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地中海的宁静 EKONIKA莫斯科旗舰店

室内设计与装修 2025年第1期 58-63页

作者：无 anna Lvovskaia Boris Lvovskiy Fedor Goreglyad maria Romanova Vasilii Portnyagin Nikita Subbotin(摄影) 秋落(编译) DA bureau 不详 Landon Studio

EKONIKA是俄罗斯最大的鞋类连锁店之一,已上市30多年。在过去的5年里,该品牌发生了重大变化,变得更加现代化,面向更年轻的受众。这些变化需要改变连锁店的视觉形象,这也是设计师工作的难点。作为EKONIKA鞋类和配饰连锁店品牌重塑的一部... 详细信息

EKONIKA是俄罗斯最大的鞋类连锁店之一,已上市30多年。在过去的5年里,该品牌发生了重大变化,变得更加现代化,面向更年轻的受众。这些变化需要改变连锁店的视觉形象,这也是设计师工作的难点。作为EKONIKA鞋类和配饰连锁店品牌重塑的一部分,设计师为该品牌的展厅开发了全新的视觉解决方案。

关键词：品牌重塑连锁店视觉形象地中海鞋类旗舰店俄罗斯 EK

Three-dimensional in vitro models of neuromuscular tissue

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Neural Regeneration Research 2022年第4期17卷 759-766页

作者： Paolo Raffa maria Easler anna Urciuolo Institute of Pediatric Research IRP PadovaItaly Molecular Medicine Department University of PadovaPadovaItaly

Skeletal muscle is a dynamic tissue in which homeostasis and function are guaranteed by a very defined three-dimensional organization of myofibers in respect to other nonmuscular components,including the extracellular matrix and the nervous *** particular,communication between myofibers and the nervous system is essential for the overall correct development and function of the skeletal muscle.A wide range of chronic,acute and genetic-based human pathologies that lead to the alteration of muscle function are associated with modified preservation of the fine interaction between motor neurons and myofibers at the neuromuscular *** advancements in the development of in vitro models for human skeletal muscle have shown that three-dimensionality and integration of multiple cell types are both key parameters required to unveil pathophysiological relevant ***,we describe recent achievement reached in skeletal muscle modeling which used biomaterials for the generation of three-dimensional constructs of myotubes integrated with motor neurons.

关键词： 3D organization bioengineering biomaterials motor neurons neuromuscular junction skeletal muscle models

Oligodendrocyte precursor cell maturation: role of adenosine receptors

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Neural Regeneration Research 2021年第9期16卷 1686-1692页

作者： Federica Cherchi anna maria Pugliese Elisabetta Coppi Department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Division of Pharmacology and ToxicologyUniversity of FlorenceFlorenceItaly

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination fails due to adverse environment. Therefore, a strategy to prompt oligodendrocyte progenitor cell differentiation towards myelinating oligodendrocytes is required. The neuromodulator adenosine, and its receptors(A1, A(2A), A(2B) and A3 receptors: A1R, A(2A)R, A(2B)R and A3R), are crucial mediators in remyelination processes. It is known that A1Rs facilitate oligodendrocyte progenitor cell maturation and migration whereas the A3Rs initiates apoptosis in oligodendrocyte progenitor cells. Our group of research contributed to the field by demonstrating that A(2A)R and A(2B)R inhibit oligodendrocyte progenitor cell maturation by reducing voltage-dependent K^+ currents necessary for cell differentiation. The present review summarizes the possible role of adenosine receptor ligands as potential therapeutic targets in demyelinating pathologies such as multiple sclerosis.

关键词： adenosine receptors K^+channels oligodendrocyte differentiation oligodendrocyte progenitor cells remyelination

Influence of uncertainties: A focus on block volume and shape assessment for rockfall analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2250-2263页

作者： Gessica Umili Battista Taboni anna maria Ferrero Department of Earth Sciences University of Turinvia Valperga Caluso 3510125TurinItaly

Block size and shape depend on the state of fracturing of the rock mass and,consequently,on the geometrical features of the discontinuity sets(mainly orientation,spacing,and persistence).The development of non-contact surveying techniques applied to rock mass characterization offers significant advantages in terms of data numerosity,precision,and accuracy,allowing for performing a rigorous statistical analysis of the *** fact is particularly evident when dealing with rockfall phenomena:uncertainties in spacing and orientation data could significantly amplify the uncertainties connected with in situ block size distribution(IBSD),which represents a relation between each possible value of the volume and its probability of not being *** addition to volume,block shape can be considered as a derived parameter that suffers from *** attempts to model the possible trajectories of blocks considering their actual shape have been proposed,aiming to reproduce the effect on *** authors proposed analytical equations for calculating the expected value and variance of volume distributions,based on the geometrically correct equation for block volume in the case of three discontinuity *** quantify and discuss the effect of both volume and shape variability through a synthetic case ***,a fictitious rock mass with three discontinuity sets is assumed as the source of *** IBSDs obtained considering different spacing datasets are quantitatively compared,and the overall uncertainty effect is assessed,proving the correctness of the proposed ***,block shape distributions are obtained and compared,confirming the variability of shapes within the same ***,a comparison between trajectory simulations on the synthetic slope is reported,aiming to highlight the effects of the propagation of uncertainties to block volume and shape *** benefits of an approach that can quantify the uncertainties are discussed

关键词： Rockfall In situ block size distribution(IBSD) Block Volume Shape Uncertainty

Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis

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Neural Regeneration Research 2022年第1期17卷 65-73页

作者： maria N.Zakharova anna A. Abramova Research Center of Neurology MoscowRussia

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting,breathing and swallowing difficulties resulting in patient’s death in two to five years after disease *** amyotrophic lateral sclerosis,both upper and lower motor neurons of the corticospinal tracts are involved in the process of neurodegeneration,accounting for great clinical heterogeneity of the *** phenotype has great impact on the pattern and rate of amyotrophic lateral sclerosis progression and overall survival *** more homogenous patient groups in order to study the effects of drug agents on specific manifestations of the disease is a challenging issue in amyotrophic lateral sclerosis clinical *** amyotrophic lateral sclerosis has low incidence rates,conduction of multicenter trials requires certain standardized approaches to disease diagnosis and *** review focuses on the current approaches in amyotrophic lateral sclerosis classification and staging system based on clinical examination and additional instrumental methods,highlighting the role of upper and lower motor neuron involvement in different phenotypes of the *** demonstrate that both clinical and instrumental findings can be useful in evaluating severity of upper motor neuron and lower motor neuron involvement and predicting the following course of the *** disease heterogeneity in amyotrophic lateral sclerosis clinical trials could lead to study designs that will assess drug efficacy in specific patient groups,based on the disease pathophysiology and spatiotemporal *** clinical evaluation can be a sufficient screening method for dividing amyotrophic lateral sclerosis patients into clinical subgroups,we provide proof that instrumental studies could provide valuable insights in the disease pathology.

关键词： amyotrophic lateral sclerosis biomarkers of progression classification diagnostic biomarkers disease heterogeneity electrodiagnostic medicine electromyography motor neuron disease neuroimaging

An integrated multiscale approach for characterization of rock masses subjected to tunnel excavation

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第3期10卷 513-522页

作者： Gessica Umili Sabrina Bonetto anna maria Ferrero Department of Earth Sciences Università degli Studi di Torino

The design of tunnels must be conducted based on the knowledge of the territory. The longer the structure, the larger the area to be investigated, and the greater the number of surveys and tests to be performed in order to thoroughly examine all the relevant features. Therefore, optimization of the investigation process is strongly required to obtain complete and reliable data for the design of the infrastructure. The fast development of remote sensing technologies and the affordability of their products have contributed to proving their benefits as supports for investigation, encouraging the spreading of automatic or semi-automatic methods for regional scale surveys. Similarly, considering the scale of the rock outcrop, photogrammetric and laser scanner techniques are well-established techniques for representing geometrical features of rock masses, and the benefits of non-contact surveys in terms of safety and time consumption are acknowledged. Unfortunately, in most cases, data obtained at different scales of investigations are only partially integrated or compared, probably due to the missing exchange of knowledge among experts of different fields（e.g. geologists and geotechnical engineers）. The authors,after experiencing such a lack of connection among the results of different surveys concerning tunnels,propose a multiscale approach for the optimization of the investigation process, starting from the regional scale, to obtain the data that can be useful not only for planning more detailed surveys in a preliminary phase, but also for making previsions on the discontinuity sets that are present in the rock masses subjected to excavations. A methodological process is proposed and illustrated by means of a case study. Preliminary results are discussed to highlight the potentiality of this method and its limitations.

关键词： Tunnel Multiscale approach Geological lineament Non-contact survey Discontinuity Digital terrain model (DTM)

The many faces of cGAS:how cGAS activation is controlled in the cytosol,the nucleus,and during mitosis

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2261-2263页

作者： anna-maria Herzner Martin Schlee Eva Bartok Department of Cancer Immunology and Immune Modulation Boehringer Ingelheim Pharma GmbH&Co.KGBiberach an der RiBGermany lnstitute of Clinical Chemistry and Clinical Pharmacology University HospitalUniversity of BonnBonnGermany Unit of Experimental Immunology Department of Biomedical SciencesInstitute of Tropical MedicineAntwerpBelgium

In their recently published study in Science,Li et al.1 unravel how hyperphosphorylation and chromatin-tethering of the double-stranded(dsDNA)sensor cGAMP synthase(cGAS)prevent self DNA recognition during mitosis(Fig.1);providing important insight into how this innate immune sensor balances its essential function for pathogen defense against potential autoinflammation.

关键词： activation sensor insight

Predictive immune biomarkers: an unattainable chimera?

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Cellular & Molecular Immunology 2018年第8期15卷 740-742页

作者： anna maria Trotta Roberto Pacelli Stefania Scala Functional Genomics Istituto Nazionale per lo Studio e la Cura dei TumoriFondazione‘G.Pascale’Via SemmolaNaplesItaly Dipartimento di Scienze Biomediche Avanzate.UniversitàFederico II.Via Pansini NaplesItaly

Immune checkpoint blockade(ICB)with antibodies interfering with cytotoxic T lymphocyte antigen 4(CTLA-4)and the programmed cell death 1(PD-1)protein tremendously revolutionized therapy for advanced ***,the activity of such agents(ipilimumab and nivolumab)is limited to a 10–45%response rate in the context of unselected populations with advanced solid *** common cancer types have demonstrated a very low frequency of response(breast,prostate and colon cancers),and heterogeneous responses have been observed between distinct tumors within the same *** to broad clinical applicability include identifying patients most likely to benefit from checkpoint inhibitors and overcoming resistance to *** immune response is a dynamic and constantly evolving process due primarily to patient-dependent factors,including genetic and tumor microenvironment(TME)features,and secondarily to treatment interventions.

关键词： immune colon likely

Safety of direct acting antiviral treatment for hepatitis C in oncologic setting:A clinical experience and a literature review

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World Journal of Hepatology 2022年第3期14卷 525-534页

作者： anna maria Spera Infectious Disease Unit Universitary Hospital OO RR San Giovanni di Dio e Ruggi d'AragonaSalerno 84131Italy

With a globally estimated 58 million people affected by,chronic hepatitis C virus(HCV)infection still represents a hard challenge for scientific community.A chronic course can occur among patients with a weak innate ad adaptive response with cirrhosis and malignancies as main *** patients undergoing chemotherapy represent a special immunocompromised population predisposed to HCV reactivation(HCVr)with undesirable changes in cancer treatment and *** of the study highlight the possibility of HCVr in oncologic population eligible to chemotherapy and its threatening consequences on cancer treatment;underline the importance of HCV screening before oncologic therapy and the utility of direct aging antivirals(DAAs).A comprehensive overview of scientific literature has been *** searched in PubMed were:“HCV reactivation in oncologic setting”“HCV screening”,“second generation DAAs”.Pharmacokinetic and Pharmacodynamics characteristics of DAAs are reported,along with drug-drug interactions among chemotherapeutic drug classes regimens and *** trials conducted among oncologic adults with HCV infection eligible to both chemotherapy and DAAs were *** eradication with DAAs in oncologic patients affected by HCV infection is safe and helps liver recovery,allowing the initiation of cancer treatment no compromising its course and success.

关键词： Hepatitis C Virus Direct aging antivirals Drug interactions Pharmacodynamic Pharmacokinetic Pre-emptive therapy