm Disability Index(BSDI)is already a widely utilised and validated selfrating score for blepharospasm whilst the functional disability score(FDS)requires further *** principle aim of this study is to repeat validation of the FDS against the BSDI,which has been validated by several groups since its original description but only in patients with ***:A randomised blinded prospective cohort study was conducted at a single unit on 38 patients with BEB,aberrant facial nerve degeneration and *** were blinded to complete the FDS followed by the BSDI or the BSDI followed by the FDS with a 30-minute ***:Both the FDS and BSDI were found to be reliable with high internal consistency and test-retest *** scales were also found to be moderately correlated with the Jankovic disease severity ***:This study is the first to use the FDS as a rating scale in patients with HFS and aberrant facial nerve *** is also the first study to formally validate the FDS as an acceptable rating scale for patients with dystonia and in particular it provides validation for its use in patients with HFS and aberrant facial nerve degeneration.

关键词： Blepharospasm botulinum toxin(BoNT) dystonia

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Precipitation kinetics of carbides during cyclical and isothermal aging of 2.25Cr–1Mo steel and its effect on mechanical properties

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Journal of Iron and Steel Research(International) 2021年第10期28卷 1282-1290页

作者： maribel Leticia Saucedo-Muñoz ESIQIE Instituto Politécnico NacionalMexico07300Mexico

The carbide precipitation was analyzed during aging of 2.25Cr–1Mo steel at 550℃.The as-received steel was aged in two different manners:the first treatment was an isothermal aging at 550℃ for time up to 1000 h,and the second one was carried out by a cyclical aging,which consisted of aging at 550℃ for 1 h,water quenching at room temperature and then newly heating at 550℃.This procedure was repeated up to 300 *** M_(23)C_(6) and M6C carbide precipitation took place intragranularly and intergranularly for both aging *** carbide coarsening was detected to occur with the increasing aging ***,the growth kinetics of precipitation occurred more rapidly in the case of cyclical *** specimen hardness decreased with the aging time in both cases;however,it occurred in shorter aging time for the cyclical *** testing indicated the increase in ductility with the aging time,and the cyclically aged specimens showed larger ductility than the isothermally aged specimens.

关键词： 2.25Cr-1Mo steel Precipitation Isothermal heating Cyclical heating Mechanical property

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Artificial intelligence model validation before its application in clinical diagnosis assistance

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World Journal of Gastroenterology 2022年第5期28卷 602-604页

作者： Gustavo Jesus Vazquez-Zapien Monica maribel Mata-Miranda Francisco Garibay-Gonzalez Miguel Sanchez-Brito Embryology Lab Escuela Militar de MedicinaCiudad de Mexico 11200CDMXMexico Cell&Tissue Biology Lab Escuela Militar de MedicinaCiudad de Mexico 11200CDMXMexico Department of Research Escuela Militar de MedicinaCiudad de Mexico 11200CDMXMexico Instituto Tecnológico de Zacatepec Industrial EngineeringTecNMZacatepec 62780MorelosMexico Instituto Tecnológico de Aguascalientes Computational SciencesTecNMAguascalientes 20256Mexico

The process of selecting an artificial intelligence(AI)model to assist clinical diagnosis of a particular pathology and its validation tests is relevant since the values of accuracy,sensitivity and specificity may not reflect the behavior of the method in a real ***,we provide helpful considerations to increase the success of using an AI model in clinical practice.

关键词： Artificial intelligence Diagnostic assistance Validation tests Leave-one-out cross-validation K-fold validation Hold-out validation

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The animal cachexia score(ACASCO)

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Animal Models and Experimental Medicine 2019年第3期2卷 201-209页

作者： Angelica Betancourt Sílvia Busquets Marta Ponce Míriam Toledo Joan Guàrdia‐Olmos maribel Peró‐cebollero Francisco J.López‐Soriano Josep M.Argilés Cancer Research Group Departament de Bioquímica i Biomedicina MolecularFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Institut de Biomedicina de la Universitat de Barcelona BarcelonaSpain Advanced Statistical Data Analysis Applied to Psychology Departament de Metodologia de les Ciències del ComportamentFacultat de PsicologiaUniversitat de BarcelonaBarcelonaSpain Institut de recerca en Cervell Cogniciói Conducta(IR3C)BarcelonaSpain

Background:None of the published studies involving cancer cachexia experimental models have included a measure of the severity of the syndrome like the scoring system previously developed for human *** aim of the present investigation was to define and validate a cachexia score usable in both rat and mouse tumor ***:In order to achieve this goal,we included in the study one rat model(Yoshida AH‐130ascites hepatoma)and two mouse models(Lewis lung carcinoma and Colon26 carcinoma).The Animal cachexia score(ACASCO)includes five components:(a)body and muscle weight loss,(b)inflammation and metabolic disturbances,(c)physical performance,(d)anorexia,and(e)quality of life measured using discomfort symptoms and behavioral ***:Using the ACASCO values,three cut‐off values were estimated by applying hierarchical cluster *** groups were originally described,one exactly below the observed mean,a second exactly over the mean,and two other groups adjusted to every cue(inferior and superior).The three cut‐off values were estimated through maximization of the classification *** was accomplished by using a similarity matrix based on the metric properties of the variables and assuming multinormal *** results show that the four groups were:no cachexia,mild cachexia,moderate cachexia and advanced ***:The results obtained allow us to conclude that the score could be very useful as an endpoint in pre‐clinical studies involving therapeutic strategies for cancer *** potential usefulness of ACASCO relates to the primary endpoint in pre‐clinical cancer cachexia drug evaluations.

关键词： anorexia cachexia classification physical performance quality of life score wasting weight loss

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