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治疗用单克隆抗体的超敏反应:表型和内型

中华临床免疫和变态反应杂志 2018年第5期12卷 583-596页

作者： Ghislaine Annie C.Isabwe Marlene Garcia Neuer Leticia de las Vecillas Sanchez Donna-Marie Lynch FNP-BC,Kathleen Marquis mariana castells 顾建青(翻译) 王良录(审校) 不详中国医学科学院、北京协和医学院、北京协和医院变态(过敏)反应科

背景单克隆抗体的广泛的应用导致了超敏反应(HSRs)发生率的增加,这阻碍了单克隆抗体作为一线治疗方法在临床上的应用。HRSs的症状、诊断方法及定向治疗方法均尚未标准化。目的我们基于临床表型、潜在的内型和生物标志物进行脱敏的治疗... 详细信息

背景单克隆抗体的广泛的应用导致了超敏反应(HSRs)发生率的增加,这阻碍了单克隆抗体作为一线治疗方法在临床上的应用。HRSs的症状、诊断方法及定向治疗方法均尚未标准化。目的我们基于临床表型、潜在的内型和生物标志物进行脱敏的治疗方法提出一种新的基于循证医学的m Ab HSR分类方法。方法描述了104例患者对16种m Abs HSR的表型、内型和生物标志物,并与526次皮下及静脉脱敏治疗结果进行比较。结果初始反应呈现4种模式:Ⅰ型样反应占63%,细胞因子释放反应占13%,混合反应占21%,Ⅳ型迟发反应占3%。与之形成鲜明对比的是,在脱敏治疗期间突发的HSRs为23%,其中52%为细胞因子释放反应,32%为Ⅰ型反应,12%为混合型反应,4%为Ⅰ型伴Ⅳ型迟发超敏反应。58例患者对10种m Abs进行皮肤试验,41%的患者出现阳性。在脱敏治疗期间,1例患者血清类胰蛋白酶水平升高,8例患者IL-6水平升高,均为细胞因子释放表型。结论 m Abs引起的HSRs可界定为Ⅰ型、细胞因子释放型、混合(Ⅰ型/细胞因子释放型)型和Ⅳ型反应,可通过生物标志物如皮肤试验、类胰蛋白酶和IL-6进行鉴别分型。当确诊为m Abs HSR时,这些表型有助于患者接受个性化和精准医学治疗,并为脱敏治疗的实施提供依据。脱敏治疗是一种安全有效的治疗手段,可使出现过变态反应的m Abs仍能作为一线治疗方法。

关键词：单克隆抗体超敏反应表型内型生物标志物类胰蛋白酶白细胞介素-6 皮肤试验脱敏疗法精准医学

Plant-herbivore assemblages under natural conditions are driven by plant size,not chemical defenses

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Journal of Plant Ecology 2017年第6期10卷 1012-1021页

作者： Eva castells Maria Morante Sandra Saura-Mas Anabel Blasco-Moreno Departament de Farmacologia Terapèutica i ToxicologiaUniversitat Autònoma de BarcelonaCerdanyola del Vallès 08193Spain CREAF Cerdanyola del Vallès 08193Spain Department de Biologia Animal Vegetal i EcologiaUniversitat Autònoma de BarcelonaCerdanyola del Vallès 08193Spain Servei d’Estadística Aplicada Universitat Autònoma de BarcelonaCerdanyola del Vallès 08193Spain

Aims Plant secondary metabolites have been traditionally recognized as key traits regulating plant-herbivore ***,the ecological relevance of secondary metabolites as resistance mecha-nisms in comparison to other plant attributes,including physical,morphological or ecological traits,has been recently *** aim to evaluate the role of chemical defenses,plant size and the presence of insect competitors on driving the differences in her-bivory damage under natural *** We performed a replicated field study on the herbivore commu-nity associated with four Senecio species(***,***,*** and ***)during a full-reproductive season in Montseny Natural Park(catalonia,NE Spain).Pyrrolizidine alka-loids(PAs),the most characteristic chemical defenses of Senecio due to their toxic effects on herbivores,were analyzed by gas *** plant size was estimated by the number of flower heads produced over the entire reproductive *** used linear mixed models to explore the relationships between total PA concentrations,plant size and herbivory *** Findings PA concentrations were not related to the natural guild of herbivores within any plant species or insect ***,no significant interactions were found between insect species sharing the same host *** contrast,herbivore abundance was positively related to plant size in ***,*** and *** found no evidence that PAs confer an increased plant resistance against herbivores in *** study supports the hypothesis that plant chemical defenses have a secondary role in determining plant-her-bivore assemblages in comparison to other plant traits under the complexity of natural conditions.

关键词： Senecio herbivory chemical defenses pyrrolizidine alkaloids plant traits

Identification of Lynch syndrome: How should we proceed in the 21^(st) century?

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World Journal of Gastroenterology 2007年第33期13卷 4413-4416页

作者： Antoni castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa Gastroenterology Department Institut de Malalties Digestives i Metabòliques Hospital ClínicCIBERehd IDIBAPS University of Barcelona BarcelonaCatalonia Spain

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years.

关键词： Hereditary non-polyposis colorectal cancer Screening Prevention Microsatellite instability Genetics

PREPARATION AND USE OF 1-ETHOXYCARBONYLALKYLIDENE DIPHENYLPOLYSTYRYLPHOSPHORANES

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Chinese Journal of Reactive Polymers 1993年第2期2卷 156-163页

作者： Josep castells Francisco LOPEZ-CALAHORA Departament de Quimica Organica Universitat de Barcelona Marti i Franques 1-11 E-08028 Barcelona Spain

1－Ethoxycarbonylalkyldiphenylpolystyrylphosphonium triflates can be easily prepared by quaternizing diphenylpolystyryl phosphine with ethyl 2-trifloxyalkanoates;base treatment of these polymer-supported phosphonium t... 详细信息

关键词：制备三苯基磷化氢 1-乙氧甲酰次烷基二苯基多苯乙烯基正膦

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拉丁美洲和全世界的铝工业

轻金属 1991年第1期 3-6,26页

作者： Enrique castells 唐颖宽

上升的总趋势 80年代出现的所有这些上升和下降只不过是临时的混乱。从长远的观点来看,它们并未严重削弱世界产量、消费量以及新产能广泛上升的趋势。 80年代后期。

关键词：铝工业拉丁美洲全世界

Isolated bilateral Tapia's syndrome after liver transplantation: A case report and review of the literature

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World Journal of Hepatology 2016年第36期8卷 1637-1644页

作者： Itxarone Bilbao Cristina Dopazo Mireia Caralt Lluis castells Elisabeth Pando Amaia Gantxegi Ramón Charco De-partment of Digestive Surgery Hepatobiliopancreatic Surgery and Liver Transplant Unit Hospital Universitario Vall d’HebrónCIBERehd Universidad Autónoma de Barcelona

AIM To describe one case of bilateral Tapia's syndrome in a liver transplanted patient and to review the *** We report a case of bilateral Tapia's syndrome in a 50-year-old man with a history of human immunodeficiency virus and hepatitis C virus child. A liver cirrhosis and a bi-nodular hepatocellular carcinoma, who underwent liver transplantation after general anesthesia under orotracheal intubation. Uneventful extubation was performed in the intensive care unit during the following hours. On postoperative day(POD) 3, he required urgent re-laparotomy due to perihepatic hematoma complicated with respiratory gram negative bacilli infection. On POD 13, patient was extubated, but required immediate re-intubation due to severe respiratory failure. At the following day a third weaning failure occurred, requiring the performance of a percutaneous tracheostomy. Five days later, the patient was taken off mechanical ventilation and severe dysphagia, sialorrea and aphonia revealed. A computerized tomography and a magnetic resonance imaging of the head and neck excluded central nervous injury. A stroboscopy showed bilateral paralysis of vocal cords and tongue and a diagnosis of bilateral Tapia's syndrome was performed. With conservative management, including a prompt establishment of a speech and swallowing rehabilitation program, the patient achieved full recovery within four months after liver transplantation. We carried out MEDLINE search for the term Tapia's syndrome. The inclusion criteria had no restriction by language or year but must provide sufficientavailable data to exclude duplicity. We described the clinical evolution of the patients, focusing on author, year of publication, age, sex, preceding problem, history of endotracheal intubation, unilateral or bilateral presentation, diagnostic procedures, type of treatment, follow-up, and *** Several authors mentioned the existence of around 70 cases, however only 54 fulfilled our inclusion cri

关键词： Liver transplantation Follow-up Outcome Postoperative complications Bilateral Tapia’s syndrome

A Simulation Model for Road and Maritime Environmental Performance Assessment

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Journal of Environmental Protection 2013年第7期4卷 683-693页

作者： J.J.Usabiaga M.castells F.X.Martínez, A.Olcer Department of Nautical Sciences and Engineering Universitat Politecnica de CatalunyaBarcelonaSpain World Maritime University International Maritime OrganizationMalmoSweden

The White Paper published in 2011, Roadmap to a Single European Transport Area [1], urges on a 30% modal shift of road freight over 300 km to other modes (rail, maritime and inland waterways) by 2030, and more than 50% by 2050. However the environmentally friendly performance of maritime transport regarding air pollutant emissions in comparison with road transport is in doubt. This paper presents a three dimension simulation model, in which performed transport work, arisen emissions and produced impact are estimated and inter-related for the assessment of the environmental performance of both road and maritime transport. The simulation model will be a valuable decision making tool for policymakers as it enables the precise assessment of considered transport alternatives in the EU27 until 2020, and hence supports the design of future intervening actions.

关键词： Transport Emissions Environmental Performance Policy Assessment

Population dynamics, pathogen detection and insecticide resistance of mosquito and sand fly in refugee camps, Greece

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Infectious Diseases of Poverty 2020年第2期9卷 50-62页

作者： Emmanouil Alexandras Fotakis loannis Apostolou Giantsis Javier castells Sierra Filianna Tanti Sofia Balaska Konstantinos Mavridis Sofoklis Kourtidis John Vontas Alexandra Chaskopoulou Department of Crop Science Pesticide Science LabAgricultural University of AthensAthensGreece Institute of Molecular Biology and Biotechnology Foundation for Research and Technology HellasHeraklionCreteGreece European Biological Control Laboratory USDA-ARSThessalonikiGreece Department of Biology National and Kapodistrian University of AthensAthensGreece General Directorate of Public Health and Social Welfare Region of Central MacedoniaThessalonikiGreece

Background:As of 2015 thousands of refugees are being hosted in temporary refugee camps in *** populations,travelling and living under poor conditions with limited access to healthcare are at a high risk of exposure to vector borne disease(VBD).This study sought to evaluate the risk for VBD transmission within refugee camps in Greece by analyzing the mosquito and sand fly populations present,in light of designing effective and efficient context specific vector and disease control ***:A vector/pathogen surveillance network targeting mosquitoes and sand flies was deployed in four temporary refugee camps in *** collections were conducted bi-weekly during June-September 2017 with the use of Centers for Disease Control(CDC)light traps and oviposition *** conventional and molecular diagnostic tools we investigated the mosquito/sand fly species composition,population dynamics,pathogen infection rates,and insecticide resistance status in the major vector ***:Important disease vectors including Anopheles sacharovi,Culex pipiens,Aedes albopictus and the Leishmania vectors Phlebotomus neglectus,*** and *** were recorded in the study refugee *** mosquito pathogens(Plasmodium parasites,flaviviruses)were detected in the analysed samples yet high sand fly Leishmania infection rates are *** pipiens mosquitoes displayed relatively high knock down resistance(kdr)mutation allelic frequencies(ranging from 41.0 to 63.3%)while kdr mutations were also detected in *** populations,but not in Anopheles and sand fly *** diflubenzuron(DFB)mutations were detected in any of the mosquito species ***:Important disease vectors and pathogens in vectors(Leishmania spp.)were recorded in the refugee camps indicating a situational risk factor for disease *** *** and *** kdr mutation frequencies recorded pose a potential threat against the effectiveness of

关键词： Refugee camp Mosquito Sand fly Insecticide resistance

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青少年糖尿病的甲状腺功能

国际儿科学杂志 1985年第4期31卷 207-210页

作者： castells S 何天焴

近几年来已发现青少年胰岛素依赖性糖尿病的甲状腺功能有异常的大量证据。控制不良的青少年糖尿病高血糖至少在两个方面影响甲状腺功能,一方面为控制下丘脑TSH释放的水平,另一方面为外周组织,T4转换为T3的水平。本文从垂体—甲状腺—外... 详细信息

近几年来已发现青少年胰岛素依赖性糖尿病的甲状腺功能有异常的大量证据。控制不良的青少年糖尿病高血糖至少在两个方面影响甲状腺功能,一方面为控制下丘脑TSH释放的水平,另一方面为外周组织,T4转换为T3的水平。本文从垂体—甲状腺—外周组织轴方面介绍糖尿病对甲状腺功能影响的新进展,并企图判定它们在临床上的意义。

关键词：胰岛素依赖性糖尿病高血糖甲状腺激素激素类药物酮症酸中毒