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基于总体死亡风险构建优化减瘤性肾切除术患者选择的IMDC-Olig模型

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临床泌尿外科杂志 2022年第9期37卷 655-660,664页

作者：李明敏吴震杰 maria carmen mir Michele Marchioni 陈琪徐逸凡宋家璈张超杨波冯翔王林辉海军军医大学第一附属医院(上海长海医院)放射科上海200433 海军军医大学第一附属医院(上海长海医院)泌尿外科西班牙瓦伦西亚肿瘤研究所泌尿外科意大利克耶地-佩斯卡拉邓南遮大学Annunziata医院泌尿外科海军军医大学军队卫生统计学教研室

目的:探索国际转移肾癌数据库联盟(International mRCC Database Consortium,IMDC)危险分层以外可以独立预测减瘤性肾切除术后患者总体死亡风险的因素,并构建联合预测模型,以指导手术适应证选择。方法:回顾性分析来自国际减瘤性肾切除... 详细信息

目的:探索国际转移肾癌数据库联盟(International mRCC Database Consortium,IMDC)危险分层以外可以独立预测减瘤性肾切除术后患者总体死亡风险的因素,并构建联合预测模型,以指导手术适应证选择。方法:回顾性分析来自国际减瘤性肾切除术临床研究协作组(International Consortium of Clinical Research on Cytoreductive Nephrectomy)全球13个医学中心减瘤性肾切除术治疗转移性肾癌264例患者资料,中位年龄63岁,男性占比73.9%,66.7%的患者合并肺转移,26.5%的患者合并骨转移,寡转移患者占比73.3%,IMDC中高危占比63.3%。基于Cox多因素分析结果构建减瘤性肾切除术后患者总体死亡风险的临床预测模型,并计算IMDC模型和联合模型的C-index值。基于纳入模型的变量系数间比例关系进行半定量赋值,绘制新模型不同分值患者队列的生存曲线并进行log-rank检验,分析新纳入变量在IMDC危险分层不同亚组的预测价值。计算新模型预测3年死亡风险的时依性ROC曲线下面积。结果:开放手术占比68.9%,术后病理学肿瘤最大径中位9(7.1,12.3) cm,透明细胞癌占81.8%,手术切缘阳性率6.1%,清扫淋巴结阳性率47.7%,二期手术行转移灶切除比例为8.3%。中位随访27.5(15.1,46.4)个月,随访期内死亡110例,总体死亡率41.7%。Cox多因素回归结果显示,IMDC危险分层和寡转移状态(Oligo-metastasis,影像学评估转移病灶数不超过5个,HR=2.089,96%CI:1.390~3.139,P0.05)。结论:IMDC-Olig模型可以很好地对IMDC中高危组患者基于总体死亡风险进行再分层,可作为手术适应证选择的重要参考。

关键词：减瘤性肾切除术生存分析危险分层手术适应证

Co-Optimization of Behind-the-Meter and Front-of-Meter Value Streams in Community Batteries

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 334-345页

作者： carmen Bas Domenech Antonella maria De Corato Pierluigi Mancarella University of Melbourne Parkville 2010VictoriaAustralia Department of Electrical and Electronic Engineering The University of ManchesterManchesterU.K. IEEE

Community batteries(CBs)are emerging to support and even enable energy communities and generally help consumers,especially space-constrained ones,to access potential techno-economic benefits from storage and support local grid ***,the economic viability of CB projects is often *** this regard,typical feasibility studies assess CB value for behind-the-meter(BTM)operation or whole-sale market participation,i.e.,front-of-meter(FOM).This work proposes a novel techno-economic operational framework that allows systematic assessment of the different options and introduces a two-meter architecture that co-optimizes both BTM and FOM benefits.A real CB project application in Australia is used to demonstrate the significant two-meter co-optimization opportunities that could enhance the business case of CB and energy communities by multi-service provision and value stacking.

关键词： Behind-the-meter community battery distributed energy resource(DER) energy community front-of-meter value stacking

Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents

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World Journal of Gastroenterology 2014年第30期20卷 10305-10315页

作者： Alfonso Clemente maria del carmen Arques Department of Physiology and Biochemistry of Nutrition Estación Experimental del Zaidín (CSIC)18008 GranadaSpain

Aberrant functioning of serine proteases in inflammatory and carcinogenic processes within the gastrointestinal tract(GIT)has prompted scientists to investigate the potential of serine protease inhibitors,both natural and synthetic,as modulators of their proteolytic *** inhibitors of the Bowman-Birk type,a major protease inhibitor family in legume seeds,which inhibit potently and specifically trypsin-and chymotrypsin-like proteases,are currently being investigated as colorectal chemopreventive *** relevant amounts of Bowman-Birk inhibitors(BBI)can reach the large intestine in active form due to their extraordinary resistance to extreme conditions within the *** in animal models have proven that dietary BBI from several legume sources,including soybean,pea,lentil and chickpea,can prevent or suppress carcinogenic and inflammatory processes within the *** the therapeutic targets and the action mechanism of BBI have not yet been elucidated,the emerging evidence suggests that BBI exert their preventive properties via protease inhibition;in this sense,serine proteases should be considered as primary targets in early stages of *** validation of candidate serine proteases as therapeutic targets together with the identification,within the wide array of natural BBI variants,of the most potent and specific protease inhibitors,are necessary to better understand the potential of this protein family as colorectal chemopreventive agents.

关键词： Bowman-Birk inhibitors Cell proliferation Chemoprevention Colorectal cancer Legumes Serine proteases

Environmental Fate of Petroleum Hydrocarbons in Soil:Review of Multiphase Transport,Mass Transfer,and Natural Attenuation Processes

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Pedosphere 2018年第6期28卷 833-847页

作者： maria BALSEIRO-ROMERO carmen MONTERROSO Juan J.CASARES Department of Chemical Engineering Centre for Research in Environmental Technologies (CRETUS)Universidade de Santiago de CompostelaSantiago de Compostela 15782(Spain) Department of Soil Science and Agricultural Chemistry Centre for Research in Environmental Technologies (CRETUS)Unzversidade de Santiago de CompostelaSantiago de Compostela 15782(Spain)

The increasing use of petroleum-derived fuels over the last few decades has subsequently augmented the risk of spills in the environment. Soil pollution with petroleum hydrocarbons(principally caused by leaks in pipelines and underground storage tanks) is one of the major sources of soil degradation. Once in soil, fuel hydrocarbons suffer from a wide variety of multiphase processes including transport(advection, diffusion, and dispersion) among and within phases(aqueous and non-aqueous liquid, gas, and soil solids), mass transfer among phases(volatilization, sorption, and solution), and other natural attenuation processes, such as biodegradation and plant uptake and metabolism. This review identifies and describes the major processes occurring in soil that have a significant influence on the environmental fate of petroleum hydrocarbons. The definition of the processes involved in pollutant migration and distribution in soil and the formulation of adequate equations using accurate parameters(e.g., diffusion coefficients, velocity of advective flows, and mass transfer coefficients) will allow prediction of the final fate of soil pollutants. In addition to transport and mass transfer processes,which are more widely studied, the incorporation of attenuation mechanisms driven by microorganisms and plants is essential to predict the final concentration of the pollutants in the whole multiphase scenario. This work underlines the importance of the determination of accurate parameters through the performance of laboratory and/or field-scale experiments to develop precise pollutant migration models.

关键词： degradation fuel-derived pollutants modelling multiphase non-aqueous phase liquid soil pollution soil processes sorption

Selective biomass conversion over novel designed tandem catalyst

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Journal of Bioresources and Bioproducts 2024年第4期9卷 508-517页

作者： Fatima-Zahra Azar Achraf El Kasmi mariaÁngeles Lillo-Ródenas maria del carmen Román-Martínez Haichao Liu Department of Inorganic Chemistry and Materials Institute Faculty of SciencesUniversity of Alicante.Alicante E-03080Spain Sustainable Materials Research Center University of Mohammed Ⅵ PolytechnicBenguerir 43150Morocco Laboratory LSIA ENSAHAbdelmalek Essaadi UniversityTetouan 93030Morocco College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Selective conversion of biomass into targeted molecules like polyols, especially, from cellulosic compounds, is being widely investigated as a sustainable process to produce biodiesel and bio- additives. The known process involves two steps, namely hydrolysis and hydrogenation. Thus, it requires two different catalytic materials or bifunctional catalysts. In this context, the present work reports a new catalytic approach based on the use of tandem catalysts, consisting of the combination of an acid solid catalyst (active for hydrolysis) and a supported metal catalyst (active for hydrogenation). Two different functionalized activated carbons and the resin Amberlyst 15 have been tested as solid acid catalysts, and Ru nanoparticles supported on the original activated carbon (SA) are the metal catalyst part of the tandem. All the tested tandem catalysts exhibited higher activity than the supported Ru catalyst did. The highest cellulose conversion and selectivity to sorbitol (70% and 86%, respectively) have been obtained over a novel tandem catalyst, which resulted from a physical mixture between a sulfuric acid modified SA carbon (SASu) and Ru loaded SA (Ru/SA), leading to a tandem catalyst (Ru/SA + SASu). This novel-designed tandem catalyst is reusable. Based on tandem catalysts with a solid-solid system combination, the adopted novel- designed catalytic approach is cost-efficient and sustainable, and can be considered promising for the green production of high-added-value chemicals.

关键词： Biomass Tandem catalysts Carbon materials One-pot conversion Sustainability

Assessing spatial variability and erosion susceptibility of soils in hilly agricultural areas in Southern Italy

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International Soil and Water Conservation Research 2020年第4期8卷 354-362页

作者： carmen maria Rosskopf Erika Di Iorio Luana Circelli Claudio Colombo Pietro P.C.Aucelli University of Molise Department of Biosciences and Territoryc.da Fonte Lappone86090PescheISItaly University of Molise Department of AgriculturalEnvironmental and Food SciencesVia F.De Sanctis186100CampobassoCBItaly University of Napoli"Parthenope" Department of Environmental SciencesCentro Direzionale Isola C/480143NapoliItaly

Soil erosion is one of the main environmental problems in the Mediterranean *** problem is becoming even more important especially in Italy,in the Apennines,where severe erosive processes occur due to the action of concentrated running *** erodibility(K-Factor)of a soil,estimated using the Revised Universal Soil Loss Equation(RUSLE),is a measure of its susceptibility to erosion and depends on several soil properties such as organic matter,texture and permeability and *** assess the spatial variability of soil properties and soil erodibility in hilly agricultural areas and to investigate the relationships between soil features and landscape morphodynamics,a detailed study in Molise region(southern Italy),in a small drainange basin located along its hilly Adriatic flank,was carried *** this catchment,63 topsoil samples(A horizons)were collected and 10 soil profiles,forming a catena crossing 3 land units,were *** calculated K-Factors ranges between 0.012 and 0.048 t ha h ha-1 MJ-1 mm-1 indicating a complex spatial distribution,due to the several local pedological and geomorphological factors affecting soil *** results give clear evidence about the relationships among soil characteristics,soil erodibility and landscape morpho-dynamics(land units).Comparing the soil loss rates estimated for the study area with those reported in literature,a good correspondence can be observed only for the more stable land unit,not characterized by intense erosive *** proposed methodology is suitable to highlight areas characterized by similar morphodynamics features,and comparable soil erodibility,for a more effective spatialization of K factor.

关键词： Hillslope morphodynamics RUSLE equation K factor Mediterranean region Soil catena Land units

Advancing drug safety and mitigating health concerns:High-resolution mass spectrometry in the levothyroxine case study

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Journal of Pharmaceutical Analysis 2024年第9期14卷 1361-1371页

作者： Hana Chmelařová maria carmen Catapano Jean-Christophe Garrigues FrantišekŠvec Lucie Nováková Department of Analytical Chemistry Faculty of Pharmacy in Hradec KrálovéCharles UniversityAkademika Heyrovského 120350005Hradec KrálovéCzech Republic Laboratoire SOFTMAT(IMRCP) Universitéde ToulouseCNRS UMR 5623UniversitéPaul Sabatier118 route de Narbonne31062 Toulouse Cedex 9France

Levothyroxine is a drug with a narrow therapeutic *** the drug formulation composition or switching between pharmaceutical brands can alter the bioavailability,which can result in major health ***,the increased adverse drug reactions have not been fully explained scientifically yet and a thorough investigation of the formulations is *** this study,we used a non-targeted analytical approach to examine the various levothyroxine formulations in detail and to reveal possible chemical ***-high-performance liquid chromatography coupled with a data-independent acquisition high-resolution mass spectrometry(UHPLC-DIA-HRMS)was ***-DIA-HRMS allowed not only the detection of levothyroxine degradation products,but also the presence of non-expected components in the *** these,we identified compounds resulting from reactions between mannitol and other excipients,such as citric acid,stearate,and palmitate,or from reactions between an excipient and an active pharmaceutical ingredient,such as levothyroxine-lactose *** addition to these compounds,undeclared phospholipids were also found in three *** non-targeted approach is not common in pharmaceutical quality control *** the presence of unexpected compounds in drug formulations proved that the current control mechanisms do not have to cover the full complexity of pharmaceutical formulations necessarily.

关键词： Levothyroxine Excipients Impurities UHPLC-DIA-HRMS Drug safety

Lack of functional link in the tadpole morphology induced by predators

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Current Zoology 2016年第3期62卷 227-235页

作者： maria Gabriela PEROTTI mariana PUETA Fabian Gaston JARA carmen Adria UBED Debora Lina MORENO AZOCAR Laboratorio de Fotobiologfa INIBIOMA CONICET-Universidad Nacional del Comahue O.uintral 1250 Bariloche Rio Negro Argentina Departamento de Biologfa General. Universidad Nacional del Comahue Quintral 1250 Bariloche Rio Negro Argentina Departamento de Zoologia INIBIOMA CONICET-Universidad Nacional del Comahue Quintral 1250 8400 Bariloche Rio Negro Argentina

Most studies of predator-induced plasticity have focused on documenting how prey species re- spond to predators by modifying phenotypic traits and how traits correlate with fitness. We have previously shown that Pleurodema thaul tadpoles exposed to the dragonfly Rhionaeschna varie- gata responded strongly by showing morphological changes, less activity, and better survival than non-exposed tadpoles. Here, we tested whether there is a functional link between morphological plasticity and increased survival in the presence of predators. Tadpoles that experienced predation risk were smaller, less developed, and much less active than tadpoles without this experience. Burst speed did not correlate significantly with morphological changes and predator-induced deeper tails did not act as a lure to divert predator strikes away from the head. Although we have previously found that tadpoles with predator-induced morphology survive better under a direct predator threat, our results on the functional link between morphology and fitness are not conclu- sive. Our results suggest that in P. thaultadpoles （1） burst speed is not important to evade preda- tors, （2） those exposed to predators reduce their activity, and （3） morphological changes do not divert predator attacks away from areas that compromise tadpole survivalEE. Our results show that morphological changes in P. thaul tadpoles do not explain burst speed or lure attraction, al- though there was a clear reduction of activity, which itself reduces predation. We propose that changes in tadpole activity could be further analyzed from another perspective, with morphological change as an indirect product of behavior mediated by physiological mechanisms.

关键词： induced morphology lure effect predator exposure swimming performance tadpoles.

Cardiovascular involvement in inflammatory bowel disease: dangerous liaisons

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World Journal of Gastroenterology 2015年第33期21卷 9688-9692页

作者： Ana maria Filimon Lucian Negreanu Michelle Doca Andreea Ciobanu carmen Monica Preda Dragos Vinereanu Internal Medicine and Cardiology Department University Hospital Carol Davila University of Medicine Bucharest Internal Medicine 2 Gastroenterology Department University HospitalCarol Davila University of Medicine Bucharest Gastroenterology Department Fundeni Clinical InstituteCarol Davila Medicine University

Increasing evidence of a link between inflammatory bowel disease(IBD) and adverse cardiovascular events has emerged during the last *** 2014,an important number of meta-analyses and cohort studies clarified the subtle dangerous liaisons between gut inflammation and cardiovascular *** evidence suggests that patients with IBD have a significantly increased risk of myocardial infarction,stroke,and cardiovascular mortality,especially during periods of IBD *** populations(e.g.,women,young patients) may have an even greater *** effective treatment of IBD is aimed at disease remission and seems to reduce cardiovascular risk in these patients.A beneficial effect was demonstrated for salicylates,but not for steroids or *** necrosis factor-α antagonists,which are highly effective in the reduction of inflammation and in the restoration of the digestive mucosa,lead to conflicting cardiovascular effects,as they seem to reduce the risk for ischemic heart disease but increase the rate of cerebrovascular *** supplemental treatment strategies that may reduce the atherothrombotic risk during periods of IBD activity should be explored.

关键词： Inflammatory bowel disease Thrombotic events Activ