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Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis:A prospective study

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World Journal of Gastroenterology 2021年第30期27卷 5112-5125页

作者： Mar Riveiro-Barciela Cristina Marcos-Fosch Fernando Martinez-Valle Fabrizio Bronte Olimpia Orozco Isidro Sanz-Pérez Daniele Torres maria-teresa salcedo Salvatore Petta Rafael Esteban Antonio Craxi maria Buti Department of Medicine of the UAB Hospital Universitari Vall d’HebronBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos IIIMadrid 28029Spain Systemic Autoimmune Diseases Unit Internal Medicine DepartmentHospital Universitari Vall d'HebronBarcelona 08035Spain Sezione di Gastroenterologia Di.Bi.M.I.SUniversity of PalermoPalermo 90133Italy Pathology Department Hospital Universitari Vall d'HebronBarcelona 08035Spain

BACKGROUND There is an increased risk of atherosclerosis in patients with chronic hepatitis C or human immunodeficiency virus,but there is scarce data on hepatitis B virus *** hypothesis of this study is that hepatitis B virus infection increases the risk of carotid plaques and subclinical atherosclerosis in naïve hepatitis B e antigen(HBeAg)negative *** To assess the rate of carotid plaques and subclinical atherosclerosis in naïve HBeAg negative subjects in comparison with a cohort of healthy *** Prospective case-control collaborative study conducted in two tertiary *** hundred and two subjects prospectively recruited at the outpatient clinic were included from May 2016 to April 2017:201 naïve HBeAg-negative hepatitis B virus-infected[49 chronic hepatitis B(CHB)and 152 inactive carriers(ICs)]and 201 healthy *** and metabolic measures,liver stiffness and carotid Doppler ultrasound were *** atherosclerosis was established on an intima-media thickness increase of≥1.2 mm and/or the presence of carotid *** distributed quantitative variables were compared with the Student t test and those with a non-normal distribution with the Mann-Whitney U *** variables were compared between groups using theχ2 or Fisher exact *** Carotid plaques were found more often in CHB(32.7%)than ICs(17.1%)or controls(18.4%)(P=0.048).Subclinical atherosclerosis was also increased in CHB(40.8%)vsICs(19.1%)or controls(19.4%)(P=0.003).No differences in the risk of atherosclerosis were observed between controls and *** factors independently associated with the presence of carotid plaques were age[odds ratio(OR)1.43,P<0.001]and CHB(OR 1.18,P=0.004)and for subclinical atherosclerosis,age(OR 1.45,P<0.001),CHB(OR 1.23,P<0.001)and diabetes(OR 1.13,P=0.028).In the subset of young subjects(<50 years),carotid plaques(12.5%vs 1.1%,P=0.027)and subclinical atherosclerosis(12.5%vs 2.2%,P=0.058

关键词： Hepatitis B virus Carotid plaques Subclinical atherosclerosis Cardiovascular risk Endothelial dysfunction Intima-media thickness

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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

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Journal of Molecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró Mónica Durán Ana Rico Diana Bou-Teen Vanesa Fernández-Majada Anthony J.Croatt Karl A.Nath maria teresa salcedo Justin H.Gundelach Daniel Batlle Richard J.Bram Anna Meseguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biomimetic Systems for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Department of Medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent Medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de Bioquímica i Biologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDINREN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition(pEMT),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EMT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB emerges as an epithelial repressor,because CypB silencing promotes epithelial differentiation,prevents TGFβ-induced EMT,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout mice subjected to unilateral ureteral obstruction,inflammatory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-buffering chaperone related to Slug *** CypB silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on CypB modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and CypB in modulating TEC plasticity and identifies CypB as a druggable target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

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Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor——an update on neuroendocrine neoplasm’s treatment:A case report

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World Journal of Hepatology 2021年第5期13卷 611-619页

作者： Oriol Mirallas Nadia Saoudi Diego Gómez-Puerto Mar Riveiro-Barciela Xavier Merino Cristina Auger Stefania Landolfi Laia Blanco Amparo Garcia-Burillo Xavier Molero maria teresa salcedo-Allende Jaume Capdevila Medical Oncology Department Vall d'Hebron University HospitalVall Hebron Institute of OncologyBarcelona 08035CatalunyaSpain Liver Unit Department of Internal MedicineCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035CatalunyaSpain Radiodiagnostic Department Vall d’Hebron University HospitalBarcelona 08035CatalunyaSpain Pathology Department Vall d'Hebron University HospitalBarcelona 08035CatalunyaSpain Hepatobiliopancreatic Surgery and Transplantation Department Vall d'Hebron University HospitalBarcelona 08034CatalunyaSpain Nuclear Medicine Department Vall d'Hebron University HospitalBarcelona 08035CatalunyaSpain

BACKGROUND Metastatic small bowel low-grade neuroendocrine tumors(NETs)have a good *** is the only curative treatment;however,this may induce advanced liver disease,particularly in long-term survivor *** hepatocerebral degeneration or Parkinsonism in cirrhosis is characterized by rapidly progressive extrapyramidal symptoms in patients with advanced liver *** SUMMARY A 70-year-old man presented to the emergency department with diminished consciousness and disorientation,and was diagnosed with hepatic *** patient was diagnosed in 1993 with a metastatic small bowel NET,for which he twice underwent hepatic surgery,with metastatic resection in 1993 and a right hepatectomy in 2002 to remove two hepatic *** 2003,the patient started first-line chemotherapy and in 2004 started the first of three consecutive biological treatments,followed by radio-molecular therapy,achieving stable disease for 14 *** progression was identified and he underwent an endoscopic retrograde ***,in 2019 advanced liver disease was *** diagnosed the development of acquired hepatocerebral degeneration,an unusual long-term side effect after multiple hepatic *** The importance of regular and ongoing surveillance in long-term NET survivors who undergo hepatic procedures should be integrated into the therapeutic management plan,as some of these negative outcomes could be prevented.

关键词： Neuroendocrine tumors Hepatocerebral degeneration Parkinsonism Somatostatin analogues Everolimus Hepatic metastases Peptide radionuclide receptor therapy Encephalopathy Paramagnetic deposits Case report

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Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients

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World Journal of Hepatology 2012年第12期4卷 382-388页

作者： Víctor Vargas Helena Allende Albert Lecube maria teresa salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe Liver Unit Department of MedicineHospital Vall d’HebronUniversitat Autònoma08028 BarcelonaSpain CIBER de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos Ⅲ28029 MadridSpain Department of Pathology Hospital Vall d’HebronUniversitat Autònoma08035 BarcelonaSpain Endocrinology Service Hospital Vall d’HebronUniversitat Autònoma08035 BarcelonaSpain Diabetes Research Unit CIBER de Diabetes y Enfermedades Metabólicas AsociadasInstituto de Salud Carlos Ⅲ28029 MadridSpain Department of Surgery Hospital Arnau de VilanovaLleida25198 BarcelonaSpain Department of Surgery Mútua de Terrassa08221 BarcelonaSpain Biochemistry and Hormones Hospital Vall d’HebronUniversitat Autònoma08035 BarcelonaSpain Biochemistry and Molecular Biology Department Biology FacultyBarcelona University08028 BarcelonaSpain

AIM: To evaluate the effects of surgical weight loss (Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.

关键词： Non alcoholic fatty liver disease Bariatric surgery Obesity Non alcoholic steatohepatitis

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On the Range of Action of Adult Culex pipiens s.l.

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Journal of Biosciences and Medicines 2024年第3期12卷 113-121页

作者： maria da Conceição Proença maria teresa Rebelo Department of Physics and MARE-ULisboa Marine and Environmental Sciences Centre & ARNET Aquatic Research Infrastructure Network Associated Laboratory Faculty of Sciences University of Lisbon Lisbon Portugal Department of Animal Biology and CESAM_Ciências Centre for Environmental and Marine Studies Faculty of Sciences University of Lisbon Lisbon Portugal

Mosquitoes are an interesting topic due to their medical importance, as they play an active role in the transmission of many pathogens and parasites, acting as vectors for various pathologies that are deadly to humans, such as dengue, yellow fever, chikungunya, West Nile virus, encephalitis and malaria, among many others that are less common. In terms of morbidity and mortality caused by vector-borne diseases, mosquitoes are the most dangerous animals for humanity and, although they also play a role in the ecosystem as a food source for other organisms, their importance for public health cannot be overlooked. As highly efficient vectors, they put more than three billion people at risk, mainly in tropical and subtropical regions as well as in Europe, since heat waves and flooding are becoming more frequent and severe, and summers are getting longer and warmer, accelerating mosquito development, biting rates, and the incubation of the pathogens within their bodies. Female mosquitoes bite to acquire proteins for the development of their ovaries and eggs and, in the process, acquire pathogens and/or parasites from one vertebrate host and transmit them to another, usually after a short period of replication. Three of their four life stages are lived in still freshwater, so it is crucial to understand their range of action when they reach adulthood and leave the water, in order to plan and implement local prevention measures. A set of georeferenced abundance data collected in mainland Portugal over seven years was linked to cartographed water bodies in a geographic information system to estimate the distances at which Culex pipiens s.l. had a significant presence, with criteria based on the size of the catches. The result allows for an estimate of the fly range of those mosquitoes, which can be used to focus countermeasures.

关键词： Mosquito Fly Distance Vector-Borne Diseases Culex pipiens s.l. Geographic Information Systems

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元宇宙商业环境对年轻一代消费者奢侈品牌购买意向的探讨

元宇宙商业环境对年轻一代消费者奢侈品牌购买意向的探讨

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作者： maria teresa Fulgieri 华东师范大学

学位级别：硕士

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面向结构动力学测试的整体叶盘数字孪生技术

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航空动力学报 2024年

作者：周标谢诚语 Giuseppe Battiato teresa maria Berruti 都灵理工大学机械与航空工程学院南京航空航天大学能源与动力学院

针对几何失谐整体叶盘结构动力学特性评估问题，开展基于先进光学几何测量技术的高保真整体叶盘数字孪生建模、高性能结构动力学仿真分析和试验验证研究。首先，采用三维结构蓝光扫描系统测取叶片几何型面的高分辨率点云模型，将其直接... 详细信息

针对几何失谐整体叶盘结构动力学特性评估问题，开展基于先进光学几何测量技术的高保真整体叶盘数字孪生建模、高性能结构动力学仿真分析和试验验证研究。首先，采用三维结构蓝光扫描系统测取叶片几何型面的高分辨率点云模型，将其直接关联至谐调整体叶盘设计有限元模型，通过网格自适应变形技术实现高保真整体叶盘数字孪生模型的高效构建。其次，整体叶盘数字孪生高性能动力学仿真分析方法立足于大规模几何失谐整体叶盘模型的新型动力学减缩技术，其核心是利用各几何失谐单扇区结构的循环对称模态振型来构建数字孪生整盘模型的减缩模态基底，以减少计算内存和时长的消耗。试验结果表明，针对实体整体叶盘模拟件结构构建的高保真数字孪生模型既能有效地捕获叶片微小几何失谐对其“扇区”频率和振型的影响，也能较为准确地预测旋转整体叶盘在发动机阶次激励作用下的失谐振动响应特性。

关键词：整体叶盘几何测量模型减缩旋转测试数字孪生

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A Comparison of Airborne Formaldehyde Field Measurements Collected in an Anatomic Pathology Laboratory

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Journal of Environmental Protection 2024年第8期15卷 827-841页

作者： maria teresa Piccardo Massimo Cipolla Alberto Izzotti Paola Canepa Vincenzo Fontana Mutagenesis& Cancer Prevention Unit IRCCS Ospedale Policlinico San Martino Genova Italy Department of Experimental Medicine (DIMES) University of Genova Genova Italy Clinical Epidemiology Unit IRCCS Ospedale Policlinico San Martino Genova Italy

Environmental monitoring of airborne formaldehyde (FA) using sensitive methodologies is fundamental to prevent health risks. The objective of this study was to compare three different FA monitoring methods during the daily activities of an anatomic pathology laboratory. Daily eight-hour measurements deriving from Radiello® passive diffusive samplers (PDS), NEMo XT continuous optical sensor (COS), and multi-gas 1512 photoacoustic monitor (MPM) were simultaneously compared over a period of 14 working days. Given the different daily distributions of the measurements performed by the three devices, all measurements were time-aligned for comparison purposes. The 95% limit of agreement (LOA) method was applied to estimate the degree of concordance of each device with respect to the others. Formaldehyde arithmetic mean measured using PDS was 32.6 ± 10.4 ppb (range: 19.8 - 62.7). The simultaneous measures performed by COS and MPM were respectively 42.4 ± 44.8 ppb (range: 7.0 - 175.0) and 189.0 ± 163.7 ppb (range: 40.0 - 2895.4). The MPM geometric mean (171.3 ppb) was approximately five times higher than those derived from COS (32.3 ppb) and PDS (31.4 ppb). The results of the LOA method applied to log-transformed FA data showed the same systematic discrepancies between MPM and the other two devices. A good agreement between PDS and COS could lead to a tailored approach according to the individual specificity of these techniques. This tool may be useful for accurately assessing the risk of FA exposure among healthcare workers. However, the limited specificity of the MPM does not support its use as a monitoring method for FA in the workplace.

关键词： Occupational Exposure Occupational Health Formaldehyde Monitoring Devices Indoor Air Quality

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The plasticity of plasticity:lesson from remote microglia induced by focal central nervous system injury

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Neural Regeneration Research 2020年第1期15卷 57-58页

作者： maria teresa Viscomi Institute of Histology and Embriology Università Cattolica del S.Cuore

The last decades have represented an important season in the re-conceptualization of brain plasticity,especially in extending the concept at events occurring beyond the developmental stage and in demonstrating the profound impact of these changes on so-called spontaneous recovery after central nervous system(CNS)*** study of the cellular,molecular,functional and structural mechanisms involved in brain plasticity has clearly emphasized the multitude of players engaged in this phenomenon,leading to the conceptualization that non-neuronal cells and non-neuronal mechanisms intervene in these changes and orchestrate some of the responses observed(Werner and Stevens,2015).Among the different non-neuronal cells and non-neuronal substrates of injury-induced plasticity is becoming increasingly recognized that microglia drive a series of intrinsic CNS responses after damage(Sandvig et al.,2018;Bisicchia et al.,2019).

关键词： plasticity system injuries

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Estrogen/Huntingtin:a novel pathway involved in neuroprotection

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Neural Regeneration Research 2016年第3期11卷 402-403页

作者： maria teresa Nuzzo maria Marino Department of Science-Division of Biomedical Sciences and Technologies University Roma Tre

Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive *** pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or *** most cases,

关键词： programmed mitochondrial pathogenesis progressively aggregation oxidative abnormal neuronal caspase physiological

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