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Evaluation of the toxic effect of insecticide chlorantraniliprole on the silkworm Bombyx mori(Lepidoptera:Bombycidae)

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Open Journal of Animal Sciences 2013年第4期3卷 343-353页

作者： Roxelle Ethienne Ferreira Munhoz Thais Souto Bignotto Naiara Climas Pereira Claudia regina das Neves Saez Rafaela Bespalhuk Veronica Aureliana Fassina Graziele Milani Pessini Mayarha Patricia dequigiovanni Baggio Lucineia de Fatima Chasko Ribeiro Rose Meire Costa Brancalhao Shunsuke Mizuno Willian Shigeaki Aita maria Aparecida Fernandez departamento de Biotecnologia Genetica e Biologia CelularUniversidade Estadual de MaringaMaringaBrasil Universidade Estadual do Oeste do Parana CascavelBrasil Fiacao de Seda Bratac S.A.Bastos Sao PauloBrasil

The silkworm Bombyx mori feeds exclusively on mulberry leaves and is highly sensitive to pesticides in general. Although mulberry plantations are free of agrochemicals, pesticide drift can occur. Chlorantraniliprole, a novel insecticide of the anthranilic diamides class, has been used to control pests in field crops. In this study, we investigated the biological effects of different concentrations of chlorantraniliprole on B. mori silkworm commercial Brazilian hybrids. To evaluate the toxicity of chlorantraniliprole, bioassays were carried out and data on the lethal concentrations, symptomatology, morphology and variables of silk production were collected. Results indicated that B. mori is extremely sensitive to chlorantraniliprole, even in low concentrations. The highest silkworm mortality rates were observed in the two highest chlorantraniliprole concentrations, 0.2 and 0.1 ppm. Although lower chlorantraniliprole concentrations did not cause death of all the silkworm larvae, various symptoms of toxicity were observed: feeding cessation, regurgitation, late development and incomplete ecdysis. Such symptoms reflect the morphological changes we observed in the midgut epithelium, which affected nutrient uptake and metabolism, and even the production of cocoons. Exposed larvae also produced?thin-shelled cocoons, which constitutes a serious economic problem because this type of cocoon is not useful for the silk industry. The results provided herein confirm the toxicity of chlorantraniliprole in silkworm larvae. Therefore, we strongly suggest that, competent authorities of the National Health Surveillance Agency, in pesticide management should take measures to reduce or eliminate the use of chlorantraniliprole in areas nearest to silkworm cultivation.

关键词： Silkworm Pesticide Drift Mortality Symptomatology Chlorantraniliprole

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Central and peripheral neurological involvement in monoclonal gammopathies of undetermined significance

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World Journal of Neuroscience 2013年第4期3卷 282-286页

作者： Edvina Galiè maria Luisa dell’ Acqua Marta Maschio Tatiana Koudriavtseva Emidio de Marco Bruno Jandolo Division of Neurology Nuovo Ospedale Civile Sant’Agostino Estens Modena Italy Division of Neurology Regina Elena National CancerInstitute Roma Italy Division of Radiology Libera Università Campus Biomedico Roma Italy

Several studies have suggested a pathogenetic role of paraproteinaemias in PNS damage. Over the few last years, the presence of symptomatic or subclinical PNS lesions in CNS diseases like multiple sclerosis has been described. On the other hand, CNS demyelinating lesions and cervical atrophy have been re- ported in patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Very few cases of MGUS associated with CNS disease alone or with both CNS and PNS disease have been re- ported. Since 1999, we have been studying 16 patients (8 M, 8 F), with a mean age 60.2 ± 13.4, affected by MGUS associated with symptomatic neurological central and/or peripheral diseases. Patients affected with lymphomas, lupus erithematosus and other immunological diseases were excluded. Involvement of both PNS and CNS was not associated to a particular type of paraproteinemia: monoclonal IgM were found in 8 patients;monoclonal IgG in 6 patients and mono- clonal IgA in 1 patient and Igl in 1 patient. High anti- nervous system autoantibodies were found in 10/16 patients and antiMAG antibodies were detected in patients with paraproteinemic demyelinating neuropathy (PDN). High reactivity anti-nervous system might support the hypothesis of a pathogenetic role of MGUS in these neurological diseases. Nevertheless, at present, we cannot exclude that there is only a circumstantial association between MGUS and neurological damages, particularly concerning CNS.

关键词： Multiple Sclerosis (MS) Monoclonal Gammopathies of Undetermined Significance (MGUS) Peripheral Nervous System (PNS) Involvement Nervous System (CNS) Involvement Central

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Risk of Upper Extremity Biomechanical Overload in Automotive Facility

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Biomedical and Environmental Sciences 2013年第1期26卷 70-75页

作者： Angela SANCINI Assunta CAPOZZELLA Tiziana CACIAR Francesco TOMEI Nadia NARDONE Barbara SCALA maria FIASCHETTI Carlotta CETICA Lara SCIMITTO PierAgostino GIOFFRè Federica SINIBALDI Claudia Di PASTENA Paola CORBOSIERO maria Pia SCHIFANO Gianfranco TOMEI Manuela CIARROCCA University of Rome "Sapienza" Department of AnatomyHistologyMedical-Legal and OrthopedicsUnit of Occupational MedicineViale Regina Elena 33600161 RomeItaly University of Rome "Sapienza" Department of Psychiatric and Psychological SciencePiazzale Aldo Moro 500185 RomeItaly

Objective To assess the risk factors for upper extremity-work-related musculoskeletal disorders（UE-WMSD） on 13 prod ucti on lines in an airbag factory using the threshold limit values-American conference of industrial hygienists-hand activity level（TLV-ACGIH-HAL） method and introduce the ergonomic improvement to reduce the repe titi veness and the peak force（Pf）.Methods Professional exposure level on 13 production lines in a automobile factory was measured using the TLV-ACGIH-HAL method and a further risk was assessed according to the ergonomic *** The first assessment of 9 produc tion lines showed that the professional exposure level was above the TLV or HAL *** second assessment showed that the professional exposure level was below the AL limit on all production lines except 1,in which the professional exposure level was between TLV and *** The assessment of UE-WMSD-related risk can ide ntif y the riskiest emplacements and evaluate the reduc tion of risk in professional exposure through interventi ons of structuralorganizati onal type.

关键词： Repe titi ve acti vity Work-related musculoskeletal disorders Assessment of work-related risk Threshold limit values-American conference of industrial hygienists Hand activity level.

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A “Self Experience” From the Gamified Literary Cards of Shakespeare’s Work: A Midsummer Night’s Dream

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Sino-US English Teaching 2020年第3期17卷 81-87页

作者： Leny Andre Pimenta maria regina Momesso The College of Letters and Sciences São Paulo State University(UNESP)AraraquaraBrazil

Based on the gamified Literary Cards of the Shakespearean work A Midsummer Night’s Dream,we intend to observe,analyze,and verify in what ways the practices of reading and rewriting create effects of meaning,providing the subject reader/player to live an“experience of oneself”,being led to observe oneself,analyzing oneself,deciphering oneself,recognizing oneself as a domain of your own truth and,in this regard,your subjectivity can build your understanding of what sexuality is or highlight the repression of misunderstood *** reflection is based on Discourse Analysis of the French“line”,Foucaultian Studies and Freud-Lacanian Psychoanalysis,in which the postulates are about the historical determination of the processes of signification,considering that the senses are constructed in a singular *** is understood that the gamification,used in Literary Cards,comprises an educational technology aimed not only at the apprehension of a dynamic and interpretive reading practice of oneself,but also as a facilitating resource for teachers to promote formal sexual education from elementary school on.

关键词： literary cards gamification experience of self sexuality

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New Technique to Produce Large Amount of Flat Silk by Biospinning

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Agricultural Sciences 2014年第14期5卷 1483-1490页

作者： Laura Beatriz Garay Andrea Nembri Alana Lucia Oro Veronica Aureliana Fassina Claudia regina das Neves Saez Alex Sandro Chiarello Naiara Climas Pereira Graziele Milani Pessini Roxelle Ethienne Ferreira Munhoz maria Aparecida Fernandez Seda y Fibras S.R.L HernandariasParaguay departamento de Biotecnologia Genetica e Biologia CelularUniversidade Estadual de MaringaMaringaBrasil

Beyond the production of silk thread, there are several studies showing that the silk is a great biomaterial for surgical sutures and grafts. This paper shows a new technique to produce silk thread changing the natural cycle of silk production, which is the production of cocoons. This new method has the purpose of producing a silk fabric free of impurities, through flat surfaces. Six different surfaces were tested: Glass, Formica Surface, Steel and Zinc Sheets, Cotton tissue and Burlap Bag. The first five surfaces had not presented enough larvae alive for statistical analysis, because there were several damages in silkworms larvae that resulted in mortality and low silk production. On the other hand, the burlap bag surface presented good results for web construction by biospinning and its use was indicated for silk industry focused on biomaterials. The present study suggested the potential of naturally biospun web, using Bombyx mori, to develop a new technique to produce silk thread matrices that will have several applications at the industry and production of biomedical materials.

关键词： Silkworm Bombyx mori L. Silk Thread Biomaterial

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Temporal trends in areas at risk for concomitant tuberculosis in a hyperendemic municipality in the Amazon region of Brazil

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Infectious Diseases of Poverty 2020年第4期9卷 162-162页

作者： Alexandre Tadashi Inomata Bruce Thais Zamboni Berra Felipe Lima dos Santos Yan Mathias Alves Ludmilla Leidianne Limirio Souza Antônio Carlos Vieira Ramos Luiz Henrique Arroyo Juliane de Almeida Crispim Ione Carvalho Pinto Pedro Fredemir Palha Aline Aparecida Monroe Mellina Yamamura regina Célia Fiorati Ana Carolina Scarpel Moncaio Dulce maria de Oliveira Gomes Ricardo Alexandre Arcêncio department of Maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of NursingRibeirão PretoSão PauloBrazil department of Nursing Federal University of São CarlosSão CarlosSão PauloBrazil department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School of the University of São PauloRibeirão PretoSão PauloBrazil department of Nursing Federal University of CatalãoCatalãoGoiásBrazil Mathematics department University ofÉvoraÉvoraPortugal

Background Although preventable and curable,tuberculosis(TB)still occurs in poor or developing countries,mainly in metropolitan regions of larger *** disease is a serious public health problem,and is directly linked to social *** analyzed temporal trend variations in areas at risk for concomitant TB,and characterized the clinical and epidemiological profiles of cases in a hyperendemic municipality in the Amazon region of *** This ecological study was performed in the municipality of Manaus,in northern *** population comprised cases with concomitant pulmonary and extrapulmonary TB,registered on the Notifiable Diseases Information System(SINAN),between January 1,2009 and december 31,*** risk cluster detection,spatial and spatiotemporal scanning statistical techniques were *** Spatial Variation in Temporal Trends(SVTT)approach was used to detect and infer clusters for significantly different time *** Between 2009 and 2018,873 concomitant TB cases were registered in *** using purely spatial scanning statistics,we identified two risk *** relative risk(RR)of the clusters was 2.21(95%confidence interval[CI]:1.57–2.88;P=0.0031)and 2.03(95%CI:1.58–2.58;P=0.0029).Using space-time scanning,we identified a risk cluster with an RR of 3.57(95%CI:2.84–4.41;P=0.014),between 2017 and *** SVTT analyses,three clusters with spatial variations were detected in the significant temporal trends:SVTT 1(P=0.042),SVTT 2(P=0.046)and SVTT 3(P=0.036).Conclusions In Brazil,several TB-determining factors such as race/color,gender,low educational level and low income overlap in needy urban areas and communities,demonstrating that it is unlikely to reach the goals,agreed and launched with the END TB Strategy within the deadlines of international agreements,if there is no reduction in existing inequities determinants and risk of illness in the country.

关键词： Tuberculosis Public health Epidemiology Spatial analysis Spatio-temporal analysis

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根管内增强纤维在儿科的应用：病例报告

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中国口腔医学继续教育杂志 2005年第3期8卷 56-58页

作者： Rachel de Oliveira Rocha Lucimara Teixeira das Neves Noely regina Marotti Marcia Turolla Wanderley maria Salete Nahás Pires Corre^a 吴南(译) 赵玉鸣(校) 不详北京大学口腔医学院北京海淀区中关村南大街22号100081

本文介绍了一种使用间接树脂冠和根管内增强纤维来修复龋坏的上颌乳切牙的方法。每颗牙齿都先进行了根管治疗。使用根管内增强纤维的优点包括：树脂冠强度增加，透明，相对操作简便。另外，使用间接树脂冠能够获得很好的外形和美观，同... 详细信息

本文介绍了一种使用间接树脂冠和根管内增强纤维来修复龋坏的上颌乳切牙的方法。每颗牙齿都先进行了根管治疗。使用根管内增强纤维的优点包括：树脂冠强度增加，透明，相对操作简便。另外，使用间接树脂冠能够获得很好的外形和美观，同时能够减少儿童的椅旁时间。间接树脂冠和根管内增强纤维在一名3岁女孩的使用以图示说明这一技术。

关键词：根管增强纤维儿科上颌乳切牙牙齿

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Low Genetic Polymorphism at the Cytochrome C Oxidase I in Silkworm Strains of the Brazilian Germplasm Bank

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Open Journal of Genetics 2014年第3期4卷 202-209页

作者： Veronica Aureliana Fassina Thais Souto Bignotto Roxelle Ethienne Ferreira Munhoz Bruno Fulan Juliana Pereira Bravo Laura B.Garay Rafaela Bespalhuk Claudia regina das Neves Saez Naiara Climas Pereira Graziele Milani Pessini maria Aparecida Fernandez departamento de Biotecnologia Genetica e Biologia CelularUniversidade Estadual de MaringaUEMParanaBrasil Seda y Fibras S.R.L. HernandariasParaguay

Nucleotide sequences have been used to distinguish species and specimens for many years. More recently, the use of a partial sequence of 650 bp of the cytochrome c oxidase I, COI mitochondrial gene, has been proposed for species identification, known as DNA barcodes. In this work, a short sequence of the DNA barcode is described—approximately 250 bp, named as “DNA mini-barcode”—to molecularly identify different silkworm strains maintained at the unique public Germplasm Bank of Bombyx mori, at the Universidade Estadual de Maringá, UEM, Brazil. Analysis revealed no significant differences among the silkworm strains. The phylogenetic tree obtained by the neighbor-joining method and K2P distance, in which specimens of B. mandarina were used as outgroup, clustered all the specimens of B. mori in a unique clade. Genetic variability detect within B. mori was low or nonexistent. In conclusion, the partial region of 250 bp of the mitochondrial gene COI herein analyzed may not be efficient to discriminate silkworm strains from the UEM Germplasm Bank of Bombyx mori.

关键词： Bombyx mori Mitochondrial Gene COI DNA Mini-Barcode

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HAND ACUPUNCTURE IN THE TREATMENT OF RHINITIS

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Journal of Integrative Medicine 2014年第3期 303-303页

作者： reginaldo Silva Filho maria regina Carneiro Eduardo Vicene Jofre

Objective: The aim of this study was to evaluate the effect of post-application of the technique of Koryo Sooji Chim Acupuncture in the treatment of stubborn runny ***: Research subjects were 16 volunteers, of both sexes, aged between 18 and 80 years, treated in a private acupuncture clinic, suffering from runny nose stubborn, with periods of exacerbations at least the past 12 *** used a leaflet about the technique of Koryo Sooji Chim Acupuncture, and get formal consent to *** the research work, evaluation questionnaire that included questions about the perception of people by the presence(in the last 12 months) of coryza stubborn checking the quality of life before treatment and post treatment was *** questionnaire was conducted weekly on acupuncture and analog scale was *** subjects were randomly assigned into two different groups, treatment group which consisted of KSC acupoints A32, A28 and C9, while the control group consisted of points H2, G6 and ***: The results with respect to stubborn runny nose were statistically *** improvement of the treatment group was 87.5%, which was much higher than the control ***: We conclude that the three-acupoint combination used in the Koryo Sooji Chim Acupuncture is a very effective method in treating this *** can alleviate symptoms and even eliminate the stubborn runny nose(at the time of observation), thus improve the quality of life of the patients affected by this disease.

关键词： HAND ACUPUNCTURE IN THE TREATMENT OF RHINITIS

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Bacteroides fragilis Supernatant Extracts Enriched in Phenylacetic Acid Induce a Cytotoxic Effect in Mammalian Cells

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Advances in Microbiology 2015年第10期5卷 730-736页

作者： Laís S.Falcao Eduardo N.F.Antunes Eliane O.Ferreira Heidi Pauer maria Teresa V.Romanos Rossiane C.Vommaro Sérgio H.Seabra Daniela S.Alviano Celuta S.Alviano Antonio Jorge R.da Silva Leandro A.Lobo regina maria C.P.Domingues departamento de Ciências Básicas Pólo Universitário de Nova FriburgoUniversidade Federal FluminenseNova FriburgoBrasil Instituto de Microbiologia Prof.Paulo de Góes Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Centro Universitário Estadual da Zona Oeste—UEZO Rio de JaneiroBrasil Instituto de Pesquisa Produtos Naturais Universidade Federal do Rio de JaneiroRio de JaneiroBrasil

Bacteroides species are nearly half of the fecal flora community and some are host symbionts crucial to host nutrition and systemic immunity. Among Bacteroides species B. fragilis strains are considered to be the opportunistic ones, being the most isolated anaerobic bacteria in clinical samples. Cell-free supernatants of 65 B. fragilis strains were assayed and they were capable of inducing vacuolating phenotype on Vero cells lineage. The supernatant of the Bacteroides fragilis ATCC 23745 strain was elicited to have the strongest vacuolating effect on Vero cells monolayers and peritoneal macrophages. Some drastic cell alterations were observed, such as a general disorganization of cytoplasm and chromatin condensation, evidencing cell death. By transmission electron microscopy it was confirmed that the vacuoles observed were, in fact, swollen mitochondria. An immunocytochemical assay, TUNEL, was used to confirm this hypothesis and showed that Vero cells and peritoneal macrophages were dying by apoptotic process after exposition of B. fragilis cell-free supernatant. Physical analysis of the apoptotic factor has revealed properties similar to short-chain fatty acids. After gas chromatography and mass spectrometry analysis, phenylacetic acid (PA) was characterized as the major compound present in the most purified active fraction. We believe that the PA is responsible for the pro-apoptotic effect elicited by the supernatant of B. fragilis cultures.

关键词： Bacteroides fragilis Vacuolization Apoptosis Vero cells Lineage Peritoneal Macrophages Phenylacetic Acid

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