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Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review

World Journal of Clinical Oncology 2021年第2期12卷 69-94页

作者： mariana Miranda Sampaio Maria Luísa Cordeiro santos Hanna santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan santos Apolonio Camilo Santana Silva Luana Kauany de Sásantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães mariana novaes santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia *** advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of *** discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL *** kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of *** therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these *** this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context.

关键词： Chronic myeloid leukemia Breakpoint cluster region-Abelson murine leukemia Immunotherapy Tyrosine kinase inhibitors Philadelphia chromosome Diagnosis

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In Vitro Evaluation of Two Tissue Substitutes for Gingival Augmentation

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Journal of Biomaterials and Nanobiotechnology 2023年第2期14卷 23-34页

作者： Tulio Cardoso dos santos Carlos Nelson Elias Alexandre Barboza Lemos Andresa Borges Soares André Antonio Pelegrine Lucas novaes Teixeira Elizabeth Ferreira Martinez Division of Oral Implantology Faculdade S&#227o Leopoldo Mandic Campinas SP Brazil Department of Materials Science Military Institute of Engineering (IME) Rio de Janeiro RJ Brazil Division of Oral Pathology Faculdade S&#227o Leopoldo Mandic Campinas SP Brazil Division of Cell Biology Faculdade S&#227o Leopoldo Mandic Campinas SP Brazil

Three-dimensional collagen matrices of porcine origin are being used as substitutes for soft tissue grafts in periodontal plastic surgery in search of aesthetic and natural results. This in vitro study aimed to compare Fibro-Gide® (GeistlichBiomaterials) and Mucoderm® (BotissBiomaterials) matrices during the initial phase of soft tissue formation. For this purpose, samples of 5 × 5 mm were obtained, and then human fibroblasts were plated on them. After 24, 48 and 72 h, cell viability was assessed using an MTT assay, and the secretion of type I collagen, MMP-2, TIMP-1 and TIMP-2 was analyzed by ELISA immunoassay. The control group (C) consisted of cells plated on polystyrene without the matrices. The morphology of the surfaces was also examined using scanning electron microscopy (SEM), as was the average roughness (Ra) of the samples by a profilometer. Topographic analysis revealed that roughness was significantly higher on Mucoderm® than on Fibro-Gide® (p 0.05). The synthesis of type I collagen, MMP-2 and TIMP-1 were significantly higher from cells plated on Fibro-Gide® than on Mucoderm®, in all time points (p ® than on Mucoderm® (p ® induced an increase in type I collagen, MMP-2 and TIMP-1 and TIMP-2.

关键词： Collagen Matrices Gingival Recession Periodontal Regeneration Matrix Metalloproteinases

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Pollen of Bauhinia *** Phanera Lour.(Leguminosae-Caesalpinioideae)from the Brazilian Caatinga

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American Journal of Plant Sciences 2012年第7期3卷 909-920页

作者： Francisco de Assis Ribeiro dos santos Danovan de Matos novaes Luciano Paganucci de Queiroz Programa de Pós-Graduacao em Botanica Universidade Estadual de Feira de SantanaFeira de SantanaBahiaBrazil

A study of pollen morphology, in species of the genera Bauhinia and Phanera (Leguminosae-Caesalpinioideae) which occur in the Brazilian caatinga, is presented. The pollen was examined using light and scanning electron microscopy. Samples were prepared by the KOH method;non-treated pollen grains were examined by scanning electron microscopy. Pollen grains in Bauhinia species (11) are colpate, but porate in B. cheilantha and B. subclavata. All four species of Phanera present colporate pollen grains;P. outimouta is the only to have syncolporate pollen grains. Species of both genera present heteromorphism in the number of apertures. Excepting P. outimouta whose pollen grains are psilate, all species in the two genera present supratectal processes (gemmae/clavae), however the exine in the two genera are dif- ferent–semitectate, reticulate in Bauhinia species, and tectate, rugulate (or psilate) in Phanera ones. Pollen characters support the segregation of Phanera from Bauhinia.

关键词： Pollen Flora Leguminosae Cercideae Taxonomy

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Energy Conversion Factor for Gasoline Engines in Real-World Driving Emission Cycle

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Automotive Innovation 2020年第2期3卷 169-180页

作者： Toshizaemom Noce Sérgio de Morais Hanriot Luis Carlos Monteiro Sales JoséRicardo Sodré Matheus Bitarães de novaes Department of Mechanical Engineering Pontifical University of Minas GeraisAv.Dom JoséGaspar 500Belo HorizonteMG 30535-901Brazil School of Engineering&Applied Science Aston UniversityAston TriangleBirmingham B47ETUK Department of Electrical Engineering Federal University of Minas GeraisAv.Pres.Antônio Carlos6627Belo HorizonteMG 31270-901Brazil

A precise energy conversion factor is required to define the impact of greenhouse gas emissions by gasoline-powered vehi-cles and policies that will guide the application of future *** current energy conversion factor adopted by many countries is based on the Willans line approach,initially proposed in 1888 for steam engines,later adapted for internal combustion *** actual energy conversion factor,which defines the energy conversion for drivers in real traffic,is *** this article,eight world-class engines are tested in an engine bench for the acquisition of specific fuel consumption 3D ***,their energy conversion factors,calculated by dividing the energy output by the energy input,are simulated in real and urban traffic,acquired according to the real driving emissions(RDE)*** addition,a reference vehicle is instrumented to measure the energy input(fuel flow)and the energy output(mechanical energy in the half axles)under the same RDE cycle *** results of both procedures are very similar,respectively,0.405±0.04 L/kWh for the simulation based on eight benchmark engines,and 0.392±0.04 L/kWh for the reference vehicle driven in RDE traffic conditions,with a 95%confidence *** turbocharged engines,the factor attained by the simulation is 0.395±0.04 L/*** values of the energy conversion factor for gasoline engines got in this research are higher than those obtained through the Willans line approach,suggesting a new standard value of 0.405 L/kWh,replacing the current 0.264 L/*** could substantially change the greenhouse gas emissions in a tank-to-wheel approach for the entire vehicle and add-on eco-innovations.

关键词： Energy conversion factor Willans line EC443 Eco-innovation CO_(2)emission

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Dyslipidemias and Related Factors in Brazilian Adolescents from Rural and Urban Areas

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Health 2014年第11期6卷 1191-1200页

作者： Daniela Alves Silva Sylvia do Carmo Castro Franceschini Juliana Faria de novaes Ricardo Henrique Silva santos Silvia Eloiza Priore Departamento de Fitotecnia Universidade Federal de Vi&ccedil osa Vi&ccedil osa Brazil Departamento de Nutriç ã o e Saúde Universidade Federal de Vi&ccedil osa Vi&ccedil osa Brazil

This study aimed to evaluate the prevalence of dyslipidemias and related factors, in Brazilian adolescents from rural and urban areas. This is a cross-sectional study with 182 adolescents aged 10 to 13 years, students, residing in the rural and urban area of Brazil;grouped according to age, gender and socioeconomic class. Sexual maturation, physical activity, blood pressure, nutritional status and body composition were evaluated. Total cholesterol, LDL, HDL and serum triglycerides were dosed. The food frequency questionnaire was applied, quantifying energy, carbohydrates, proteins, lipids, full fat and fibers. Bivariate and multiple analyses were carried out, by logistic regression. It was verified that 84.6% (n = 154) adolescents presented some lipid profile alteration. There was no difference in the lipid profile between adolescents for residence place. However, as for gender, it was noticed that girls presented higher levels of total cholesterol and HDL (p < 0.05). In addition, adolescents with excess weight and body fat showed lower HDL and higher triglycerides values compared with eutrophic and with those with appropriate body fat percentage (p < 0.05). In the multiple analyses, it was observed that gender and signs of sexual maturation were associated with total cholesterol;fiber intake remained associated with HDL and signs of sexual maturation with LDL (p < 0.05). For triglycerides the related factors were gender, nutritional status and protein intake (p < 0.05). The elevated prevalence of dyslipidemias found between adolescents from rural and urban areas reinforces the importance of monitoring these alterations and information as for the related risk factors, with programs for correction of changeable factors.

关键词： Dyslipidemias Adolescents Lifestyle Puberty

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Clinical use of estimating glomerular filtration rate equ-ations during pregnancy

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Health 2011年第1期3卷 32-36页

作者： Luiz Paulo José Marques Regina Rocco Maria Helena Victor Benedita Calheiros de novaes Ana Luiza Batista de Carvalho Omar da Rosa santos 不详

Background: Kidney disease, even when mild, was once considered so major an impediment to successful pregnancy and so dangerous to the mother’s wellbeing. High-risk pregnancy mainly associated to renal impairment may occur in 10-20% of gestations and it is very important that renal function is closely monitored to prevent or minimize maternal and fetal complications. This study was designed to investigate the performance of Cockcroft-Gault CGeq and the simplified MDRDeq equations in healthy pregnant women to assess renal function. Methods: We studied 167 normal ambulatory pregnant women and kidney function was contemporaneously estimated through the CGeq and the simplified MDRDeq and calculated through the creatinine clearance (Ccr). Serum and urinary creatinine were assayed using Jaffé reaction method in the same AutoAnalyser. Results: When we compared calculated and estimated clearences for measurement of kidney function we observed that CGeq overestimated renal function (CGeq = 168.41 ± 38.80 ml/ min/1.73 m2, Ccr = 146.27 ± 30.49 ml/min / 1.73 m2, p < 0.001), MDRDeq underestimated renal function (Ccr = 146.27 ± 30.49 ml/min / 1.73 m2, MDRDeq = 129.15 ± 29.28 ml/min / 1.73m2, p < 0.001). Conclusions: Our results demonstrated that CGeq overestimated, MDRDeq underestimated significantly kidney function during gestation in healthy women and cannot be recommended to assess renal function in obstetric practice. Ccr remains a useful clinical tool in pregnant women until the development of a specific equation that considers the several important maternal renal physiological alterations and provides the measure of GFR the most unbiased and precise as possible.

关键词： Pregnancy Kidney function Glomerular Filtration Rate MDRD equation Cockcroft-Gault equation.

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