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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2382-2394页

作者： Parisa PIROOZFAR Samad ALIPOUR Soroush MODABBERI David cohen Department of Geology Faculty of SciencesUrmia University School of Geology University of Tehran School of Biological Earth and Environmental SciencesNew South Wales University

This study considered the possibility of using visible and near infrared(VNIR) spectral absorption feature parameters(SAFPs) in predicting the concentration and mapping the distribution of heavy metals in sediments of the Takab area. In total, 60 sediment samples were collected along main streams draining from the mining districts and tailing sites, in order to measure the concentration of As, Co, V, Cu, Cr, Ni, Hg, Ti, Pb and Zn and the reflectance spectra(350–2500 nm). The quantitative relationship between SAFPs(Depth500 nm, R610/500 nm, R1344/778 nm, Area500 nm, Depth2200 nm, Area2200 nm, Asym2200 nm) and geochemical data were assessed using stepwise multiple linear regression(SMLR) and enter multiple linear regression(EMLR) methods. The results showed a strong negative correlation between Ni and Cr with Area2200 nm, a significant positive correlation between As and Asym2200 nm, Ni and Co with Depth2200 nm, as well as Co, V and total values with Depth500 nm. The EMLR method eventuated in a significant prediction result for Ni, Cr, Co and As concentrations based on spectral parameters, whereas the prediction for Zn, V and total value was relatively weak. The spatial distribution pattern of geochemical data showed that mining activities, along with the natural weathering of base metal occurrences and rock units, has caused high concentrations of heavy metals in sediments of the Sarough River tributaries.

关键词： heavy metals SAFPs VNIR spectroscopy multiple linear regression Takab Iran

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Pioneering the direct large-scale laser printing of flexible“graphenic silicon”self-standing thin films as ultrahigh-performance lithium-ion battery anodes

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Carbon Energy 2024年第7期6卷 26-40页

作者： Avinash Kothuru Adam cohen Gil Daffan Yonatan Juhl Fernando Patolsky School of Chemistry Faculty of Exact SciencesTel Aviv UniversityTel AvivIsrael Department of Materials Science and Engineering The Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael

Recent technological advancements,such as portable electronics and electric vehicles,have created a pressing need for more efficient energy storage ***-ion batteries(LIBs)have been the preferred choice for these applications,with graphite being the standard anode material due to its ***,graphite falls short of meeting the growing demand for higher energy density,possessing a theoretical capacity that lags *** address this,researchers are actively seeking alternative materials to replace graphite in commercial *** promising avenue involves lithiumalloying materials like silicon and phosphorus,which offer high theoretical ***-silicon composites have emerged as a viable option,showing improved capacity and performance over traditional graphite or pure silicon ***,the existing methods for synthesizing these composites remain complex,energy-intensive,and costly,preventing widespread adoption.A groundbreaking approach is presented here:the use of a laser writing strategy to rapidly transform common organic carbon precursors and silicon blends into efficient“graphenic silicon”composite thin *** films exhibit exceptional structural and energy storage *** resulting three-dimensional porous composite anodes showcase impressive attributes,including ultrahigh silicon content,remarkable cyclic stability(over 4500 cycles with∼40%retention),rapid charging rates(up to 10 A g^(-1)),substantial areal capacity(>5.1 mAh cm^(-2)),and excellent gravimetric capacity(>2400 mAh g^(-1) at 0.2 A g^(-1)).This strategy marks a significant step toward the scalable production of high-performance LIB *** widely available,cost-effective precursors,the laser-printed“graphenic silicon”composites demonstrate unparalleled performance,potentially streamlining anode production while maintaining exceptional *** innovation not only paves the way for advanced LIBs but also sets a precedent for

关键词： 4D printing energy storage fast-charging laser-induced graphene lithium-ion silicon carbon composite anodes

Inorganic arsenic： A non-genotoxic carcinogen

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Journal of Environmental Sciences 2016年第11期28卷 28-37页

作者： Samuel M.cohen Aparajita Chowdhury Lora L.Arnold Department of Pathology and Microbiology University of Nebraska Medical Center Omaha NE 68198-3135 USA.

Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for cancer and non-cancer effects involves the metabolic generation of trivalent arsenicals and their reaction with sulfhydryl groups within critical proteins in various cell types which leads to the biological response. In epithelial cells, the response is cell death with consequent regenerative proliferation. If this continues for a long period of time, it can result in an increased risk of cancer. Arsenicals do not react with DNA. There is evidence for indirect genotoxicity in various in vitro and in vivo systems, but these involve exposures at cytotoxic concentrations and are not the basis for cancer development. The resulting markers of genotoxicity could readily be due to the cytotoxicity rather than an effect on the DNA itself. Evidence for genotoxicity in humans has involved detection of chromosomal aberrations, sister chromatid exchanges in lymphocytes and micronucleus formation in lymphocytes, buccal mucosal cells, and exfoliated urothelial cells in the urine. Numerous difficulties have been identified in the interpretation of such results, including inadequate assessment of exposure to arsenic, measurement of micronuclei, and potential confounding factors such as tobacco exposure, folate deficiency, and others. Overall, the data strongly supports a non-linear dose response for the effects of inorganic arsenic. In various in vitro and in vivo models and in human epidemiology studies there appears to be a threshold for biological responses, including cancer.

关键词： Arsenic Cancer Genotoxicity Cytotoxicity Regeneration Cell proliferation

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Uncertainty and filtering of hidden Markov models in discrete time

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Probability, Uncertainty and Quantitative Risk 2020年第1期5卷 68-101页

作者： Samuel N.cohen Mathematical Institute University of OxfordWoodstock RoadOxfordUK

We consider the problem of filtering an unseen Markov chain from noisy observations,in the presence of uncertainty regarding the parameters of the processes *** the theory of nonlinear expectations,we describe the uncertainty in terms of a penalty function,which can be propagated forward in time in the place of the *** also investigate a simple control problem in this context.

关键词： Filtering Optimal control Robustness Nonlinear expectation

Global chronostratigraphical correlation table for the last 2.7 million years

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Episodes 2008年第2期31卷 243-247页

作者： Philip Gibbard Kim M. cohen Cambridge Quaternary Department of Geography University of Cambridge Cambridge CB2 3EN England. Utrecht Centre of Geosciences Department of Physical Geography Utrecht University P.O.Box 80.115 3508TC Utrecht The Netherlands.

The table provides a correlation of chronostratigraphical subdivisions of late Cenozoic geological time, spanning the last 2. 7 million years. The formal division of the Quaternary is the responsibility of the International Commission on Stratigraphy＇s （ICS） Subcommission on Quaternary Stratigraphy （SQS）, in partnership with the International Union for Quaternary Research＇s （INQUA） Commission on Stratigraphy and Chronology （SACCOM）. This is the third published version of the chart. Earlier versions are Gibbard et al., 2004, 2005. See http：//***/correlation/ for history.

关键词：地球新生界地质第四纪地质时代

Theoretical Aspects of Nucleate Pool Boiling with Dielectric Liquids

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Journal of Thermal Science 1992年第1期1卷 46-47页

作者： AvramBan－cohen WeiTong 等 DepartmentofMechanicalEngineeringUniversityofMinnesota MinneapolisMN55455U.S.A DepartmentofMechanic

Direct cooling with inert,dielectric liquids may well become the technique of choice for the thermal manage- ment of future electronic *** to the efficiency of phase-change processes and the simplicity of natural circulation,nucleate pool boiling is of great interest for this *** paper examines the characteristics of vapor bubbles and nucleate pool boiling of the dielectric *** results provide a theoretical foundation for understanding and interpreting the often complex empirical results reported in the literature.

关键词： nucleate pool boiling dielectric liquids thermo-fluid properties dissolved gas contact angle hystereses embryo formation boiling incipience bubble-vapor flow regime wake-pumping effect.

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Use of perioperative chemotherapy in colorectal cancer metastatic to the liver

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Gastroenterology Report 2019年第5期7卷 301-311,I0001页

作者： Lynn K.Symonds Stacey A.cohen Division of Oncology University of WashingtonSeattleWAUSA Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA

A curative-intent approach may improve survival in carefully selected patients with oligometastatic colorectal *** treatments are most frequently administered to patients with isolated liver metastasis,though they may be judiciously considered for other sites of *** be considered for curative intent with surgery,patients must have disease that can be definitively treated while leaving a sufficient functional liver *** chemotherapy may be used for upfront resectable disease as a test of tumor biology and/or for upfront unresectable disease to increase the likelihood of resectability(so-called‘conversion’chemotherapy).While conversion chemotherapy in this setting aims to improve survival,the choice of a regimen remains a complex and highly individualized *** this review,we discuss the role of RAS status,primary site,sidedness,and other clinical features that affect chemotherapy treatment selection as well as key factors of patients that guide individualized patient-treatment recommendations for colorectal-cancer patients being considered for definitive treatment with metastasectomy.

关键词： metastatic colorectal cancer perioperative chemotherapy conversion chemotherapy liver resection KRAS steatohepatitis

Herbaceous peony in warm climate:Modelling stem elongation and growers profit responses to dormancy conditions

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Information Processing in Agriculture 2016年第3期3卷 175-182页

作者： Menashe cohen Rina Kamenetsky Gregory Yom Din Northern R&D MigalP.O.Box 831Kiryat Shmona 11016Israel Institute of Plant Science Agricultural Research OrganizationVolcani CenterBet Dagan 50250Israel Open University of Israel RaananaIsrael Faculty of Exact Sciences Tel Aviv UniversityTel AvivIsrael

We analysed the data collected for herbaceous peony cultivated in a warm climate region and stored in winter under three constant chilling *** used the quadratic regression model to describe the stem elongation responses to winter dormancy conditions,and the logistic function to describe the weekly stems *** predicted maximal stem length from the first model was used as the input parameter for the second *** than 4000 data for various(a)chilling constant temperatures during dormancy,(b)dormancy duration,and(c)germination duration,were *** models were applied to determine the optimal number of chill *** this purpose,two criteria were used in different versions of the model:the maximal stem length and the maximal profit of *** the two chilling temperatures of 2℃ and 6℃,the optimal values of chill units(in the models of a maximal stem length and maximal profit of farmers)are close to one another,and the values of a maximal stem length and maximal profit are significantly *** the case of the third chilling temperature of 10℃,the model failed to determine the optimal number of chill *** method of inverse confidence intervals for testing the significance of the optimal number of chill units was used.

关键词： Peony Dormancy Regression Logistic function Inverse confidence intervals Profit

Signal-induced PARP1-Erk synergism mediates IEG expression

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Signal Transduction and Targeted Therapy 2019年第1期4卷 580-587页

作者： Malka cohen-Armon Adva Yeheskel John M.Pascal Department of Physiology and Pharmacology Sackler School of MedicineTel-Aviv UniversityTel-Aviv 69978Israel Sagol School of Neuroscience Tel-Aviv UniversityTel-Aviv 69978Israel Bioinformatics Unit George S.Wise Faculty of Life SciencesTel-Aviv UniversityTel-Aviv 69978Israel Department of Biochemistry and Molecular Medicine University of MontrealQuébecCanada

A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes(IEG)in response to a variety of extra-and intra-cellular signals implicated in memory acquisition,development and ***,we review this mechanism,which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the *** binding maintains their long-lasting activity in a synergism,which offers a new pattern for targeted therapy.

关键词： PARP1 Erk stimulation

Weakly supervised 2D human pose transfer

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Science China(Information Sciences) 2021年第11期64卷 36-51页

作者： Qian ZHENG Yajie LIU Zhizhao LIN Dani LISCHINSKI Daniel cohen-OR Hui HUANG College of Computer Science and Software Engineering Shenzhen University School of Computer Science and Engineering The Hebrew University of Jerusalem

We present a novel method for pose transfer between two 2 D human skeletons. When the bone lengths and proportions between the two skeletons are significantly different, pose transfer becomes a challenging task, which cannot be accomplished by simply copying the joint positions or the bone *** data-driven approach utilizes a deep neural network trained, in a weakly supervised fashion, to encode a skeleton into two separate latent codes, one representing its pose, and another representing the skeleton’s proportions(skeleton-ID). The network is given two skeletons, and learns to combine the pose of one with the skeleton-ID of the other. Lacking supervision on the poses, we develop a novel loss that qualitatively compares poses of different skeletons. We evaluate the performance of our method on a large set of *** advantages of avoiding supervision are demonstrated by showing transfer of extreme poses, as well as between uncommon skeleton proportions.

关键词： pose transfer weak supervision human skeleton