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Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2023年第3期8卷 229-237,I0074-I0085页

作者： Sabine L Collette Michael P Rodgers marianne a a van walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper M Martens Gert J de Borst Gert Jan R Luijckx Charles B L M Majoie Aad van der Lugt Reinoud P H Bokkers Maarten Uyttenboogaart University Medical Centre Groningen University of GroningenGroningenThe Netherlands Leiden University Medical Centre LeidenThe Netherlands Erasmus MC University Medical CentreRotterdamThe Netherlands Amsterdam University Medical Centres University of AmsterdamAmsterdamThe Netherlands Rijnstate Hospital ArnhemThe Netherlands University Medical Centre Utrecht University of UtrechtUtrechtThe Netherlands

Background The optimal management of ipsilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is *** compared the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).Methods In this observational study,we included patients who had an acute ischaemic stroke undergoing EVT and a concomitant ipsilateral extracranial ICA stenosis of≥50%or occlusion of presumed atherosclerotic origin,from the Dutch Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry(2014-2017).The primary endpoint was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤*** endpoints were successful intracranial reperfusion,new clot in a different vascular territory,symptomatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse *** Of the 433 included patients,169(39%)underwent EVT with *** 123/168(73%)patients,CAS was performed before intracranial *** 42/224(19%)patients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was *** with and without CAS were associated with similar proportions of good functional outcome(47%vs 42%,respectively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the groups in any of the secondary endpoints,except for the increased odds of a new clot in a different vascular territory in the EVT with CAS group(aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comparable after EVT with and without *** during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.

关键词： stenosis carotid treatment

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Study of relationship between motion of mechanisms in gas operated weapon and its shock absorber

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Defence Technology（防务技术） 2024年第3期33卷 42-54页

作者： Jiri Balla Roman Vitek Dung Nguyen van Zbynek Krist Hung Nguyen van Department of Weapons and Ammunition University of Defence BrnoCzech Republic Department of Weapons Le Quy Don Technical UniversityHanoiViet Nam Department of Design and Special Engineering Alexander Dubcek University of TrencinSlovakia

The article deals with the motion of the breech block carrier and the weapon casing of an automatic weapon mounted on a flexible carriage and the base of the *** works,which did not consider the dynamic properties of the base of the weapon,did not allow to reconcile the calculated and experimental results of the weapon casing displacement when shooting from firing *** the analysis of the motion of individual parts,the methods of mathematical modelling and firing experiments using a high-speed camera were *** show the best accord with experiment when modelling the system with 4 degrees of *** oscillation of the system regarding the movement of the breech block carrier and the weapon casing was investigated under changed conditions of rate of fire,the use of a muzzle brake and different types of shock *** velocities and displacements of the weapon casing and the breech block carrier at different values of the impulse of the gases to the breech block carrier were determined.

关键词： Shock absorber Gas-operated weapon Force-impulse diagram Recoil system Breech block carrier

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Stereoselective recognition of morphine enantiomers by μ-opioid receptor

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National Science Review 2024年第3期11卷 183-191页

作者： Yibo Wang van A.Ngo Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of Sciences Advanced Computing for Life Sciences and Engineering Group Science Engagement Section National Center for Computational Sciences Oak Ridge National Lab School of Applied Chemistry and Engineering University of Science and Technology of China Beijing National Laboratory for Molecular Sciences

Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor（MOR） exhibits binding affinity towards（-）-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the（+）-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of（-）-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast,（+）-morphine fails to sustain the activation state of ***, the results suggest that specific residues, namely D1142.50and D1473.32, are deprotonated in the active state of MOR bound to（-）-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.

关键词： stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

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Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non‑essential blood AA profile in pigs

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1336-1346页

作者： Maximiliano Muller Elout van Liefferinge Alan Tilbrook Robert van Barneveld Eugeni Roura Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueensland 4072Australia Laboratory of Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyGhent University339000 GhentFlandersBelgium Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation and the School of Veterinary ScienceThe University of QueenslandBrisbaneQueensland 4072Australia SunPork Group BrisbaneQueensland 4009Australia

Background Commercial diets are frequently formulated to meet or exceed nutrient levels including those of lim-iting essential amino acids(AA)covering potential individual variations within the ***,the provision of dietary excess of AA,such as Lys,may lead to reduced appetite and growth in *** mechanisms modulat-ing these responses have not been extensively *** study evaluated the effect of Lys dietary excesses on performance and satiety biomarkers in post weaning *** Twenty-four pigs aged 21 d and weighing 6.81±0.12kg(mean±SEM)were individually housed and offered 1 of 4 dietary treatments for 3weeks:a diet containing a standardized ileal digestible Lys reaching 100%(T0),120%(T1),150%(T2)or 200%(T3)of the NRC(2012)*** the end of the experiment,blood samples from the cephalic vein of the T0 and T3 groups were obtained for AA *** addition,primary intestinal cultures from T0 pigs were used,following their humane killing,to evaluate the effect of Lys on gut hormone secretion and AA sensors gene expression under ex vivo *** Feed intake was linearly reduced(P<0.001)and the weight gain to feed ratio reduced(P<0.10)with increased dietary levels of Lys during the third-and first-week post weaning,*** con-centration(P<0.05)and the metabotropic glutamate receptor 1 and the solute carrier family 7 member 2(P<0.10)gene expression was enhanced in proximal jejunum tissues incubated with Lys at 20mmol/L when compared to the control(Lys 0mmol/L).Plasma Lys and Glu(P<0.05)concentration increased in the T3 compared to T0 *** contrast,plasma levels of His,Val,Thr,Leu(P<0.05)and Gln(P<0.10)were lower in T3 than T0 *** The present results confirm that excess dietary Lys inhibits hunger in ***,the results provide evidence of pre-and post-absorptive mechanisms modulating these *** dietary excesses should be nar-rowed,when possible,to avoid negative effects of

关键词： Amino acid Blood Cholecystokinin Feed intake Lysine Pig Satiety

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Transient responses of double-curved sandwich two-layer shells resting on Kerr's foundations with laminated three-phase polymer/GNP/fiber surface and auxetic honeycomb core subjected to the blast load

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Defence Technology（防务技术） 2024年第5期35卷 222-247页

作者： Nguyen Thi Hai van Thi Hong Nguyen Researcher&Lecturer Faculty of Industrial EducationThe University of Danang-University of Technology and Education48 Cao ThangDanang550000Viet Nam Researcher&Lecturer Faculty of Mechanical EngineeringThuyloi University175 Tay SonDong DaHanoi100000Viet Nam

This work uses refined first-order shear theory to analyze the free vibration and transient responses of double-curved sandwich two-layer shells made of auxetic honeycomb core and laminated three-phase polymer/GNP/fiber surface subjected to the blast *** of the two layers that make up the double-curved shell structure is made up of an auxetic honeycomb core and two laminated sheets of three-phase polymer/GNP/*** exterior is supported by a Kerr elastic foundation with three *** key innovation of the proposed theory is that the transverse shear stresses are zero at two free surfaces of each *** contrast to previous first-order shear deformation theories,no shear correction factor is ***'s exact solution was used to treat the double-curved shell problem with a single title boundary,while the finite element technique and an eight-node quadrilateral were used to address the other boundary *** ensure the accuracy of these results,a thorough comparison technique is employed in conjunction with credible *** problem model's edge cases allow for this kind of *** study's findings may be used in the post-construction evaluation of military and civil works structures for their ability to sustain explosive *** addition,this is also an important basis for the calculation and design of shell structures made of smart materials when subjected to shock waves or explosive loads.

关键词： Blast load Two-layer shell Polymer/GNP/Fiber surface Auxetic honeycomb Shear connectors

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No evidence of predator odor avoidance in a North American bird community

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Avian Research 2024年第1期15卷 133-138页

作者： Austin Dotta Batur Yaman Alex van Huynh Department of Biology DeSales University2755 Station AvenueCenter ValleyPAUSA

Recent advances in our understanding of avian chemical communication have highlighted the importance of olfaction in many aspects of avian *** studies investigating predator avoidance behaviors in response to predator odor cues have produced mixed results across species and *** we assess if a community of birds in eastern Pennsylvania displays avoidance behaviors towards predator odor cues in a natural foraging *** use clay caterpillars to measure foraging activity by birds in the presence of predator(bobcat)urine,non-predator(rabbit)urine,and water controls in two different environmental contexts(field ***).Although we detected a weak trend for birds to forage less at predator urine-treated sites,we found no significant difference in avian foraging between the site *** did find that foraging rates between environmental contexts changed significantly over the course of the experiment,with forest sites showing decreasing foraging rates and field sites showing increasing foraging *** results reinforce the published literature that avoidance of predator odors by birds may not be ubiquitous across contexts and species.

关键词： Foraging Odor Olfaction Predation Predator-avoidance

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An isogeometric approach to static and transient analysis of fluid-infiltrated porous metal foam piezoelectric nanoplates with flexoelectric effects and variable nonlocal parameters

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 461-489页

作者： Quoc-Hoa PHAM van Ke Tran Phu-Cuong Nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh City 700000Vietnam

In this work,a novel refined higher-order shear deformation plate theory is integrated with nonlocal elasticity theory for analyzing the free vibration,bending,and transient behaviors of fluid-infiltrated porous metal foam piezoelectric nanoplates resting on Pasternak elastic foundation with flexoelectric *** analysis(IGA)and the Navier solution are applied to the *** innovation in the present study is that the influence of the in-plane variation of the nonlocal parameter on the free and forced vibration of the piezoelectric nanoplates is investigated for the first *** nonlocal parameter and material characteristics are assumed to be material-dependent and vary gradually over the thickness of *** on Hamilton’s principle,equations of motion are built,then the IGA approach combined with the Navier solution is used to analyze the static and dynamic response of the ***,we investigate the effects of the porosity coefficients,flexoelectric parameters,elastic stiffness,thickness,and variation of the nonlocal parameters on the mechanical behaviors of the rectangular and elliptical piezoelectric nanoplates.

关键词： isogeometric analysis fluid-infiltrated porous piezoelectric nanoplates static and transient analysis flexoelectric effect variable nonlocal parameters

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SUPERCHARGED Express couriers meet China's ever-evolving need for delivery speed By Elsbeth van Paridon

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Beijing Review 2024年第5期67卷 12-15页

作者： Elsbeth van Paridon 不详

Jingdong ayi lai la!Or"The Jing Dongauntie is here!"in plain *** cheeks,unmistakably the result of spending a lot of time outdoors in the ice box that is Beijing winter,He Fang emerges from behind a long line of delivery karts,wrapped in several *** outer layer is a perfect match for the tiny three-wheeled vehicles:red and emblazoned with"JDL."The three letters stand for JD Logistics,the shipping and delivery arm of ***,launched in 2004 and now one of China's three key e-commerce players,together with Alibaba and PDD.

关键词： Express perfect winter

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Active self-training for weakly supervised 3D scene semantic segmentation

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Computational Visual Media 2024年第3期10卷 425-438页

作者： Gengxin Liu Oliver van Kaick Hui Huang Ruizhen Hu College of Computer Science&Software Engineering Shenzhen UniversityShenzhen 518060China School of Computer Science Carleton UniversityOttawa K1S 5B6Canada

Since the preparation of labeled datafor training semantic segmentation networks of pointclouds is a time-consuming process, weakly supervisedapproaches have been introduced to learn fromonly a small fraction of data. These methods aretypically based on learning with contrastive losses whileautomatically deriving per-point pseudo-labels from asparse set of user-annotated labels. In this paper, ourkey observation is that the selection of which samplesto annotate is as important as how these samplesare used for training. Thus, we introduce a methodfor weakly supervised segmentation of 3D scenes thatcombines self-training with active learning. Activelearning selects points for annotation that are likelyto result in improvements to the trained model, whileself-training makes efficient use of the user-providedlabels for learning the model. We demonstrate thatour approach leads to an effective method that providesimprovements in scene segmentation over previouswork and baselines, while requiring only a few userannotations.

关键词： semantic segmentation weakly supervised self-training active learning

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Recent advances and innovations in the design and fabrication of wearable flexible biosensors and human health monitoring systems based on conjugated polymers

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Bio-Design and Manufacturing 2024年第4期7卷 476-516页

作者： Vinh van Tran Viet-Duc Phung Daeho Lee Department of Mechanical Engineering Gachon UniversitySeongnam 13120Republic of Korea Institute of Fundamental and Applied Sciences Duy Tan UniversityHo Chi Minh City 700000Vietnam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDa Nang 550000Vietnam

Wearable biosensors have received great interest as patient-friendly diagnostic technologies because of their high flexibility and *** growing research and utilization of novel materials in designing wearable biosensors have accelerated the development of point-of-care sensing platforms and implantable biomedical devices in human health *** numerous potential materials,conjugated polymers(CPs)are emerging as ideal choices for constructing high-performance wearable biosensors because of their outstanding conductive and mechanical ***,CPs have been extensively incorporated into various wearable biosensors to monitor a range of target ***,fabricating highly reliable CP-based wearable biosensors for practical applications remains a significant challenge,necessitating novel developmental strategies for enhancing the viability of such ***,this review aims to provide consolidated scientific evidence by summarizing and evaluating recent studies focused on designing and fabricating CP-based wearable biosensors,thereby facilitating future *** the superior properties and benefits of CPs,this review aims to clarify their potential applicability within this ***,the fundamentals and main components of CP-based wearable biosensors and their sensing mechanisms are discussed in *** recent advancements in CP nanostructures and hybridizations for improved sensing performance,along with recent innovations in next-generation wearable biosensors are *** wearable biosensors have been—and will continue to be—an ideal platform for developing effective and user-friendly diagnostic technologies for human health monitoring.

关键词： Conjugated polymers Wearable biosensors E-skin electronics Implantable biosensors Conductive polymer hydrogels

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