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Sequential tumor-directed and lobar radioembolization before major hepatectomy for hepatocellular carcinoma

World Journal of Hepatology 2017年第36期9卷 1372-1377页

作者： Michael Vouche Thierry Degrez Fikri Bouazza Philippe Delatte maria gomez galdon Alain Hendlisz Patrick Flamen Vincent Donckier Department of Radiology Institut Jules Bordet Université Libre de Bruxelles Department of Gastroenterology CHR Sambre et Meuse Department of Abdominal Surgery Institut JulesBordet Université Libre de Bruxelles Department of Pathology Institut Jules Bordet Université Libre de Bruxelles Department of Digestive Oncology Institut Jules Bordet Université Libre de Bruxelles Department of Nuclear Medicine Institut Jules Bordet Université Libre de Bruxelles Department of Abdominal Surgery Institut Jules Bordet Centre de Chirurgie Hépato-Biliaire de l’ULB (CCHB-ULB) Université Libre de Bruxelles

Preoperative radioembolization may improve the resectability of liver tumor by inducing tumor shrinkage, atrophy of the embolized liver and compensatory hypertrophy of non-embolized liver. We describe the case of a cirrhotic Child-Pugh A patient with a segment Ⅳ hepatocellular carcinoma requiring a left hepatectomy. Preoperative angiography demonstrated 2 separated left hepatic arteries, for segment Ⅳ and segments Ⅱ-Ⅲ. This anatomic variant allowed sequential radioembolizations, delivering high-dose ^(90)Yttrium(160 Gy) to the tumor, followed 28 d later by lower dose(120 Gy) to segments Ⅱ-Ⅲ. After 3 mo, significant tumor response and atrophy of the future resected liver were obtained, allowing uneventful left hepatectomy. This case illustrates that, when anatomic disposition permits it, sequential radioembolizations, delivering different ^(90)Yttrium doses to the tumor and the future resected liver, could represent a new strategy to prepare major hepatectomy in cirrhotic patients, allowing optimal tumoricidal effect while reducing the toxicity of the global procedure.

关键词： Hepatocellular carcinoma Cirrhosis Resectability Radioembolization sequential efficacy safety

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Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第32期21卷 9666-9670页

作者： Fikri Bouazza Arthur Poncelet Camilo Alejandro Garcia Philippe Delatte Jean Luc Engelhom maria gomez galdon Amélie Deleporte Alain Hendlisz Bruno Vanderlinden Patrick Flamen Vincent Donckier Abdominal Surgery Institut Jules Bordet Université Libre de Bruxelles Nuclear Medicine Institut Jules Bordet Université Libre de Bruxelles Radiology Institut Jules Bordet Université Libre de Bruxelles Pathology Institut Jules Bordet Université Libre de Bruxelles Digestive Oncology Institut Jules Bordet Université Libre de Bruxelles Abdominal Surgery Institut Jules Bordet Centre de Chirurgie Hépato-Biliaire de l’ULB Université Libre de Bruxelles

Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver. The patient subsequently underwent extended right hepatectomy with no postoperativesigns of liver decompensation. Pathological examination demonstrated a margin-free resection and major tumor response. This new therapeutic sequence, combining efficient tumor targeting and subsequent portal vein embolization, could improve the feasibility and safety of major liver resection for hepatocellular carcinoma in patients with liver injury.

关键词： Hepatocellular carcinoma Chronic liver disease Rad

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Activation of stress-response genes by retrograde signaling-mediated destabilization of nuclear importin IMPα-9 and its interactor TPR2

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Molecular Plant 2024年第6期17卷 884-899页

作者： Liping Zeng maria Fernanda gomez Mendez Jingzhe Guo Jishan Jiang Bailong Zhang Hao Chen Brandon Le Haiyan Ke Katayoon Dehesh Department of Botany and Plant Sciences Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideRiversideCA 92521USA School of Medicine University of CaliforniaRiversideRiversideCA 92521USA

Stress-induced retrograde signal transmission from the plastids to the nucleus has long puzzled plant *** address this,we performed a suppressor screen of the ceh1 mutant,which contains elevated 2-C-methyl-d-erythritol-2,4-cyclopyrophosphate(MEcPP)levels,and identified the gain-of-function mutant impα-9,which shows reversed dwarfism and suppressed expression of stress-response genes in the ceh1 background despite heightened *** genetic and biochemical analyses established that the accumulation of MEcPP initiates an upsurge in Arabidopsis SKP1-like 1(ASK1)abundance,a pivotal component in the proteasome degradation *** increase in ASK1 prompts the degradation of IMPα-***,we uncovered a protein-protein interaction between IMPα-9 and TPR2,a transcriptional co-suppressor and found that a reduction in IMPα-9 levels coincides with a decrease in TPR2 ***,the interaction between IMPα-9 and TPR2 was disrupted in impα-9 mutants,highlighting the critical role of a single amino acid alteration in maintaining their *** of their interaction results in the reversal of MEcPP-associated *** immunoprecipitation coupled with sequencing analyses revealed that TPR2 binds globally to stress-response genes and suggested that IMPα-9 associates with the *** function together to suppress the expression of stress-response genes under normal conditions,but this suppression is alleviated in response to stress through the degradation of the suppressing *** biological relevance of our discoveries was validated under high light stress,marked by MEcPP accumulation,elevated ASK1 levels,IMPα-9 degredation,reduced TPR2 abundance,and subsequent activation of a network of stress-response *** summary,our study collectively unveils fresh insights into plant adaptive mechanisms,highlighting intricate interactions among retrograde signaling,the proteasome,and nuclear transport machinery.

关键词： plastidial retrograde signal MEcPP ASK1 impα-9 TPR2

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从美声唱法视角下对女高音咏叹调《严刑酷罚千般万种》的诠释性建议

从美声唱法视角下对女高音咏叹调《严刑酷罚千般万种》的诠释性建...

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作者： maria GUADALUPE SALAZAR gomez 成都大学

学位级别：硕士

选自沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart)的歌剧《后宫诱逃》(Die Entführung aus dem Serail)的咏叹调“Marten Aller Arten”,被认为是最具挑战性的女高音咏叹调之一。演唱这首咏叹调需要歌唱者具备较高的歌唱技... 详细信息

选自沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart)的歌剧《后宫诱逃》(Die Entführung aus dem Serail)的咏叹调“Marten Aller Arten”,被认为是最具挑战性的女高音咏叹调之一。演唱这首咏叹调需要歌唱者具备较高的歌唱技术,包含歌唱中气息的灵活性、音与音之间的过渡和衔接、可长时间保持发声与音准的气息强度。此外,还需要歌唱者拥有宽广的音域和能够随时转换音高的能力。现今大众仍普遍认同的观点是,戏剧性的声音是沉重的、强烈的、甚至阴暗的,这与敏捷、灵活与明亮的声音几乎是对立的。通常情况下,敏捷、清晰的声音会更多地与闹剧或喜剧作品联系在一起,而沉重、强烈的声音则更多地与戏剧联系在一起。本文中,笔者尝试证明这两种音色可以同时存在于一个曲目中,由抒情花腔女高音扮演的康斯坦斯这一角色正好可以证明笔者的观点。本文提出了一些可供参考的观点,以帮助读者从不同的技术角度了解女高音如何处理声区转换,以支持其在主要音域中以饱满的嗓音演唱歌曲,使声音放开,并实现咏叹调“Marten Aller Arten”所要求的戏剧性。同时,本文以意大利美声学派的原则为基础,介绍了该咏叹调的技术方法——其重点集中于四个声区:胸声区、弱混声区、强混声区和头声区。本文比较了意大利美声学派的一些歌唱方法和关于声区的不同技术的概念。尽管这些概念仍会引起混淆,但这一新的视角有助于帮助人们理解女高音声区的结构,并将其更清晰地带入实践当中。了解了这四个音区的工作原理,女高音歌唱家就能更自如地去演绎这首咏叹调,并将嗓音发挥到极致,帮助歌唱家们更深入地了解自己的“乐器”,加强声音本身的柔韧性、肌肉和嗓音的调节能力,这些都是演唱咏叹调“Marten Aller Arten”所需要的。

关键词： Marten Aller Arten 美声学派音区女高音

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A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease

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Asian Journal of Urology 2024年第2期11卷 208-220页

作者： Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya maria Borodina Georg Salomon Juan gomez Rivas Dmitry Enikeev Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Young Academic Urologists EAUthe Netherlands Department of Urology James Buchanan Brady Urological InstituteThe Johns Hopkins University School of MedicineBaltimoreUSA Department of Urology Institut Mutualiste MontsourisParisFrance Sechenov University MoscowRussia Hertsen Moscow Oncology Research InstituteMoscowRussia Hertsen Moscow Oncology Research Institute MoscowRussia Martini Clinic University Medical Center Hamburg-EppendorfHamburgGermany Department of Urology Clinico San Carlos University HospitalMadridSpain Department of Urology Medical University of ViennaViennaAustria

Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this ***: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional ***: In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, p=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% vs. 90.8%, p<0.0001). Severe incontinence occurred seldom (2.5%-18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%.Conclusion: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.

关键词： Systematicreview Prostatecancer Oligometastatic Bone metastases Cytoreductive prostatectomy

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto gomez-Carballa maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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Effect of synthesis variables of plasma synthesized polymers on growth of HepG2 cells

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BIOCELL 2017年第2期41卷 41-43页

作者： ELIZABETH PEREZ-TEJADA JUAN MORALES-CORONA LUIS ERNESTO gomez-QUIROZ maria CONCEPCIONGUTIERREZ-RUIZ ROBERTO OLAYO Departamento de Química.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Ciencias de la Salud.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaCDMXCP 09340 Departamento de Física.Universidad Autónoma Metropolitana Unidad IztapalapaApdo.Postal 55-534IztapalapaMéxicoD.F.CP 09340 CECyT No.8 Instituto Politécnico NacionalAve.de las Granjas 618Jardín AzpeitiaAzcapotzalcoCDMXCP 02530

Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both *** were polymerized on glass substrates under the same reaction *** of allylamine was also studied at different operating *** thin polymer films were used as culture surfaces for HepG2 cells,a cell line derived from a human *** proliferation,differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis,the physicochemical characteristics obtained and the performance as substrates for the cellular growth.

关键词： Hepatocytes Pyrrole Allylamine Plasma Polymerization

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Influence of in vitro capacitation time on structural and functional human sperm parameters

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Asian Journal of Andrology 2020年第5期22卷 447-453页

作者： Paula Saez-Espinosa Natalia Huerta-Retamal Laura Robles-gomez Manuel Aviles Jon Aizpurua Irene Velasco Alejandro Romero maria Jose gomez-Torres Department of Biotechnology Faculty of ScienceUniversity of AlicanteAlicante 03080Spain FISABI0-University Hospital of San Juan de Alicante Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Departm ent of Cell Biology and Histology Faculty of MedicineUniversity of Murcia and IMIB-ArrixacaMurcia 30100Spain IVF Spain Reproductive MedicineAlicante 03540Spain University Hospital of San Juan de Alicante Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Human Fertility Cathedra University of AlicanteAlicante 03080Spain.

A cascade of dramatic physiological events is linked to the sperm acrosome reaction and binding to the oocyte's zona pellucida during human sperm ***,structural and functional sperm changes during capacitation currently remain poorly ***,we performed a multibiomarker approach based on the utilization of sperm concentration,motility,viability,morphology,acrosome reaction,tyrosine phosphorylation,DNA fragmentation,and lectin-binding sites to analyze the impact caused by swim-up selection times(uncapacitated,1 h capacitated,and 4 h capacitated)on sperm function and structure in normozoospermic *** found that a 4 h swim-up capacitation increased sperm quality,because a large number of cells with normal morphology and lower DNA fragmentation rates were ***,the long-term capacitation induced a higher percentage of cells with tyrosine phosphorylation of the principal piece as well as a redistribution of lectin-binding ***,the multivariate biomarkers analyzed showed a less variable distribution on spermatozoa recovered after 4 h capacitation than that with the shorter capacitation *** findings stress the importance of capacitation time as a relevant factor in sperm quality with potential biological reproductive implications both for basic research and in assisted reproduction techniques.

关键词： acrosome reaction capacitation DNA fragmentation glycocalyx lectin-binding sites membrane integrity protein phosphorylation sperm selection

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Optimal Coordinated Operation of Distributed Static Series Compensators for Wide-area Network Congestion Relief

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1374-1384页

作者： Camilo Andres Ordonez M Antonio gomez-Exposito Guillermo EVinasco M Jose maria Maza-Ortega IEEE Smart Wires Union CityUSA Department of Electrical Engineering University of SevilleSevillaSpain Interconexion Electrica SA Intercolombia Sevilla Spain

Relieving network congestions is a critical goal for the safe and flexible operation of modern power systems, especially in the presence of intermittent renewables or distributed generation. This paper deals with the real-time coordinated operation of distributed static series compensators(DSSCs) to remove network congestions by suitable modifications of the branch reactance. Several objective functions are considered and discussed to minimize the number of the devices involved in the control actions, the total losses or the total reactive power exchanged, leading to a non-convex mixed-integer non-linear programming problem. Then, a heuristic methodology combining the solution of a regular NLP with k-means clustering algorithm is proposed to get rid of the binary variables, in an attempt to reduce the computational cost. The proposed coordinated operation strategy of the DSSCs is tested on several benchmark systems, providing feasible and sufficiently optimal solutions in a reasonable time frame for practical systems.

关键词： Distributed static series compensation(DSSC) flexible AC transmission system(FACTS) mixed-integer non-linear programming(MINLP) wide-area network control

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中国与拉丁美洲及加勒比地区国家战略结盟的可行性及对策研究

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商场现代化 2008年第8期 21-23页

作者：孙赫 maria Juliana gomez 上海大学

本文阐述了中国与拉丁美洲及加勒比地区国家经济及政治合作的状况,对双方进行战略结盟的有利因素和不利因素进行了详细分析,论述了中国与拉丁美洲及加勒比地区国家战略结盟的可行性,并针对存在的主要问题提出了相应的对策建议。

关键词：中国拉丁美洲加勒比战略结盟

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