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Specificity of electrophysical and gas-sensitive properties of nanocomposite ZnO–TiO_(2) films formed by solid-phase pyrolysis

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ChemPhysMater 2024年第3期3卷 314-319页

作者： Victor V.Petrov maria G.Volkova Alexsandra P.Ivanishcheva Gleb V.Tolstyak Ekaterina M.Bayanb Institute of Nanotechnologies Electronicsand Equipment EngineeringSouthern Federal UniversityTaganrog 347922Russia Faculty of Chemistry Southern Federal UniversityRostov-on-Don 344090Russia

ZnO–TiO_(2) thin films containing 0.5 mol%,1.0 mol%,and 5.0 mol%ZnO were synthesized by oxidative solidphase *** materials contained anatase and rutile phases with particle size of 6–13 nm,as confirmed using X-ray phase analysis and scanning electron *** a certain number of ZnO crystallites appeared in the TiO_(2) film structure in the temperature range of room temperature to 220℃,a two-level response of the film resistance was observed,differing by approximately 10%,as obtained by electrophysical *** two-level response correlates with the formation of two donor energy levels of 0.28 and 0.33 eV in the band structure of the ZnO–TiO_(2) *** donor level with a higher activation energy corresponded to the Ti vacancy(V−Ti),and that with a lower activation energy corresponded to the Zn vacancy(V−Zn).Two levels of gas-sensitive properties were noted for 0.5ZnO–TiO_(2),1ZnO–TiO_(2),and 5ZnO–TiO_(2) under the influence of 50 ppm NO_(2) at 250℃.Such two-level responses can be ascribed to the pinning of the Fermi level on ZnO and TiO_(2) *** mechanism of the beak-shaped and two-level responses of sensors based on composite nanomaterials when exposed to various gases was elucidated.

关键词： Thin film ZnO TiO_(2) Nanocomposites Pyrolysis Gas sensors

SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom M.Green Stephen A.Shaw Lauren J.Bonilla Shannon E.Ronca maria Elena Bottazzi Farrah Kheradmand Jill E.Weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of Medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical Medicine One Baylor PlazaHoustonTX 77030USA Molecular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

Advancing Malaria Prediction in Uganda through AI and Geospatial Analysis Models

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Journal of Geographic Information System 2024年第2期16卷 115-135页

作者： maria Assumpta Komugabe Richard Caballero Itamar Shabtai Simon Peter Musinguzi Center for Information Systems & Technology Claremont Graduate University Claremont California USA Department of Information Technology Faculty of Business and ICT University of Kisubi Entebbe Uganda Faculty of Health Sciences University of Kisubi Entebbe Uganda Department of Agriculture Production Faculty of Agriculture Kyambogo University Kyambogo Uganda Department of Agriculture and Natural Sciences Faculty of Agriculture Uganda Martyrs University Kampala Uganda

The resurgence of locally acquired malaria cases in the USA and the persistent global challenge of malaria transmission highlight the urgent need for research to prevent this disease. Despite significant eradication efforts, malaria remains a serious threat, particularly in regions like Africa. This study explores how integrating Gregor’s Type IV theory with Geographic Information Systems (GIS) improves our understanding of disease dynamics, especially Malaria transmission patterns in Uganda. By combining data-driven algorithms, artificial intelligence, and geospatial analysis, the research aims to determine the most reliable predictors of Malaria incident rates and assess the impact of different factors on transmission. Using diverse predictive modeling techniques including Linear Regression, K-Nearest Neighbor, Neural Network, and Random Forest, the study found that;Random Forest model outperformed the others, demonstrating superior predictive accuracy with an R2 of approximately 0.88 and a Mean Squared Error (MSE) of 0.0534, Antimalarial treatment was identified as the most influential factor, with mosquito net access associated with a significant reduction in incident rates, while higher temperatures correlated with increased rates. Our study concluded that the Random Forest model was effective in predicting malaria incident rates in Uganda and highlighted the significance of climate factors and preventive measures such as mosquito nets and antimalarial drugs. We recommended that districts with malaria hotspots lacking Indoor Residual Spraying (IRS) coverage prioritize its implementation to mitigate incident rates, while those with high malaria rates in 2020 require immediate attention. By advocating for the use of appropriate predictive models, our research emphasized the importance of evidence-based decision-making in malaria control strategies, aiming to reduce transmission rates and save lives.

关键词： Malaria Predictive Modeling Geospatial Analysis Climate Factors Preventive Measures

Semantic Segmentation of the Intertidal Zone of an Estuary—In Search of the Best Solution

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Journal of Geoscience and Environment Protection 2024年第7期12卷 1-13页

作者： maria da Conceição Proença Ricardo Nogueira Mendes Ricardo Melo Marine and Environmental Sciences Centre (MARE-ULisboa) & ArNet Lisbon Portugal Department of Physics Faculty of Sciences University of Lisbon Lisbon Portugal Department of Animal Biology Faculty of Sciences University of Lisbon Lisbon Portugal Department of Plant Biology Faculty of Sciences University of Lisbon Lisbon Portugal

An aerial photographic coverage acquired on two consecutive days in October 2021 with a ground resolution of 20 cm and a spectral resolution of 4 bands (red, green, blue and near infrared), allowed to distinguish most of the classes of interest present in the intertidal zone of the Sado estuary. We explored the possibilities of thematic classification in the powerful and complex software ArcGIS Pro;we presented the methodology used in a detailed way that allows others with minimal knowledge of GIS to reproduce the classification process without having to decipher the specifics of the software. The classification implemented used ground truth from four classes related to the macro-occupations of the area. In a first phase we explore the standard algorithms with object-based capabilities, like K-Nearest Neighbor, Random Trees Forest and Support Vector Machine, and in a second phase we proceed to test three deep learning classifiers that provide semantic segmentation: a U-Net configuration, a Pyramid Scene Parsing Network and DeepLabV3. The resulting classifications were quantitatively evaluated with a set of 500 control points in a test area of 37,500 × 12,500 pixels, using confusion matrices and resorting to Cohen’s kappa statistic and the concept of global accuracy, achieving a Kappa in the range [0.72, 0.81] and a global accuracy between 88.9% and 92.9%;the option U-Net had the most interesting results. This work establishes a methodology to provide a baseline for assessing future changes in the distribution of Sado estuarine habitats, which can be replicated in other wetland ecosystems for conservation and management purposes.

关键词： Estuary Intertidal Zone ArcGIS Pro Segmentation Global Changes

Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch Hannah maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

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地球磁鞘中动理学尺度磁洞的研究进展

中国科学：地球科学 2024年第9期54卷 2789-2822页

作者：史全岐姚淑涛 maria HAMRIN 刘吉山东大学空间科学研究院山东省光学天文与日地环境重点实验室威海264209 Department of Physics UmeåUniversityUmeå90746Sweden Department of Physics University of AlbertaEdmonton T6K 2P6Canada

离子到电子动理学尺度上的磁洞(Kinetic Scale Magnetic Holes, KSMHs)是磁化的湍流等离子体中产生的极其微小的结构之一.近年来,借助磁层多尺度卫星(MMS)超高精度的观测数据, KSMHs的研究取得了显著进展.本文总结了地球磁鞘湍流中观测... 详细信息

离子到电子动理学尺度上的磁洞(Kinetic Scale Magnetic Holes, KSMHs)是磁化的湍流等离子体中产生的极其微小的结构之一.近年来,借助磁层多尺度卫星(MMS)超高精度的观测数据, KSMHs的研究取得了显著进展.本文总结了地球磁鞘湍流中观测到的KSMHs的最新特性,以及它们对空间等离子体的影响.研究人员发现,KSMHs呈现出由电子抗磁漂移引起的准圆形电子涡旋结构.这些电子表现出明显的各向异性并被加速.在地球的磁鞘中, KSMHs的发生率明显高于太阳风和磁尾,表明湍动的磁鞘是其主要的产生区域.此外,研究发现,KSMHs能够在针对等离子体湍流的模拟中产生,并成功地被动理学平衡模型所复现.研究证实了KSMHs能够通过非绝热加速机制加速电子,并可能成为磁重联过程中能量耗散的额外途径.值得注意的是, KSMHs能够在空间等离子体中产生多种波现象,包括哨声波、静电孤立波和电子回旋波.这些结果突显了KSMHs的影响,如波粒相互作用、能量级联/耗散以及粒子加速/加热等.本文梳理了这些发现,探讨了它们的产生机制、类似结构,以及在地球磁尾和太阳风中的观测.未来在这一活跃的研究领域需要展开更深入探索.

关键词：磁洞电子涡旋镜像模磁鞘湍流相干结构动理学尺度电子加速哨声波

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑Garcia Laura Morales‑Fernandez Javier Garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian Garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

A Comparison of Airborne Formaldehyde Field Measurements Collected in an Anatomic Pathology Laboratory

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Journal of Environmental Protection 2024年第8期15卷 827-841页

作者： maria Teresa Piccardo Massimo Cipolla Alberto Izzotti Paola Canepa Vincenzo Fontana Mutagenesis& Cancer Prevention Unit IRCCS Ospedale Policlinico San Martino Genova Italy Department of Experimental Medicine (DIMES) University of Genova Genova Italy Clinical Epidemiology Unit IRCCS Ospedale Policlinico San Martino Genova Italy

Environmental monitoring of airborne formaldehyde (FA) using sensitive methodologies is fundamental to prevent health risks. The objective of this study was to compare three different FA monitoring methods during the daily activities of an anatomic pathology laboratory. Daily eight-hour measurements deriving from Radiello® passive diffusive samplers (PDS), NEMo XT continuous optical sensor (COS), and multi-gas 1512 photoacoustic monitor (MPM) were simultaneously compared over a period of 14 working days. Given the different daily distributions of the measurements performed by the three devices, all measurements were time-aligned for comparison purposes. The 95% limit of agreement (LOA) method was applied to estimate the degree of concordance of each device with respect to the others. Formaldehyde arithmetic mean measured using PDS was 32.6 ± 10.4 ppb (range: 19.8 - 62.7). The simultaneous measures performed by COS and MPM were respectively 42.4 ± 44.8 ppb (range: 7.0 - 175.0) and 189.0 ± 163.7 ppb (range: 40.0 - 2895.4). The MPM geometric mean (171.3 ppb) was approximately five times higher than those derived from COS (32.3 ppb) and PDS (31.4 ppb). The results of the LOA method applied to log-transformed FA data showed the same systematic discrepancies between MPM and the other two devices. A good agreement between PDS and COS could lead to a tailored approach according to the individual specificity of these techniques. This tool may be useful for accurately assessing the risk of FA exposure among healthcare workers. However, the limited specificity of the MPM does not support its use as a monitoring method for FA in the workplace.

关键词： Occupational Exposure Occupational Health Formaldehyde Monitoring Devices Indoor Air Quality