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异种移植有关的动物传染病

国外医学情报 1994年第23期15卷 13-17页

作者： marian G Michaels Richard L Simmons 耿稚江

实体器官同种移植是对各种器官末期疾病有效的治疗。在技术再精炼和制定特异有效的免疫抑制方案时,用此方法的受益人数目会继续增长。不幸的是供者来源不能保持,非人类器官的来源成为可能的选择。最近已进行了3例用狒狒和猪的肝脏移植... 详细信息

实体器官同种移植是对各种器官末期疾病有效的治疗。在技术再精炼和制定特异有效的免疫抑制方案时,用此方法的受益人数目会继续增长。不幸的是供者来源不能保持,非人类器官的来源成为可能的选择。最近已进行了3例用狒狒和猪的肝脏移植于人的异种移植。很多异种移植的文献着重于技术和免疫问题。对成功移植后传染病的感染危险性却很少彻底地沦述。本文回顾了异种移植可能的传染病危险,并提出研究与预防的可能战略。一些动物的传染病被认为对人可能致命。

关键词：异种移植动物传染病疱疹病毒感染反录病毒同种移植非人灵长类病原菌微生物狒狒种属特异性

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儿童注意缺陷多动障碍

英国医学杂志中文版 2017年第11期20卷 650-659页

作者： Nienke Verkuijl marian Perkins Mina Fazel 牛曼曼韩颖 Department ofPsychiatry University of OxfoudOxford OX3 7JX UK Child and Adolescent Neuropsychiatry Service Oxfond Health NHS Foundation TrustOxfordUK Childre's Psychological Medicine The Children's HospilalOxford UniversityHospitals NHS Trust Oxford UK 北京大学第一医院儿科

注意缺陷多动障碍（ADHD）是儿童时期第二大最常见的精神障碍。2010年全球性疾病研究表明，儿童ADHD在全世界范围内的点患病率为男性2．2％、女性0．7％。但是，对于ADHD的诊断和治疗，不同的国家和地区各不相同，这种不确定性成为ADHD... 详细信息

注意缺陷多动障碍（ADHD）是儿童时期第二大最常见的精神障碍。2010年全球性疾病研究表明，儿童ADHD在全世界范围内的点患病率为男性2．2％、女性0．7％。但是，对于ADHD的诊断和治疗，不同的国家和地区各不相同，这种不确定性成为ADHD管理的一大特点。

关键词：儿童缺陷多动障碍精神障碍治疗方法

The Vienna Cancer Stem Cell Club （VCSCC）： First 10 Years and Future Perspectives

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Journal of Life Sciences 2013年第6期7卷 577-585页

作者： Peter Valent Thomas Grunt Heidrun Karlic Harald Herrmann Brigitte marian Axel Schulenburg Edgar Seizer Stefan Woehrer Hubert Pehamberger Ulrich Jager Christoph C. Zielinski Ludwig Boltzmann Cluster Oncology Medical University of Vienna Vienna 1090 Austria Department of Medicine I Division of Hematology & Hemostaseology Medical University of Vienna Vienna 1090 Austria Department of Medicine I Division of Clinical Oncology Medical University of Vienna Vienna 1090 Austria Department of lnternal Medicine III Division of Hematology/Oncology Hanusch Hospital Vienna 1140 Austria Department of Radiation Oncology Medical University of Vienna Vienna 1090 Austria Department of Medicine I Institute of Cancer Research Medical University of Vienna Vienna 1090 Austria Department of Medicine I Stem Cell Transplantation Unit Medical University of Vienna Vienna 1090 Austria Department of Dermatology Medical University of Vienna Vienna 1090 Austria

In 2002, the Vienna Cancer Stem Cell Club (VCSCC) was inaugurated by a group of scientists at the Medical University of Vienna, with the primary goal to initiate and promote cancer stem cell (CSC) research in Austria and to exploit knowledge from this new discipline in translational approaches. During the first years following inauguration, the VCSCC-community was small and left without major funding. However, over time the consortium was able to launch several major project-lines, supported in part by the National Science Funds, a Genome Program, and the Ludwig-Boltzmann Society. Today, the VCSCC provides a robust intellectual platform for ongoing research in the field of translational oncology and CSC-research in Austria. In addition, the VCSCC is connected to several major CSC-networks and centers in Europe and in North America, and is a well-recognized group in the field. The VCSCC also organized a series of CSC Meetings and Conferences, and contributed essentially to a recently published classification of CSC. There is also hope that the VCSCC-consortium will further advance the field of CSC research in the future, and will create novel concepts, with the ultimate aim to improve anti-cancer therapy through elimination, suppression, or long-term control of cancer-initiating cells.

关键词： Stem cells cancer stem cells molecular targets targeted drug therapies curative anti-cancer approaches.

类泛素蛋白FAT10对缺氧/复氧下心肌细胞保护作用以及机制的研究

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类泛素蛋白FAT10对缺氧/复氧下心肌细胞保护作用以及机制的研究

对抗网络生成的艺术作品为何比人类艺术家更受欢迎?

第十二次全国医学遗传学学术会议

作者：彭小刚邵江华申阳周云国曹青胡金柱贺文凤余新 Ali J marian 洪葵南昌大学第二附属医院心血管内科江西分子医学重点实验室南昌大学第二附属医院南昌大学第二附属医院普通外科德克萨斯大学心血管遗传中心德克萨斯健康科学中心德克萨斯心脏研究所

背景FAT10是近期被发现的类泛素蛋白家族成员之一,其在心脏中的生物学功能尚未被定义。本研究的目的是确定FAT10在心肌细胞凋亡中发挥的作用。方法(1)通过结扎冠脉左前降支构建大鼠心梗模型,检测梗死边缘区FAT10的蛋白表达。(2)体外构建... 详细信息

背景FAT10是近期被发现的类泛素蛋白家族成员之一,其在心脏中的生物学功能尚未被定义。本研究的目的是确定FAT10在心肌细胞凋亡中发挥的作用。方法(1)通过结扎冠脉左前降支构建大鼠心梗模型,检测梗死边缘区FAT10的蛋白表达。(2)体外构建FAT10过表达慢病毒,转染大鼠原代心肌细胞后暴露于缺氧/复氧的环境中,通过流式细胞术与TUNEL染色检测心肌细胞凋亡率,用Westernblot检测凋亡相关蛋白BCL-2与BAX的表达量。(3)在原代大鼠心肌细胞中过表达FAT10后,分别利用Wes ternblot与qRT-PCR检测下游通路蛋白与microRNA的表达水平。结果在梗死大鼠心肌梗死边缘区与缺氧/复氧处理的大鼠原代心肌细胞中,FAT10表达量明显升高。在大鼠原代心肌细胞中过表达FAT10可以降低缺氧/复氧引起的细胞凋亡,并且升高抗凋亡蛋白BCL-2的表达,下调促凋亡蛋白BAX的表达。缺氧/复氧可以促进P53的表达,但是过表达FAT10可以显著减弱这一趋势,进而抑制了P53下游一个起着促凋亡作用的microRNA(miR-34a)的表达,最终达到升高BCL-2降低BAX而起到对抗心肌细胞凋亡的作用。结论FAT10在心脏和原代大鼠心肌细胞缺氧/复氧应激作用下的表达量升高。上调的FAT10可通过抑制p53和miR-34a的表达以及改变BCL2/BAX通路而防止心肌细胞凋亡。因此,我们得出结论FAT10是一个心脏保护性基因,FAT10的表达上调可能对心肌细胞凋亡相关的病理改变起有益作用。

关键词： FAT10 心肌细胞 apoptosis p53 BCL2 microRNA

来源： cnki会议评论

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机器人产业 2017年第4期 34-37页

作者：张含阳 Ahmed Elgammal Bingchen Liu Mohamed Elhoseiny marian Mazzone Department of Computer Science Rutgers University Facebook AI Research Department of Art History College of Charleston The Art & AI Laboratory-Rutgers University

深度学习如何像人类一样产生"创造力",一直是AI科学家们研究的热点。罗格斯大学和查尔斯顿学院近日联合发布了一篇论文,发布了一种全新的深度学习模型——创意对抗网络(Creative Adversarial Networks,CANs)。CAN通过学习风格和偏离风... 详细信息

深度学习如何像人类一样产生"创造力",一直是AI科学家们研究的热点。罗格斯大学和查尔斯顿学院近日联合发布了一篇论文,发布了一种全新的深度学习模型——创意对抗网络(Creative Adversarial Networks,CANs)。CAN通过学习风格和偏离风格规范来生成"艺术作品"。该论文是在2017年6月20日至6月22日在亚特兰大举行的第八届国际计算创意大会(ICCC)发布的论文的扩展版本。

关键词：鉴别器艺术家人类

Influence of Random Track Irregularities on Dynamic Response of Bridge/Track Structure/High-Speed Train Systems

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Journal of Civil Engineering and Architecture 2014年第10期8卷 1335-1352页

作者： marian Klasztomy Monika Podwoma Department of Mechanics and Applied Computer Science Faculty of Mechanical Engineering Military University of TechnologyWarsaw 00-908 Poland Department of Dynamics of Structures Faculty of Civil Engineering Wroclaw University of Technology Wroclaw 50-370 Poland

Random vertical track irregularities are one of essential vibration sources in bridge, track structure and high-speed train systems. The common model of such irregularities is a stationary and ergodic Gaussian process. The study presents the results of numerical dynamic analysis of advanced virtual models of composite BTT (bridge/ballasted track structure/high-speed train) systems. The analysis has been conducted for a series of types of single-span simply-supported railway composite (steel-concrete) bridges, with a symmetric platform, located on lines with ballasted track structure adapted for high-speed trains. The bridges are designed according to Polish bridge standards. A new methodology of numerical modeling and simulation of dynamic processes in BTT systems has been applied. The methodology takes into consideration viscoelastic suspensions of rail-vehicles, nonlinear Hertz wheel-rail contact stiffness and one-side wheel-rail contact, physically nonlinear elastic-damping properties of the track structure, random vertical track irregularities, approach slabs and other features. Computer algorithms of FE (finite element) modeling and simulation were programmed in Delphi. Both static and dynamic numerical investigations of the bridges forming the series of types have been carried out. It has been proved that in the case of common structural solutions of bridges and ballasted track structures, it is necessary to put certain limitations on operating speeds, macadam ballast and vertical track roughness.

关键词：轨道不平顺轨道结构列车系统随机动态响应桥梁非线性弹性高速列车

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Hua Deng Sketches

China Today 2019年第2期68卷 57-57页

作者： Staicu marian Jiang Jiaxin

Liuyang fireworks are made from gun powder,one of the Four Great Inventions of ancient *** traditional craftsmanship with a history of over 1,000 years is elaborate and *** is inseparably connected with Chinese customs of festival and *** documentary has four chapters:history,production,design,and show,in which it vividly tells the tale of Liuyang *** focuses on the precise craftsmanship behind the colorful fireworks,presenting its inheritance,development,and innovation in modern society.

关键词： Soul Living Sparkle

Urinary Schistosomiasis in Children—Still a Concern in Part of the Ghanaian Capital City

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Open Journal of Medical Microbiology 2013年第3期3卷 151-158页

作者： Patience B. Tetteh-Quarcoo Simon K. Attah Eric S. Donkor marian Nyako Andrew A. Minamor Emmanuel Afutu Edward T. Hervie Patrick F. Ayeh-Kumi Department of Biochemistry Cell and Molecular Biology University of Ghana Accra Ghana Department of Medical Laboratory Sciences University of Ghana School of Allied Health Sciences Accra Ghana Department of Microbiology University of Ghana Medical School Accra Ghana Department of Science Laboratory Technology Accra Polytechnic Accra Ghana Neglected Tropical Disease Program Disease Control & Prevention Department Ghana Health Service Accra Ghana

Schistosomiasis is a parasitic disease of the tropics which is estimated to affect up to 300 million people worldwide. While it is being successfully controlled in many countries, it remains a major public health problem, especially in developing countries including Ghana. Extensive work on schistosomiasis has been undertaken along theVoltaRiverbasin, leaving very little data and information on this infection in the urban and peri-urban areas inGhana. This study was aimed at determining the urinary schistosomiasis burden among children of school going age within Zenu, a suburb of the capital city. Urine samples were taken from 274 school children within the Zenu community and examined with urine chemistry dipsticks for detection and confirmation of haematuria, followed by microscopy for detection of Schistosoma haematobium ova. Prevalence of urinary schistosomiasis was 30.7% (95% CI: 25.2-36.2). 44 (52%) of the positive samples were collected from males whiles 40 (48%) were collected from females, but prevalence of the infection was not significantly associated with gender (χ2 = 0.041, DF = 1, P-Value = 0.839). Among the S. haematobium positive children, haematuria was detected by the dipstick in 88.1% (74/84, 95% CI: 81.2- 95.0), but it was not detected in 11.9% (10/84, 95% CI: 5.0-18.8). Meanwhile, the dipstick detected haematuria in 7.3% (20/274, 95% CI: 4.3-7.3) of the total population but microscopy could not detect the presence of Schistosoma ova in those children. An association was found between Schistosoma infection and haematuria detected by dipstick (χ2 = 84.715, DF = 1,

关键词： Schistosomiasis Haematuria Schistosoma haematobium Accra

SPONTANEOUS AMPUTATION OF THE CERVIX UTERI: REPORT OF CASE

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中华医学杂志(英文版) 1949年第2期67卷 99-99页

作者： marian E. MANLY Chin I School of Midwifery Affiliated with the West China Union University Chengtu Szechuan