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Computational Stochastic Investigations for the Socio-Ecological Dynamics with Reef Ecosystems

Computers, Materials & Continua 2022年第12期73卷 5589-5607页

作者： Thongchai Botmart Zulqurnain Sabir Afaf S.Alwabli Salem Ben Said Qasem Al-Mdallal maria emilia camargo Wajaree Weera Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen 40002Thailand Department of Mathematical Sciences United Arab Emirates UniversityP.O.Box 15551Al AinUAE Department of Mathematics and Statistics Hazara UniversityMansehraPakistan Department of Biological Sciences Rabigh College of Science and ArtsKing Abdulaziz UniversityJeddahSaudi Arabia Graduate Program in Administration Federal University of Santa MariaSanta Maria 93458Brazil

The motive of this work is to present a computational design using the stochastic scaled conjugate gradient(SCG)neural networks(NNs)called as SCGNNs for the socio-ecological dynamics(SED)with reef ecosystems and conservation *** mathematical descriptions of the SED model are provided that is dependent upon five categories,macroalgae M(v),breathing coral C(v),algal turf T(v),the density of parrotfish P(v)and the opinion of human opinion X(v).The stochastic SCGNNs process is applied to formulate the SEDmodel based on the sample statistics,testing,accreditation and *** different variations of the SED have been provided to authenticate the stochastic SCGNNs performance through the statics for training,accreditation,and testing are 77%,12%and 11%,*** obtained numerical performances have been compared with the Runge-Kutta approach to solve the *** reduction of mean square error(MSE)is used to investigate the numericalmeasures through the SCGNNs for solving the SED *** precision of the SCGNNs is validated through the comparison of the results and the absolute error *** reliability of the SCGNNs is performed by using the correlation values,state transitions(STs),error histograms(EHs),MSE measures and regression analysis.

关键词： Socio-ecological state conservation estimation neural networks reef ecosystems scaled conjugate gradient numerical study

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An Artificial Approach for the Fractional Order Rape and Its Control Model

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Computers, Materials & Continua 2023年第2期74卷 3421-3438页

作者： Wajaree Weera Zulqurnain Sabir Muhammad Asif Zahoor Raja Salem Ben Said maria emilia camargo Chantapish Zamart Thongchai Botmart Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen40002Thailand Department of Mathematics Near East UniversityNicosia99138Cyprus Future Technology Research Center National Yunlin University of Science and TechnologyDouliouYunlin64002Taiwan Department of Mathematical Science College of ScienceUnited Arab Emirates UniversityAl AinAbu Dhabi15551UAE Graduate Program in Administration Federal University of Santa MariaSanta Maria93458Brazil

The current investigations provide the solutions of the nonlinear fractional order mathematical rape and its controlmodel using the strength of artificial neural networks(ANNs)along with the Levenberg-Marquardt backpropagation approach(LMBA),i.e.,artificial neural networks-Levenberg-Marquardt backpropagation approach(ANNs-LMBA).The fractional order investigations have been presented to find more realistic results of the mathematical form of the rape and its control *** differential mathematical form of the nonlinear fractional order mathematical rape and its control model has six classes:susceptible native girls,infected immature girls,susceptible knowledgeable girls,infected knowledgeable girls,susceptible rapist population and infective rapist *** rape and its control differential system using three different fractional order values is authenticated to perform the correctness of *** data is used to present the rape and its control differential system is designated as 70%for training,14%for authorization and 16%for *** obtained performances of the ANNs-LMBA are compared with the dataset of the Adams-Bashforth-Moulton *** substantiate the consistency,aptitude,validity,exactness,and capability of the LMBA neural networks,the obtained numerical values are provided using the state transitions(STs),correlation,regression,mean square error(MSE)and error histograms(EHs).

关键词： Rape and its control differential system neural networks fractional order levenberg-marquardt backpropagation approach reference solutions

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Artificial intelligence as a tool in drug discovery and development

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World Journal of Experimental Medicine 2024年第3期14卷 11-19页

作者： maria Kokudeva Mincho Vichev emilia Naseva Dimitrina Georgieva Miteva Tsvetelina Velikova Department of Pharmacology and Toxicology Faculty of PharmacyMedical University of SofiaSofia 1000Bulgaria Healthcare Solutions Sofia 1404Bulgaria Faculty of Public Health Medical University of SofiaSofia 1431Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria Tsvetelina Velikova Medical FacultySofia University St.Kliment OhridskiSofia 1407Bulgaria

The rapidly advancing field of artificial intelligence(AI)has garnered substantial attention for its potential application in drug discovery and *** opinion review critically examined the feasibility and prospects of integrating AI as a transformative tool in the pharmaceutical ***,encompassing machine learning algorithms,deep learning,and data analytics,offers unprecedented opportunities to streamline and enhance various stages of drug *** opinion review delved into the current landscape of AI-driven approaches,discussing their utilization in target identification,lead optimization,and predictive modeling of pharmacokinetics and *** aimed to scrutinize the integration of large-scale omics data,electronic health records,and chemical informatics,highlighting the power of AI in uncovering novel therapeutic targets and accelerating drug repurposing *** the considerable potential of AI,the review also addressed inherent challenges,including data privacy concerns,interpretability of AI models,and the need for robust validation in realworld clinical ***,we explored ethical considerations surrounding AI-driven decision-making in drug *** opinion review provided a nuanced perspective on the transformative role of AI in drug discovery by discussing the existing literature and emerging trends,presenting critical insights and addressing potential *** conclusion,this study aimed to stimulate discourse within the scientific community and guide future endeavors to harness the full potential of AI in drug development.

关键词： Artificial intelligence Drug discovery Drug development Decision-making AI-driven medicine Healthcare Public health

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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da Silva Abreu Taysse Holanda Joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio Silva dos Santos Thais Benincá Patrícia da Silva Malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle maria Madalena de camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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Designs andmethodologies to recreate in vitro human gutmicrobiota models

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Bio-Design and Manufacturing 2023年第3期6卷 298-318页

作者： Francesco Biagini Costanza Daddi Marco Calvigioni Carmelo De maria Yu Shrike Zhang emilia Ghelardi Giovanni Vozzi Research Center(E.Piaggio) University of PisaPisaItaly Department of Information Engineering University of PisaPisaItaly Department of Translational Research and New Technologies in Medicine and Surgery University of PisaPisaItaly Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMAUSA

The human gut microbiota is widely considered to be a metabolic organ hidden within our bodies,playing a crucial role in the host’s *** factors affect its composition,so a wide variety of microbes residing in the gut are present in the world *** excessive imbalances in microbial composition are often associated with human disorders and pathologies,and new investigative strategies to gain insight into these pathologies and define pharmaceutical therapies for their treatment are *** vitro models of the human gut microbiota are commonly used to study microbial fermentation patterns,community composition,and host-microbe *** and microfluidic devices have been designed to culture microorganisms from the human gut microbiota in a dynamic environment in the presence or absence of eukaryotic cells to interact *** this review,we will describe the overall elements required to create a functioning,reproducible,and accurate in vitro culture of the human gut *** addition,we will analyze some of the devices currently used to study fermentation processes and relationships between the human gut microbiota and host eukaryotic cells.

关键词： Gut microbiota In vitro models Bioreactors Host-microbiome Fermentation

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National trend of heart failure and other cardiovascular diseases in people living with human immunodeficiency virus

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World Journal of Cardiology 2022年第7期14卷 427-437页

作者： Dae Yong Park Seokyung An maria emilia Romero Mukunthan Murthi Ramtej Atluri Department of Medicine Cook County HealthChicagoIL 60612United States Department of Biomedical Science Seoul National University Graduate SchoolSeoul 03080South Korea Department of Medicine John H.StrogerJr.Hospital of Cook CountyChicagoIL 60612United States

BACKGROUND As people living with human immunodeficiency virus(HIV)(PLWH)enjoy longer life expectancy with highly effective antiretroviral therapy,they are encountering challenging cardiovascular health *** To retrospectively examine the increasing burden of cardiovascular diseases in PLWH over the past *** All hospitalizations for heart failure(HF),ischemic heart disease(IHD),and cerebrovascular disease(CeVD)in PLWH were identified using the International Classification of Diseases,Ninth Revision,Clinical Modification(ICD-9-CM)and ICD-10-CM codes in the National Inpatient Sample from 2008 to *** included number of hospitalizations,in-hospital mortality,length of stay,and total hospital *** of the outcomes from 2008 to 2018 were analyzed using Cochran-Armitage_(trend)test and simple linear *** The number of hospitalizations for HF in PLWH increased from 4212 in 2008 to 6700 in 2018(P_(trend)<0.01).Similar increasing_(trend)was seen with those for IHD and CeVD over the decade(P_(trend)<0.01).A decreasing_(trend)of in-hospital mortality was observed in all hospitalizations of PLWH(P_(trend)<0.01)and CeVD in PLWH(P_(trend)<0.01),but not in those for HF(P_(trend)=0.67)and IHD(P_(trend)=0.13).The_(trend)of length of stay was decreasing in all hospitalizations of PLWH(P_(trend)<0.01),but increasing in those for HF in PLWH(P_(trend)<0.01).An increasing_(trend)of total hospital charge was observed in hospitalizations for HF,IHD,and CeVD(P_(trend)<0.01).CONCLUSION The burden of cardiovascular diseases has significantly increased in hospitalizations of PLWH from 2008 to *** efforts are needed to address the additional cardiovascular risks in this vulnerable population.

关键词： Cardiovascular Heart failure Trend Human immunodeficiency virus People living with human immunodeficiency virus

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Giant splenic artery aneurysm presenting with massive upper gastrointestinal bleeding:A case report and review of literature

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World Journal of Gastroenterology 2020年第22期26卷 3110-3117页

作者： Francesco Panzera Riccardo Inchingolo Marina Rizzi Assunta Biscaglia maria Grazia Schievenin emilia Tallarico Giancarlo Pacifico Beatrice Di Venere Division of Gastroenterology Department of SurgeryMadonna delle Grazie HospitalMatera 75100Italy Division of Interventional Radiology Department of RadiologyMadonna delle Grazie HospitalMatera 75100Italy Department of Intensive Care Madonna delle Grazie HospitalMatera 75100Italy Department of Pathology Madonna delle Grazie HospitalMatera 75100Italy Division of General Surgery Department of SurgeryMadonna delle Grazie HospitalMatera 75100Italy

BACKGROUND Splenic artery aneurysm(SAA)and pseudoaneurysm are rare vessel’s *** is often symptomatic and secondary to pancreatitis or *** SAA is the most common aneurysm of visceral *** contrast to pseudoaneurysm,SAA is usually asymptomatic until the rupture,with high mortality *** clinical onset of SSA’s rupture is a massive life-threatening bleeding with hemodynamic instability,usually into the free peritoneal space and more rarely into the gastrointestinal *** SUMMARY We describe the case of a 35-year-old male patient,with negative past medical history,who presented to the emergency department for massive upper gastrointestinal bleeding,severe anemia and *** esophagogastroduodenoscopy performed in emergency showed a gastric bulging in the greater curvature/posterior wall with a small erosion on its surface,with a visible vessel,but no active *** injection therapy with cyanoacrylate glue was *** contrast-enhanced computed tomography was carried out due to the clinical scenario and the unclear endoscopic aspect:The radiological examination showed a giant SAA which was adherent to posterior stomach wall,and some smaller aneurysms of the left gastric and ileocolic *** of the high risk of a two-stage rupture of the giant SAA with dramatic outcome,the patient underwent immediate open surgery with aneurysmectomy,splenectomy and distal pancreatectomy with a good postoperative *** The management of a ruptured giant SAA into the stomach can be successful with surgical approach.

关键词： Splenic artery aneurysm Upper gastrointestinal bleeding Hemorrhagic shock Computed tomography Endoscopy Case report

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Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice

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World Journal of Gastroenterology 2018年第18期24卷 1995-2008页

作者： maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A camargo Gabriela F Persinoti José Barreto C Carvalheira Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP) Brazilian Bioethanol Science and Technology Laboratory (CTBE) Brazilian Center for Research in Energy and Materials (CNPEM)

AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC.

关键词： Intestinal microbiota Chemoprevention Lactobacillus acidophilus Lactobacillus rhamnosus Bifidobacterium bifidum

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Shared-role of vegetation types,elevation and soil affecting plant diversity in an old-tropical mountain hotspot

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Journal of Mountain Science 2023年第7期20卷 1842-1853页

作者： Priscilla P.LOIOLA Leonor Patrícia Cerdeira MORELLATO maria Gabriela Gutierrez camargo Vitor A.KAMIMURA Jacqueline S.MATTOS Annia Susin STREHER Soizig LE STRADIC Department of Biodiversity Laboratory of PhenologySão Paulo State University(UNESP)Av 24A 151513506-900Rio ClaroSão PauloBrazil Instituto Tecnológico Vale(ITV) R.Boaventura da Silva955BelémPará66055-090Brazil Laboratory of Evolutionary Ecology and Plant Genomics Department of Plant BiologyInstitute of BiologyUniversity of CampinasBrazil Earth Observation and Geoinformatics Division National Institute for Space Research(INPE)São Josédos CamposBrazil French National Institute for Agriculture Foodand Environment(INRAE)UMR 1202 INRAE/Univ Bordeaux-BIOGECOParisFrance

Despite the exceptional species richness and endemism,the environmental drivers of plant diversity along old tropical mountains remain *** respective importance of vegetation types,elevation,slope,and soil to drive diversity across life-forms is poorly ***,we tested whether environmental variables drove local and regional plant diversity along an old tropical mountain according to the three main life-forms:graminoids,herbaceous and woody *** sampled all Angiosperm species on 180 plots across five elevations,at the tropical old-mountain region of Serra do Cipó,South-eastern *** assessed soil,slope,and vegetation types,and calculated richness and beta-diversity,applying generalized least square models,linear mixed-models and partial Mantel tests to test for *** of graminoids and herbaceous species increased with greater elevation and more nutrient-impoverished soils,while woody richness showed the inverse ***-diversity was primarily driven by species turnover,correlated with elevation and soil and higher in less dominant vegetation types,with unique *** the limited elevational range in these old mountains,it still played an important role in filtering woody species,while fostering graminoid and herbaceous *** and restoration actions need to foster the high regional diversity supported by the old mountain heterogeneous landscape and the diversity of life-forms,especially the dominant and highly diverse grassy component.

关键词： Beta-diversity Campos rupestres Cerrado Grassland Herbaceous Species turnover

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