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Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/ xylazine anesthesia and the effect of Acanthopanax senticosus extract

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动物模型与实验医学(英文) 2023年第5期6卷 474-488页

作者： Anton Misak marian Grman Lenka Tomasova Ondrej Makara Zuzana Rostakova Iveta Waczulikova Karol Ondrias Institute of Clinical and Translational Research Department of Molecular PhysiologyBiomedical Research CenterSlovak Academy of SciencesBratislavaSlovak Republic Forest Arboretum Liptovsky Hradok Liptovsky HradokSlovak Republic Institute of Measurement Science Department of Theoretical MethodsSlovak Academy of SciencesBratislavaSlovak Republic Faculty of Mathematics Physics and InformaticsComenius UniversityBratislavaSlovak Republic

Background : Information obtained from arterial pulse waveforms (APW) can be usefulfor characterizing the cardiovascular system. To achieve this, it is necessary to know thedetailed characteristics of APWs in different states of an organism, which would allowAPW parameters (APW- Ps) to be assigned to particular (patho)physiological ***, our work aimed to characterize 35 APW- Ps in rats under the influence ofisoflurane (ISO) and Zoletil/xylazine (ZO/XY) anesthesia and to study the effect of rootextract from Acanthopanax senticosus (ASRE) in these anesthetic *** : The right jugular vein of anesthetized rats was cannulated for the administrationof ASRE and the left carotid artery for the detection of APWs from which 35APW- Ps were *** : We obtained data on 35 APW- Ps, which significantly depended on the anesthesia,and thus, they characterized the cardiovascular system under these two *** transiently modulated all 35 APW- Ps, including a transient decrease insystolic and diastolic blood pressure (BP) and heart rate or increases in pulse BP, d P /d t max , and systolic and diastolic areas. Whereas the transient effects of ASRE weresimilar, the extract had prolonged disturbing effects on the cardiovascular system inrats under ZO/XY but not under ISO anesthesia. This negative effect can result fromthe disturbance caused by ZO/XY anesthesia on the cardiovascular *** : We characterized 35 APW- Ps of rats under ISO and ZO/XY anesthesiaand found that ASRE contains compounds that can modulate the properties of thecardiovascular system, which significantly depended on the status of the cardiovascularsystem. This should be considered when using ASRE as a nutritional supplementby individuals with cardiovascular problems.

关键词： Acanthopanax senticosus arterial pulse waveform blood pressure hemodynamic parameters isoflurane Zoletil/xylazine

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Cancer Status: Mocb and tPSA Prostate Cancer Markers

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Journal of Cancer Therapy 2012年第6期3卷 1101-1103页

作者： marian Surma Department of Physics Optics Laboratory Adam Mickiewicz University Poznań Poland

On the basis of the results of magneto-optical studies and their comparison with the outcome of medical tests magneto-optical MOCB and tPSA serum markers of cancer/recovered patient are presented. Status of the cancer serum donor is recognized as presence of the laevorotatory optical active molecules of (-)p density in serum while status of the recovered donor is recognized as quantitative domination of the dextrorotatory (+)p molecules in serum. These molecular information carriers (-)p and (+)p are recorded by the magneto-optical circular birefringence MOCB effect in B2 magnetic field. The laevo/dextrorotatory carriers are enantiomers in the case of (-)p = (+)p relations fulfilled for any individual cancer and the same recovered patient. The positive predictive value PPV of MOCB results is 100%.

关键词： Serum Molecular MOCB Marker tPSA Marke

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Challenges in the implementation of food safety and quality assurance systems in small-scale fisheries

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Food Quality and Safety 2023年第1期7卷 178-186页

作者： Esther GarridoGamarro Cecilie Smith Svanevik Anne-Katrine Lundebye Monica Sanden Enrica D'Agostino marian Kjellevold Lauren Pincus Johannes Pucher Fisheries and Aquaculture Division Food and Agriculture Organization of the United NationsViale delle Terme di CaracallaRomeItaly Institute of Marine Research BergenNorway WorldFish Jalan Batu MaungBatu MaungPenangMalaysia German Federal Institute for Risk Assessment Department Experimental Toxicology and ZEBETBerlinGermany Shared first authorship

Ninety percent of the world’s fishers are directly involved in small-scale fisheries(SSFs),and many food safety and quality issues along the food value chains may be both irreversible and *** safe,high-quality aquatic products are key to sustaining life,promoting good health,and avoiding adverse health *** This paper aimed to highlight factors preventing the implementation of safety and quality assurance systems in SSFs by analysing the results from surveys on the implementation of Article 11 of the Food and Agriculture Organization of the United Nations(FAO)Code of Conduct for Responsible Fisheries(2017,2019,and 2022).Materials and methods The analysis considered responses to 15 closed-ended questions on food safety and quality obtained from 143 FAO Members and the European Union,and 87 open-ended replies addressing challenges in *** The major factors preventing the implementation of the Code’s food safety and quality provisions were lack of sanitation and monitoring programmes,lack of infrastructure(particularly refrigeration facilities)lack of technical capacities and limited management of food safety risks along the value *** and quality assurance efforts were focused on international markets,resulting in less attention being paid to domestic markets where a high degree of informality was *** Improved implementation of safety and quality assurance systems will lead to safer food with higher nutritional quality,extended shelf-life and reduced post-harvest *** awareness of food safety issues in SSFs is a prerequisite for achieving several of the UN Sustainable Development Goals.

关键词： Food security policy monitoring legislation value chain domestic market international trade

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Enantiomers Present in Serum Carry Cancer and/or Recovery Status Information

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Journal of Cancer Therapy 2014年第6期5卷 618-621页

作者： marian Surma Department of Physics Optics Laboratory Adam Mickiewicz University Poznan Poland

Human blood serum of cancer, cancer-recovered and healthy patients contains laevorotatory and dextrorotatory B2 active molecules. The laevorotatory B2 active carriers in patient serum carry information on the cancer status while the dextrorotatory B2 active carriers carry information on the recovered and/or healthy patient status. Their magneto-optical characteristic is analysed by the B2 Magneto Optical Circular Birefringence. By applying the MOCB experimental technique, it is possible to differentiate between the cancer and non-cancer patients. The paper introduces a purely molecular physics approach for description of the cancer/recovered and also non-cancer patients status.

关键词： Cancer Serum Optical Activity Enantiomers Electric Quadrupole Magnetic Dipolar Molecules

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Unsteady shock front waviness in shock-buffet of transonic aircraft

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Advances in Aerodynamics 2020年第1期2卷 182-198页

作者： Razvan marian Apetrei Vlad Ciobaca Jose Luis Curiel-Sosa Ning Qin Department of Mechanical Engineering The University of SheffieldSheffieldUK DLR Institute of Aerodynamics and Flow TechnologyBraunschweigGermany

The unsteady transonic aerodynamics of a wing-body configuration is investigated by solving the Unsteady Reynolds-averaged Navier-Stokes equations closed with the full Reynolds Stress *** work presents the prediction of flow field characteristics during deep shock-buffet penetration of a transport aircraftrepresentative *** number of 0.85,and Reynolds number of 5 million based on the mean chord,are selected to reproduce experimental test conditions that serve as validating *** results obtained give information about both surface and flow field shock-buffet *** unsteady shock front is observed on the suction side of the wing which gives birth to the so-called buffet *** field characteristics are dominated by the presence of lambda-shaped shocks and fully separated boundary layer over a significant part of the wing.

关键词： Aerodynamics CFD Shock-buffet

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An Impromptu Dance at Dusk

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考试与评价（英语高考专刊） 2015年第24期 19-20,23页

作者： marian Gormley

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Electrochemical hydrogen compression and purification versus competing technologies: Part Ⅱ. Challenges in electrocatalysis

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Chinese Journal of Catalysis 2020年第5期41卷 770-782页

作者： Marine Trégaro Maha Rhandi Florence Druart Jonathan Deseure marian Chatenet Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSGrenoble-INPLEPMI38000 GrenobleFrance

Hydrogen will be at the basis of the World’s energy policy in forthcoming decades, owing to its decarbonized nature, at least when produced from renewables. For now, hydrogen is still essentially produced from fossil feedstock(and to a minor extent from biomass);in consequence the present hydrogen gas on the market is containing non-negligible amounts of impurities that prevent its immediate usage in specialty chemistry or as an energy carrier in fuel cells, e.g. in transportation applications(cars, buses, trains, boats, etc.) that gradually spread on the planet. For these purposes, hydrogen must be of sufficient purity but also sufficiently compressed(at high pressures, typically 70 MPa), rendering purification and compression steps unavoidable in the hydrogen cycle. As shown in the first part of this contribution "Electrochemical hydrogen compression and purification versus competing technologies: Part I. pros and cons", electrochemical hydrogen compressors(EHCs), which enable both hydrogen purification and compression, exhibit many theoretical(thermodynamic) and practical(kinetics) advantages over their mechanical counterparts. However, in order to be competitive, EHCs must operate in very intensive conditions(high current density and low cell voltage) that can only be reached if their core materials, e.g. the membrane and the electrodes/electrocatalysts, are optimized. This contribution will particularly focus on the properties electrocatalysts must exhibit to be used in EHCs: they shall promote(very) fast hydrogen oxidation reaction(HOR) in presence of impurities, which implies that they are(very) tolerant to poisons as well. This consists of a prerequisite for the operation of the anode of an EHC used for the purification-compression of hydrogen, and the materials developed for poison-tolerance in the vast literature on low-temperature fuel cells, may not always satisfy these two criteria, as this contribution will review.

关键词： Electrochemical hydrogen compression Electrochemical hydrogen purification Electrocatalysts Hydrogen oxidation Poison tolerance

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Electrochemical hydrogen compression and purification versus competing technologies: Part Ⅰ. Pros and cons

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Chinese Journal of Catalysis 2020年第5期41卷 756-769页

作者： Maha Rhandi Marine Trégaro Florence Druart Jonathan Deseure marian Chatenet Univ.Savoie Mont Blanc CNRSGrenoble-INPLEPMI38000 GrenobleFrance

It is undisputed that hydrogen will play a great role in our future energetic mix, because it enables the storage of renewable electricity(power-to-H2) and the reversible conversion into electricity in fuel cell, not to speak of its wide use in the(petro)chemical industry. Whereas in these applications, pure hydrogen is required, today’s hydrogen production is still largely based on fossil fuels and can therefore not be considered pure. Therefore, purification of hydrogen is mandatory, at a large scale. In addition, hydrogen being the lightest gas, its volumetric energy content is well-below its competing fuels, unless it is compressed at high pressures(typically 70 MPa), making compression unavoidable as well. This contribution will detail the means available today for both purification and for compression of hydrogen. It will show that among the available technologies, the electrochemical hydrogen compressor(EHC), which also enables hydrogen purification, has numerous advantages compared to the classical technologies currently used at the industrial scale. EHC has their thermodynamic and operational advantages, but also their ease of use. However, the deployment of EHCs will be viable only if they reach sufficient performances, which implies some specifications that their base materials should stick to. The present contribution will detail these specifications.

关键词： Electrochemical hydrogen compression Hydrogen energy Electrochemical hydrogen purification Thermdynamics Efficiency

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Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan(Isatis tinctoria)leads to glucobrassicin

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Journal of Integrative Plant Biology 2021年第12期63卷 2058-2074页

作者： Pingyin Guan Jianning Zhou Sergey Girel Xin Zhu marian Schwab Kunxi Zhang Qiyan Wang-Müller Laurent Bigler Peter Nick Molecular Cell Biology Botanical InstituteKarlsruhe Institute of TechnologyFritz-Haber-Weg 4Karlsruhe 76131Germany Department of Chemistry University of ZürichWinterthurerstr.190CH-8057ZurichSwitzerland Research Institute of Organic Agriculture FiBL Ackerstrasse 113CH-5070FrickSwitzerland College of Horticulture China Agricultural UniversityBeijing 100193China Institute of Pharmaceutical Sciences of Western Switzerland University of GenevaRue Michel-Servet 1CH-1211Geneva 4Switzerland Swiss Chinese Herbal Medicine and Functional Food Innovation Center Mainaustrasse 21CH-8046ZurichSwitzerland

Traditional Chinese medicine(TCM)belongs to the most elaborate and extensive systems of plant-based *** herb Northern Ban Lan(Isatis tinctoria)is famous for its antiviral and anti-inflammatory *** numerous components isolated from *** have been characterized so far,their modes of action have remained ***,we show that extracts from *** exert antimicrotubular *** time-lapse microscopy in living tobacco BY-2(Nicotiana tabacum ***2)cellsexpressing greenfluorescentprotein-tubulin,weuse activity-guided fractionation to screen out the biologically active compounds of *** 54 fractions obtained from either leaves or roots of *** by methanol(MeOH/H_(2)O 8:2),or ethyl acetate extraction,one specific methanolic root fraction was selected,because it efficiently and rapidly eliminated *** combination of further purification with ultrahigh-performance liquid chromatography and high-resolution tandem mass spectrometry most of the bioactivity could be assigned to the glucosinolate compound *** can also affect microtubules and induce apoptosis in HeLa *** the light of these findings,the antiviral activity of Northern Ban Lan is discussed in the context of microtubules being hijacked by many viral pathogens for cell-to-cell spread.

关键词： anti-microtubule activity cytoskeleton glucobrassicin high-performance liquid chromatography(HPLC) high-resolution tandem mass spectrometry(HRMS/MS) Isatis tinctoria Northern Ban Lan traditional Chinese medicine(TCM)

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Key stakeholders’ perspectives on the ideal partnering culture in construction projects

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Frontiers of Engineering Management 2022年第2期9卷 312-325页

作者： Gunnar J.LUHR marian G.C.BOSCH-REKVELDT Mladen RADUJKOVIC Alma Mater Europaea ECM 2000 MariborSlovenia Delft University of Technology 2600 AA DelftThe Netherlands

This paper examines the current state of project cultures in the German turnkey construction industry and the ideal project cultures in terms of partnering from the perspective of various key stakeholders(i.e.,Investors,General Contractors,(Sub-)Contractors and Designers).To investigate the current and ideal cultures,data were gathered among the key stakeholders by means of a survey study with 72 respondents divided over 12 *** respondents rated the current and desired cultures by using the Organizational Culture Assessment Instrument,which belongs to the Competing Values *** investigations show many similarities and differences between the stakeholder perspectives of the current and the idealized partnering project ***,the General Contractors desire more cooperative behaviors than the(Sub-)Contractors,and the Investors desire more pronounced flexibility than the General *** stakeholders desire a cultural change from highly competitive behaviors toward more *** in terms of clear procedures or more flexibility are only desired by the *** both the current and an ideal partnering project culture enables academics and project managers to compare their actual project cultures to an ideal *** such an approach,academics and project managers could measure whether new tools or changes in resources affect their project cultures toward a partnering project culture.

关键词： project culture organisational culture partnering construction culture stakeholder perspectives German

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