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Anti-Candida and anti-Cryptococcus evaluation of 15 non-alkaloidal compounds from Pterogyne nitens

Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 841-845页

作者： Caroline Sprengel Lima Carlos Roberto Polaquini mariana bastos dos santos Fernanda Patricia Gullo Fernanda Sangalli Leite Liliane Scorzoni Vanderlan da Silva Bolzani Maria Jose Soares Mendes-Giannini Ana Marisa Fusco-Almeida Andréia Alves Rezende Luis Octavio Regasini Laboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Letters and Exact Sciences Sao Paulo State University (UNESP) Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) Department of Biology and Animal Sciences Faculty of Engineering Sao Paulo State University (UNESP)

Objective: To evaluate anti-Candida and anti-Cryptococcus activities of 15 nonalkaloidal compounds from Pterogyne nitens Tulasne(Leguminosae), a South American medicinal ***: Compounds were submitted to antifungal assays, using microdilution method described by Clinical and Laboratory Standards Institute document, with minor modifications. Five species of Candida and two species of Cryptococcus, including clinical isolates were screened. Antifungal activity was expressed by minimum inhibitory concentration(MIC). Amphotericin B and fluconazole were used as standard antifungal ***: Among tested compounds, six substances presented fungal growth inhibition(MIC < 31.2 mg/m L) [three flavone derivatives(1–3), a glycosylated flavonol derivative(5)and two phenolic acids(10 and 12)]. Sorbifolin(1), exhibited potent antifungal activity,demonstrating MIC value of 3.90 mg/m L against Candida glabrata ATCC 90030, Cryptococcus gattii 118 and fluconazole-resistant clinical isolate of Cryptococcus neoformans var. grubii. Pedalin(2) and nitensoside B(3), two glycosylated flavone derivatives, were active against Cryptococcus neoformans ATCC 90012(MIC = 7.80 mg/m L).Conclusions: Flavone derivatives from Pterogyne nitens can serve as prototypes for the design and development of innovative anti-Candida and anti-Cryptococcus hits.

关键词： Candida Cryptococcus Antifungal Pterogyne nitens Flavonoid Opportunistic fungi

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Capacitorless Solid-state Power Filter for Single-phase DC-AC Converters

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CES Transactions on Electrical Machines and Systems 2024年第3期8卷 367-377页

作者： Haitham Kanakri Euzeli C.dos santos Purdue University Electrical and Computer Engineering DepartmentIndianapolisIN46202 USA

Converters rely on passive filtering as a crucial element due to the high-frequency operational characteristics of power *** filtering methods involve a dual inductor-capacitor(LC)cell or an inductor-capacitor-inductor(LCL)***,capacitors are susceptible to wear-out mechanisms and failure ***,the necessity for monitoring and regular replacement adds to an elevated cost of ownership for such *** utilization of an active output power filter can be used to diminish the dimensions of the LC filter and the electrolytic dc-link capacitor,even though the inclusion of capacitors remains an indispensable part of the *** paper introduces capacitorless solid-state power filter(SSPF)for single-phase dc-ac *** proposed configuration is capable of generating a sinusoidal ac voltage without relying on *** proposed filter,composed of a planar transformer and an H-bridge converter operating at high frequency,injects voltage harmonics to attain a sinusoidal output *** design parameters of the planar transformer are incorporated,and the impact of magnetizing and leakage inductances on the operation of the SSPF is *** analysis,supported by simulation and experimental results,are provided for a design example for a single-phase *** total harmonic distortion observed in the output voltage is well below the IEEE 519 *** system operation is experimentally tested under both steady-state and dynamic conditions.A comparison with existing technology is presented,demonstrating that the proposed topology reduces the passive components used for filtering.

关键词： Solid-state power filter(SSPF) Capacitorless topology Active output power filter(AOF) Planar transformer Electrolytic capacitor Lifetime Wear-out mechanisms

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Pharmacological therapy used in the elimination of Helicobacter pylori infection:A review

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World Journal of Gastroenterology 2015年第1期21卷 139-154页

作者： Ariolana A dos santos Adriana A Carvalho Department of Pharmacy Federal University of SergipeCampus Lagarto49400-00 LagartoSergipeBrazil

The optimal therapy for Helicobacter pylori(***) infection should combine a high cure rate and a short treatment duration with a favorable side-effect profile and should maintain a low *** strategies have been proposed to increase the *** eradication rate,including the extension of the treatment duration to 14 d,the use of a four-drug regimen(quadruple,sequential,and concomitant treatments),and the use of novel antibiotics,such as ***,triple therapy remains the most widely accepted firstline treatment regimen in Brazil and the United Statesand throughout *** this therapy is limited by resistance to clarithromycin,other therapeutic regimens have been investigated *** review describes the current literature involving studies directly comparing these different therapies and their efficacies.

关键词： Clarithromycin resistant Helicobacter pylori Pepti

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Can small-scale altitudinal gradients predict spatial and temporal patterns in tropical forests?

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Journal of Forestry Research 2021年第5期32卷 1854-1865页

作者： mariana Caroline Moreira Morelli Cléber Rodrigo de Souza Jean Daniel Morel Vinícius Andrade Maia Alisson Borges Miranda santos Kaline Fernandes Miranda Rubens Manoel dos santos Forest Sciences Department Federal University of LavrasCampus UniversitárioCx.P.3037LavrasMGCEP 37200-000Brazil Department of Biology Federal University of LavrasCampus UniversitárioLavrasMGCEP 37200-000Brazil

In tropical montane forests,compositional and structural changes are commonly driven by broad-scale altitudinal ***,given the lack of knowledge on small-scale vegetation changes and temporal dynamics,we address the effects of small-scale variations in soil and altitude on tree community structure,temporal dynamics and phylogenetic diversity in a semi-deciduous tropical forest of the Atlantic Forest Domain,southeastern *** 2010 and 2015 we sampled thirty plots of 400 m^(2),set up along an altitudinal gradient between 1000 and 1500 m a.s.I..In each plot,we collected soil samples for chemical and textural *** fitted linear models to test the effects of altitude and soil on community dynamics and phylogenetic *** and soil explained the spatial variation in number of individuals and phylogenetic diversity *** lower to higher altitudes,we found decreasing fertility,increasing tree density and decreasing phylogenetic *** significantly influenced the increases in total biomass(from 240.9 to 255.4 t ha^(-1))and individual biomass(from 0.15 to 0.17 t)recorded in the *** while community temporal dynamics had rates of 1.96%for mortality,1.02%for recruitment,1.61%for biomass loss and 2.81%for biomass gain,none of them were explained by altitude or *** species substitution averaged0.1 in the ***,these results suggest that the small-scale variations in altitude and soil likely determine the conditions and resources that drive community assembly and structure,which are expressed by spatial variations along the altitudinal *** the same time,temporal patterns were not influenced by altitude-related environmental variation,resulting in a similar dynamic behaviour across the gradient,suggesting that broad-scale factors may play a more important role than local ones.

关键词： Fine-scale Semideciduous forests Montane forests Dynamic patterns

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Challenges in maintaining the probiotic potential in alcoholic beverage development

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Food Bioscience 2023年第2期52卷 133-142页

作者： Daiane Costa dos santos Josemar Goncalves de Oliveira Filho Juliana Risso Andretta Fabiano Guimaraes Silva mariana Buranelo Egea Goias Federal University(UFG) Institute of Tropical Pathology and Public HealthIPTSP-UFGStreet 235s/nEast University Sector74605-450GoianiaGOBrazil Sao Paulo State University(UNESP) Sacholo of Pharmaceutical SciencesRodovia Araraquara-Jau Km 114800-903AraraquaraSao PauloBrazil Goiano Federal Institute of Education Science and TechnologyCampus Rio VerdeRod.Sul GoianaKm 01Cx Postal 6675901-970Rio VerdeGOBrazil

The development of new functional alcoholic beverages to promote health benefits is a major challenge for current *** review presents the main applications of microorganisms with functional potential and resistant to the alcoholic environment as well as the characteristics that enable the use of alcoholic beverages as vehicles for probiotic *** our online search,it was possible to notice that the most prominent microorganisms with functional potential and that present alcohol resistance were Saccharomyces cerevisiae *** and water-kefir(composed of Saccharomyces sp.,Lactobacillus sp.,Leuconostoc sp.,Acetobacter sp.,Bifidobacterium sp.).Processing conditions,temperature,fermentation time,and raw materials used in the production of beverages are important parameters that are evaluated and are dependent on the alcohol concentration and cellular viability of the desired probiotic microorganism(s).Viability studies of probiotic microorganisms in vegetable matrices have been conducted for water-kefir and Saccharomyces *** was successfully incorporated into the developmental process of alcoholic beverages with alcohol contents ranging from 3.83 to 23%(v/v),whereas kefir beverage had an alcohol content ranging from 0.8 to 4.96%(v/v).Furthermore,to ensure the maintenance of probiotic viability in alcoholic matrices,the encapsulation technique can be used as an alternative to promote greater protection and viability of probiotics against adverse conditions.

关键词： Functional beverage Microbiological resistance Alcohol concentration

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Saturated anisotropic hydraulic conductivity of a compacted lateritic soil

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第5期10卷 986-991页

作者： Roberto Aguiar dos santos Edmundo Rogerio Esquivel Varzea Grande Institute of Engineering Federal University of Mato Grosso Cuiaba Mato Grosso Brazil Sao Carlos School of Engineering University of Sao Paulo Sao Carlos Sao Paulo Brazil

This study focuses on the saturated anisotropic hydraulic conductivity of a compacted lateritic clayey sandy soil. The effects of the molding water content and the confining stress on the anisotropic hydraulic conductivity are investigated. The hydraulic conductivity is measured with a flexible-wall permeameter. Samples are dynamically compacted into the three compaction states of a standard Proctor compaction curve： the dry branch, optimum water content and wet branch. Depending on the molding water content and confining stress, the hydraulic conductivity may increase or decrease. In addition, the results indicate that, when the samples are compacted to the optimum water content, lower hydraulic conductivity is obtained, except at a confining stress equal to 50 kPa. The increase of the confining stress decreases the hydraulic conductivity for each of the evaluated compaction states. In the wet branch, horizontal hy- draulic conductivity is about 8 times higher than the vertical value. The anisotropic hydraulic conduc- tivities of the dry and wet branches decrease when the confining stress increases, and the opposite is observed in the optimum water content state.

关键词： Hydraulic conductivity Anisotropic behavior Lateritic soil Tropical soil Compacted soil

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Influence of a non-rotating shoulder on heat generation,microstructure and mechanical properties of dissimilar AA2024/AA7050 FSW joints

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Journal of Materials Science & Technology 2018年第1期34卷 119-127页

作者： Alessandro Barbini Jan Carstensen Jorge F.dos santos Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics Solid-State Joining Processes (WMP)

Friction stir welding （FSW） and stationary shoulder friction stir welding （SSFSW） were carried out for the butt joining of dissimilar AA2024-T3 and AA7050-T7651 aluminium alloys with thicknesses of 2 mm. A comparison between the two processes was performed by varying the welding speed while keeping the rotational speed constant, Through the analysis of the force and torque produced during welding and a simple analytical model, it was possible to show that in SSFSW there is more effective coupling with the tool and the heat produced is more efficiently distributed. This process decreases both the welding area and the diffusion at the interface of the two alloys compared with FSW. The minimum microhardness occurred at the advancing side （AS） at the interface between the thermo-mechanically affected zone （TMAZ） and the stir zone （SZ） in both processes, although the decrease was more gradual in SSFSW. This interface is also where all specimens failed for both welding technologies. An increase in tensile strength was measured in SSFSW compared with standard FSW. Furthermore, it was possible to establish the mechanical performance of the material in the fracture zone using digital image correlation.

关键词： Stationary shoulder friction stir welding Friction stir welding Dissimilar welded joints Process analysis Microstructure analysis Mechanical behaviour

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Microencapsulated oregano and cinnamon essential oils as a natural alternative to reduce Listeria monocytogenes in Italian salami

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Food Bioscience 2022年第6期50卷 1766-1773页

作者： Franciele Maria Gottardo Bárbara Biduski Lára Franco dos santos Jucilene Sena dos santos Laura Beatriz Rodrigues Luciana Ruschel dos santos Graduate Program in Food Science and Technology University of Passo FundoBR 28599052-900Passo FundoRSBrazil Food Quality and Sensory Science Department Teagasc Food Research CentreAshtownDublinD15 KN3KIreland Graduate Program in Bioexperimentation University of Passo FundoBR 28599052-900Passo FundoRSBrazil College of Agronomy and Veterinary Science University of Passo FundoBR 28599052-900Passo FundoRSBrazil

Meat products are classified as perishable foods and have favourable conditions for the multiplication of microorganisms such as Listeria monocytogenes,an important pathogen associated with ready-to-eat *** compounds are used for food preservation combined with encapsulation techniques to improve *** study evaluated the anti-Listeria potential of isolated and combined microencapsulated oregano(OEO)and cinnamon(CEO)essential oils in Italian *** combination ratios of OEO and CEO were tested and 50:50 ratio(OEO:CEO)was encapsulated using sodium *** microcapsules were evaluated for encapsulation efficiency(EE),morphology and action against *** in a meat *** microcapsules and 50/50 combined EO were incorporated into the Italian salami to evaluate the physicochemical,microbiological and sensory *** combinations of EO showed *** inhibition zone and CIM with 1:16 *** microencapsulated EO had 98.36%encapsulation *** 2%microcapsule had a significant reduction of *** from the *** though the panellists mentioned the sandy attribute in the CATA,the salami with EO microcapsules texture did not differ from the *** the essential oils had high encapsulation efficiency,the smell and flavour of cinnamon and oregano interfered negatively with the sensory ***,the encapsulation of the combined essential oils(50/50)significantly reduced *** in Italian salami.

关键词： Natural antimicrobial Sodium alginate Ready-to-eat Encapsulation

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Red propolis:Chemical composition and pharmacological activity

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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 591-598页

作者： Luciane Corbellini Rufatto Denis Amilton dos santos Flávio Marinho Joao Antonio Pegas Henriques mariana Roesch Ely Sidnei Moura Laboratory of Biotechnology of Natural and Synthetics Products-Biotechnology Institute University of Caxias do SulBrazil Laboratory of Genomics Proteomics and DNA Repair-Biotechnology InstituteUniversity of Caxias do SulBrazil

Propolis has been used worldwide for years in folk medicine and currently marketed by the pharmaceutical industry. In Brazil, propolis was classified into 13 groups based on their organoleptics and physicochemical characteristics. The 13th type named red propolis has been an important source of investigation since late 90s. Their property comes from the countless compounds, including terpenes, pterocarpans, prenylated benzophenones and especially the flavonoids. This last compound class has been indicated as the responsible for its potent pharmacological actions, highlighting the antimicrobial, antiinflammatory, antioxidant, healing and antiproliferative activities. The red propolis can also be found in other countries, especially Cuba, which has similar features as the Brazilian. Therefore, with the compilation of 80 papers, this review aims to provide a key reference for researchers interested in natural products and discovery of new active compounds, such as from propolis.

关键词： Red propolis Bioactivity Chemical composition Review

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Building capabilities in natural resource-dependent economies:An innovation systems analysis of the TVET program in Guyana

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International Journal of Innovation Studies 2019年第1期3卷 1-11页

作者： Chantal dos santos Friedrich-Alexander University Erlangen-Nuremberg 91054 ErlangenGermany

This paper examines Guyana's technical and vocational education and training(TVET)system in relation to diversifying the country's economy away from natural resource *** innovation systems approach is used to examine the effectiveness of TVET as a means of building capabilities in Guyana's key industries,gold and sugar,providing a snapshot of the state of the system in early,*** interviewees across several areas of expertise were consulted in Georgetown,*** analysis of primary and secondary research finds TVET's effectiveness to be limited by a lack of labor market information and funding,energy costs,a“brain drain”,and insufficient information communication technology skills and *** remedies include increasing the frequency of labor market surveys,attracting the Guyanese diaspora back to share knowledge,reducing the cost of energy by taking advantage of domestic renewable energy potential,and setting up a Sovereign Wealth Fund.

关键词： Innovation systems Guyana CARICOM Natural resources TVET

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