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The Art of War： Tradition and Innovation in the Iconographic Representation of Alentejo Fortresses （17th-18th Centuries）

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History Research 2013年第5期3卷 353-364页

作者： antonia Fialho Conde University of Evora Evora Portugal

The novelties in the representation of strongholds in Alentejo-southem Portugal, frontier with Spain, considered as a ＂theater of war＂ during the 17th and 18th centuries-followed European influences, which the theorists responsible for training the engineers in active in the country at this time, Luis Serrao Pimentel and Manuel de Azevedo Fortes, intend to apply. Several drawings bring testimony to this, by showing different ways of representing natural or built elements, allowing for comparisons with other regions of the country or even Europe. The comparison with earlier projects, and given the information contained mainly in the works of Luis Serr^o Pimentel and Manuel de Azevedo Fortes, lead us not only to the conclusion of the acceptance of the proposed rules, in order to enrich the profile of military engineers in Portugal, but also to notice the changes that this acceptance signified, emphasizing especially the technical and artistic sensibility of the authors of these projects of military architecture.

关键词： Luis Serrao Pimentel Manuel de Azevedo Fortes military engineering south of Portugal modemperiod iconography

Study on the Antioxidant Activity of Grape Stems (<i>Vitis vinifera</i>). A Preliminary Assessment of Crude Extracts

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Food and Nutrition Sciences 2012年第4期3卷 500-504页

作者： antonia Llobera Department of Chemistry University of Illes Balears Palma de Mallorca Spain.

The antioxidant activity of 80% ethanol and 70% acetone extracts of stems from red and white grapes (Vitis vinifera) used in wine industry were evaluated to determine their feasibility as natural antioxidants. The results showed that all grape stem extracts were rich in total polyphenolic compounds and flavanols and had clear antioxidant activities. The free radical-scavenging capacity of the extracts was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The extracts obtained from red grape stem present EC50 values of 0.14 g dm/g DPPH (acetone extract) and 0.20 g dm/g DPPH (ethanol extract) while the extracts obtained from white grape stem present EC50 values of 0.26 g dm/g DPPH (acetone extract) and 0.37 g dm/g DPPH (ethanol extract). There are significant correlations between the total content of polyphenols and the antioxidant activity (R2 = 0.9352) and between the flavanols content and the antioxidant activity (R2 = 0.9404) of the grape stem extracts obtained.

关键词： Grape Stem Antioxidant Activity Stem Extracts Polyphenols Radical Scavenging Activity DPPH

Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury

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Neuroscience Bulletin 2011年第4期27卷 275-285页

作者： Daniel Alonso-Alconada antonia Alvarez Enrique Hilario 国立巴斯克大学医学与牙医学院细胞生物学与组织学系

Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal brain lesions due to the complexity of neonatal hypoxic-ischemic pathophysiology, the search of new neuroprotective therapies is of great interest. In this regard, therapeutic possibilities of the endocannabinoid system have grown lately. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. Concerning perinatal asphyxia, the neuroprotective role of this endogenous system is emerging these years. The present review mainly focused on the current knowledge of the cannabinoids as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.

关键词： perinatal hypoxia-ischemia brain injury neuroprotective strategies endocannabinoid system

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Journal of Computer and Communications 2023年第9期11卷 18-43页

作者： antonia Stefani Bill Vassiliadis Department of Management Science and Technology University of Patras Patras Greece

Evaluating complex information systems necessitates deep contextual knowledge of technology, user needs, and quality. The quality evaluation challenges increase with the system’s complexity, especially when multiple services supported by varied technological modules, are offered. Existing standards for software quality, such as the ISO25000 series, provide a broad framework for evaluation. Broadness offers initial implementation ease albeit, it often lacks specificity to cater to individual system modules. This paper maps 48 data metrics and 175 software metrics on specific system modules while aligning them with ISO standard quality traits. Using the ISO25000 series as a foundation, especially ISO25010 and 25012, this research seeks to augment the applicability of these standards to multi-faceted systems, exemplified by five distinct software modules prevalent in modern information ecosystems.

关键词： Software Quality Information Systems Quality Standards Quality Metrics ISO25000

Acalculous cholecystitis due to Salmonella enteritidis

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World Journal of Gastroenterology 2008年第41期14卷 6408-6409页

作者： maria Lourdes Ruiz-Rebollo Gloria Sánchez-Antolín Félix García-Pajares maria antonia Vallecillo-Sande Pilar Fernández-Orcajo Rosario Velicia-Llames Agustín Caro-Patón Gastroenterology Unit Hospital Río Hortega

Acute acalculous cholecystitis (AAC) is defi ned as an acute infl ammation of the gallbladder in the absence of stones. We herein report a case of a young man who developed AAC after a Salmonella enteritidis gastroint... 详细信息

关键词： Cholecystitis Young adult Infectious Salmonella enteritidis

A Quality Assurance Reference Framework for Assessing Educational Data

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Journal of Data Analysis and Information Processing 2021年第4期9卷 283-297页

作者： antonia Stefani Bill Vassiliadis Department of Management Science and Technology University of Patras Patras Greece

Digital educational content is gaining importance as an incubator of pedagogical methodologies in formal and informal online educational settings. Its educational efficiency is directly dependent on its quality, however educational content is more than information and data. This paper presents a new data quality framework for assessing digital educational content used for teaching in distance learning environments. The model relies on the ISO2500 series quality standard and beside providing the mechanisms for multi-facet quality assessment it also supports organizations that design, create, manage and use educational content with the quality tools (expressed as quality metrics and measurement methods) to provide a more efficient distance education experience. The model describes the quality characteristics of the educational material content using data and software quality characteristics.

关键词： Quality Assurance Framework Data Model Digital Educational Content ISO25000 Series

A Certification Framework for E-Commerce Digital Competencies

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Open Journal of Applied Sciences 2023年第5期13卷 758-774页

作者： antonia Stefani Bill Vassiliadis Department of Management Science and Technology University of Patras Patras Greece

In this paper, we introduce a comprehensive certification framework for digital competencies. This framework delineates the regulations, processes, and administration necessary for executing certification of a particular subset of competencies within the DigComp framework. It stipulates distinct requisites for the methodology employed, assessment instruments, evaluation criteria, and procedures for awarding certificates. The framework encompasses the enhancement of fundamental skills, particularly digital competencies, as well as involving digitally disenfranchised demographics with technology. It can be used to evaluate and certify varying degrees of digital proficiency and to instruct individuals in utilizing essential business-to-consumer e-commerce functionalities.

关键词： Certification System DigComp Electronic Commerce

Fern extracts potentiate fluconazole activity and inhibit morphological changes in Candida species

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1025-1030页

作者： maria A.Freitas antonia T.L.Santos Antonio J.T.Machado Ana Raquel P.Silva Fábia F.Campina maria S.Costa Gioconda M.A.B.Martins maria Flaviana B.Morais-Braga Saulo R.Tintino Irwin R.A.Menezes Jaime Ribeiro-Filho Altevir P.Medeiros Adeliana S.Oliveira Patrício B.Maracajá Henrique D.M.Coutinho Universidade Regional do Cariri-URCA Universidade Federal Rural do Semi-A′rido-UFERSA Universidade Federal do Rio Grande do Norte-UFRN Universidade Federal de Campina Grande-UFCG

Objective: To investigate the antifungal activity of the fern species Lygodium venustum(L. venustum) and Pityrogramma calomelanos(P. calomelanos) against Candida albicans and Candida tropicalis ***: The microdilution method was used to evaluate the antifungal activity, as well as the modulating effects of ethanolic extracts of these plants in combination with fluconazole. The minimum inhibitory concentration(MIC), minimum fungicide concentration and morphological changes were also ***: The extract obtained from L. venustum presented a MIC > 8 192 mg/m L, while the extract obtained from and P. calomelanos presented a MIC = 8 192 mg/m L, indicating that they present weak antifungal activity. However, combination of the extracts with Fluconazole potentiated the antifungal activity of this drug. At different experimental conditions, such as concentration of the extract and type of strain, the extracts inhibited hyphae and pseudohyphae formation, indicating that these fern species can affect the morphology of the ***: The extracts obtained from the fern species L. venustum and P. calomelanos dose not present significant antifungal activity. However, P. calomelanos potentiates the activity of fluconazole and both extracts inhibits the morphological changes in Candida species, indicating that they have potential pharmacological activity as modulators of fungal biology. Therefore, novel studies are required to characterize the interference of these extracts in the virulence and pathogenicity of Candida species as well as the potential of fern species to treat fungal infections.

关键词： Dimorphism Candida species Ferns Lygodium venustum Pityrogramma calomelanos

Addicts with chronic hepatitis C:Difficult to reach,manage or treat?

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World Journal of Gastroenterology 2013年第44期19卷 8011-8019页

作者： Barbara Zanini Federica Benini Marie Graciella Pigozzi Patrizia Furba Ernesto Giacò antonia Cinquegrana mariagrazia Fasoli Alberto Lanzini Department of Clinical and Experimental Sciences Gastroenterology Unit University and Spedali Civili of Brescia I-25123 Brescia Italy Territorial Addiction Service (SerT) Local Health Authority (ASL) of Brescia I-25100 Brescia Italy

AIM:To assess the acceptance,safety and efficacy of care and treatment for chronic hepatitis C(CHC)in drug ***:We designed a multidisciplinary,phase IV prospective cohort *** illicit drug users(IDUs)visited a Territorial Addiction Service(SerT)in the District of Brescia,and hepatitis C antibody(HCVAb)testing positive were offered as part of a standardised hepatologic visit in our Gastroenterology *** with confirmed CHC and without medical contraindications were administered peginterferon alfa-2b 1.5μg/kg per week plus ribavirin(800-1400 mg/d)for *** IDUs were unselected because of ongoing addiction and read and signed an informed consent *** responses at weeks 4 and 12 of therapy,at the end of treatment and 24 wk after the end of treatment were the main measures of *** was estimated according to the 80/80/80 ***:From November 2007 to December 2009,162 HCVAb+IDUs were ***-seven patients(41%of the initial cohort)completed the diagnostic procedure,and CHC was diagnosed in 54(33%of the total).Forty-nine patients were offered therapy,and 39agreed(80%of acceptance rate).The prevalent HCV genotype was type 1,and the HCV RNA baseline level was over 5.6 log/mL in 61%of *** patients dropped out,two because of severe adverse events(SAEs)and three without medical ***-three and 14 patients achieved end of treatment responses(ETRs;59%)and sustained virologic responses(SVRs;36%),***-one patients were fully compliant with the study protocol(80%adherence).The prevalence of host and viral characteristics negatively affecting the treatment response was high:age over40 years(54%),male gender(85%),overweight body type(36%),previous unsuccessful antiviral therapy(21%),HCV genotype and viral load(60%and 62%,respectively),earlier contact with HBV(40%)and steatosis and fibrosis(44%and 17%,respectively).In a univariate analysis,alcohol intake was associated with a non-respon

关键词： Chronic hepatitis C Addiction Antiviral therapy Interferon Multidisciplinary