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SUSTAINABLE LIGHTING FOR HEALTHCARE FACILITIES: MORE THAN JUST LUMENS PER WATT

Journal of Green Building 2008年第1期3卷 74-89页

作者： mariana figueiro Lighting Research Center Rensselaer Polytechnic Institute

INTRODUCTIONSustainability is, as the name implies, a movement to ensure long-term, effi cient utilization of resources. Sustainabilitydoes not imply that resources should be restricted nor that resource utilization should be subsidized. BillMcDonough (McDonough and Braungart 2002) has described sustainability in terms of the three E’s: environment,equity, and economy. In the last quarter century the lighting industry has dramatically improved the energy effi ciency(environment “E”) and life-cycle cost of lighting (economy “E”). Much less attention has been given to the equity “E.”Lighting standards are still set primarily in terms of illuminances (lumens per square meter) and lumens per watt,both of which are based upon the implicit assumption that the value of lighting can be characterized by the *** lumen is, however, unrelated to other non-visual effects of light, such as the circadian system, and is only indirectlyrelated to our perceptual system. In particular, our current architectural practices do not adequately support themost fragile segments of the population. And no matter how much energy is conserved or how much value engineeringis applied, we are not designing or implementing sustainable lighting because we are not supporting many of thepeople in our built environments. In fact, the role of lighting as it affects human perceptual and circadian functionsis almost completely ignored in standards. Arguably, the failure to consider these two human domain functions canbe ignored in many modern applications because of the inherent fl exibility and robustness of the human species. Onesegment of construction where the equity “E” should always be more seriously considered, however, is healthcare *** applications contain our most fragile humans, and lighting has been shown, for example, to demonstrablyaffect the lives of seniors and premature infants. But there are no standards to assist architects and engineers insupporting the well-being o

关键词： supporting implies lighting

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Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies

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Neural Regeneration Research 2024年第11期19卷 2365-2376页

作者： Victoria Cunha Alves Eva Carro Joana figueiro-Silva Neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedical Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotraumatology and Subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiology of Alzheimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical Genetics University of ZurichZurichSwitzerland Department of Molecular Life Science University of ZurichZurichSwitzerland

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA *** review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease *** examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease *** entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the ***,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal ***,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory *** complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation *** the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease *** research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关键词： Alzheimer’s disease ANK1 BIN1 DNA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2

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Architectural Guidelines Aimed at the Resocialization of Brazilian Prisoners

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Journal of Civil Engineering and Architecture 2019年第10期13卷 653-661页

作者： Gabriele Santin figueiro Luisa Batista de Oliveira Silva Alcindo Neckel Henrique Aniceto Kujawa Stricto Sensu Postgraduate Program in Architecture and Urbanism(PPGARQ-IMED) Passo Fundo/RS99070-220Brazil

The worsening of the Brazilian prison crisis is the result of multiple factors,aggravated by the lack of maintenance of penal *** overall objective of the manuscript is to analyze the architectural guidelines aimed at resocialization of the Brazilian prisoners in the prisons of Passo Fundo/RS and Santa Luzia/***,we sought to understand the functionality of the Regional Prison of Passo Fundo/RS(common system)and the prison of Santa Luzia/MG(The Association of Protection and Assistance to the Convicts(APAC)methodology),with architectural guidelines in evaluating the efficiency of *** results showed that architectural conservation and resocialization programs positively influence the decrease in criminal recidivism.

关键词： Criminal architecture penitentiary system resocialization

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Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study

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World Journal of Transplantation 2021年第4期11卷 114-128页

作者： Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu Department of Anesthesiology University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Department of Surgery Miami Transplant Institute/University of Miami/Jackson Memorial HospitalMiamiFL 33136United States Division of Nephrology of the Department of Medicine University of Miami/Jackson Memorial HospitalMiamiFL 33136United States

BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney *** exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is *** To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 *** primary outcome was the occurrence of *** The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/*** We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine.

关键词： Delayed graft function Outcome Kidney transplant Risk factors Phenylephrine Mean arterial pressure

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In vitro and in vivo trypanocidal action of aescin and aescin liposomes against Trypanosoma evansi in experimental mice

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 947-951页

作者： Matheus Dellamea Baldissera Nathieli Bianchin Bottari Thirssa Helena Grando Roberto Christ Vianna Santos Ana Julia figueiro Dalcin Patrfcia Gomes Renata Platcheck Raffin Carine Eloise Prestes Zimmerman Janio Morais Santurio Silvia Gonzalez Monteiro Aleksandro Schafer Da Silva Department of Microbiology and Parasitology Universidade Federal de Santa Maria(UFSM) Laboratory of Microbiology Centro Universitdrio Franciscano Laboratory of Nanotechnology Centro Universitdrio Franciscano Department of Animal Science Universidade do Estado de Santa Catarina(UDESC)

Objective:To verify the trypanocidal effectiveness of aescin and aescin liposomes against Trypanosoma evansi in vitro and in ***:Aescin and aescin liposomes were used in vitro on trypomastigotes at different concentrations(0.5%,1.0%and 2.0%) and exposure times(0,1,3,6 and 9 h).In vivo tests were performed using mice as the experimental *** evansi infected mice were treated with aescin and aescin liposomes with doses of 60 and 100 mg/kg during 4 ***:The three concentrations tested in free form and nanoencapsulated showed trypanocidal activity in vitro,completely eliminating the parasites in small concentration after6 h of *** treated with aescin(100 mg/kg) and aescin liposomes(100 mg/kg)showed increase in longevity,however without curative ***:Active compounds present in natural products,such as aescin,may potentiate the treatment of trypanosomosis when used in association with other trypanocidal drugs.

关键词： Surra Nanotechnology Aesculus hippocastanum Trypanosome

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