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Systematic review of ablative therapy for the treatment of renal allograft neoplasms

World Journal of Clinical Cases 2019年第17期7卷 2487-2504页

作者： Evaldo Favi Nicholas Raison Federico Ambrogi Serena Delbue maria chiara clementi Luca Lamperti Marta Perego Matteo Bischeri mariano Ferraresso Renal Transplantation Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilan 20122Italy MRC Centre for Transplantation King’s College LondonLondon WC2R 2LSUnited Kingdom Department of Clinical Sciences and Community Health University of MilanMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20100Italy

BACKGROUND To date,there are no guidelines on the treatment of solid neoplasms in the transplanted ***,allograft nephrectomy has been considered the only reasonable *** recently,nephron-sparing surgery (NSS) and ablative therapy (AT) have been proposed as alternative procedures in selected *** To review outcomes of AT for the treatment of renal allograft *** We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 *** was searched in March 2019 without time restrictions for all papers reporting on radiofrequency ablation (RFA),cryoablation (CA),microwave ablation (MWA),high-intensity focused ultrasound (HIFU),and irreversible electroporation (IRE) of solid tumours of the kidney *** original manuscripts describing actual cases and edited in English were *** relevant articles were accessed in full *** searches included all pertinent *** studies were also assessed for methodological quality using a tool based on a modification of the Newcastle Ottawa *** on recipient characteristics,transplant characteristics,disease characteristics,treatment protocols,and treatment outcomes were extracted and *** the nature and the quality of the studies available (mostly retrospective case reports and small retrospective uncontrolled case series),a descriptive summary was *** Twenty-eight relevant studies were selected describing a total of 100 AT procedures in 92 *** age at diagnosis ranged from 21 to 71 years whereas time from transplant to diagnosis ranged from 0.1 to 312 *** of the neoplasms were asymptomatic and diagnosed incidentally during imaging carried out for screening purposes or for other clinical *** diagnostic modality was Doppler-ultrasound scan followed by computed tomography scan,and magnetic resonance *** tumour types were: pa

关键词： Ablative therapy Cryoablation Radiofrequency ablation Microwave ablation High-intensity focused ultrasonography Irreversible electroporation Neoplasm Kidney transplant Renal allograft Systematic review

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Safety and feasibility of thullium laser transurethral resection of prostate for the treatment of benign prostatic enlargement in overweight patients

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Asian Journal of Urology 2019年第3期6卷 270-274页

作者： Luca Carmignani maria chiara clementi Claudia Signorini Gloria Motta Sebastiano Nazzani Franco Palmisano Elisa De Lorenzis Michele Catellani Alessandro Francesco Mistretta Andrea Conti Valeria Tringali maria Beatrice Costa Damiano Vizziello Policlinico San Donato UrologySan DonatoMilaneseItaly Ospedale Maggiore Policlinico UrologyMilanItaly Istituto Europeo di Oncologia UrologyMilanItaly Ospedale San Giuseppe UrologyMilanItaly

Objective:We aimed to determine safety and feasibility of thulium laser transurethral vapoenucleation of prostate(ThuVEP)for treatment of obese patients affected by benign prostatic hyperplasia(BPH).Methods:We retrospectively analysed data of 452 patients with BPH who underwent ThuVEP from February 2012 to March 2016 in a single *** were divided into three groups according to body mass index(BMI,kg/m^2):Normal weight(18.5≤BMI0.05).There was no statistically significant difference among three groups as for hospital stay and days of catheterization(p>0.05).Conclusion:Our results showed that ThuVEP was safe and feasible even in overweight patients with substantially enlarged prostate.

关键词： Laser Thulium Prostate Overweight

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Evolution of computers and simulations: from science and technology to the foundations of society

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Science China Chemistry 2014年第10期57卷 1317-1329页

作者： clementi Enrico International Academy of Quantum Molecular Science

We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.

关键词： constraints for Homo Sapiens evolution of continents human life electronic computers knowledge the scientificmethod vs. tradition computational chemistry inter-disciplinary science

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Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients

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Journal of Pharmaceutical Analysis 2016年第6期6卷 396-403页

作者： Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo Emilio clementi Unit of Clinical Pharmacology Department of Biomedical and Clinical Sciences L. Sacco University Hospital Università di Milano 20157 Milan Italy Clinical Pharmacology Unit CNR Institute of Neuroscience Department of Biomedical and Clinical Sciences L. Sacco University Hospital Università di Milano 20157 Milan Italy Scientific Institute IRCCS Eugenio Medea Bosisio Parini Italy

A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human *** the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of *** chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run *** curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all *** intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs *** solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in *** extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring.

关键词： HPLC–UV Antiretrovirals Bioanalytical method validation

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Soil bacterial communities under slash and burn in Mozambique as revealed by a metataxonomic approach

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Pedosphere 2023年第3期33卷 508-520页

作者： Dominique SERRANI Ilario FERROCINO Cristiana GAROFALO Andrea OSIMANI maria Rita CORVAGLIA Vesna MILANOVIĆ Lucia AQUILANTI Stefania COCCO Valeria CARDELLI Rogério Borguete Alves RAFAEL Elena FRANCIOSI Kieran TUOHY Francesca clementi Giuseppe CORTI Department of Agriculture Food and Environmental SciencesPolytechnic University of MarcheAncona 60131(Italy) Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco 10095(Italy) Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257(Mozambique) Research and Innovation Center Fondazione Edmund Mach(FEM)San Michele all'Adige 38010(Italy)

The slash-and-burn system is a subsistence agronomical practice widespread in tropical areas *** system has been extensively studied,especially for its impacts on agronomical aspects and soil physicochemical properties;however,knowledge of soil microbial diversity under slash and bum is *** this study,for the first time,soil bacterial diversity of three locations from Central Mozambique,where slash and burn has been practiced for different durations of the forest fallow period(ca.25,35,and 50 years),was elucidated through a metataxonomic *** communities were evaluated in the genetic horizons of soils under charcoal kilns,crop fields,and *** aim of this study was to examine the influence of spatial(location and land use),temporal(forest fallow period),and vertical(horizon)variations on bacterial community structure in relation to soil physicochemical *** analysis detected 25 different phyla whose distribution varied horizontally and vertically in relation to soil properties(i.e.,p H,easily oxidizable organic carbon,total nitrogen,and available phosphorus),as well as particle size distribution and mineralogical *** properties were strongly affected and altered by land-use management;in particular,charcoal kilns exhibited better soil properties and greater differences in bacterial community than crop fields and forests,which were quite *** might suggest the inability of a forest fallow period shorter than 50 years to improve soil fertility and induce changes in bacterial *** uncommon application of the pedological approach for microbial evaluation facilitated the detection of a clear separation in bacterial composition along the soil profile,with eutrophic bacteria mainly located in the A horizon whereas oligotrophic bacteria were found in the Bo *** horizontal and vertical heterogeneities in the same study represent a novelty for bacterial metataxonomic analysis.

关键词： 16S rRNA gene agroforestry land use soil microbiota soil physicochemical property

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Capillary hydrodynamic fractionation of hydrophobic colloids:Errors in the estimated particle size distribution

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Particuology 2014年第6期12卷 97-105页

作者： Luis A.clementi Zohartze Artetxe Ziortza Aguirreurreta Amaia Agirre Jose R.Leiza Luis M.Gugliotta Jorge R.Vega INTEC(CONICET and Universidad Nacional del Litoral) FRSF-UTN(Facultad Regional Santa Fe-Universidad Tecnologica Nacional) POLYMAT Kimika Aplikatua SailaKimika Zientzien FakultateaUniversity of the Basque Country UPV/EHUJoxe Mari Korta Zentroa

Capillary hydrodynamic fractionation（CHDF） with turbidity detection at a single wavelength is an analytical technique that is often used for sizing the sub-micrometric particles of hydrophobic *** article investigates three sources of errors that affect the particle size distribution（PSD） estimated by CHDF：diameter calibration errors,uncertainties in the particle refractive index（PRI）,and instrumental broadening（IB）.The study is based on simulated and experimental examples that involve unimodal and bimodal *** errors in the diameter calibration curve can produce important deviations in the number average diameter due to systematic shifts suffered by the PSD *** uncertainties in the PRI are unimportant in the analysis of unimodal PSDs,but in the specific case of bimodal PSDs,errors in the PRI can strongly affect the estimated number concentration of each *** typical IB correction（based on the IB function estimated from narrow standards） produces slightly erroneous average diameters but can lead to PSDs with underestimated widths and distorted *** practice,the three investigated sources of errors can be present simultaneously,and uncertainties in the average diameters,the shape and width of the PSD,and the number concentration of the PSD modes are unavoidable.

关键词： Particle size distribution Capillary hydrodynamic fractionation Nanoparticle Particle refractive index Instrumental broadening

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A chip-scale second-harmonic source via self-injection-locked all-optical poling

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Light(Science & Applications) 2023年第12期12卷 2778-2787页

作者： Marco clementi Edgars Nitiss Junqiu Liu Elena Durán-Valdeiglesias Sofiane Belahsene Hélène Debrégeas Tobias JKippenberg Camille-Sophie Brès Photonic Systems Laboratory(PHOSL) École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Laboratory of Photonics and Quantum Measurements(LPQM) École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Almae Technologies Route de Nozay91460 MarcoussisFrance

Second-harmonic generation allows for coherently bridging distant regions of the optical spectrum,with applications ranging from laser technology to self-referencing of frequency ***,accessing the nonlinear response of a medium typically requires high-power bulk sources,specific nonlinear crystals,and complex optical setups,hindering the path toward large-scale *** we address all of these issues by engineering a chip-scale second-harmonic(SH)source based on the frequency doubling of a semiconductor laser self-injection-locked to a silicon nitride *** injection-locking mechanism,combined with a high-Q microresonator,results in an ultra-narrow intrinsic linewidth at the fundamental harmonic frequency as small as 41 *** to the extreme resonant field enhancement,quasi-phase-matched second-order nonlinearity is photoinduced through the coherent photogalvanic effect and the high coherence is mapped on the generated SH *** show how such optical poling technique can be engineered to provide efficient SH generation across the whole C and L telecom bands,in a reconfigurable fashion,overcoming the need for poling *** device operates with milliwatt-level pumping and outputs SH power exceeding 2 mW,for an efficiency as high as 280%/W under electrical *** findings suggest that standalone,highly-coherent,and efficient SH sources can be integrated in current silicon nitride photonics,unlocking the potential of x(2)processes in the next generation of integrated photonic devices.

关键词： resonator harmonic injection

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从原子到大分子体系的计算机模拟——计算化学50年

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化学进展 2011年第9期23卷 1795-1830页

作者： Enrico clementi Giorgina Corongiu 帅志刚马忠云张天尚远 Via Carloni 38 22100 ComoItaly Dipartimento di Scienze Chimiche e Ambientali Università dell'Insubria 清华大学化学系

本文综述并修订了从20世纪50年代末至今,我们在计算化学领域所做的一些有意义的工作。序言部分把我们的工作置于当代科学的背景之下。然后我们以一种经典的基准测试体系——一种新的单粒子表象(即替代传统的原子和分子自旋轨道的化学自... 详细信息

本文综述并修订了从20世纪50年代末至今,我们在计算化学领域所做的一些有意义的工作。序言部分把我们的工作置于当代科学的背景之下。然后我们以一种经典的基准测试体系——一种新的单粒子表象(即替代传统的原子和分子自旋轨道的化学自旋轨道)所构建的氢分子(H2)波函数——作为开始。用Hartree-Fock-Heitler-London(HF-HL)对从双原子分子到小的多原子分子进行计算所得的结果,与用传统的Hartree-Fock(HF)和Heitler-London(HL)计算的结果进行了对比;我们推断出,使用HF-HL水平的解决方案是计算量子化学的一个通用而且合理的选择。此外,我们也指出用化学自旋轨道构建的波函数,与HF-HL模型所得的波函数是等同的。除了这些计算之外,我们还对相关能、威格纳(Wigner)和库仑空穴(Coulomb Hole)泛函进行了评判性分析。上述研究工作是Hartree-Fock早期工作的继承与发展,这一时期以对原子和分子体系的先驱性计算为特征,包括基组优化、在HF和后HF(post Hartree-Fock)方法水平上的原子能量表格化以及用超级分子方法获得势能面。但是,要处理大分子体系并清楚地考察温度和时间,我们必须改用统计方法;我们回顾了用蒙特卡罗(Monte Carlo)、分子动力学和朗之万(Langevin)动力学,首先针对平衡的体系,而后在非平衡的开放体系中的模拟。对把这些模型联合起来建立的全局模拟法,也进行了详细的讨论。以上所有的工作既需要计算机硬件,也需要应用于计算化学各分支的程序。本文重温了过去半个世纪中人们编写、存档、免费发布的量子化学原子和分子程序以及统计力学程序。也回顾了20世纪80年代初,我们在设计和组装并行性超级计算机架构方面所做的先驱性工作,这些工作实现了计算化学上的第一个大规模并行计算。

关键词：全局模拟量子化学平衡和非平衡动力学生物分子计算机设计并行性

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双峰分布颗粒体系的多角度动态光散射数据反演（英文）

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光子学报 2017年第2期46卷 121-132页

作者：徐敏申晋朱新军 THOMAS John C clementi Luis A VEGA Jorge R 山东理工大学电气与电子工程学院山东淄博255049 天津工业大学电气工程与自动化学院天津300387 Group Scientific Pty Ltd 23 Pine Lodge Crescent Institute of Technological Development for the Chemical Industry(INTEC UNL-CONICET)

采用多角度动态光散射和加权正则化反演方法,对4组模拟的双峰分布颗粒体系(100/600nm,200/600nm,300/600nm和350/600nm)分别选取1、3、6和10个散射角进行测量.粒度反演结果表明,采用加权正则化方法反演双峰颗粒体系的多角度动态光散射... 详细信息

采用多角度动态光散射和加权正则化反演方法,对4组模拟的双峰分布颗粒体系(100/600nm,200/600nm,300/600nm和350/600nm)分别选取1、3、6和10个散射角进行测量.粒度反演结果表明,采用加权正则化方法反演双峰颗粒体系的多角度动态光散射测量数据,可获得峰值位置比小于2∶1且含有大粒径(>350nm)颗粒的双峰颗粒粒度分布.采用标准聚苯乙烯乳胶颗粒进行实测的结果验证了这一结论.得到含大粒径颗粒的双峰粒度分布反演结果的原因在于,多角度动态光散射能提供更多的大粒径颗粒的粒度信息,加权正则化反演方法能减少测量数据中的噪声,因而多角度动态光散射测量数据的加权反演能实现峰值位置比小于2∶1且含有大粒径颗粒的双峰颗粒体系的测量.

关键词：动态光散射粒度分布加权约束正则化峰值位置比吉洪诺夫正则化

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Mixture Optimization by the CARSO Procedure and DCM Strategies

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Applied Mathematics 2014年第19期5卷 3026-3039页

作者： Sergio clementi Mauro Fernandi Diego Decastri Matteo Bazzurri Chemistry Department University of Perugia Perugia Italy M.I.A. Multivariate Infometric Analysis Srl Perugia Italy Flint Group Italia Cinisello Balsamo Milano Italy

The paper illustrates a new way of using the CARSO procedure for response surfaces analyses derived from innovative experimental designs in multivariate spaces, based on Double Circulant Matrices (DCMs). We report a case study regarding a design based on a DCM for 4 variables. The final response surface model is obtained by the formerly developed CARSO method.

关键词： CARSO Procedure Design Strategies Circulant Matrices (DCM) Optimization

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