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Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

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Infectious Diseases of Poverty 2018年第1期7卷 448-459页

作者： Virginia Araujo Pereira Juan Camilo Sanchez-Arcila mariana Pinheiro Alves Vasconcelos Amanda Ribeiro Ferreira Lorene de Souza Videira Antonio Teva Daiana Perce-da-Silva maria teresa Queiroz Marques Luzia Helena de Carvalho Dalma maria Banic Luiz Cristovao Sobrino Porto Joseli Oliveira-Ferreira Laboratory of Immunoparasitology Oswaldo Cruz Institute/FiocruzAv.Brasil 4365ManguinhosRio de JaneiroBrazil Institute of Infectology Emilio Ribas São PauloSao PauloBrazil Laboratory of Immunodiagnosis Departament of Biological SciencesNational School of Public Health/FiocruzRio de JaneiroBrazil Laboratory of Clinical Immunology Oswaldo Cruz Institute/FiocruzRio de JaneiroBrazil Laboratory of Histocompatibility and Cryopreservation–HLA of DHE/IBRAG/UERJ Rio de JaneiroBrazil Molecular Biology and Malaria Immunology Research Group Centro de Pesquisas Rene Rachou/FiocruzBelo HorizonteMinas GeraisBrazil

Background:Brazil has seen a great decline in malaria and the country is moving towards ***,for eventual elimination,the control program needs efficient tools in order to monitor malaria exposure and *** this study,we aimed to evaluate whether seroprevalence to the circumsporozoite protein(CSP)is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian ***:Cross-sectional surveys were conducted in a rural area of Porto Velho,Rondônia *** infection was detected by microscopy and polymerase chain *** to the sporozoite CSP repeats of Plasmodium vivax,***,and ***(PvCS,PfCS,and PmCS)were detected using the enzyme-linked immunosorbent assay *** leukocyte antigen(HLA)-DRB1 and DQB1 genes were typed using Luminex®xMAP®***:The prevalence of immunoglobulin G against *** CSP peptide(62%)was higher than ***(49%)and ***(46%)CSP *** of the studied individuals had antibodies to at least one of the three peptides(72%),34%had antibodies to all three peptides and 28%were *** the majority of the population was not infected at the time of the survey,74.3%of parasite-negative individuals had antibodies to at least one of the ***,among individuals carrying the haplotypes DRB1*04~DQB1*03,there was a significantly higher frequency of PfCS responders,and DRB1*16~DQB1*03 haplotype for PvCS and PfCS *** contrast,HLA-DRB1*01 and HLA-DQB1*05 allelic groups were associated with a lack of antibodies to *** and *** CSP repeats,and the haplotype DRB1*01~DQB1*05 was also associated with non-responders,including non-responders to ***:Our results show that in low transmission settings,naturally acquired antibody responses against the CSP repeats of ***,***,and *** in a single cross-sectional study may n

关键词： Malaria Circumsporozoite protein Serological marker Human leucocyte antigen IgG antibody Porto Velho Rondônia Brazil

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Towards the Recovery of By-Product Metals from Mine Wastes:An X-Ray Absorption Spectroscopy Study on the Binding State of Rhenium in Debris from a Centennial Iberian Pyrite Belt Mine

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Journal of Minerals and Materials Characterization and Engineering 2014年第2期2卷 135-143页

作者： maria-Ondina Figueiredo teresa Pereira da Silva Joao Pedro Veiga Daniel de Oliveira maria Joao Batista CENIMAT/I3N Faculty of Sciences and TechnologyNew University of LisbonCampus da CaparicaLisbonPortugal Unit of Mineral Resources and Geophysics National Laboratory for Energy and GeologyAmadoraPortugal

Rhenium is a very scarce element, occurring in the Earth's crust mainly carried by molybdenite (MoS2). Due to a very low availability comparative to actual industrial demand, rhenium is nowadays one of the most expensive mineral commodities and an increased interest is focused on ex- ploring residues resulting from a long-term mining, particularly of sulphide ore deposits. It is therefore noteworthy to assign the presence of rhenium (in a concentration up to 3 ppm) in the waste materials from the old sulphur factory at the abandoned mine of Sao Domingos (Iberian Pyrite Belt, Southeast Portugal), exploited since the Roman occupation of Iberia. Aiming at a potential sustainable recovery of rhenium as a by-product, X-ray near-edge absorption spectroscopy (XANES) was applied to clarify the Re-binding and mode of occurrence by comparing Re L3-edge XANES spectra obtained from mine waste samples (previously fully characterized by X-ray laboratory techniques) with similar spectra collected from Re-rich molybdenites (Mo1-xRexS2) and from Re-O model compounds configuring various valences and coordination environments of rhenium ions. Obtained results are commented, ruling out a possible Re-S binding and rather conforming with the binding of rhenium to oxygen in the analysed mine waste materials.

关键词： Mine Waste Materials By-Products Iberian Pyrite Belt Rhenium XANES Re L_(3)-Edge

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Present and future of metastatic colorectal cancer treatment: A review of new candidate targets

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World Journal of Gastroenterology 2017年第26期23卷 4675-4688页

作者： Giulia Martini teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli Department of Internal and Experimental Medicine“F.Magrassi e A.Lanzara” Institute of Medical OncologyUniversitàdegli studi della Campania Luigi Vanvitelli Department of Internal and Experimental Medicine Magrassi-LanzaraInstitute of RadiologyUniversitàdegli studi della Campania Luigi Vanvitelli Gastroenterology Unit Ospedale Umberto I Unit of Colorectal Surgery Department of MedicalSurgicalNeurologicalMetabolic and Ageing SciencesUniversità degli studi della Campania Luigi Vanvitelli

In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon.

关键词： Novel biomarkers Monoclonal antibodies Resistance Mutation RAS Target therapy Metastatic colorectal cancer

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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

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Journal of Molecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró Mónica Durán Ana Rico Diana Bou-Teen Vanesa Fernández-Majada Anthony J.Croatt Karl A.Nath maria teresa Salcedo Justin H.Gundelach Daniel Batlle Richard J.Bram Anna Meseguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biomimetic Systems for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Department of Medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent Medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de Bioquímica i Biologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDINREN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition(pEMT),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EMT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB emerges as an epithelial repressor,because CypB silencing promotes epithelial differentiation,prevents TGFβ-induced EMT,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout mice subjected to unilateral ureteral obstruction,inflammatory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-buffering chaperone related to Slug *** CypB silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on CypB modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and CypB in modulating TEC plasticity and identifies CypB as a druggable target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

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Oxfendazole as successful treatment of Taenia hydatigena metacestodes in naturally infected pigs

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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 971-973页

作者： Luis Antonio Gomez-Puerta Armando Emiliano Gonzalez Cesar Gavidia Viterbo Ayvar Hector Hugo Garcia maria teresa Lopez-Urbina for the Cysticercosis Working Group in Peru School of Veterinary Medicine National University of San Marcos Cysticercosis Elimination Program and Center for Global Health Tumbes Cayetano Heredia University Department of Microbiology School of SciencesCayetano Heredia University

The efficacy of oxfendazole(OFZ) on Taenia hydatigena metacestodes, also called Cysticercus tenuicollis(C. tenuicollis), was studied in 648 raising pigs. This study was performed in Tumbes Department in Peru, an endemic area for cysticercosis. Pigs were randomized in two groups; untreated group(n = 142) did not receive any treatment and treated group(n = 506) received OFZ treatment at a single dose of 30 mg/kg body *** months after treatment, the pigs were necropsied. The prevalence of infection by C. tenuicollis among the pigs was 27.5%(39/142) and 2.0%(10/506) in untreated and treated groups, respectively. Untreated group was infested only with viable cysts, whereas treated group had no viable cysts. All the cysts found in treated group presented degeneration, with a thick membrane, and they contained milky fluid and fibrous tissue. A single dose of OFZ was effective against C. tenuicollis, thus providing an alternative drug for controlling this parasite in pigs.

关键词： Taenia hydatigena Cysticercus tenuicollis Oxfendaz

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Meiotic behavior and pollinic viability in bean cultivars

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BIOCELL 2014年第1期38卷 33-38页

作者： Gracieli DALLA NORA Solange Bosio TEDESCO Tamara PASTORI Viviane Dal-Souto FRESCURA Nerinéia Dalfollo RIBEIRO Haywood Dail LAUGHINGHOUSE IV Sidinei JoséLOPES maria teresa SCHIFINO-WITTMANN Laboratory of Cytogenetics and Plant Genotoxicity Department of BiologyCenter for Natural and Exact SciencesFederal University of Santa Maria(UFSM)Rio Grande do SulBrazil

The aims of this study were to determine the meiotic behavior and to estimate pollen grains via-bility in bean(Phaseolus vulgaris L.)*** buds were collected during different developmental stages of the Mesoamerican bean cultivars IAPAR 44,Guapo Brilhante,BRS Expedito,BRS Valente,Guateian 6662 and Pérola,and the Andean bean cultivar Iraí,grown in a *** meiotic index was determined by anther squashing of material fixed in absolute ethanol-glacial acetic acid(3:1)and stained with acetic *** meiotic abnormalities were observed and the meiotic indices were high for all cultivars,indicating that the mismatch generated during crosses is not related to any meiotic *** of pollen viability was made by comparing acetic orcein staining ***’s reactive:pollen viability was high in all cultivars with either stain,but was significantly higher when using the acetic orcein stain(>99%).Though some cultivar showed a significantly smaller pollen size,the range of variation among cultivars was low(means’range 51-66μm).

关键词： Acetic orcein Phaseolus vulgaris pollen Alexander’s reactive

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Modeling and Numerical Simulation of Ammonia Synthesis Reactors Using Compositional Approach

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Advances in Chemical Engineering and Science 2018年第3期8卷 124-143页

作者： Diogo Silva Sanches Jorqueira Antonio Marinho Barbosa Neto maria teresa Moreira Rodrigues Department of Chemical Systems Engineering Campinas University Campinas Brazil Simworx Engineering Research & Development Campinas Brazil

Ammonia synthesis reactors operate in conditions of high pressure and high temperature. Consequently, the flow inside these reactors always presents interaction between components in the feed mixture. A modeling accounts these interactions with pressure, temperature and the molar fraction is essential to converter simulation more realistic. The compositional approach based on cubic equations of state provides the influences of the component of a gas mixture using mixing rules and binary interaction parameters. This multicomponent description makes the model more robust and reliable for properties mixture prediction. In this work, two models of ammonia synthesis reactors were simulated: adiabatic and autothermal. The fitted expression of Singh and Saraf was used. The adiabatic reactor model presented a maximum relative error of 1.6% in temperature and 11.4% in conversion while the autothermal reactor model presents a maximum error of 2.7% in temperature, when compared to plant data. Furthermore, a sensitivity analysis in input variables of both converter models was performed to predict operational limits and performance of the Models for Ammonia Reactor Simulation (MARS).

关键词： Cubic Equation of State Adiabatic Converter Autothermal Converter Temkin-Pyzhev Expression

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Laboratory markers in ulcerative colitis: Current insights and future advances

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World Journal of Gastrointestinal Pathophysiology 2015年第1期6卷 13-22页

作者： Michele Cioffi Antonella De Rosa Rosalba Serao Ilaria Picone maria teresa Vietri Department of Biochemistry Biophysics and General PathologySecond Medical School Naples

Ulcerative colitis(UC)and Crohn’s disease(CD)are the major forms of inflammatory bowel diseases(IBD)in *** some common features,these forms can be distinguished by different genetic predisposition,risk factors and clinical,endoscopic and histological *** aetiology of both CD and UC remains unknown,but several evidences suggest that CD and perhaps UC are due to an excessive immuneresponse directed against normal constituents of the intestinal bacterial *** sometimes invasive are routine for the diagnosis and care of patients with *** of UC is based on clinical symptoms combined with radiological and endoscopic *** employment of non-invasive biomarkers is *** biomarkers have the potential to avoid invasive diagnostic tests that may result in discomfort and potential *** ability to determine the type,severity,prognosis and response to therapy of UC,using biomarkers has long been a goal of clinical *** describe the biomarkers assessed in UC,with special reference to acute-phase proteins and serologic markers and thereafter,we describe the new biological markers and the biological markers could be developed in the future:(1)serum markers of acute phase response:The laboratory tests most used to measure the acute-phase proteins in clinical practice are the serum concentration of C-reactive protein and the erythrocyte sedimentation *** biomarkers of inflammation in UC include platelet count,leukocyte count,and serum albumin and serum orosomucoid concentrations;(2)serologic markers/antibodies:In the last decades serological and immunologic biomarkers have been studied extensively in immunology and have been used in clinical practice to detect specific *** UC,the presence of these antibodies can aid as surrogate markers for the aberrant host immune response;and(3)future biomarkers:The development of biomarkers in UC will be very important in the *** progress of

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn’s disease Serologic markers Acute phase response

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Social Accounting Matrix on the Base of the Mexican System of National Accounting

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Economics World 2016年第3期4卷 111-127页

作者： Dora Elena Ledesma-Carrion Lidia Hernandez-Hernandez maria teresa Leonor Mucino-Porras Instituto Nacional de Estadistica y Geografia Ciudad de Mexico Mexico

Links between institutional sectors and economic activities with National Accounting System of Mexico are studied used accounting multipliers. Key sectors had changed to strategic or leading as oil and gas extraction and dairy product manufacturing, i.e., Mexico went from a producer of goods to a service provider country, losing value added in their production chains. The mixed income is leading/independent economic activity for woman whose income is between 1 and 5 minimum wages. This is really important in the domestic economy through its impact on solidarity activities： providing care and support and providing food. Moreover, non-financial corporations and households of 10 or more minimum wages for income investing in strategic sectors such as retail trade and wholesale and manufacturing products derived from oil and coal. This is evidence of two Mexicos： the traditional and industrialized.

关键词： social accounting matrix national accounting linkages accounting multipliers input-output tableau

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The cross-talk between family and pediatrician: The case of bronchial asthma

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Health 2013年第2期5卷 307-312页

作者： Salvatore Leonardi Rossella Pecoraro maria teresa Garozzo Alfina Coco Mario La Rosa Department of Pediatrics Bronchopneumoallergology and Cystic Fibrosis Unit University of Catania Catania Italy

Today the most important challenge facing the pediatrician is the increasing prevalence of chronic diseases. With this regard, pediatricians play a key role in the management of these conditions. The closeness with the family, the knowledge of the clinical case and the care continuity allow the pediatrician to acquire a position of director of every case. When pathological events have a chronic feature, suddenly the quality of life of the whole family changes. For this reason the first communication of chronic disease is very important and the task of the pediatrician should be to provide a positive message to help the family in facing the difficulty of this new challenge. The bronchial asthma is the most common chronic disease worldwide. The incidence, the prevalence, and the mortality of the disease have increased in children over the past decades. These trends are particularly marked above all in preschool children. The success reached by Pediatricians is closely related to the compliance and the implementation of the therapy followed by the little patient and his family. With this regard authors, in this review, focus on the illustration of several strategies, based on the pediatrician’ skills and medicine documents, that can be used for the improvement of communication among pedia- trician-family and child, never forgetting the hu- man aspect of the same doctor, that should con- ciliate with the scientific knowledge in the taking care of a specific chronic disease.

关键词： Cross-Talk Bronchial Asthma Children

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