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Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient

World Journal of Gastroenterology 2015年第36期21卷 10475-10479页

作者： maria salvado Victor Vargas Marta Vidal Macarena Simon-Talero Jessica Camacho Josep Gamez ALS Unit Neurology DepartmentHospital Universitari Vall d'HebronVall d'Hebron Research InstituteAutonomous University of Barcelona Liver Unit Department of MedicineHospital Universitari Vall d'HebronVall d'Hebron Research InstituteAutonomous University of BarcelonaBarcelona. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Instituto de Salud Carlos IIIMadridSpain Pathology Department Hospital Universitari Vall d’HebronVall d’HebronAutonomous University of Barcelona

We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib,a tyrosine kinase inhibitor,is usually transient with mild elevation of transaminases,although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication.

关键词： Drug-induced liver injury Masitinib Amyotrophic la

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Standardization of BIM Objects: Development of a Proposal for Portugal

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Open Journal of Civil Engineering 2016年第3期6卷 469-474页

作者： Filipa salvado maria João Falcão Silva Paula Couto Álvaro Vale e Azevedo Buildings Department LNEC Lisbon Portugal

The management of information systems contributes to the economic development of the construction sector by organizing and structuring technical and economic information. It is proposed how BIM (Building Information Modelling) and a Portuguese information system-ProNIC (abbreviation for Protocol for the Standardization of Construction Technical Information) may be interconnected. The scope of this information transmission in construction sector is a step to solve several problems that have been identified in conception of BIM models.

关键词： BIM Objects Standardization Technical Information ProNIC

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Roadmap Proposal for Implementing Building Information Modelling (BIM) in Portugal

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Open Journal of Civil Engineering 2016年第3期6卷 475-481页

作者： maria João Falcão Silva Filipa salvado Paula Couto Álvaro Vale e Azevedo Buildings Department LNEC Lisboa Portugal

Building Information Modeling (BIM) is a process involving generation and management of digital representations of physical and functional characteristics of places, which can be exchanged or networked to support decision-making in architecture, engineering and construction (AEC) sector. BIM is a relatively new technology in an industry typically slow to adopt changes, especially in Portugal. The present paper aims to frame the international implementation of BIM in order to propose a roadmap to spread the use of BIM methodologies in Portugal in the next decade.

关键词： BIM Roadmap International Implementation Strategies and Actions

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