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Low utility of plasma Nociceptin/orphanin FQ in the diagnosis of hepatocellular carcinoma

World Journal of Gastroenterology 2006年第29期12卷 4716-4720页

作者： Aldo Spadaro Antonino Ajello Carmelo Luigiano Carmela Morace maria Letizia Resta Grazia Berlinghieri Salvatore Campo Claudio Scisca Angela Alibrandi Graziella D'arrigo Nunziata Alessi Oscar Ferraù maria antonietta freni Dipartimento Clinico Sperimentale di Medicina e Farmacologia Clinica Medica Pad.CAOUVia Consolare Valeria No.1Messina 98125Italy

AIM： The utility of serum alpha-fetoprotein （α-FP） in the detection of hepatocellular carcinoma （HCC） is questionable. Very high circulating levels of nociceptin/ orphanin FQ （N/OFQ）, a ligand for a novel opioid receptor, have recently been reported in HCC. The aim of this study was to assess the role of plasma N/OFQ in the diagnosis of HCC arising in patients with liver cirrhosis. METHODS： Plasma N/OFQ levels were measured by ELISA in 58 patients （28 HCC and 30 liver cirrhosis） and in 25 healthy controls. The values were correlated with clinical and laboratory features including α-FP. Spearman index, biserial correlation coefficient, non parametric combination （NPC） test and discriminant stepwise analysis were used for statistical evaluation of data.RESULTS： The upper normal limit of nociceptin was 122 pg/mL. Plasma levels above this cut-off were found in 21.4% of patients with HCC, in 23.3% of those with cirrhosis and in 8% of healthy subjects. α-FP serum levels〉200 ng/mL were found in 46.4% of the patients with HCC and in none of those with cirrhosis. No correlation was found between N/OFQ levels and any of the clinical and laboratory features, including α-FP. By NPC test, HCC and cirrhotic patients were different with regard to α-FP （P = 0.000） but not in terms of nociceptin （P = 0.595）. By point biserial correlation, HCC presence was positively correlated with α-FP （rpb = 0.52, P = 0.000） but not with N/OFQ （rpb = 0.16, P = 0.157）. In a discriminant analysis, α-FP was significant in the Wilks test （Y = -0.709 ＋ 0.03 α-FP） and properly classified 81% of all patients and 61% of HCC. N/OFQ had lower sensitivity, specificity and predictive values than α-FP. CONCLUSION： Nociceptin is increased in patients with chronic liver disease, independently of the presence of HCC, although the underlying mechanism has yet to be clarified. We conclude it is not a useful marker for HCC.

关键词： Hepatocellular carcinoma Nociceptin/orphanin FQ Liver cirrhosis Alpha-fetoprotein

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High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

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World Journal of Gastroenterology 2008年第10期14卷 1549-1552页

作者： Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù maria antonietta freni Department of Medicine and Pharmacology University Hospital Messina 98125 Italy Department of Statistics University oMessina Messina 98125 Italy

AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.

关键词： D-dimers Liver cirrhosis Ascites Hepatocellular carcinoma Hyperfibrinolysis

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Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits

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World Journal of Gastroenterology 2005年第13期11卷 1987-1990页

作者： Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù maria antonietta freni Dipartimento Clinico Sperimentale di Medicina e Farmacologia Dipartimento di Statistica Dipartimento di Scienze Radiologiche Unità Operativa di Gastroenterologia

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC). METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD) as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, non-parametric combination test and confidence interval analysis were used for statistical analysis. RESULTS: Serum CgA above normal values (100 ng/mL) were found in 83% of HCC patients, in 48% of LC patients, in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1046), in LC (249±369), in CH (87±94), in CRF (1390±1401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18). HCC patients had higher CgA values (P200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between a-FP and CgA in patients with HCC and in patients with cirrhosis. CONCLUSION: When HCC is suspected and a-FP

关键词： Chromogranin-A Hepatocellular carcinoma Liver cirrhosis Chronic hepatitis Diagnosis

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Tokenomics and blockchain tokens: A design-oriented morphological framework

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Blockchain(Research and Applications) 2022年第1期3卷 80-95页

作者： Pierluigi freni Enrico Ferro Roberto Moncada Business Model Innovation LINKS FoundationTurin10138Italy

Blockchain technology has been around for more than ten years,nevertheless,the knowledge about its economic and business implications is still fragmented and *** present article intends to tackle this issue with a twofold *** first is an analysis of the shift from economics to tokenomics highlighting the central role played by tokens within blockchain-based *** second is a framework for tokens design leveraging a morphological analysis deeply grounded in the *** blockchain becomes a mainstream phenomenon,the value of the work proposed lies in lowering the cognitive barriers and in clarifying the space of available options for private and public actors willing to leverage tokenization in their daily operations.

关键词： Blockchain Tokenization Tokenomics Classification framework Token design

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Unusual clinical presentation of primary aortoduodenal fistula

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Gastroenterology Report 2015年第2期3卷 170-174页

作者： Daniele Bissacco Luca freni Luca Attisani Iacopo Barbetta Raffaello Dallatana Piergiorgio Settembrini Daniele Bissacco Luca FreniLuca AttisaniIacopo BarbettaRaffaello DallatanaPiergiorgio Settembrini

Primary aorto-enteric fistula(PAEF)develops between the native aorta and the gastro-intestinal tract,in the presence of an abdominal aortic *** is a rare,life-threatening condition and appears to be less frequent than secondary aortoenteric fistula,which is associated with previous aortic prosthetic *** untreated,the overall mortality rate is almost 100%.Diagnosis may be challenging until the occurrence of a massive *** the presence of gross contamination,patients tend to a worse ***-anatomical bypass and repair of the enteric tract is the treatment of choice in case of gross *** situ reconstruction is often reported in cases of mild bacterial *** treatment has recently become a valid option in haemodynamically unstable patients,but a staged approach,with delayed surgical treatment,seems advisable.

关键词： aorto-enteric fistula aortoduodenal fistula gastro-intestinal bleeding abdominal aortic aneurysm abdominal pulsatile mass

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Synthesis of SAPO-34/graphite composites for low temperature heat adsorption pumps

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Journal of Energy Chemistry 2013年第2期22卷 245-250页

作者： L. Bonaccorsi L. Calabrese E. Proverbio A. Frazzica A. freni G. Restuccia E. Piperopoulos C. Milone Department of Electronic Engineering Chemistry and Industrial Engineering Contrada di Dio 98166 Messina Italy CNR-Institute for Advanced Energy Technologies "Nicola Giordano" Via Salita S. Lucia sopra Contesse 5 98126 Messina Italy

Low temperature heat adsorption pumps represent the innovative cooling systems, where cold is generated through adsorption/desorption cycle of water by a suitable adsorbent with good adsorption and high thermal conductive properties. In this work, the hydrothermal synthesis of zeolite SAPO-34 on thermal conductive grapbitic supports, aiming at the development of highly pertbrming adsorbent materials, is reported. The synthesis was carried out using as-received and oxidized commercial carbon papers, and graphite plate. Composites were characterized by XRD, SEM and also by a thermogravimetric method, using a Cahn microbalance. The water adsorbing capacity showed typical S-shape trend and the maximum water loading was around 25 wt%, a value close to water adsorption capability of pure SAPO-34. These results are very promising for their application in heat adsorption pumps.

关键词： carbon composite SAPO-34 hydrothermal synthesis low temperature heat adsorption pump

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一种可以产生三种OAM模式的螺旋线缝隙天线阵

一种可以产生三种OAM模式的螺旋线缝隙天线阵

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2021年全国天线年会

作者：徐鑫 Mazzinghi Agnese freni Angelo Hirokawa Jiro 东南大学东京工业大学佛罗伦萨大学

本文提出了一种用于60 GHz近场多路复用通信系统的多模OAM天线阵列。通过巴特勒矩阵对RLSA进行馈电,RLSA可以产生多种OAM模式。测试结果表明天线在设计频点可以产生0、-1和+1三种OAM模式,且主模即模式0的方向性大于35 dBi。

关键词： 60 GHz近场通信轨道角动量天线阵列螺旋线缝隙天线阵

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