检索结果-南通市图书馆

A 3R-Tau-mediated mechanism in oligodendrocytes:could it be the key for neuroprotection after stroke?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第12期16卷 2401-2402页

作者： Mario Villa Gonzalez maria joséPérez-Álvarez Departamento de Biología(Fisiología Animal) Facultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Biología Molecular“Severo Ochoa” Departamento de Neuropatología Molecular CSIC-UAMMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Anoverview of cerebral ischemia:Cerebrovascular accident or stroke have a high global *** most common types of stroke are ischemic,accounting for 87%of the total number,and they are triggered by a reduction or interruption of blood flow to the central nervous system,usually caused by a thrombus,embolus or atherosclerotic *** severity of brain damage caused by this kind of stroke is directly related to the size of the vessel that is occluded and the duration of occlusion.

关键词： cerebral ischemia damage

GenoDrawing:An Autoencoder Framework for Image Prediction from SNP Markers

在线全文

学校读者我要写书评

暂无评论

Plant Phenomics 2023年第4期5卷 816-824页

作者： Federico Jurado-Ruiz David Rousseau Juan A.Botía maria josé Aranzana Center for Research in Agricultural Genomics(CRAG) 08193 BarcelonaCerdanyolaSpain Universitéd'Angers LARISINRAe UMR IRHS49000 AngersFrance Department of Information and Communication Engineering University of Murcia30071 MurciaSpain IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain

Advancements in genome sequencing have facilitated whole-genome characterization of numerous plant species,providing an abundance of genotypic data for genomic *** selection and neural networks(NNs),particularly deep learning,have been developed to predict complex traits from dense genotypic ***,an NN model to extract features from images in an unsupervised manner,has proven to be useful for plant *** study introduces an autoencoder framework,GenoDrawing,for predicting and retrieving apple images from a low-depth single-nucleotide polymorphism(SNP)array,potentially useful in predicting traits that are difficult to *** demonstrates proficiency in its task using a small dataset of shape-related *** indicate that the use of SNPs associated with visual traits has substantial impact on the generated images,consistent with biological *** using substantial SNPs is crucial,incorporating additional,unrelated SNPs results in performance degradation for simple NN architectures that cannot easily identify the most important *** proposed GenoDrawing method is a practical framework for exploring genomic prediction in fruit tree phenotyping,particularly beneficial for small to medium breeding companies to predict economically substantial heritable *** GenoDrawing has limitations,it sets the groundwork for future research in image prediction from genomic *** studies should focus on using stronger models for image reproduction,SNP information extraction,and dataset balance in terms of phenotypes for more precise outcomes.

关键词： Auto Drawing prediction

Attention sports fans! The far-reaching contributions of bud sport mutants to horticulture and plant biology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2018年第1期5卷 447-459页

作者： Toshi M.Foster maria joséAranzana The New Zealand Institute for Plant and Food Research Limited Private Bag 11600Palmerston North4474New Zealand IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UABBellaterraBarcelonaSpain

A bud sport is a lateral shoot,inflorescence or single flower/fruit with a visibly different phenotype from the rest of the *** new phenotype is often caused by a stable somatic mutation in a single cell that is passed on to its clonal descendants and eventually populates part or all of a *** many cases,a bud sport can be vegetatively propagated,thereby preserving the novel phenotype without sexual *** sports provide new characteristics while retaining the desirable qualities of the parent plant,which is why many bud sports have been developed into popular *** present an overview of the history of bud sports,the causes and methods of detecting somaclonal variation,and the types of mutant phenotypes that have arisen *** focus on examples where the molecular or cytological changes causing the phenotype have been *** of these sports has provided valuable insight into developmental processes,gene function and regulation,and in some cases has revealed new information about layer-specific roles of some *** of the molecular changes causing a phenotype and in some cases reversion back to the original state has contributed to our understanding of the mechanisms that drive genomic evolution.

关键词： culture eventually sports

Breeding effects on the genotype×environment interaction for yield of durum wheat grown after the Green Revolution:The case of Spain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2020年第4期8卷 623-634页

作者： Fadia Chairi Nieves Aparicio maria Dolores Serret josé Luis Araus Section of Plant Physiology University of BarcelonaBarcelonaSpain AGROTECNIO(Center of Research in Agrotechnology) LleidaSpain Instituto de Tecnología Agraria de Castilla y León(ITACyL) ValladolidSpain

This study evaluates the changes caused by breeding in the genotype by environment(G×E)interaction of the durum wheat varieties most widely cultivated in Spain after the Green Revolution.A set of 12 cultivars was tested in 27 environments,which are understood as the combination of different sites,years,and treatments(water regime and planting dates),representative of the durum wheat growing conditions in Spain with average grain yields(GY)ranging between 2.8 and 9.1 Mg ha^-*** most important environmental factors affecting the G×E interaction for yield were themaximum and the mean temperature during the entire crop *** improvement in genetic yield was observed in warm environments and under optimal water conditions that resemble those where the germplasm originated(essentially as advanced lines)before its release in ***,the adaptation of semi-dwarf durum in Spain has shown a tendency to specific adaptation rather than large-scale *** different patterns of selection have been reported due the G×E interaction and changes in the ranking of genotypes:in the high yielding environments(GY>5 Mg ha^-1),plants favor increased water uptake,with higher levels of transpiration and more open stomata(more negative values of carbon isotope composition,δ^13 C,and higher canopy temperature depression,CTD),whereas,in low yielding environments(GY<5 Mg ha^-1)plants close their stomata and favor greater water use efficiency(less negativeδ^13 C values and lower CTD values).

关键词： breeding cultivar dwarf

Influence of occult hepatitis B virus infection in chronic hepatitis C outcomes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第12期17卷 1558-1562页

作者： Conrado M Fernandez-Rodriguez maria Luisa Gutierrez joséLuis Lledó maria Luisa Casas Service of Gastroenterology Hospital Universitario Fundación AlcorcónUniversity King Juan CarlosAv Budapest-128922 AlcorcónMadridSpain Service of Biochemestry Hospital Universitario Fundación AlcorcónUniversity King Juan CarlosAv Budapest-128922 AlcorcónMadridSpain

Persistence of hepatitis B virus-DNA in the sera,peripheral blood mononuclear cells or in the liver of hepatitis B surface antigen(HBsAg) -negative patients with or without serological markers of previous exposure(antibodies to HBsAg and/or to HB-core antigen) defines the entity called occult hepatitis B infection(OBI).Co-infection with hepatitis B and hepatitis C viruses is frequent in highly endemic *** this co-infection increases the risk of liver disease progression,development of cirrhosis and hepatocellular carcinoma and also increases the rate of therapeutic failure to interferon-based treatments than either virus alone,a potentially negative effect of OBI on clinical outcomes and of therapeutic response to current antiviral regimes of patients with chronic hepatitis C remains inconclusive.

关键词： Occult hepatitis B infection Chronic hepatitis C Outcomes

Glial cells in the center of future ischemic stroke treatments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第12期17卷 2659-2660页

作者： IvóH.Hernández maria joséPérez-Álvarez Genomic Instability Group Spanish National Cancer Research Centre(CNIO)MadridSpain Departamento de Biología(Fisiología Animal)Facultad de Ciencias Universidad Autónoma de Madridand Instituto de Biología Molecular-CBMSOUAM/CSICMadridSpain

In the last century,increasing knowledge about glial cells has revealed their importance in brain physiology and disease and an exciting potential target for new therapeutic interventions(Hernández et al.,2021).Ischemic stroke is the most common of all types of *** the second leading cause of disability and mortality,ischemic stroke is a serious socio-economic burden *** it has been strongly associated with aging,during 2020 COVID-19 emerged as a new risk factor for ischemic stroke in younger patients(Cagnazzo et al.,2021).The only therapy or intervention currently available for humans is early reperfusion after the onset of the first ***,due to the high risk of brain hemorrhage,these treatments are suitable for only a small percentage of ***,reperfusion does not prevent post-injury neurodegeneration,hence the importance of finding new therapeutic alternatives to ameliorate ischemic damage and improve post-stroke quality of life.

关键词： mortality treatment younger

The Colíder Paleoproterozoic felsic volcanism:New insights into stratigraphy and petrogenesis in the southern Amazonian Craton

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2024年第2期15卷 274-303页

作者： André Massanobu Ueno Kunifoshita Felipe Holanda dos Santos maria joséMesquita Instituto de Geociências Universidade Estadual de Campinas(UNICAMP)Rua Carlos Gomes250CEP:13083-855 CampinasSão PauloBrazil Departamento de Geologia Universidade Federal do CearáCampus do PiciBloco 912CEP:60440-554 FortalezaCearáBrazi

The eastern side of Alta Floresta Mineral Province(AFMP)(União do Norte region)comprises an effusive/-subvolcanic phase,explosive phase,and epiclastic *** effusive/subvolcanic phase comprises massive porphyritic rhyolite with different degrees of crystallinity,porphyritic rhyolite with flow structure,and microcrystalline *** explosive phase is characterized by welded lapilli tuff,lapilli tuff with flow structure,stratified lapilli tuff,and tuff with accretionary *** and siltstones characterize epiclastic *** are porphyritic rhyolite dikes that cut the volcanic *** rocks of the Colíder Group are rhyolites(>70%SiO2)with calcic-alkaline to alkaline-calcic affinity.A rhyolitic rock is predominantly ferroan and metaluminous,while a pyroclastic rock is predominantly magnesian to ferroan and meta-to peraluminous in *** rocks have a high LREE content,and slight fractionation of HREE suggests they have hybrid geochemical characteristics of high potassium calc-alkaline,shoshonitic,and suggestive affinities of A-type magmas,probably produced in a post-collisional orogenic *** rocks have a relatively high level of Ba and Rb and a negative anomaly for Sr,P,Nb,Ta,and Ti,suggesting an intra-plate mantle source with contributions from a metasomatized mantle *** rocks do not have adakitic characteristics nor fertility for Cu-Au(Sr/Y<1.9 and LaN/YbN<38.0)as in other regions of the *** welded lapilli tuff rocks show U-Pb age of 1838±17 Ma and 1817±2 Ma and are the older explosive *** effusive/subvolcanic phase has U-Pb ages of 1800±3 Ma and 1792±3 Ma obtained in the massive porphyritic *** age interval of approximately 46 Ma(1838–1792 Ma)suggests the presence of two or more volcanic cycles or distinct volcanic *** on the interpretation of volcanic and epiclastic deposits and remote sensing products,the paleoenvironmental reconstruction includes subaerial with effusive/subvolcani

关键词： Paleoproterozoic volcanism Eroded volcanic caldera Lithofacies analysis Colíder Group Amazonian Craton

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 46-69页

作者： Sarah Lépine maria josé Castellanos-Montiel Thomas Martin Durcan The Neuro’s Early Drug Discovery Unit(EDDU) Department of Neurology and NeurosurgeryMontreal Neurological Institute-HospitalMcGill University3801 University StreetMontrealQC H3A 2B4Canada Faculty of Medicine and Health Sciences McGill University3605 De La MontagneMontrealQC H3G 2M1Canada

Amyotrophic lateral sclerosis(ALS)is a disease characterized by upper and lower motor neuron(MN)loss with a signature feature of cytoplasmic aggregates containing TDP-43,which are detected in nearly all *** in the gene that encodes TDP-43(TARBDP)are known to result in both familial and sporadic *** ALS,disruption of neuro-muscular junctions(NMJs)constitutes a critical event in disease pathogenesis,leading to denervation atrophy,motor impairments and *** defects and impaired synaptic transmission at NMJs have been reported in several TDP-43 animal models and in vitro,linking TDP-43 dysregulation to the loss of NMJ integrity in *** the lens of the dying-back and dying-forward hypotheses of ALS,this review discusses the roles of TDP-43 related to synaptic function,with a focus on the potential molecular mechanisms occurring within MNs,skeletal muscles and glial cells that may contribute to NMJ disruption in ALS.

关键词： Amyotrophic lateral sclerosis Denervation Neuromuscular junction TDP-43 Dying-back Dying-forward

Hepatocyte transplantation program:Lessons learned andfuture strategies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第2期22卷 874-886页

作者： Eugenia Pareja Ibars Miriam Cortes Laia Tolosa maria joséGómez-Lechón Slivia López joséVicente Castell joséMir Unidad de Terapia Celular Hepatica Instituto de Investigación Sanitaria La FeHospital Universitario y Politécnico La Fe de Valencia46026 ValenciaSpain Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante Hepático Hospital Universitario y Politécnico La Fe de Valencia46026 ValenciaSpain Liver transplantation Institute of Liver StudiesKing’s College HospitalInstitute of Liver StudiesSE5 9RS LondonUnited Kingdom Unidad de Hepatologıa Experimental Instituto de Investigación Sanitaria La FeHospital Universitario y Politécnico La Fe de Valencia46026 ValenciaSpain CIBERehd FIS08036 BarcelonaSpain

This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used.

关键词： Hepatocyte transplantation Hepatocyteisolation Cell therapy Inborn errors of metabolism Neonatal hepatocytes Cryopreservation