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Antimicrobial Activities of Essential Oils against Common Hospital Fungi Species

Open Journal of Preventive Medicine 2014年第10期4卷 801-807页

作者： maria Dolores Masia Silvia Deidda grazia maria Deriu Bianca maria Are Mario Chessa Giacomo Petretto Marzia Foddai Giorgio Maida Giorgio Pintore Andrea Piana Department of Biomedical Sciences Hygiene and Preventive Medicine University of Sassari Sassari Italy Department of Chemistry and Pharmacy University of Sassari Sassari Italy

Introduction: In hospitals and other healthcare settings the presence of airborne and sedimented fungi is an extrinsic risk factor for opportunistic infections involving both immunocompromised and non-immunocompromised persons. In hospitalized patients, it is estimated that 9% of hospital-acquired infections are caused by fungi. Lethality rate varies from 40% to 100% depending on the immunosuppression degree of stakeholders. To prevent healthcare-associated infections, the control of environmental fungal contamination through use of sanitizing/disinfecting practices is basic. However, the widespread use of common disinfectants could promote the growth of antibiotic-resistant superbugs and cause environmental harm. These aspects stimulated the search of new antimicrobial agents. The aim of this study was to evaluate the antimicrobial activity of essential oils of Mentha insularis Req., Mentha pulegium L., Mentha requienii Bentham, Artemisia caerulescens L. ssp. densiflora (Viv), Rosmarinus officinalis L. var. albiflorus, Rosmarinus officinalis L. var. lavandulescens, and Ocotea puchury major Mart. against fungi species frequently found in hospitals and potentially responsible for opportunistic mycoses. Methods: The essential oils’ antifungal activity was carried out by agar disc diffusion technique. Results: All tested essential oils are effective, though to a different degree, against both molds that yeasts assessed. The major antifungal activity was showed by Mentha oils. Particularly, Mentha requienii and Mentha insularis oils were active until 1:8 dilution against Rhodotorula spp. and 1:16 dilution against mixed molds, while M. pulegium was strongly active until 1:2 against both fungi. Conclusions: To the best of our knowledge, few or no data are available in literature on the activity of essential oils against hospital environmental isolates of fungi. Results suggest their potential application in sanitation procedures of the hospital, and in general, of the “ca

关键词： Hospital Environment Opportunistic Mycoses Essential Oils Antifungal Activity

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Sustainable Discoloration of Textile Chromo-Baths by Spent Mushroom Substrate from the Industrial Cultivation of Pleurotus ostreatus

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Journal of Environmental Protection 2010年第2期1卷 85-94页

作者： Simona Di Gregorio Francesco Balestri maria Basile Valentina Matteini Francesco Gini Stefania Giansanti maria grazia Tozzi Riccardo Basosi Roberto Lorenzi 不详

Synthetic dyes are recalcitrant to degradation and toxic to different organisms. Physical-chemical treatments of textile wastewaters are not sustainable in terms of costs. Biological treatments can be more convenient and the lig-nin-degrading extracellular enzymatic battery of basidiomycetes are capable to discolor synthetic dyes. Many basidi-omycetes are edible mushrooms whose industrial production generates significant amount of spent mushroom substrate (SMS) with residual high levels of lignin-degrading extracellular enzymatic activities. We have demon-strated that the low cost organic substrate, the SMS deriving from the cultivation of the basidiomycetes Pleurotus ostreatus, is able to discolor anthraquinonic, diazo and monoazo-dyes when incubated in dying chromo-reactive and chromo-acid baths containing surfactants and anti-foams, where the concentrations of the different dyes are exceeding the one recovered in the corresponding wastewaters. Laccase was the lignin-degrading extracellular enzyme involved in the discolouring process. The exploitation of the low cost SMS in the treatment of textile wastewaters is proposed. Accordingly, a toxicological assessment, based on a cyto-toxicity test on a human amnion epithelial cell line (WISH) and the estimation of the germination index (GI%) of Lactuca sativa, Cucumis sativus and Sorghum bicolor, has been performed, showing the loss of toxicity of the chromo-baths after being discoloured by the SMS.

关键词： Anthraquinonic Dye Diazo Dye Laccase Monoazo Dye White Rot Fungi Spent Mushroom Substrate

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Management of hepatitis C infection before and after liver transplantation

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World Journal of Gastroenterology 2015年第15期21卷 4447-4456页

作者： Stefano Fagiuoli Roberto Ravasio maria grazia Lucà Anna Baldan Silvia Pecere Alessandro Vitale Luisa Pasulo Gastroenterology and Transplant Hepatology Papa Giovanni XXIII Hospital PHarm ES Milano Liver Transplantation and Hepatobiliary Surgical Unit Padua University Hospital

Chronic hepatitis C(CHC) is the most common indication for liver transplantation(LT). Aggressive treatment of hepatitis C virus(HCV) infection before cirrhosis development or decompensation may reduce LT need and risk of HCV recurrence post-LT. Factors associated with increased HCV risk or severity of recurrence include older age, immunosuppression, HCV genotype 1 and high viral load at LT. HCV recurrence post-LT leads to accelerated liver disease and cirrhosis development with reduced graft and patient survival. Currently, interferon(IFN)-based regimens can be used in dualagent regimens with ribavirin, in triple-agent antiviral strategies with direct-acting antivirals(e.g., protease inhibitors telaprevir or boceprevir), or before transplant in compensated patients to reduce HCV viral load to prevent or reduce the risk of post-LT recurrence and complications; they cannot be used in patients with decompensated cirrhosis. IFN-based regimens are used in less than half of HCV-infected patients waiting for LT due to extremely low efficacy and poor tolerability. However, antiviral therapy is indicated after LT in patients with histologically confirmed CHC despite tolerability issues. Improvements in side effect management have increased survival in patients achieving therapeutic targets. HCV treatment pre- and post-LT results in significant health care costs especially when lack of efficacy leads to disease worsening, although studies have shown sofosbuvir treatment before LT vs conventional post-LT dual antiviral is cost effective. The suboptimal efficacy and tolerability of IFN-based therapies, plus the significant economic burden, means the need for effective and well tolerated IFN-free antiHCV therapy for pre- and post-LT remains high.

关键词： Hepatitis C virus Orthotopic liver trans plantation Interferon-free treatment Decompensated cirrhosis Chronic hepatitis C

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Age-specific distribution of Human Papilloma Virus (HPV) mucosal infection among young females

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Open Journal of Obstetrics and Gynecology 2011年第3期1卷 104-108页

作者： Annalisa Pieralli maria grazia Fallani Virginia Lozza Serena Corioni Manuela Longinotti Massimiliano Fambrini Carlo Penna 不详

The goal of our study was to describe the age-specific distribution of HPV genotypes and related disease among females under the age of 25 years. A prospective cohort study was carried out. We enrolled 85 young females aged 16 - 25 years (30 aged 16 - 19 and 55 aged 20 - 25 years) referred to our colposcopic unit after a repeated abnormal Pap smear result. Every patient underwent an HPV DNA testing, a colposcopy and eventually a cervical biopsy. Participants were proposed to follow-up or treatment on request. Treatment was performed by destructive or excisional laser CO2 therapy. Data were analyzed by Fisher’s Exact test. The overall prevalence of low-risk HPV amounted to 80% among 16 - 19-year-old girls, while the overall prevalence of high-risk HPV was 85.5% among 20 - 25-year-old patients. The univariate analysis of chosen characteristics of HPV-disease demonstrates the statistically significative difference of this infection between the two groups of age (P < 0.005). We observed a particular age-specific stratification of HPV genotypes and related disease, which appeared to be characterized by a cut-off at the age of 20 years. According to our data, cervical screening program in Italy seems to start later than the beginning of HPV-related pathology.

关键词： HPV Epidemiology Adolescents Genital Warts

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维纳科公园与国际雕塑创作营

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雕塑 2019年第5期 68-71页

作者： maria grazia Collini 张金佳(翻译) 不详

维纳科公园位于意大利东北部弗留利-威尼斯朱利亚大区的一个小村庄.每年六月.这里都会聚集来自世界各地雕塑家,成为一个充满活力的雕塑创作空间,一个聚会、工作和交流的场所。由"II Faro"文化协会组织的弗留利-威尼斯朱利亚国际石雕创... 详细信息

维纳科公园位于意大利东北部弗留利-威尼斯朱利亚大区的一个小村庄.每年六月.这里都会聚集来自世界各地雕塑家,成为一个充满活力的雕塑创作空间,一个聚会、工作和交流的场所。由"II Faro"文化协会组织的弗留利-威尼斯朱利亚国际石雕创作营诞生于1998年,并于2019年举办了第22届。为什么在弗留利-威尼斯朱利亚区域举办这一活动呢?

关键词：雕塑创作朱利亚维纳雕塑家威尼斯公园石雕创作意大利

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Valentino:把刺绣发挥到极致

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中国制衣 2014年第1期 22-23页

作者： maria grazia Chiuri Pier Paolo Piccioli

“我理解的高级定制不只是为了出席奢靡的场合或仪式，就算身着拼接狮首图案的双面羊绒人字呢大衣也可以走到路边挥手招出租车。”没有刺绣的高级定制，似乎少了份奢靡和看头。经过几百年的传承，刺绣是能真正体现高级定制精髓的主要元素。

关键词：刺绣定制出租车大衣羊绒双面

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Larynx Organ Preservation in Patients with Hypopharyngeal-Laryngeal Cancer

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第1期2卷 27-33页

作者： Salvatore Conticello Andrea Fulcheri Salvatore Aversa Gabriella Gorzegno Alessio Petrelli Giuseppe Malinverni Simona Allis Pietro Gabriele Cristina Ondolo maria grazia Ruo Redda Department of Medical Oncology University of Turin San Luigi Gonzaga Hospital Turin Italy Department of Otolaryngology University of Turin San Luigi Gonzaga Hospital Turin Italy Department of Radiotherapy Institute for Cancer Research and Treatment Turin Italy Epidemiology Unit Turin Italy Radiation Oncology Unit University of Turin San Luigi Gonzaga Hospital Turin Italy

Object: The therapeutic options for advanced laryngeal-hypopharyngeal cancer have broadened in the last decades, in the attempt to cure the cancer sparing laryngeal functions and to improve quality of life (functional surgery, chemo- radiotherapy, combined therapy). Methods: We propose a single-centre based retrospective study on the results of the treatment of larynx-hypopharynx cancer on the basis of the different therapies offered, focusing on advanced-stage cancers. Among 146 patients with laryngeal-hypopharyngeal cancer treated in the period 1999-2006, we focused on 64 patients with advanced stage resectable cancer. In the larynx cancer group ?n = 40-, 32 patients had surgery and 8 patients had CT-RT (refusal of laryngectomy or relative contraindications to surgery). In the hypopharynx cancer group ?n = 24-, 16 patients underwent surgery and 8 patients had CT-RT. The outcome measure considered has been overall survival. Results: Larynx cancer group. Overall survival: after surgery we observed a 3-year survival of 62%, and a 5-year survival of 44%, while after CT-RT we had a 3-year survival of 25% and a 5-year survival of 12%. Hypopharynx cancer group. Overall survival: surgery: 3-year survival: 40%, 5-year survival 32%;CT-RT: 3-year survival: 50%, 5-year survival: 34%. Conclusion: The results emphasize the use of larynx-preserving approaches for appropriately selected patients without a compromise in survival;in our case series, surgery had better outcome than CT-RT in advanced-stage larynx cancer;whilst no significant differences were observed in the treatment of hypopharynx cancer.

关键词： Advanced Laryngeal-Hypopharyngeal Cancer Survival Surgery Combined Therapy Chemoradiotherapy

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Minimally invasive surgery for paediatric inflammatory bowel disease: Personal experience and literature review

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World Journal of Gastroenterology 2015年第40期21卷 11312-11320页

作者： Alessio Pini-Prato maria grazia Faticato Arrigo Barabino Serena Arrigo Paolo Gandullia Cinzia Mazzola Nicola Disma Giovanni Montobbio Girolamo Mattioli Istituto Giannina Gaslini DINOGMI University of Genoa

The incidence of paediatric inflammatory bowel disease(PIBD) has dramatically increased in the last 20 years. Although first reported in mid 1970s',diagnostic laparoscopy has started to be routinely adopted in paediatric surgical practice since late 1990s'. Minimally invasive surgery was first limited to diagnostic purposes. After 2002 it was also applied to the radical treatment of PIBD,either Crohn's disease(CD) or Ulcerative colitis. During the last decade minimally invasive approaches to PIBD have gained popularity and have recently became the "gold standard" for the treatment of such invalidating and troublesome chronic diseases. The authors describe and track the historical evolution of minimally invasive surgery for PIBD and address all available opportunities,including most recent advancements such as robotic surgery,single port approaches and minimally invasive treatment of perianal fistulising CD. A systematic review of all series of PIBD treated with minimally invasive approaches published so far is provided in order to determine the incidence and type of patients' complications reported up to present days. The authors also describe their experience with minimally invasive surgery for PIBD and will report the results of 104 laparoscopic procedures performed in a series of 61 patients between January 2006 and December 2014.

关键词： Paediatric inflammatory bowel disease Ulcerative c

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伦敦光之瀑布住宅

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现代装饰 2019年第12期 54-63页

作者： Vincent Nowak Annarita Papeschi maria grazia Savito 刘印梅 FLOW Architecture Magrits

本案位于伦敦Kensington—条绿树成荫的宁静道路上,建筑原为维多利亚式的连栋房屋。伦敦建筑事务所FLOW Architecture和Magrits共同完成了该住宅项目的改造与扩建工作。设计团队不仅对这栋建于1851年的四层排屋进行了彻底的空间改造,并... 详细信息

本案位于伦敦Kensington—条绿树成荫的宁静道路上,建筑原为维多利亚式的连栋房屋。伦敦建筑事务所FLOW Architecture和Magrits共同完成了该住宅项目的改造与扩建工作。设计团队不仅对这栋建于1851年的四层排屋进行了彻底的空间改造,并在此基础上,增加了一个地下室和一个位于住宅后端的两层高的延伸空间。

关键词：建筑事务所空间改造住宅项目地下室改造与扩建排屋设计团队维多利亚

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Construction of a Simple Rectum Model Using Image Guidance in Prostate Patients Treated with 3D Conformal Radiotherapy

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Journal of Cancer Therapy 2014年第12期5卷 1039-1048页

作者： Marco D’Andrea maria Daniela Falco Dahlia Fedele Elisabetta Ponti Barbara Tolu Daniela Di Cristino Rosaria Barbarino Luana Di Murro grazia Tortorelli Andrea Duggento Paolo Bagalà maria Guerrisi Riccardo Santoni Laboratory of Medical Physics and Expert Systems National Cancer Institute Regina Elena Rome Italy Department of Diagnostic Imaging Molecular Imaging Interventional Radiology and Radiotherapy Tor Vergata University General Hospital Rome Italy Department of Biomedicine and Prevention Medical Physics Section Tor Vergata University Rome Italy

Purpose: To evaluate the performance of a rectum model in predicting late rectal toxicity of prostate patients undergoing 3D conformal radiation therapy while following a dietary protocol combined with image guidance. Methods: A linear accelerator equipped with a Cone Beam Computed Tomography (CBCT) system was used to treat 20 patients who were following a dietary protocol. The set-up was verified by co-registering CBCT scans with the planning CT scan (pCT). A mean dose volume histogram () as the arithmetical mean of the rectum DVHs from each CBCT scan was obtained. A suitably defined 3D rectum model (Average Rectum, AR) was defined and its DVH (DVHAR) was calculated. DVHs were also evaluated for the first five CBCT scans using both methods (5 >?and DVHAR5). The Lyman-Kutcher-Burman NTCP model with QUANTEC parameters was used to compare the calculated DVHs. The QUANTEC dose values were used to describe the time behaviour of the relative volumes using the Gamma Distribution for the frequency of the relative rectum volumes at each QUANTEC dose value. Results: No statistically significant differences between NTCPAR5 and NTCPAR and between NTCP and NTCP were found. The best agreement with the observed toxicity rate (0%) was obtained form DVHAR. The Gamma Distributions of the rectum volumes at the QUANTEC dose levels were found to be highly variable among the patients. Conclusions: Both dietary protocol and image guidance were found effective in limiting late rectal toxicity. AR was a better predictor for late rectal toxicity and better described the rectum volume during the treatment course. Finally, from the Gamma distributions, and from our toxicity data, we can suggest V75 as the best predictor of late rectal toxicity.

关键词： Organ Motion Prostate Cancer Rectal Toxicity Radiotherapy

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