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Effectiveness of mesenchymal stem cellconditioned medium in bone regeneration in animal and human models:a systematic review and meta-analysis

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Cell Regeneration 2020年第1期9卷 27-48页

作者： maria paula benavides-castellanos Nathaly Garzón-Orjuela Itali Linero Research Group of Oral and Maxillofacial Surgery Faculty of DentistryUniversidad Nacional de ColombiaBogotáColombia Research Group on Equity in Health Faculty of MedicineUniversidad Nacional de ColombiaBogotáColombia Research Group of Oral and Maxillofacial Surgery Faculty of DentistryResearch Group of Stem Cell BiologyFaculty of MedicineUniversidad Nacional de ColombiaBogotáColombia Faculty of Dentistry Universidad Nacional de ColombiaCiudad UniversitariaEdificio 210BogotáColombia

Background:Given the limitations of current therapies for the reconstruction of bone defects,regenerative medicine has arisen as a new therapeutic strategy along with mesenchymal stem cells(MSCs),which,because of their osteogenic potential and immunomodulatory properties,have emerged as a promising alternative for the treatment of bone *** vivo studies have demonstrated that MSCs have a positive effect on regeneration due to their secretion of cytokines and growth factors that,when collected in conditioned medium(MSC-CM)and applied to an injured tissue,can modulate and promote the formation of new ***:To evaluate the effectiveness of application of conditioned medium derived from mesenchymal stem cells in bone regeneration in animal and human ***:We conducted a systematic review with a comprehensive search through February of 2018 using several electronic databases(MEDLINE,EMBASE,SCOPUS,CENTRAL(Ovid),and LILACS),and we also used the“snowballing technique”.Articles that met the inclusion criteria were selected through abstract review and subsequent assessment of the full *** assessed the risk of bias with the SYRCLE and Cochrane tools,and three metaanalyses were ***:We included 21 articles,19 of which used animal models and 2 of which used human *** animal models,the application of MSC-CM significantly increased the regeneration of bone defects in comparison with control *** studies reported early mineralization in regenerated bones,and no bone resorption,inflammation,nor local or systemic alterations were observed in any *** meta-analysis showed an overall favorable effect of the application of ***:The application of MSC-CM to bone defects has a positive and favorable effect on the repair and regeneration of bone tissue,particularly in animal *** is necessary to perform additional studies to support the application of MSC-CM in clinical practice.

关键词： Bone regeneration Conditioned medium Mesenchymal stem cell Secretome Regenerative medicine

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