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The transient receptor potential melastatin 2:a new therapeutical target for Parkinson's disease?

Neural Regeneration Research 2023年第8期18卷 1652-1656页

作者： Ana Flávia F.ferreira Luiz Roberto G.Britto Department of Physiology and Biophysics Institute of Biomedical SciencesUniversity of São PauloSão PauloBrazil

The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating mechanism is dependent on reactive oxygen species. In pathological conditions, transient receptor potential melastatin 2 is overactivated, leading to a Ca~(2+) influx that alters cell homeostasis and promotes cell death. The role of transient receptor potential melastatin 2 in neurodegenerative diseases, including Alzheimer's disease and ischemia, has already been described and reviewed. However, data on transient receptor potential melastatin 2 involvement in Parkinson's disease pathology has emerged only in recent years and the issue lacks review studies that focus specifically on this topic. The present review aims to elucidate the role of the transient receptor potential melastatin 2 channel in Parkinson's disease by reviewing, summarizing, and discussing the in vitro, in vivo, and human studies published until August 2022. Here we describe fourteen studies that evaluated the transient receptor potential melastatin 2 channel in Parkinson's disease. The Parkinson's disease model used, transient receptor potential melastatin 2 antagonist and genetic approaches, and the main outcomes reported were discussed. The studies described transient receptor potential melastatin 2 activation and enhanced expression in different Parkinson's disease models. They also evidenced protective and restorative effects when using transient receptor potential melastatin 2 antagonists, knockout, or silencing. This review provides a literature overview and suggests where there is a need for more research. As a perspective point, this review shows evidence that supports transient receptor potential melastatin 2 as a pharmacological target for Parkinson's disease in the future.

关键词： 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine(MPTP) 1-methyl-4-phenylpyridinium(MPP+) 6-hydroxydopamine AG490 clotrimazole flufenamic acid N-(p-amylcinnamoyl)anthranilic acid Parkinson's disease poly-ADPR polymerase type 1(PARP1) rotenone paraquat transient receptor potential melastatin 2(TRPM2)

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Crop residues: applications of lignocellulosic biomass in the context of a biorefinery

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Frontiers in Energy 2022年第2期16卷 224-245页

作者： Maria Carolina ANDRADE Caio de Oliveira GORGULHO SILVA Leonora Rios de SOUZA MOREIRA Edivaldo Ximenes ferreira FILHO Laboratory of Enzymology Department of Cellular BiologyUniversity of BrasiliaBrasiliaDFBrazil

Interest in lignocellulosic biomass conversion technologies has increased recently because of their potential to reduce the dependency on non-renewable feedstocks. Residues from a variety of crops are the major source of lignocellulose, which is being produced in increasingly large quantities worldwide. The commercial exploitation of crop residues as feedstocks for biorefineries which could be used to produce a variety of goods such as biofuels, biochemicals, bioplastics, and enzymes is an attractive approach not only for adding value to residues but also for providing renewable products required by the expanding bioeconomy market. Moreover, the implementation of biorefineries in different regions has the potential to add value to the specific crop residues produced in the region. In this review, several aspects of crop residue application in biorefineries are discussed, including the role of crop residues in the bioeconomy and circular economy concepts, the main technical aspects of crop residue conversion in biorefineries, the main crop residues generated in different regions of the world and their availability, the potential value-added bioproducts that can be extracted or produced from each crop residue, and the major advantages and challenges associated with crop residue utilization in biorefineries. Despite their potential, most biomass refining technologies are not sufficiently advanced or financially viable. Several technical obstacles, especially with regard to crop residue collection, handling, and pre-treatment, prevent the implementation of biorefineries on a commercial scale. Further research is needed to resolve these scale-up-related challenges. Increased governmental incentives and bioeconomic strategies are expected to boost the biorefinery market and the cost competitiveness of biorefinery products.

关键词： crop residue biorefinery bioproduct biomass circular bioeconomy enzyme

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Prediction of ground-borne vibration induced by impact pile driving:numerical approach and experimental validation

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 921-935页

作者： A.Colaço P.Alves Costa C.ferreira C.Parente J.Fernandez-Ruiz CONSTRUCT-FEUP University of PortoRua Dr.Roberto Frias4200-465 PortoPortugal University of La Coruña Department of Civil EngineeringCampus de Elviña 15071La CoruñaSpain

Deep foundations are currently used in engineering practice to solve problems caused by weak geotechnical characteristics of the *** pile driving is an interesting and viable solution from economic and technical points of ***,it is necessary to ensure that the environmental drawbacks,namely ground-borne vibration,are adequately *** this purpose,the authors propose an axisymmetric finite element method-perfectly matched layer(FEM-PML)approach,where the nonlinear behavior of the soil is addressed through an equivalent linear *** the complexity of the problem,an experimental test site was developed and fully *** experimental work comprised in-situ and laboratory soil characterization,as well as the measurement of vibrations induced during pile *** comparison between experimental and numerical results demonstrated a very good agreement,from which it can be concluded that the proposed numerical approach is suitable for the prediction of vibrations induced by impact pile *** experimental database is available as supplemental data and may be used by other researchers in the validation of their prediction models.

关键词： pile driving ground-borne vibrations numerical modeling experimental validation

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Activation of non-basal ＜c + a> slip in multicomponent Mg alloys

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Journal of Magnesium and Alloys 2022年第2期10卷 585-597页

作者： Hyo-Sun Jang Jong-Kwan Lee Antonio Jo?o Seco ferreira Tapia Nack Joon Kim Byeong-Joo Lee Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Graduate Institute of Ferrous Technology Pohang University of Science and Technology (POSTECH)

Activating non-basal slip is a key method to improve room temperature ductility and formability of Mg alloys. However, the detailed criterion for activation of the slip in multicomponent Mg alloys, which can be utilized in commercial Mg alloys, requires further understanding. The present authors investigated the mechanism and criterion using a molecular statics simulation on dislocation behaviors in multicomponent Mg alloys. We found that if multicomponent Mg alloys have an equivalent dislocation binding intensity to associated binary Mg alloys that are optimized to minimize the critical resolved shear stress anisotropy and thus activate the slip,then the critical resolved shear stress anisotropy between slip systems of the multicomponent Mg alloys can also be minimized, resulting in activation of the slip. The activation is maximized in multicomponent Mg alloys when alloying a large amount of weak dislocation binding elements. It was confirmed through experiments that the multicomponent Mg alloys satisfying the above criterion show higher room-temperature tensile elongation and formability than other alloys.

关键词： Mg–Zn–Ca alloy Molecular statics simulation Ductility Formability

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Further investigation on the fusion of ^(6)Li with ^(209)Bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin G.de Angelis M.Siciliano R.Menegazzo S.M.Lenzi J.L.ferreira J.Rangel Serkan Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly Dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly Dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)Bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICF)products were re-quantified experimentally for this reaction *** results reveal that the ICF cross section is equivalent to that of complete fusion(CF)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CDCC)method was performed for the aforementioned CF and ICF cross sections;the result is consistent with the *** universal fusion function(UFF)was also compared with the measured CF cross section for different barrier parameters,demonstrating that the CF suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

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Thermal and photoperiodic requirements of the seedling stage of three tropical forest species

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Journal of Forestry Research 2023年第1期34卷 209-220页

作者： Fabrina Bolzan Martins Mábele de Cássia ferreira Flávia Fernanda Azevedo Fagundes Gabriel Wilson Lorena Florêncio Natural Resource Institute Federal University of ItajubáItajubáMinas Gerais 37500-903Brazil

Air temperature and photoperiod play an important role in the seedling development for tropical forest *** variables are sensitive to climate,and so evaluating thermal and photoperiodic effects on seedling development is fundamental,especially for climate change *** to quantify thermal time and the energy required for plants to reach a development stage include air temperature and cardinal *** photoperiod will also affect physiological reactions of a plant and thus its *** we evaluated the six thermal time methods widely used to compute thermal requirement,and identified the influence of the photoperiod from the 2015 and2016 growing seasons and 12 sowing dates in Itajubá,Minas Gerais state,Brazil,on seedling development of three native tropical forest species Psidium guajava L.(Myrtaceae),Citharexylum myrianthum Cham.(Verbenaceae),and Bixa orellana L.(Bixaceae).The method used to quantify thermal time influenced the analytical results of seedling development;the one that considered three cardinal temperatures and compared them with the mean air temperature(Method5)performed better in computing thermal *** influence of photoperiod on seedling development was inconclusive for the three species,but all three developed better in mild temperatures(between 13.3℃and 26.9℃)with a photoperiod shorter than 13 h.

关键词： Phyllochron Thermal time Day length Seedling stage Phenology

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Soil loss and runoff obtained with customized precipitation patterns simulated by InfiAsper

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International Soil and Water Conservation Research 2022年第3期10卷 407-413页

作者： Daniel Fonseca de Carvalho Pietro Menezes Sanchez Macedo Marinaldo ferreira Pinto Wilk Sampaio de Almeida Nivaldo Schultz Department of Engineering Institute of TechnologyFederal Rural University of Rio de JaneiroSeropedicaRio de JaneiroBrazil Postgraduate Program in Agronomy-Soil Sciences Federal Rural University of Rio de JaneiroSeropedicaRio de JaneiroBrazil Agronomy Department Federal Institute of EducationScience and Technology of RondoniaCampus AriquemesRO 257Km 13AriquemesRO76870-000Brazil Department of Soil Science Institute of AgronomyFederal Rural University of Rio de JaneiroSeropedicaRJBrazil

Applying constant precipitation intensity,which does not occur in natural events,is one of the main limitations concerning rainfall simulators in soil erosion *** present work evaluated the InfiAsper rainfall simulator operating with a new control panel to program rainfalls with different precipitation intensities(PI).Infiltration rates and soil and water losses were evaluated in a Distrophic Acrisol(clay loam texture)with simulated rainfalls of 30 mm and duration of 40 min,considering advanced(AD),intermediate(IN),delayed(DE),and inverted intermediate(II)patterns,all with PI peaks of 110 mm h^(-1),and a constant(CT)*** experimental design was in randomized blocks with five treatments(rainfall patterns)and experimental units measuring 2.5×2.5 *** simulator worked satisfactorily,applying the rainfall according to the preconfigured *** simulated rainfall with the CT and II patterns did not promote runoff nor soil *** and runoff rates varied according to the applied rainfall pattern,reaching 97.8 and 27.3 mm h^(-1)(AD),82.1 and 39.5 mm h^(-1)(IN),and 76.2 and 49.7 mm h^(-1)(DE),*** loss and surface runoff totaled each 4.77 g m^(-2)and 3.9 mm(AD),6.70 g m^(-2)and 6.8 mm(IN),and 6.03 g m^(-2)and 7.0 mm(DE).The InfiAsper simulator modified enables varying precipitation intensity besides obtaining satisfactory results in the field and information consistent with the expected characteristics of natural rainfall *** the intermediate and delayed rainfall patterns,soil and water losses are higher than in the advanced.

关键词： Water erosion Rainfall simulator Precipitation intensity

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A Systematic Review of Forensic Approaches to Disasters: Gaps and Challenges

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International Journal of Disaster Risk Science 2023年第5期14卷 722-735页

作者： Adriano Mota ferreira Victor Marchezini Tatiana Sussel Gonçalves Mendes Miguel Angel Trejo-Rangel Allan Yu Iwama Graduate Program in Disasters Institute of Science and TechnologySão Paulo State University(Unesp)São Josédos CamposSP12247-004Brazil Cemaden–National Center for Monitoring and Early Warning of Natural Disasters São Josédos CamposSP12247-004Brazil Natural Hazards Center Institute of Behavioral ScienceUniversity of Colorado BoulderBoulderCO80309USA Department of Environmental Engineering Institute of Science and TechnologySão Paulo State University(Unesp)São Josédos CamposSP12247-004Brazil Irish Climate Analysis and Research UnitS(ICARUS) Department of GeographyMaynooth UniversityMaynoothW23 F2H6KildareIreland Graduate Program in Development and Environment Federal University of ParaíbaJoão PessoaPB58051-900Brazil

Disaster forensic approaches aim to identify the causes of disasters to support disaster risk ***,few studies have conducted a systematic literature review of scientific articles that labeled themselves as a forensic approach to *** article provides a qualitative analysis of these forensic studies,focusing on five main issues:(1)the methodologies applied;(2)the forensic approaches used in the disaster risk management phases;(3)the hazards addressed;(4)if the methodologies involve social participation,and using what types of participation;and(5)if there are references to urban planning in the scientific studies *** results showed a predominance of the Forensic Investigations of Disasters(FORIN)and Post-Event Review Capability(PERC)methodologies used in isolation or *** is a need for methodologies that engage people in participatory FORIN,fostering the co-production of knowledge and action research approaches.

关键词： Dynamic pressures Forensic investigation Participatory research Risk drivers Root causes

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Application of data science in the prediction of solar energy for the Amazon basin:a study case

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Clean Energy 2023年第6期7卷 1344-1355页

作者： AndréLuis ferreira Marques Márcio JoséTeixeira Felipe Valencia de Almeida Pedro Luiz Pizzigatti Corrêa Polytechnic School of the University of Sao Paulo Av.Prof.Luciano Gualberto380-ButantaSao Paulo-SP05508-010Brazil Institute of Physics of the University of Sao Paulo Brazil

The need for renewable energy sources has challenged most countries to comply with environmental protection actions and to handle climate *** energy figures as a natural option,despite its *** has a green energy matrix with significant expansion of solar form in recent *** preserve the Amazon basin,the use of solar energy can help communities and cities improve their living standards without new hydroelectric units or even to burn biomass,avoiding harsh environmental *** novelty of this work is using data science with machine-learning tools to predict the solar incidence(W.h/m^(2))in four cities in Amazonas state(north-west Brazil),using data from NASA satellites within the period of ***-tree-based models and vector autoregressive(time-series)models were used with three time aggregations:day,week and *** predictor model can aid in the economic assessment of solar energy in the Amazon basin and the use of satellite data was encouraged by the lack of data from ground *** mean absolute error was selected as the output indicator,with the lowest values obtained close to 0.20,from the adaptive boosting and light gradient boosting algorithms,in the same order of magnitude of similar references.

关键词： solar energy renewable energy Amazon basin machine learning time series data science decision-trees ensemble vector autoregression

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Groundwater quality in the vicinity of a dumpsite in Lagos metropolis,Nigeria

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Geography and Sustainability 2023年第4期4卷 379-390页

作者： Carla S.S.ferreira Onyanta Adama-Ajonye Anosike EIkenna Zahra Kalantari Department of Physical Geography and Bolin Centre for Climate Research Stockholm UniversitySE-10691 StockholmSweden Polytechnic Institute of Coimbr1 Applied Research InstituteRua da Misericórdi1Lagar dos Cortiços-S.Martinho do Bispo3045-093 Coimbr1Portugal Research Centre for Natural Resources Environment and Society(CERNAS)Polytechnic Institute of Coimbr1Bencant13045-601 Coimbr1Portugal Department of Human Geography Stockholm UniversitySE-10691 StockholmSweden University of Lagos Akok1Yab1LagosNigeria Department of Sustainable Development Environmental Science and EngineeringKTH Royal Institute of TechnologySE-10044 StockholmSweden

Inappropriate management of municipal solid waste dumpsites is a major cause of groundwater contamination in developing countries,but the extent of the problem is not *** study investigated groundwater quality in the vicinity of Olusosun dumpsite in Lagos,Nigeria,the most populous city in sub-Saharan *** 2020,monthly groundwater samples were collected in 17 wells and boreholes used as drinking water sources,and analysed for 20 physico-chemical *** between sites and seasons were statistically assessed,together with changes in water quality index(WQI).The results indicated that heavy metals(Pb^(2+),Ni^(+),Mn^(2+),Fe^(2+),Cr^(6+)),cations(Ca^(2+),Mg^(2+),K^(+)),total hardness and pH were the main parameters impairing water *** water quality standards from both the World Health Organization and Nigeria government were exceeded more often in the wet season than in the dry *** groundwater properties were negatively correlated with distance to dumpsite(e.g.,Fe^(2+),Pb^(2+),NO_(3)^(−)).Significant differences between sites were identified,but with no clear spatial *** varied from excellent(6%-24%of the sites over the study period)to unsuitable for drinking water purposes(12%-18%),with good quality prevailing at most sites(35%-47%).Although groundwater quality declined at 24%of the sites over 2020,the results indicated improvements compared with previous *** strategies must be implemented to safeguard public health and the sustainability of water resources.

关键词： Municipal solid waste dumpsite Groundwater quality Seasonal variation Heavy metals Nigeria

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