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Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc

Signal Transduction and Targeted Therapy 2017年第1期2卷 100-107页

作者： Estelle C Collin Oliver Carroll Michelle Kilcoyne marianna peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit Centre for Research in Medical Devices(CÚRAM) National University of IrelandGalwayIreland Department of Microbiology School of Natural SciencesNational University of IrelandGalwayIreland Glycoscience Group National University of IrelandGalwayIreland AO Research Institute DavosSwitzerland Institut fur Laboratoriums-und Transfusionsmedizin Herz-und Diabeteszentrum Nordrhein-WestfalenUniversitatsklinik der Ruhr-Universitat BochumBad OeynhausenGermany

The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc *** date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD *** behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD ***,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were *** expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing *** are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 *** changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair.

关键词： ageing representing synthetic

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