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Journal of Geriatric Cardiology 2020年第7期17卷 441-446页

作者： Francisco J Romeo Maximiliano Smietniansky Mariela Cal Cristian Garmendia Juan M Valle Raleigh Ignacio MSeropian mariano falconi Pablo Oberti Vadim Kotowicz Carla RAgatiello Daniel H Berroca Division of Interventional Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Internal Medicine and Geriatrics Hospital Italiano de Buenos AiresBuenos AiresArgentina Division Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Cardiovascular Surgery Hospital Italiano de Buenos AiresBuenos AiresArgentina

Frailty is generally defined as a clinical syndrome of decreased physiologic reserve which drives to increased vulnerability and susceptibility to different stressors together with poor recovery to homeostasis.[1]The relevance of frailty status in a wide range of prospective cohorts is mostly related to an increasing burden in both mortality,hospital readmissions,disability,and falls.

关键词： Aortic stenosis Frailty Transcatheter aortic valve replacement

Twin-Wire Networks for Zero Interconnect,High-Density 4-Wire Electrical Characterizations of Materials

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Research 2022年第2期2022卷 225-234页

作者： Nerio Andres Montoya Valeria Criscuolo Andrea Lo Presti Raffaele Vecchione Christian falconi Department of Electronic Engincering University of Rome Tor VergataVia del Politecnico 1Roma 00133Italy School of Physics Universidad Nacional de ColombiaA.A.3840 MedellinColombia Center for Advanced Biomaterial for Health Care Istituto Italiano di TecnologiaLargo Barsantie Matteucci 53Naples 80125Italy

Four-wire measurements have been introduced by Lord Kelvin in 1861 and have since become the standard technique for characterizing small resistances and ***,high-density 4-wire measurements are generally complex,time-consuming,and inefficient because of constraints on interconnects,pads,external wires,and mechanical contacts,thus reducing reproducibility,statistical significance,and throu ***,we introduce,systematically design,analyze,and experimentally validate zero interconnect networks interfaced to external instrumentation by couples of twin wire.3D-printed holders with magnets,interconnects,nonadhesive layers,and spacers can effortlessly establish excellent electrical connections with tunable or minimum contact forces and enable accurate measurements even for delicate devices,such as thin metals on soft *** an example,we measured all the resistances of a twin-wire 29-resistor network made of silver-nanoparticle ink printed on polyimide,paper,or photo paper,including during sintering or temperature calibration,resulting in anunprecedentedly easy and accurate characterization of both resistivity and its temperature *** theoretical framework and experimental strategies reported here represent a breakthrough toward zero interconnect,simple,and efficient high-density 4-wire characterizations,can be generalized to other 4-wire measurements(impedances,sensors)and can open the way to more statistically meaningful and reproducible analyses of materials,high-throughput measurements,and minimally invasive characterizations of biomaterials.

关键词： impedance characterization breakthrough

Endoscopic ultrasound radiofrequency ablation of pancreatic insulinoma in elderly patients:Three case reports

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World Journal of Clinical Cases 2022年第19期10卷 6514-6519页

作者： Gemma Rossi Maria Chiara Petrone Gabriele Capurso Stefano Partelli Massimo falconi Paolo Giorgio Arcidiacono Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita-Salute San Raffaele UniversityMilano 20132Italy Department of Pancreatic Surgery Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita-Salute San Raffaele UniversityMilano 20132Italy

BACKGROUND Endoscopic ultrasound(EUS)-guided radiofrequency ablation(RFA)has recently been proposed as a local treatment for functional pancreatic neuroendocrine neoplasms in patients unfit for surgery,in order to obtain clinical syndrome *** on the safety and long-term effectiveness of this approach are scarce,and EUS-RFA procedures are not *** SUMMARY The present case series reports 3 elderly patients with a pancreatic insulinoma and comorbidities,locally treated by EUS-guided RFA with clinical success in terms of hypoglycemic *** procedures were performed during deep sedation,under EUS control with a 19 G needle,an electrode 5-mm in size at a power of 30 W and multiple RFA applications during the same session in order to treat the whole area of the *** relief of symptoms was evident in 2 patients after the first EUS-RFA,while in the third patient a second endoscopic treatment was *** 3 patients are symptom-free without need of medications after 24 mo of follow-up with imaging follow-up showing no disease recurrence.A single adverse event of intraprocedural bleeding occurred,which was successfully treated *** EUS-RFA represents an effective and safe alternative to surgery for the treatment of insulinomas in elderly patients at high surgical ***,larger multicenter studies withlonger follow-up are needed in order to better assess its safety and clinical success.

关键词： Endoscopic ultrasound Radiofrequency ablation Insulinomas Neuroendocrine neoplasms Ablative therapies Case report

Feasibility of therapeutic endoscopic ultrasound in the bridge-to-surgery scenario:The example of pancreatic adenocarcinoma

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World Journal of Gastroenterology 2022年第10期28卷 976-984页

作者： Giuseppe Vanella Domenico Tamburrino Gabriele Capurso Michiel Bronswijk Michele Reni Giuseppe Dell'Anna Stefano Crippa Schalk Van der Merwe Massimo falconi Paolo Giorgio Arcidiacono Pancreatobiliary Endoscopy and EUS Division Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilan 20132Italy Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilan 20132Italy Department of Gastroenterology and Hepatology University Hospital GasthuisbergUniversity of LeuvenLeuven 3000Belgium Department of Gastroenterology and Hepatology Imelda HospitalBonheiden 2820Belgium Department of Medical Oncology Pancreas Translational&Clinical Research CenterIRCCS San Raffaele Scientific InstituteMilan 20132Italy

Upfront resection is becoming a rarer indication for pancreatic ductal adenocarcinoma,as biologic behavior and natural history of the disease has boosted indications for neoadjuvant ***,gastric outlet obstruction and acute cholecystitis can frequently complicate this window of opportunity,resulting in potentially deleterious chemotherapy discontinuation,whose resumption relies on effective,prompt and long-lasting management of these *** therapeutic endoscopic ultrasound(t-EUS)can potentially offer some advantages over comparators,its use in potentially resectable patients is primal and has unfairly been restricted for fear of potential technical difficulties during subsequent *** is a narrative review of available evidence regarding EUS-guided choledochoduodenostomy,gastrojejunostomy and gallbladder drainage in the bridge-to-surgery ***-ofconcept evidence suggests no influence of t-EUS procedures on outcomes of eventual subsequent ***,the very high efficacy-invasiveness ratio over comparators in managing pancreatic cancer-related symptoms or complications can provide a powerful weapon against chemotherapy discontinuation,potentially resulting in higher subsequent *** evidence is discussed in this short paper,together with technical notes that might be useful for endoscopists and surgeons operating in this *** published evidence supports restricting t-EUS in potential surgical candidates,especially in the setting of pancreatic cancer patients undergoing neoadjuvant ***-to-surgery tEUS deserves further prospective evaluation.

关键词： Endosonography Gastrojejunostomy Choledochoduodenostomy Gallbladder drainage Pancreatic cancer Pancreatic surgery

Screening for pancreatic cancer-a compelling challenge

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 264-266页

作者： Gabriele Capurso Salvatore Paiella Massimo falconi Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilanItaly General and Pancreatic Surgery Unit Pancreas InstituteUniversity of VeronaVeronaItaly Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSUniversitàVita-SaluteMilanItaly

Efficacy of pancreatic cancer surveillance programs The publication of the American Gastroenterology Association(AGA)Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals(HRIs)underlines the increasing attention for this topic(1).Secondary prevention(surveillance)for pancreatic ductal adenocarcinoma(PDAC),however,remains a challenge with many unsolved questions(Table 1).

关键词： prevention cancer Cancer

Equilibrium Piezoelectric Potential Distribution in a Deformed ZnO Nanowire

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Nano Research 2009年第8期2卷 624-629页

作者： Giulia Mantini Yifan Gao A.DʼAmico C.falconi Zhong Lin Wang School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332-0245USA Department of Electronic Engineering University of Tor VergataVia del Politecnico 100133 RomaItaly

The equilibrium piezoelectric potential distribution in a deformed ZnO semiconductive nanowire has been systematically investigated in order to reveal its dependence on the donor concentration,applied force,and geometric *** particular,the donor concentration markedly affects the magnitude and distribution of the electric *** a donor concentration of ND>1018 cm-3,the piezopotential is almost entirely *** the other parameters,a variation in the length of the nanowire does not signifi cantly affect the potential distribution.

关键词： Nanogenerator ZnO nanowire

Chaotic dynamics and coexistence in a three species interaction model

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International Journal of Biomathematics 2015年第2期8卷 135-159页

作者： Eduardo Saez Eduardo Stange Ivan Szanto Eduardo Gonzalez-Olivares Manuel falconi Departamento de Matematica Universidad Tecnica Federico Santa Maria Valparaiso Chile Instituto de Matemdticas Universidad de Valparaiso Valparaiso Chile Departamento de Matemdtica Universidad Tdcnica Federico Santa Maria Valparaiso Chile Departamento de Matemdticas Facultad de Ciencias Universidad Nacional Autonoma de Mdxico Ciudad de Mexico Mexico

This work deals with a three-dimensional system, which describes a food web model consisting of a prey, a specialist predator and a top predator which is generalist as it consumes the other two species. Using tools of dynamical systems we prove that the trajectories of system are bounded and that open subsets of parameters exist, such that the system in the first octant has at most two singularities. For an open subset of the parameters space, the system is shown to have an invariant compact set and this is a topologically transitive attractor set. Finally, we find another open set in the parameters space, such that the system has two limit cycles each contained in different invariant planes. The work is completed with a numeric simulation showing the attractor is a strange attractor .

关键词：混沌动力学三维系统动模共存参数空间极限循环奇怪吸引子使用工具

Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology

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World Journal of Gastroenterology 2016年第45期22卷 9944-9953页

作者： Stefano Crippa Stefano Partelli Giulio Belfiori Marco Palucci Francesca Muffatti Olga Adamenko Luca Cardinali Claudio Doglioni Giuseppe Zamboni Massimo falconi Division of Pancreatic Surgery Pancreas Translational and Clinical Research Center San Raffaele Scientific Institute Vita e Salute University Department of Surgery Università Politecnica delle Marche Ospedali Riuniti Department of Pathology Pancreas Translational and Clinical Research Center San Raffaele Scientific Institute Vita e Salute University Department of Pathology Ospedale Sacro Cuore-Don Calabria

Neuroendocrine carcinomas(NEC) of the pancreas are defined by a mitotic count > 20 mitoses/10 high power fields and/or Ki67 index > 20%, and included all the tumors previously classified as poorly differentiated endocrine carcinomas. These latter are aggressive malignancies with a high propensity for distant metastases and poor prognosis, and they can be further divided into small- and large-cell subtypes. However in the NEC category are included also neuroendocrine tumors with a well differentiated morphology but ki67 index > 20%. This category is associated with better prognosis and does not significantly respond to cisplatin-based chemotherapy, which represents the gold standard therapeutic approach for poorly differentiated NEC. In this review, the differences between well differentiated and poorly differentiated NEC are discussed considering both pathology, imaging features, treatment and prognostic implications. Diagnostic and therapeutic flowcharts are proposed. The need for a revision of current classification system is stressed being well differentiated NEC a more indolent disease compared to poorly differentiated tumors.

关键词：胰腺的 neuroendocrine 肿瘤外科 Neuroendocrine 癌化疗预后转移形态学增长

Medical treatment for gastro-entero-pancreatic neuroendocrine tumours

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World Journal of Gastrointestinal Oncology 2016年第4期8卷 389-401页

作者： Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo falconi Stefano Cascinu Department of Medical Oncology Università Politecnica delle Marche Chirurgia del Pancreas Ospedale San Raffaele IRCCS Università Vita e Salute

Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing.

关键词： Neuroendocrine neoplasms of the gastro-entero-pancreatic system Chemotherapy Targeted agents Somatostatin analogues Everolimus Sunitinib

Characterization of Chitotriosidase Enzyme Activity in the Serum of the American Alligator (<i>Alligator mississippiensis</i>)

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Advances in Biological Chemistry 2018年第5期8卷 81-90页

作者： Kenneth Kidder Rodolfo falconi Mark Merchant Department of Chemistry McNeese State University Lake Charles USA

Chitotriosidase (ChT) is an endoglucosaminidase enzyme that cleaves chitinous substrates and has been strongly associated with innate immune activity and the ability to identify non-selftissues. This enzyme activity was detected and characterized the serum from the American alligator (Alligator mississippiensis) using a fluorometric probe. Alligator serum exhibited volume-dependent activity, with activity (2.1 ± 0.3 μmol/min) observed at dilutions as low as a 1:150, and maximum activity (5.2 ± 0.6 μmol/min) measured at a dilution of 1:30. Alligator serum ChT showed linear activity for approximately 20 min, at which time activity decreased exponentially, presumably due to the depletion of substrate. In addition, the ChT activity in alligator serum was temperature-dependent with low activity at 5°C, a sharp increase from 10°C - 30°C, and maximal activity from 30°C - 40°C. The activity was inhibited in the presence of water-soluble chitin, but not mannan, indicating the specificity of the enzyme. The presence of ChT in alligator serum is likely to be partially responsible for the potent innate immune system of these crocodylians, and particularly antifungal activities.

关键词： Antifungal Crocodilian Crocodylian Innate Immunity