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Clinicopathological description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

Importance of complementary data to histopathological image analysis of oral leukoplakia and carcinoma using deep neural networks

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Intelligent Medicine 2023年第4期3卷 258-266页

作者： Leandro Muniz de Lima maria Clara Falcão Ribeiro de Assis Júlia Pessini Soares Tânia regina Grão-Velloso Liliana Aparecida Pimenta de Barros Danielle Resende Camisasca Renato Antonio Krohling Nature-inspired Computing Lab Federal University of Espirito SantoVitoriaBrazil Graduate Program in Computer Science Federal University of Espirito SantoVitoriaBrazil School of dentistry Departamento de Clinica OdontologicaFederal University of Espirito SantoVitoriaBrazil Graduate Program in Clinical dentistry Federal University of Espirito SantoVitoriaBrazil

Background Oral cancer is one of the most common types of cancer in men causing mortality if not *** recent years,computer-aided diagnosis(CAD)using artificial intelligence techniques,in particular,deepneural networks have been investigated and several approaches have been proposed to deal with the automateddetection of various pathologies using digital *** studies indicate that the fusion of images with thepatient’s clinical information is important for the final clinical *** such dataset does not yet exist fororal cancer,as far as the authors are aware,a new dataset was collected consisting of histopathological images,demographic and clinical *** study evaluated the importance of complementary data to histopathologicalimage analysis of oral leukoplakia and carcinoma for *** A new dataset(NDB-UFES)was collected from 2011 to 2021 consisting of histopathological imagesand *** 237 samples were curated and analyzed by oral pathologists generating the gold standardfor ***-of-the-art image fusion architectures and complementary data(Concatenation,MutualAttention,MetaBlock and MetaNet)using the latest deep learning backbones were investigated for 4 distincttasks to identify oral squamous cell carcinoma,leukoplakia with dysplasia and leukoplakia without *** evaluate them using balanced accuracy,precision,recall and area under the ROC curve *** Experimental results indicate that the best models present balanced accuracy of 83.24%using images,demographic and clinical information with MetaBlock fusion and ResNetV2 *** represents an improvement in performance of 30.68%(19.54 pp)in the task to differentiate samples diagnosed with oral squamous cellcarcinoma and leukoplakia with or without *** This study indicates that cured demographic and clinical data may positively influence the performance of artificial intelligence models in automated classification of

关键词： Leukoplakia Squamous carcinoma Pathology deep learning Transfer learning

Implementation of a High-Risk Outpatient Clinic for Children with Complex Congenital Heart Disease in a Reference Service in Brazil

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Congenital Heart Disease 2023年第6期18卷 649-656页

作者： Gustavo Foronda Vanessa Ferreira Amorim de Melo Claudia regina Pinheiro de Castro Grau Ingrid Magatti Piva Glaucia maria Penha Tavares Ana Cristina Sayuri Tanaka Nana Miura department of Pediatric Cardiology and Adult Congenital Heart Diseases Heart Institute of the University of São PauloSão PauloBrazil Foronda Clinic São PauloBrazil Institute of Orthopedics and Traumatology University of São PauloSão PauloBrazil department of Echocardiography Heart Institute of the University of São PauloSão PauloBrazil

Background:Children with congenital heart disease(CHD),even after surgical approaches,and especially those who undergo staged procedures in theﬁrst months of life,remain vulnerable to readmissions and complications,requiring very close monitoring and differentiated intervention ***:descriptive and exploratory study,of the experience report type,which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases(AAR)at the Instituto do Coração(InCor).Results:Report of the path taken to structure the AAR,demonstrating the organization,interface with the multidisciplinary team,admission and discharge criteria,training,and patient proﬁ*** theseﬁve years of care,275 patients were treated,59.65%with biventricular interstage physiology,followed by univentricular interstage physiology(34.55%),residual defects after surgical procedures(3.63%),tumors with risk of mechanical obstruction(1.45%)and patients with an intrauterine approach(0.72%).The signiﬁcant number of critical patients who were successfully discharged from hospital(44.72%),the low mortality rate due to sudden deaths at home and the high adherence to follow-up cor-roborate the impact of this specialized ***:despite the limitations of the study,this experi-ence report showed that with few resources,there is the possibility of organizing an AAR with differentiated care,with the objective of early detection and treatment of residual injuries,identiﬁcation of early interventions,edu-cation of parents for follow-up of their children,resulting in individualized treatment,promoting a better quality of life for this population.

关键词： Congenital heart defects ambulatory care heart defects

Propranolol hydrochloride degradation using La@TiO_(2) functionalized with CMCD

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Journal of Rare Earths 2022年第4期40卷 579-585,I0003页

作者： Gustavo Lopes Colpani Vitor Follmann Santos Rubieli Carla Frezza Zeferino Micheli Zanetti Josiane maria Muneron de Mello Luciano Luiz Silva Natan Padoin regina de Fatima Peralta Muniz Moreira Márcio Antônio Fiori Cíntia Soaresc Post-Graduate Program in Technology and Innovation Management Community University of ChapecóRegionChapecó89809-900Brazil department of Chemical Engineering Community University of ChapecóRegionChapecó89809-900Brazil Laboratory of Materials and Scientific Computing(LabMAC) Department of Chemical and Food EngineeringFederal University of Santa CatarinaFlorianópolis88040-900Brazil

Propranolol hydrochloride can be considered a persistent and bioaccumulative pharmaceutical in the *** drug and its by-products are potentially toxic and have adverse effects,since these compounds have been associated with endocrine-disrupting effects,reproductive deficiencies,embryo abnormalities and pericardial ***_(2)–La 0.05%–carboxymethyl-β-cyclodextrin(CMCD)nanoparticles were successfully prepared by a simple two-step method,which consists of sonification and *** characterization analyses reveal that lanthanum is dispersed on the semiconductor surface,probably forming Ti–O–La bonds,which can induce oxygen vacancies and surface defects that effectively restrain the recombination of photogenerated electron/holes *** efficiency of TiO_(2)–La 0.05%–CMCD samples in degradation of propranolol under UV-light irradiation is higher than that of pristine TiO_(2) within 20 min reaction,probably due to complex formation between theβ-blocker and the oligosaccharide,which allows us to propose a photocatalytic mechanism based on the formation of intermediates and competition of these compounds to the radicals and CMCD cavities.

关键词： TiO_(2) Lanthanum CMCD Propranolol Photocatalysis Functionalization

Viticulture in Argentina under extreme weather scenarios:Actual challenges,future perspectives

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Geography and Sustainability 2023年第2期4卷 161-169页

作者： Eugenio Straffelini Natalia Carrillo Carlos Schilardi regina Aguilera maria Jimena Estrella Orrego Paolo Tarolli department of Land EnvironmentAgriculture and ForestryUniversity of PadovaAgripolisViale dell’Università16Legnaro(PD)35020Italy Universidad Nacional de Cuyo Facultad de Ciencias AgrariasChacras de CoriaMendozaArgentina

Viticulture in Argentina is an important socioeconomic sector,reflected in a significant wine market and ***,climate change and related extreme events are serious *** main issues are heatwaves,hail-storms,and heavy rainfall,resulting in damage to *** climate change impacts have already been discussed for regions such as the Mediterranean,the literature lacks an up-to-date overview of Argentine viticul-ture and potential mitigation *** a country culturally and economically connected to the world of wine,it is strategic to bridge this gap to be prepared for a climatically adverse *** perspective paper presents an overview of Argentine viticulture and its relationship to climate *** focus on the Mendoza region,one of the most productive areas and home to cultural landscapes where internationally recognized wines are *** change is already occurring,a fact we observed by analyzing data from the past *** discussed how heatwaves in the lowlands drive farmers to move to the Andes slopes looking for more favorable *** new threats arise,such as extreme *** to surface hydrological processes,they can cause land degradation and compromise *** investigate these phenomena in detail,highlighting how they represent a growing challenge that must be addressed for the sustainable development of future viticulture in the ***,we propose mitigation strategies for more resilient production,drawing inspiration from the Sustainable development Goals and suggesting a framework that can be extended to broader contexts worldwide。

关键词： Viticulture Wine Climate change Adaptation Argentina South America

Ontogenetic niche specialization of the spider crab Libinia ferreirae associated with the medusa Lychnorhiza lucerna

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Current Zoology 2022年第5期68卷 549-559页

作者： Geslaine Rafaela Lemos Gonçalves Milena regina Wolf mariana Antunes Felipe Wanderley Amorim maria Lucia Negreiros-Fransozo Antonio Leão Castilho Group of Studies on Crustacean Biology Ecology and Culture-NEBECCBiosciences InstituteSão Paulo State UniversityBotucatuSP 18618-689Brazil and Laboratory of Pollination Ecology and Interactions-LEPI Biosciences InstituteSão Paulo State UniversityBotucatuSP 18618-689Brazil

Symbiotic relationships in marine environments are not fixed and can change throughout the animal’s *** study investigated the ontogeny of symbiosis of the spider crab Libinia ferreirae with the host medusa Lychnorhiza *** described the type of relationship,the temporal correlation among species,and food *** than 50%of the sampled crabs were symbionts,most in early life *** highest number of crabs found in a single medusa was *** was observed throughout most of the year but was more evident in warm *** crab has many benefits in this relationship with a *** is the use of food resources captured by the medusa,primarily *** the crab steals the medusa’s food,it is a kleptoparasitic *** is a niche partition between symbiont and the free-living crabs as they occupy different habitats and use nonoverlapping food *** research reported that symbiosis first developed during the crab’s last larval phase(megalopa)when crab and medusa are in the same *** of the crab’s behavior shows that symbiosis occurs when the crab can grab to the medusa when the host touches the sea *** crab also took advantage of water currents,releasing itself from the substrate and then drifting toward the *** symbiotic relationship that crabs have with the medusa provides then with a nursery,food resources,shelter,dispersion,and decreased competition with free-living adult crabs,all essential for the crab’s survival.

关键词： behavior development kleptoparasitism megalopa niche segregation

FeedefficiencyService: An architecture for the comparison of data from multiple studies related to dairy cattle feed efficiency indices

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Information Processing in Agriculture 2022年第3期9卷 378-396页

作者： Heitor Magaldi Linhares regina Braga Wagner Antonio Arbex mariana Magalhaes Campos Fernanda Campos Jose maria N.David Victor Stroele Programa de Pos-Graduacao em Ciencia da Computacao Universidade Federal de Juiz de ForaCampus UniversitarioRua JoseLourenco Kelmers/n-Sao PedroJuiz de ForaMinas Gerais 36036-900Brasil Brazilian Agricultural Research Corporation-Embrapa Av.Eugenio do Nascimento610-AeroportoJuiz de Fora-MGMinas Gerais 36038-330Brasil

The increased demand for food worldwide,the reduced land availability for livestock pro-duction,the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more *** tackle this problem,we propose the use of computational support to help researchers compare data on feed efficiency,therefore improving economic and environ-mental *** a solution,we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency *** proposed architecture,called FeedefficiencyService,classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference *** results obtained from a case study with researchers from the Brazilian Agri-cultural Research Corporation–Dairy Cattle(EMBRAPA)demonstrate that this architecture is a supporting tool in their daily work *** researchers highlighted the importance of the proposed architecture as it allows analyzing animal data,comparing experiments,having reliable data analyses,and standardizing and organizing data from *** novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related *** store such data,relationships,and analyses of results in an inte-grated *** solution ensures unified access to the processing history and data from diverse experiments,including those conducted at external research centers.

关键词： Dairy Cattle

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国际护理知识网络建设的调查研究

International Journal of Nursing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： Margareth Santos Zanchetta Suzanne Fredericks Kateryna Metersky Geraldine Martorella Pammla Petrucka Laurie Clune Kelly Graziani Giacchero Vedana Cristina Rosa Soares Lavareda Baixinho Cristianne maria Famer Rocha Sara Campagna Sally Zhang He Márcia Teles de Oliveira Gouveia Marcelo Medeiros denize Bouttelet Munari Daniel Gonzalo Eslava Albarracin Carlos Aguilera-Serrano Walterlania Silva Santos Toronto Metropolitan University TorontoCanada Florida State University TallahasseeUSA University of Saskatchewan ReginaCanada University of regina ReginaCanada State of Sao Paulo University Ribeirao PretoBrazil Lisbon Superior School of Nursing LisbonPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil University of Turin TurinItaly Scarborough Health Network ScarboroughCanada Federal University of Piauí TeresinaBrazil Federal University of Goias GoianiaBrazil Fundacion Universitaria Cafam BogotaColombia University of Malaga MalagaSpain University of Brasília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress

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World Journal of Gastroenterology 2017年第28期23卷 5146-5157页

作者： Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia maria Barros de Lorena Vláudia maria Assis Costa Alvaro Aguiar Coelho Teixeira regina Celia Bressan Queiroz Figueiredo Sheilla andrade de Oliveira Centro de Pesquisas Aggeu Magalhaes Fundacao Oswaldo Cruz Immunopathogenesis Section Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaMDUSA and Laboratório de Doencas Parasitárias e infecciosasFaculdade de MedicinaUniversidade Federal de Minas Gerais departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de Pernambuco departamento de Biofísica e Radiobiologia Universidade Federal de Pernambuco Centro Acadêmico de Vitória Universidade Federal de Pernambuco departamento de Medicina Tropical Universidade Federal de Pernambuco

AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors.

关键词：单核白血球骨头髓 mononuclear 房间房间治疗巨噬细胞谷胱甘肽肝纤维变性