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ORS1, an H2O2-Responsive NAC Transcription Factor, Controls Senescence in Arabidopsis thaliana

Molecular Plant 2011年第2期4卷 346-360页

作者： Salma Balazadeh Miroslaw Kwasniewski Camila Caldana Mohammad Mehrnia maria Ines Zanor Gang-Ping Xue Bernd Mueller-Roeber University of Potsdam Institute of Biochemistry and Biology KarI-Liebknecht-Straβe 24-25 Haus 20 14476 Potsdam-Golm Germany Max-Planck Institute of Molecular Plant Physiology Am Muhlenberg 1 14476 Potsdam-Golm Germany University of Silesia Department of Genetics Jagiellonska 28 40-032 Katowice Poland CSIRO Plant Industry 306 Carmody Road St Lucia QLD 4067 Australia Present address: Instituto de Biologia Molecular y Celular de Rosario (IBR-CONICET). Facultad de Ciencias Bioquimicas y Farmaceuticas (UNR) Suipacha 530 Rosario S2002LRK Argentina

We report here that ORS1, a previously uncharacterized member of the NAC transcription factor family, controls leaf senescence in Arabidopsis thaliana. Overexpression of ORS1 accelerates senescence in transgenic plants, whereas its inhibition delays it. Genes acting downstream of ORS1 were identified by global expression analysis using transgenic plants producing dexamethasone-inducible ORSl-GR fusion protein. Of the 42 up-regulated genes, 30 （-70%） were pre- viously shown to be up-regulated during age-dependent senescence, We also observed that 32 （-76%） of the ORSl-dependent genes were induced by long-term （4 d）, but not short-term （6 h） salinity stress （150 mM NaCI）. Furthermore, expression of 16 and 24 genes, respectively, was induced after 1 and 5 h of treatment with hydrogen peroxide （H2O2）, a reactive oxygen species known to accumulate during salinity stress. ORS1 itself was found to be rapidly and strongly induced by H2O2 treatment in both leaves and roots. Using in vitro binding site selection, we determined the preferred binding motif of ORS1 and found it to be present in half of the ORSl-dependent genes. ORS1 is a paralog of ORE1/ ANACO92/AtNAC2, a previously reported regulator of leaf senescence. Phylogenetic footprinting revealed evolutionary conservation of the ORS1 and ORE1 promoter sequences in different Brassicaceae species, indicating strong positive selection acting on both genes. We conclude that ORS1, similarly to ORE1, triggers expression of senescence-associated genes through a regulatory network that may involve cross-talk with saltand H2O2-dependent signaling pathways.

关键词： NAC transcription factor leaf senescence gene expression gene regulatory network hydrogen peroxide

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Does Playing Games Contribute to Develop Better Attitudes？

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Psychology Research 2014年第4期4卷 301-309页

作者： maria Thereza Costa Coelho de Souza Ana lucia Petty Camila Tarif Ferreira Folquitto mariana Ines Garbarino Tamires Alves Monteiro University of Sao Paulo S~o Paulo Brazil

This research was held at the Laboratory of Studies about Development and Learning (Institute of Psychology, University of Sao Paulo) for the period of three semesters in which children with learning disabilities aged 7-11 years were observed in a game context mediated by professionals. It investigated in which categories playing games interfered in the construction of favorable attitudes towards the learning and development processes. To collect data researchers used a questionnaire, answered in the beginning and at the end of each semester, and where attitudes were registered considering four categories: time, space, objects and interaction. A total of 88 questionnaires were analyzed. Results show that: (1) All categories increased scores; (2) There was no decrease in any category; (3) At space and objects there were more visible changes, comparing high scores between the first and third semesters, increasing 25% and 36% respectively; (4) At time and interaction, changes showed 20% high score increase in both, also comparing first with third semester; and (5) It was identified a decrease in low scores at time and there were not visible changes at interaction. Taking Piaget"s theory as reference and the practice in seeing children with learning disabilities at the laboratory, playing games in an intervention context contributes to help them build up better attitudes towards reasoning and social development.

关键词：游戏背景学习障碍开发专业人士研究人员相互作用社会发展实验室

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Characterization of the Ear Canal Bacterial Flora Present in Hearing Aids (HA)Wearing Subjects

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Advances in Microbiology（微生物学） 2019年第7期

作者： Marta Aleandri Cecilia Ambrosi maria Stefania Lepanto Antonietta lucia Conte Massimiliano Marazzato Catia Longhi Mauro Nicoletti Carlo Zagaglia Paola Goldoni Francesco Bussu Roberta Anzivino Roberto Gallus maria Pina Battista maria Pia Conte Anna Teresa Palamara

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The Neurologist in the Emergency Room: Prospective Study of the Neurological Emergency Group in Lombardia

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Journal of Health Science 2019年第4期7卷 254-261页

作者： mariaLuisa Delodovici Marco Mauri Megi Meneri Marco Gallazzi Elena Ballabio Giuseppina Borutti maria Vittoria Calloni Elisa Candeloro Bruno Censori Claudio De Piazza Laura Fusi Franca Mazzucchelli Ignazio Santilli Elisabetta Forapani Chiara Scaccabarozzi maria Sessa lucia Tancredi Massimiliano Braga Dept. of Neurology and Stroke Unit Ospedale di Circolo e Fondazione MacchiUniversità dell’InsubriaASST-Settelaghile Luigi Borri 57 21100 VareseItaly Dept. of Neurology Ospedale di Desio (MB) Director G. Mazzini 1 20832 Desio (MB)Italy Dept. of Neurology ASST Lecco-Ospedale A. Manzonidell’Eremo 9/11 23900 LeccoItaly Dept. of Neurology Ospedale di Cremona ASST Cremona Directorle Concordia 1 26100 CremonaItaly Dept. of Neurology Ospedale Sant’Anna ComoRavona 20 22042 SFermo della BattagliaComoItaly Dept. of Neurology Ospedale di Vimercate (MB) Santi Cosma e Damiano 10 20871 Vimercate (MB)Italy Dept. of Neurology Ospedale S. Carlo BorromeoA. Mosca 12 20152 MilanoItaly Dept. of Neurology Director Ospedale Civile di VogheraVolturno 14 Voghera 27058 (PV)Italy Dept. of Neurology Ospedale di Legnano ASST Ovest MilanesePapa Giovanni Paolo II20025 Legnano (MI)Italy Dept. of Neurology Fondazione IRCCS C. Mondino Mondino 2Pavia 27100Italy Dept. of Neurology ASST Papa Giovanni XXIII Piazza OMS 1 24127 BergamoItaly Dept. of Neurology Ospedale Valduce ComoDante Alighieri 11 22100 ComoItaly Dept. of Neurology Ospedale di Saronno ASST Valle olonaPiazzale Borella 1 Saronno 21047 (VA)Italy Dept. of Neurology Ospedale S. Antonio Abate Gallarate. Pastori 4 21013 Gallarate VareseItaly

Purpose of the work was to quantify the workloads and the neurologist’s commitment in ER, to verify the management of urgencies and appropriateness of neurological counseling requests. Neurologic emergencies are frequent in elderly patients and are associated with high morbidity and mortality. Due to the aging population, neurologic pathologies in emergency room (ER) are widely expected to increase. The role of the neurologist in this context is controversial. Methods: in 14 operative units of neurology a prospective collection of neurological evaluations in ER was carried out using boards of detection of the most frequent neurological clinical pictures seen in the course of a week. Data were collected from 738 cases. Attention was focused on cerebrovascular diseases (CVD), impairment of consciousness, epilepsy, headache, dizziness, head trauma and disorders of the peripheral nervous system (PNS). Achievements: neurological consultations were on average 5% of total accesses to ER. The most common pathology seen was ischemic stroke. After counseling most patients were discharged home. The CVD required the greatest commitment to the specialist. The usefulness of the specialized neurological “filter” has been confirmed in a non-simple operative context, aimed at optimizing the appropriateness of the hospitalization and the economy of the diagnostic path.

关键词： Emergency room neurological diseases neurology workload

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Collateral findings during computed tomography scan for atrial fibrillation ablation:Let's take a look around

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World Journal of Cardiology 2016年第4期8卷 310-316页

作者： Francesco Perna Michela Casella maria lucia Narducci Antonio Dello Russo Gianluigi Bencardino Gianluca Pontone Gemma Pelargonio Daniele Andreini Nicola Vitulano Francesca Pizzamiglio Edoardo Conte Filippo Crea Claudio Tondo Cardiac Arrhythmia Unit Agostino Gemelli University Hospital Cardiac Arrhythmia Research Centre Centro Cardiologico MonzinoIRCCS

The growing number of atrial fibrillation catheter ablation procedures warranted the development of advanced cardiac mapping techniques, such as image integration between electroanatomical map and cardiac computed tomography. While scanning the chest before catheter ablation, it is frequent to detect cardiac and extracardiac collateral findings. Most collateral findings are promptly recognized as benign and do not require further attention. However, sometimes clinically relevant collateral findings are detected, which often warrant extra diagnostic examinations or even invasive procedure, and sometimes need to be followed-up over time. Even though reporting and further investigating collateral findings has not shown a clear survival benefit, almost all the working groups providing data on collateral findings reported some collateral findings eventually coming out to be malignancies, sometimes at an early stage. Therefore, there is currently no clear agreement about the right strategy to be followed.

关键词： Collateral findings Incidental findings Incidentalomas Cardiac computed tomography Image integration

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肠道子宫内膜异位症诊断和治疗的新观点

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国际妇产科学杂志 2020年第6期47卷 676-683,F0003页

作者：梁炎春韦雅婧杨如玉姚书忠(译/审校) Nassir Habib Gabriele Centini lucia Lazzeri Nicola Amoruso Lionel El Khoury Errico Zupi Karolina Afors 不详 Department of Obstetrics and Gynaecology Beaujon Hospital-University of ParisClichy Cedex 92110France Department of Molecular and Developmental Medicine University of SienaOspedale Santa Maria alle ScotteSiena 53100Italy Department of Colorectal Surgery-Delafontaine Hospital Saint Denis 93200France Department of Obstetrics and Gynaecology Whittington HospitalLondon 中山大学附属第一医院妇科广东510080

子宫内膜异位症是一种主要影响育龄妇女的慢性疾病。部分肠道子宫内膜异位症患者可能是无症状的,除了不孕之外,有部分患者表现为各种各样的症状,如排便习惯改变(便秘或腹泻)、排便困难、痛经和性交痛等。迄今为止,对于疑似有肠道受累的... 详细信息

子宫内膜异位症是一种主要影响育龄妇女的慢性疾病。部分肠道子宫内膜异位症患者可能是无症状的,除了不孕之外,有部分患者表现为各种各样的症状,如排便习惯改变(便秘或腹泻)、排便困难、痛经和性交痛等。迄今为止,对于疑似有肠道受累的子宫内膜异位症患者,尚无明确的评估指南。目前的检查手段包括经阴道或经直肠超声检查、核磁共振成像和气钡双重对比造影。不同的检查方法可提供更多的信息,包括是否存在病灶、病灶的位置和累及的范围等,确保患者充分了解病情,同时也可对术前计划进行优化。如需手术治疗,应由经验丰富的医生在有多学科护理条件的中心进行手术。治疗应根据患者的症状和意愿进行调整,目的是尽可能切除所有病灶的同时保留器官的功能。本综述将讨论肠道子宫内膜异位症诊断和处理的最新观点。

关键词：子宫内膜异位症肠道子宫内膜异位症节段性切除术复发不孕

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Nuclear imaging in detection and monitoring of cardiotoxicity

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World Journal of Radiology 2014年第7期6卷 486-492页

作者： Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino marianna D’Amato lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi Department of Advanced Biomedical Sciences Federico II University SDN Foundation Institute of Diagnostic and Nuclear Development

Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and *** coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor *** ventricular dysfunction is the most typical manifestation and can lead to heart *** ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial *** non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic *** echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical *** aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity.

关键词： Cardiotoxicity Cardiac nuclear imaging Early diagnosis Scintigraphy Positron emission tomography

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Early onset versus late onset in Alzheimer’s disease: What is the reliable cut-off?

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Advances in Alzheimer's Disease 2013年第1期2卷 40-47页

作者： Gianfranco Spalletta Vincenzo De Luca Alessandro Padovani Luca Rozzini Roberta Perri Amalia Bruni Vincenzo Canonico Alberto Trequattrini Giuseppe Bellelli Carla Pettenati Floriana Pazzelli Carlo Caltagirone maria Donata Orfei Azienda Sanitaria Locale Città di Castello Perugia Italy Centro Regionale Alzheimer Azienda Ospedaliera Guido Salvini Passirana Italy Centro Regionale Di Neurogenetica Azienda Sanitaria Provinciale Catanzaro Lamezia Terme Italy Department of Clinical and Behavioral Neurology IRCCS Santa Lucia Foundation Rome Italy Department of Geriatrics University of Naples Naples Italy Department of Neurology University of Brescia Brescia Italy Department of Neuroscience Tor Vergata University of Rome Rome Italy Department of Prevention and Clinical Medicine University of Milano-Bicocca Monza Italy Department of Psychiatry University of Toronto Toronto Canada NESMOS Department Sapienza University of Rome Rome Italy

Objective: As the literature on conventional criteria for discriminating early-onset (EO) from late-onset (LO) Alzheimer’s disease (AD) is sparse and controversial, the aim of this study was to establish a precise age at onset (AAO) criterion, by using a specific statistical procedure, and to describe the clinical characteristics of the two sub-groups. Methods: Admixture analysis was performed to establish the AAO cut-off in a multi-center study including 2000 AD patients consecutively recruited in eight Italian Memory Clinics. None of the patients were taking acetylcholinesterase inhibitors, antipsychoticor anti-depressant drugs. At the first diagnosticvisit, they were administered the Mini Mental StateExamination, the Basic and Instrumental Activities of Daily Living and the Neuropsychiatric Inventorytoassess clinical phenomenology. Results: Using a specific statistical procedure, we established that AAO that discriminated EO-from LO-AD was 66. Compared with the LO-AD group, the EO-AD group showed longer duration of illness and a higher educational level as well as less severe functional impairment and delusions. Conclusions: Differences in sociodemographic and clinical characteristics, such as duration of illness, education and delusion severity, suggested the involvement of different pathogenic processes. Additional studies are needed to further investigate the mechanisms underlying the disorder in the two sub-groups of AD patients.

关键词： Alzheimer’s Disease Onset Neuropsychiatric Symptoms Admixture Analysis Pathogenesis Cognitive Reserve

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Mobilizing Crop Biodiversity

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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn J.Bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar Dario Grattipaglia Robert Henry maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey Graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard maria Jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester Jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural

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Outcome in obscure gastrointestinal bleeding after capsule endoscopy

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World Journal of Gastrointestinal Endoscopy 2013年第11期5卷 551-558页

作者： Alex Caas-Ventura lucia Márque Xavier Bessa Josep maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez Department of Gastroenterology Hospital del Mar Research InstitutePompeu Fabra University Endoscopic Unit Gastroenterology DepartmentICMDiM. Hospital Clínic

AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions.

关键词： Capsule endoscopy Obscure gastrointestinal bleeding Small bowel Angiodysplasia Enteroscopy

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