检索结果-南通市图书馆

Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch Hannah maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

来源：评论

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第5期16卷 430-441页

作者： Simona Sivori paola Vacca Genny Del Zotto Enrico Munari maria Cristina Mingari Lorenzo Moretta Department of Experimental Medicine(DIMES)and Centre of Excellence for Biomedical Research(CEBR) University of GenoaGenoaItaly Department of Immunology IRCCS Bambino GesuChildren’s HospitalRomeItaly Department of Research and Diagnostics Istituto G.GasliniGenoaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of Pathology Sacro Cuore Don CalabriaNegrarVRItaly UOC Immunologia IRCCS Ospedale Policlinico San Martino GenovaGenoaItaly

NK cells play important roles in innate defenses against viruses and in the control of tumor growth and *** regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface *** humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and *** receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor *** HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy *** receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell ***-1 also may be expressed by NK cells in cancer *** PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK ***,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 ***,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell *** most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging *** translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias.

关键词： Human NK cells NK receptors Inhibitory checkpoints Immunotherapy

Partial closure with a self-made fenestrated device of secundum atrial septal defect with severe pulmonary artery hypertension in adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第6期18卷 498-504页

作者： Tullio Tesorio Luigi Salemme Sebastiano Verdoliva Marco Ferrone paola Tesorio Eustaquio maria Onorato Unitàdi Cardiologia Interventistica Emodinamica Casa di Cura MontevergineVia Mario MalzoniMercoglianoItaly Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)University School of MilanMilanItaly

Secundum atrial septal defect(ASD)repres-ents one of the most common congenital heart diseases,accounting for up to 10%of all congenital heart *** is often diagnosed in adulthood due to the absence of clinical symptoms.[1]By the age of 40 years,90%of untreated patients have symptoms of exertional dyspnea,fatigue,pal-pitation,sustained arrhythmia,or even evidence of heart failure.

关键词： septal sustained atrial

Safety ranking definition for infrastructures with high PTW flow

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2018年第5期5卷 406-416页

作者： Antonella Ragnoli maria Vittoria Corazza paola Di Mascio Department of Civil Building and Environmental Engineering Sapienza University of Rome

Powered two-wheelers （PTWs） provide a suitable mode for a large portion of population in many cities due to rider＇s personal convenience and the vehicle supposed easiness of manoeuvring. At the same time PTWs present serious safety issues compared to other motorized vehicles. This paper reports the main outcome of study carried out in Rome, where this mode is very popular and assesses the economic efforts to make infrastructure safer for PTWs. The methodology, extensively described in the paper, includes three steps： the accident analysis, the development of economic indicators of accidents costs, the maintenance priority. In the first step the location of the PTWs local accidents are iden- tified, then the accidents are analyzed by means of the suitable indicators and, among these the safety potential （SAPO）. Lastly, according to the results of the analyzed indicators the need of infrastructure maintenance will be defined. Usually SAPO is applied to rural areas, but here it has been adapted to describe the phenomena of the urban area in hand. As a result, the estimation of the saving potential to improve the infrastructure safety levels, thus reducing the amount of accidents, is presented, along with recommendations on how to upscale the SAPO at city level.

关键词： Safety Accident costsl Powered two-wheeler (PTW) Maintenance

Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第2期8卷 167-169页

作者： Francesca maria Trovato paola Castrogiovanni Lorenzo Malatino Giuseppe Musumeci Department of Clinical and Experimental Medicine Human Anatomy and Histology SectionSchool of MedicineUniversity of CataniaCataniaItaly Department of Biomedical and Biotechnological Sciences Human Anatomy and Histology SectionSchool of MedicineUniversity of CataniaCataniaItaly

Nonalcoholic fatty liver disease(NAFLD)is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity(1).Indeed,metabolic syndrome and insulin resistance play a role in the pathogenesis of NAFLD,which involves intrahepatic triglyceride accumulation and inflammation(2).NAFLD is a consequence of genetic predisposition interacting with environmental and behavioral *** within the literature strongly support the idea that it represents the hepatic feature of a multisystem disease together with type 2 diabetes,cardiovascular disease(CVD),chronic kidney disease and osteoporosis(3).Nevertheless,the exact mechanism of hepatic fat accumulation and the progression to nonalcoholic steatohepatitis(NASH)is not completely *** fat is closely related to cardiometabolic risk(4)and,in order to decrease intrahepatic lipid(IHL)content and improve NAFLD,lifestyle interventions involving both diet and physical activity are recommended(2).In particular,great attention is focused on Mediterranean diet,which seems to help in gradually improving the severity of NAFLD(5).A randomized,cross-over intervention study demonstrated that in just 6 weeks,an olive-oil rich Mediterranean diet can result in a 40%relative reduction in liver fat measured by magnetic resonance in the form of IHL%(6).NAFLD improvement was associated with increased insulin sensitivity and reduced circulating insulin concentrations,even without a change in body weight(6).

关键词： NAFLD prevention hepatic

Managing sidewalk pavement maintenance:A case study to increase pedestrian safety

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2016年第3期3卷 203-214页

作者： maria Vittoria Corazza paola Di Mascio Laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of Rome

Comfort is a major requirement in planning pedestrian facilities. Pedestrians walk where they feel comfortable and when they do not feel at ease, they walk elsewhere. A typical example is that filthy, distressed, or too narrow sidewalks induce pedestrians to walk on carriageways. This behaviour jeopardizes road safety and highly dangerous to most users, leave them vulnerable. Unsuitable pavements can be the result of irregular maintenance operations to restore evenness after shock damage, weather phenomena, installation of equipment （e.g., posts, fences, urban furniture） with a reduction of walkable surface, or substandard repair work on pavements and patches due to emergency operations. These problems can be solved with an appropriate maintenance management system, which optimizes financial resources to make smart decisions about how to intervene with an adequate and lasting maintenance operation. This paper defines an evaluation index for sidewalk conditions as a part of an efficient set-up of a Sidewalk Management System, which is similar to the better known Road Management System. The study relies on sur- veys, as well as the classification and analysis of sidewalk distresses. The authors adapted an index already standardized by ASTM for roads and airports： the Pavement Condition Index （PCI）. PCI has been modified to consider the specific types on the sidewalks studied within this paper. To validate the method, a case study of a residential district in Rome, Italy, was carried out. The chosen area lacks regular maintenance and has therefore resulted in a network of unsafe sidewalks. Frequent detour routes were surveyed and related to the level of distresses within a general assessment of safety. This study con- centrates on sidewalks with flexible pavements because this type of pavement is the only one adopted in the survey areas and, in general, throughout Italy.

关键词： Sidewalks Maintenance Condition index Pedestrians Safety Asphalt pavements

From landslide characterization to nature reserve management:The“Scialimata Grande di Torre Alfina”landslide Geosite(Central Apennines,Italy)

在线全文

学校读者我要写书评

暂无评论

山地科学学报（英文） 2023年第3期20卷 585-606页

作者： Gianluca TRONTI Francesca VERGARI Irene maria BOLLATI Filippo BELISARIO Maurizio DELMONTE Manuela PELFINI paola FREDI Earth Sciences Department"Ardito Desio" University La StataleMilan 20133(MI)Italy Monte Rufeno Nature Reserve Acquapendente 01021(VT)Italy Earth Sciences Department University La SapienzaRome 00185(RM)Italy

Italy is characterized by widespread geomorphological instability,among which landslides leave impressive marks on the ***,landslide bodies may represent key sites for thematic and educational itineraries,especially in protected areas,where their management becomes an important *** study focuses on the"Monte Rufeno Nature Reserve"(Central Apennines,Italy),where iconic landslides are ***,the"Scialimata Grande di Torre Alfina"landslide(SGTA)is listed in the regional Geosite *** work aims to propose a multiscale procedure for landslide analysis,in terms of both hazard sources but also educational and geoheritage enhancement opportunities in natural *** performing a Landslide Susceptibility conditional Analysis(LSA)for the reserve territory,attention was focused on the SGTA,to define properly its features and morphodynamics.A multi-disciplinary approach was adopted,by applying both remote sensing(UAV structure from motion,Photointerpretation)and field survey(geomorphological and GPS monitoring).From the LSA,based on drainage density,curvature,and slope triggering factors,the road and trail susceptibility maps were derived,as base tools for future risk assessments and trail paths management within the *** the SGTA scale,the monitoring showed a displacement of up to 23 m during the time interval between 2015 and *** landslide dynamics seem to be driven by alternating dry and extremely wet periods;moreover,leaks from the aqueduct in the detachment area and piping effects through clays may have also decreased the substrate *** SGTA complex influence on the Paglia River valley geometry was also hypothesized,underlining the action of landslide through different spatial scales(on-site and off-site)and on different environment features(sediment connectivity,hydrology).Finally,the SGTA appears highly representative of the geomorphic dynamics within the Nature Reserve(i.e.,scientific value)and it could be

关键词： Landslides Geoheritage Geosites Nature reserves management UAV structure from motion Landslides conditional analyses

Patient-reported outcomes in subjects with neuroendocrine tumors of the pancreas

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第40期15卷 5067-5073页

作者： Raffaele Pezzilli Davide Campana Antonio M Morselli-Labate maria C Fabbri Emilio Brocchi paola Tomassetti Department of Digestive Diseases and Internal Medicine Sant'Orsola-Malpighi HospitalUniversity of Bologna

AIM: To assess the patient-reported outcomes (PROs) of pancreatic neuroendocrine tumor (PNET) patients. METHODS: Fifty-one consecutive patients (21 male, 30 female, 61.0 ± 10.3 years) with proven PNETs were studied. An SF-12 questionnaire capable of exploring the physical (PCS) and mental (MCS) aspects of daily life was used. Four questionnaires were also used [12 items General Health Questionnaire (GHQ-12) for non-psychotic psychiatric disorders, State Trait AnxietyInventory (STAI) Y-1 and Y-2 for anxiety and BDI-for depressive symptoms] to explore the psychological aspects of the disease. Forty-four sex-and age-matched Italian normative subjects were included and evaluated using the SF-12, STAI Y-1 and Y-2 ***: Seven patients refused to participate to the study; they were clinically similar to the 44 participants who agreed to complete the questionnaires. PNET patients had a PCS score (44.7 ± 11.0) were not signifi cantly different from the norms (46.1 ± 9.9, P = 0.610), whereas the MCS score was signifi cantly lower in patients (42.4 ± 13.0) as compared to the norms (48.2 ± 9.8, P = 0.036). GHQ-12 identified 11 patients (25.0%) as having non-psychotic psychiatric *** STAI scores were similar in the patients and inthe normative population. Finally, BDI-identifiedeight patients (18.2%) with moderate depression and 9 (20.5%) with mild depression whereas 27 patients (61.4%) had no ***: The PNET patients had a good physical but an impaired mental component of their quality of life; in addition, mild or moderate depressive symptoms are present in about 40% of PNET patients.

关键词： Endocrine gland neoplasms Pancreatic neoplasms Somatostatin Quality of life Quality indicators Health care

Rectal hepatoid carcinoma with liver metastases in a patient affected by ulcerative colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2008年第5期7卷 539-543页

作者： Giacomo Borgonovo Francesco Razzetta Michela Assalino Emanuela Varaldo maria Puglisi paola Ceppa Dipartimento di Discipline Chirurgiche Morfo- logiche e Metodologie Integrate(DiCMI)Universitàdegli Studi di Genova.Largo Benzi8.16132 GenovaItaly

BACKGROUND:Hepatoid tumors(HTs)are rare extra-hepatic neoplasms with the histological features, biochemical profile and,sometimes,even clinical course of hepatocellular *** present a case of rectal hepatoid adenocarcinoma with metachronous liver metastases. METHODS:Four months after total procto-colectomy for a rectal adenocarcinoma(Astler-Coller C2),a 42-year-old man with ulcerative colitis showed hypoechoic masses in the hepatic parenchyma by abdominal ultrasonography. Carcinoembryonic antigen was normal,but alpha- fetoprotein was 32 000μg/***-needle biopsy revealed that liver masses were positive for hepatocellular carcinoma. The patient underwent left hepatectomy and alcoholisation of a small deep nodule in segment 8. RESULTS:Immunohistochemistry and albumin mRNA in situ hybridization suggested that the nodules were metastases of a *** patient was well during the first 6 months and refused any adjuvant *** died from liver failure 19 months after initial diagnosis. CONCLUSIONS:HT is a rare colon *** preoperative diagnosis of this tumor requires a high degree of suspicion,the availability of a panel of immunohistochemical markers,and a certain amount of *** prognosis is poor despite an aggressive andmultimodal therapeutic *** far,none of the hypotheses proposed about the origin and the biology of these tumors is convincing.

关键词： colon cancer ulcerative colitis hepatocellular carcinoma hepatectomy alpha-fetoprotein