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Phytochemical composition and gastroprotective effect of Feijoa sellowiana Berg fruits from Sicily

Journal of Coastal Life Medicine 2014年第1期 14-21页

作者： maria teresa Monforte Francesco Lanuzza Fabio Mondello Clara Naccari Simona Pergolizzi Enza maria Galati SCIFAR Department University of MessinaMessinaItaly Department of Economics BusinessEnvironment and Quantitative MethodsUniversity of MessinaMessinaItaly Fondazione“Prof.Antonio Imbesi”–SCIFAR Department University of MessinaMessinaItaly S.A.S.T.A.S.Department University of MessinaMessinaItaly

Objective:To assess the fruit of Feijoa sellowiana Berg *** and gorgiona,cultured in Sicily,for its gastroprotective effect,in association with performing phytochemical ***:The gastroprotective effect was investigated on ethanol-induced ulcers in rats,with sucralfate as reference *** of gastric mucosae,stained by periodic acid-Shiff and haematoxylin/eosin,were observed by light ***:By means of HPLC,vitamin E complex and polyphenol compounds were ***,while δ was only in *** whole fruit of two varieties,catechin,eriodictyol,eriocitrin,pyrocatechol,quercetin,rutin,ellagic,gallic and syringic acid were *** fruit showed gastroprotective effect(ulcer index:***=1.07,***=1.02).The efficacy was comparable to that of sucralfate(ulcer index 1.10).Histological examination confirmed the inhibition of ulcerogenic activity of the ***:In pulp and peel samples of both varieties of fruit α,β and γ tocopherols were and show beneficial effects on various diseases,particularly those caused by oxidative processes resulting in cell *** amount of polyphenols and vitamin E complex confirms the nutritional value of this fruit,grown in pedoclimatic condition very different from the origin *** principles of Feijoa sellowiana can play an important role in human diet and show beneficial effects on various diseases,particularly those caused by oxidative processes resulting in cell *** amount of polyphenols and vitamin E complex confirms the nutritional value of this fruit,grown in pedoclimatic condition very different from the origin area.

关键词： Feijoa sellowiana Berg var.coolidge and gorgiona Polyphenols Tocopherols Gastroprotective effect HPLC Peel Pulp

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Alcoholic liver disease:Utility of animal models

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World Journal of Gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-Paz Fengjie Hao Leonard J Nelson maria teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of Genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： Steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

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Individual factors related to chronic condition in Portuguese adolescents: Highlights from the HBSC/WHO study

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Health 2013年第11期5卷 25-34页

作者： teresa Santos Margarida Gaspar de Matos maria Celeste Simoes Helena Fonseca maria do Ceu Machado Faculdade de Motricidade Humana(“Social Adventure”Team) Universidade de LisboaLisboaPortugal Centro de Malaria e Doencas Tropicais/IHMT Universidade Nova de LisboaLisboaPortugal Departamento de Pediatria do Hospital de Santa maria

Background: Adolescence includes a period (10 to 19 years) of profound biopsychosocial changes, constituting potentially difficult challenges, which may become more pronounced in the presence of a chronic condition and its limitations. Responses are not homogeneous and can be quite variable, depending on various specific individual factors. Research comparing adolescents with or without chronic illness, or comparing across different conditions, has been contradictory, not confirming a direct relationship between the degree of suffering and the chronic condition. Objective: To characterize and assess the impact of 1) having a chronic condition (CC) and 2) how CC affects school participation;and its association with life satisfaction and perception of wellness, controlling for demographic factors: age, gender and family socioeconomic status (SES). Methods: 5050 Portuguese adolescents with an average age of 14 years participated in the Health Behaviour in School-aged Children/WHO (HBSC). Results: The majority of the adolescents with CC reported that their conditions did not affect school participation. Adolescents with CC who indicated that CC affected school participation felt more frequently unwell and presented lower life satisfaction. Being a boy, younger and having high family socio economic status (SES) were identified as predictors of higher life satisfaction;on the other hand, being a girl, older, having lower SES, living with CC and feeling that CC affects school participation are predictors for feeling more frequently unwell. Conclusions: These adolescents showed an increased vulnerability, presenting internalized symptoms and lower life satisfaction. Furthermore, when there was simultaneous occurrence of living with CC and that CC affected school participation, the impact was even higher. Thus, it is crucial that future interventions should include the identified predictors, combined with “listen to the voice” of adolescents, throughout the adaptation proces

关键词： Adolescent Health Chronic Condition Health Promotion and Prevention Quality of Life

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Characterization and Biological Activities of Protein-Bound Polysaccharides Produced by Cultures of Pleurotus ostreatus

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Journal of Agricultural Science and Technology(A) 2012年第11期2卷 1296-1306页

作者： Catia Salvador maria do Rosario Martins maria de Fatima Candelas Amin Karmali Jose maria Arteiro Ana teresa Caldeira Chemistry Department and Chemistry Centre of Evora University of Evora Evora 7000-671 Portugal Chemistry Department and ICAAM-Institute of Mediterranean Agricultural and Environmental Sciences University of EvoraEvora7002-554 Portugal Chemical Engineering Department and Chemical Engineering and Biotechnology Research Center Lisbon Superior EngineeringInstitute Lisboa 1950-062 Portugal

Several species of mushrooms, as Pleurotus ostreatus, have been valued as edible and medicinal resources. These mushrooms may be an important source of polysaccharides with medicinal properties as antioxidant, antitumoral, antimicrobial and immunological properties. The aim of this work was to produce and to evaluate the biological properties of protein-bound polysaccharide complexes, extra intracellular （E-PPS and I-PPS）, extracted from P. ostreatus cultures, using agricultural sunflower wastes as carbon source. Three main compounds in the E-PPS and four main compounds in the I-PPS were identified by SEC-UV-RI-HPLC. These complexes of P. ostreatus present no toxicity in Artemia salina cultures, after 24 h of incubation. Antioxidant properties of the complexes were evaluated by radical scavenging activity using DPPH method and lipid peroxidation inhibition capacity, determined by erytbsocytes hemolysis. Additionally, E-PPS and I-PPS extracts revealed capacity to mimetize superoxide dismutase and catalase enzymatic activities. The hepatoprotector effect of E-PPS extracts in Wistar rats was evaluated by AST, ALT, ALP and y-GT activities, showing capacity to reduce the liver damage induced by ethanol-administration. This hepatoprotective effect is equivalent to that observed by silymarin, a standard drug. Our results suggests that the extracts of E-PPS and I-PPS produced by P. ostreatus cultures, using agricultural sunflower wastes as main carbon source, can be used as an important source of bioactive compounds with potential medicinal value.

关键词： Protein-polysaccharides Pleurotus ostreatus edible mushrooms submerged fermentation agro-industrial residues bioactive compounds antioxidant properties hepatoprotective effect.

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Mesocosm Hatcheries Using Semi-intensive Methodologies and Species Diversification in Aquaculture

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Journal of Agricultural Science and Technology(B) 2012年第4期2卷 428-437页

作者： Carlos Andrade Natacha Nogueira Paula Silva maria teresa Dinis Luis Narciso Centro de Marieultura da Calheta Direccao Regional de Pescas Calheta 9370-133 Madeira Portugal CCMAR Universidade do Algarve Campus de Gambelas Faro 8005-139 Portugal Centro de Oceanografia Laboratorio Maritimo da Guia FCUL Avenida N. S. do Cabo 939 Caseais 2750-642 Portugal

Mesocosm hatcheries using semi-intensive culture methodologies are characterized by large tanks （40 m3） for fish larvae production at low densities （2-8 larvae/L）, with live prey production within the tank supplemented by exogenous sources of feed. Due to the high biological quality of larvae produced and low level of technological input, these methodologies are regarded as an interesting option to meet the increasing fry demand from the aquaculture industry. This study aimed to describe the experience at Centro de Maricultura da Calheta, Madeira Island, Portugal, with the establishment of a mesocosm hatchery for the production of marine fish larvae. Production trials were initiated with gilthead seabream Sparus aurata. This larval species presented faster growth in total body length （TL） per day （TL = 3.7516e~ ~293day, R2 = 0.9404）, higher survival rate （SR = 31.9%） and comparable swimbladder inflation rates （SB = 90%） to those of larvae reared with intensive methodologies. High larval performance was obtained with two candidate species for aquaculture： the red porgy Pagruspagrus （TL = 3.212e~~39day, R2 = 0.995; SR = 15.3%; SB = 95.7%） and the white seabream Diplodus sargus （TL = 3.6355e~~413day, R2= 0.9824; SR = 25%; SB --- 100%）. Testing ofa 110 m3 mesocosm rearing tank with white seabream larvae revealed limitations associated to larger tanks namely, the amount and quality of live feed required daily. First trials with striped jack （Pseudocararoc dentex） larvae resulted in low larval survival （0.04%）, but the use of a white tank avoided culture management constraints related to positive phototropism. The present results suggest that a mesocosm using semi-intensive methodologies may contribute to species diversification and consequently, to the sustainable development of aquaculture.

关键词： Mesocosm hatchery fish larvae performance Sparus aurata Pagrus pagrus Diplodus sargus Pseudocarartx dentex.

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Sterilization Efficacy of Demolizer Technology for Onsite Treatment of Sharps and Other Regulated Medical Waste against Staphylococcus aureus, Escherichia coli, Candida albicans,Mycobacterium phleiand Bacillus subtilisSpores

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Open Journal of Medical Microbiology 2012年第3期2卷 77-83页

作者： James Marsden Jasdeep Saini maria teresa Ortega Diane Gorder Pamela Hatesohl Department of Animal Science and Industry Kansas State University Manhattan USA

This study was performed to evaluate the efficacy of the Demolizer? technology for the on-site sterilization of low vo-lumes of regulated medical waste. The objective was to demonstrate a minimum of 6 log10 reduction of the dry heat sterilization process applied by the Demolizer? II system for the representative organisms, Staphylococcus aureus, Escherichia coli, Candida albicans, Mycobacterium phlei and Bacillus subtilis spores (formerly Bacillus subtilis) on simulated medical waste consistent with numerous regulatory standards for medical waste treatment. The system cycle was heat treatment at a minimum temperature of 350?F and held at or above this temperature for a minimum of 90 minutes. Upon completion of treatment, there was no evidence of growth in the bacterial species after treatment. Given the minimum detection level of 4 CFU/ml, the Demolizer? II system demonstrated a minimum sterilization efficacy of 6.6 log10 for both S. aureus and E. coli as representative gram-positive and gram-negative bacteria species. Candida albicans (6.7 log10 CFU/ml), Mycobacterium phlei (9.0 log10 CFU/ml) and Bacillus subtilis (6.3 log10 CFU/ml) were completely eliminated after sterilizing representative medical waste in the Demolizer? II system for 90 minutes at a minimum temperature of 350?F. Also, the Demolizer? II exceeded typical recognized standards for medical waste treatment of a 6 log10 reduction of Mycobacteria and a 4 log10 reduction of the appropriate Bacillus endospore.

关键词： Regulated Medical Waste Onsite Treatment Sharps Demolizer Technology

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Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

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Infectious Diseases of Poverty 2018年第1期7卷 448-459页

作者： Virginia Araujo Pereira Juan Camilo Sanchez-Arcila mariana Pinheiro Alves Vasconcelos Amanda Ribeiro Ferreira Lorene de Souza Videira Antonio Teva Daiana Perce-da-Silva maria teresa Queiroz Marques Luzia Helena de Carvalho Dalma maria Banic Luiz Cristovao Sobrino Porto Joseli Oliveira-Ferreira Laboratory of Immunoparasitology Oswaldo Cruz Institute/FiocruzAv.Brasil 4365ManguinhosRio de JaneiroBrazil Institute of Infectology Emilio Ribas São PauloSao PauloBrazil Laboratory of Immunodiagnosis Departament of Biological SciencesNational School of Public Health/FiocruzRio de JaneiroBrazil Laboratory of Clinical Immunology Oswaldo Cruz Institute/FiocruzRio de JaneiroBrazil Laboratory of Histocompatibility and Cryopreservation–HLA of DHE/IBRAG/UERJ Rio de JaneiroBrazil Molecular Biology and Malaria Immunology Research Group Centro de Pesquisas Rene Rachou/FiocruzBelo HorizonteMinas GeraisBrazil

Background:Brazil has seen a great decline in malaria and the country is moving towards ***,for eventual elimination,the control program needs efficient tools in order to monitor malaria exposure and *** this study,we aimed to evaluate whether seroprevalence to the circumsporozoite protein(CSP)is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian ***:Cross-sectional surveys were conducted in a rural area of Porto Velho,Rondônia *** infection was detected by microscopy and polymerase chain *** to the sporozoite CSP repeats of Plasmodium vivax,***,and ***(PvCS,PfCS,and PmCS)were detected using the enzyme-linked immunosorbent assay *** leukocyte antigen(HLA)-DRB1 and DQB1 genes were typed using Luminex®xMAP®***:The prevalence of immunoglobulin G against *** CSP peptide(62%)was higher than ***(49%)and ***(46%)CSP *** of the studied individuals had antibodies to at least one of the three peptides(72%),34%had antibodies to all three peptides and 28%were *** the majority of the population was not infected at the time of the survey,74.3%of parasite-negative individuals had antibodies to at least one of the ***,among individuals carrying the haplotypes DRB1*04~DQB1*03,there was a significantly higher frequency of PfCS responders,and DRB1*16~DQB1*03 haplotype for PvCS and PfCS *** contrast,HLA-DRB1*01 and HLA-DQB1*05 allelic groups were associated with a lack of antibodies to *** and *** CSP repeats,and the haplotype DRB1*01~DQB1*05 was also associated with non-responders,including non-responders to ***:Our results show that in low transmission settings,naturally acquired antibody responses against the CSP repeats of ***,***,and *** in a single cross-sectional study may n

关键词： Malaria Circumsporozoite protein Serological marker Human leucocyte antigen IgG antibody Porto Velho Rondônia Brazil

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Towards the Recovery of By-Product Metals from Mine Wastes:An X-Ray Absorption Spectroscopy Study on the Binding State of Rhenium in Debris from a Centennial Iberian Pyrite Belt Mine

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Journal of Minerals and Materials Characterization and Engineering 2014年第2期2卷 135-143页

作者： maria-Ondina Figueiredo teresa Pereira da Silva Joao Pedro Veiga Daniel de Oliveira maria Joao Batista CENIMAT/I3N Faculty of Sciences and TechnologyNew University of LisbonCampus da CaparicaLisbonPortugal Unit of Mineral Resources and Geophysics National Laboratory for Energy and GeologyAmadoraPortugal

Rhenium is a very scarce element, occurring in the Earth's crust mainly carried by molybdenite (MoS2). Due to a very low availability comparative to actual industrial demand, rhenium is nowadays one of the most expensive mineral commodities and an increased interest is focused on ex- ploring residues resulting from a long-term mining, particularly of sulphide ore deposits. It is therefore noteworthy to assign the presence of rhenium (in a concentration up to 3 ppm) in the waste materials from the old sulphur factory at the abandoned mine of Sao Domingos (Iberian Pyrite Belt, Southeast Portugal), exploited since the Roman occupation of Iberia. Aiming at a potential sustainable recovery of rhenium as a by-product, X-ray near-edge absorption spectroscopy (XANES) was applied to clarify the Re-binding and mode of occurrence by comparing Re L3-edge XANES spectra obtained from mine waste samples (previously fully characterized by X-ray laboratory techniques) with similar spectra collected from Re-rich molybdenites (Mo1-xRexS2) and from Re-O model compounds configuring various valences and coordination environments of rhenium ions. Obtained results are commented, ruling out a possible Re-S binding and rather conforming with the binding of rhenium to oxygen in the analysed mine waste materials.

关键词： Mine Waste Materials By-Products Iberian Pyrite Belt Rhenium XANES Re L_(3)-Edge

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Present and future of metastatic colorectal cancer treatment: A review of new candidate targets

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World Journal of Gastroenterology 2017年第26期23卷 4675-4688页

作者： Giulia Martini teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli Department of Internal and Experimental Medicine“F.Magrassi e A.Lanzara” Institute of Medical OncologyUniversitàdegli studi della Campania Luigi Vanvitelli Department of Internal and Experimental Medicine Magrassi-LanzaraInstitute of RadiologyUniversitàdegli studi della Campania Luigi Vanvitelli Gastroenterology Unit Ospedale Umberto I Unit of Colorectal Surgery Department of MedicalSurgicalNeurologicalMetabolic and Ageing SciencesUniversità degli studi della Campania Luigi Vanvitelli

In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon.

关键词： Novel biomarkers Monoclonal antibodies Resistance Mutation RAS Target therapy Metastatic colorectal cancer

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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

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Journal of Molecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró Mónica Durán Ana Rico Diana Bou-Teen Vanesa Fernández-Majada Anthony J.Croatt Karl A.Nath maria teresa Salcedo Justin H.Gundelach Daniel Batlle Richard J.Bram Anna Meseguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biomimetic Systems for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Department of Medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent Medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de Bioquímica i Biologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDINREN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition(pEMT),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EMT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB emerges as an epithelial repressor,because CypB silencing promotes epithelial differentiation,prevents TGFβ-induced EMT,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout mice subjected to unilateral ureteral obstruction,inflammatory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-buffering chaperone related to Slug *** CypB silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on CypB modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and CypB in modulating TEC plasticity and identifies CypB as a druggable target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

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