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Healthcare Professionals’ Adherence to Contact Precautions at a Maternal and Child Teaching Hospital

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Open Journal of Nursing 2023年第12期13卷 839-854页

作者： Lucas Eduardo Luizão Marli de Carvalho Jericó angela Silveira Gagliardo Calil Viviane Decicera Colombo Oliveira Alexandre Lins Werneck Ingrid de Campos Truzzi Eliana Ofelia Lapa Rodriguez maria Rita Rodrigues Vieira Pedro Paulo de Carvalho Jericó Medical School in Sã o Jose do Rio Preto S&#227o Jose do Rio Preto Brazil Federal University of Sergipe Sergipe Brazil

Background: Healthcare-associated infections affect hundreds of millions of patients worldwide. Children have greater susceptibility to healthcare-associated infections due to the immaturity of their immune system. Contact precautions aim to promote safety, protection and prevention of contamination. Thus, the objective of this study was to verify adherence to contact precaution measures, as well as compliance to the use of personal protective equipment. Methods: This cross-sectional observational study was carried out from July to October 2019 using a checklist to evaluate health professionals’ adherence to hand hygiene procedures and the use of gloves and surgical gowns when assisting children on contact precautions. Results: A total of 941 observations were carried out in a total of 300.532 hours. Hand hygiene was performed before and after contact with the patient in 58.84% and 75.09% of the cases, respectively and a surgical gown was used in 86.40% of the cases. The use of gloves was the variable most adhered to by professionals (87.57%). Intensive care unit professionals were the care workers who most complied with the regulation regarding hand hygiene after contact with the patient (p = 0.009) and the use of the surgical gown (p < 0.001). The correct hand hygiene technique was the recommendation with least adherence. Non-compliance to the hand hygiene technique was statistically significant among intensive care unit professionals (p = 0.002). Conclusions: Adherence to hand hygiene before contact with the patient and compliance with the hand hygiene technique were neglected by most professionals. However, there was good adherence to the use of surgical gloves and gowns, as well as high compliance to the techniques of removing these items. .

关键词： Hospital Infection Universal Precautions Patient Safety Pediatric Nursing Isolation of Patients Microbial Drug Resistance

Functional Characterization of Bifidobacteria of Human Origin: A Case Study by the Students of Food Science and Technology of the University of Foggia (Southern Italy)

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Food and Nutrition Sciences 2014年第13期5卷 1153-1161页

作者： Emanuela Ciuffreda Angino Veronica Antonietta Cifelli Rossana Foti Rosaria Ilenia Forte Fabio Graziani Andrea Giuseppe Longo angela Longo Valeria Maglia Emilio Francesco Ricciardi Alessandra Sabatino Annamaria Tomaiuolo maria Rosaria Corbo Milena Sinigaglia Antonio Bevilacqua Department of the Science of Agriculture Food and Environment (SAFE) University of Foggia Foggia Italy

The aim of this paper was to study the potential technological and probiotic properties of bifidobacteria isolated from human feces. Bifidobacteria, naturally present in the dominant colonic microbiota, represent up to 25% of the cultivable faecal bacteria in adults and 80% in infants. Bifidobacteria have been shown to adhere and colonize in high numbers different types of cultured intestinal epithelial cells;moreover some authors reported that some strains are able to stabilize the intestinal microbiota during and after antibiotic therapy, modulate the immune system, protecting against chemically induced intestinal inflammation and reducing symptoms of colitis. Eight isolates of bifidobacteria were studied to assess their technological and probiotic traits;the technological characterization relied on the assessment of enzymatic activities (proteolytic and lipolytic activity), growth under various conditions (pH, temperature and addition of salt), acidifying ability and metabolism (arginine deamination, esculin, esculin hydrolysis and citrate metabolism). The study of the probiotic characteristics focused on the evaluation of the survival at low pH and with bile salts added, antibiotic resistance, and hydrophobic properties. As a result of this process, two promising strains were selected for further studies.

关键词： Bifidobacteria Technology Probiotic Traits Functional Characterization

LUCC （Land Use and Cover Change） and the Environmental-Economic Accounts System in Brazil

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Journal of Earth Science and Engineering 2013年第12期3卷 840-844页

作者： Rodrigo de Campos Macedo Mauricio Zacharias Moreira Eloisa Domingues angela maria Resende Couto Gama Fabio Eduardo de Giusti Sanson Felipe Wolk Teixeira Fernando Peres Dias Femando Yutaka Yamaguchi Luiz Roberto de Campos Jacintho National Institute of Spatial Research Seo Jose dos Campos-SP 12227-010 Brazil Brazilian Institute of Geography and Statistics Florianepolis-SC 88015-600 Brazil

The objective of this work is to produce statistics that are going to show changes occurred in Brazil＇s ecosystems and these statistics are going to join the SEEA （Environmental-Economic Accounts System）. It is based by a SEEA＇s methodology, diffused by UN （United Nations）, which aims an approach between economic and environmental statistics, producing international comparability and conceptual uniformity to evaluate change process in land cover and land use that occurs in several countries. It is necessary to verifying the suitability of methodological procedures to Brazilian reality and the access to all information and files needed. The first step was analysing MODIS （Moderate Resolution Imaging Spectroradiometer） as orbital instrument on the purposed classification method. The choice of this sensor was made because of the product＇s quality and its capacity to generate images of a large area, though the challenge is to identify accurate Land usage＇s categories in images with a spatial resolution of approximately 250 m. After the final classification, the next step is to make a quantification and comparison of data from these different years using a 1 km2 grids, as proposed in an already used methodology by the European Environment Agency. This procedure will allow evaluate and identify the process of changing in each grid of the land cover and land use, and provide historical series of the chosen years.

关键词： Remote sensing land use and cover change environmental statistics geoprocessing.

可手术乳腺癌CMF辅助化疗随机研究的30年随访:队列研究

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英国医学杂志中文版 2005年第3期8卷 148-151页

作者： Gianni Bonadonna angela Moliterni Milvia Zambetti maria Grazia Daidone Silvana Pilotti Luca Gianni Pinuccia Valagussa 樊英 Istituto Nazionale Tumori 20133 Milano Italy

目的根据1973年6月至1980年12月期间的3项连续随机试验和1项观察研究,评价有复发风险的可手术乳腺癌患者使用环磷酰胺、甲氨蝶呤和氟尿嘧啶(CMF)辅助治疗的长期有效性。设计队列研究。地点意大利米兰国家肿瘤研究所。主要结局指标无复... 详细信息

目的根据1973年6月至1980年12月期间的3项连续随机试验和1项观察研究,评价有复发风险的可手术乳腺癌患者使用环磷酰胺、甲氨蝶呤和氟尿嘧啶(CMF)辅助治疗的长期有效性。设计队列研究。地点意大利米兰国家肿瘤研究所。主要结局指标无复发生存和总生存,采用单变量和多变量分析。结果在首项研究随访平均28.5年后,发现辅助CMF能显著降低复发的相对危险度(危险比为0.71,95%可信区间0.56～0.91,P=0.005)并减少死亡(0.79,0.63～0.98,P=0.04)。12个周期的CMF似乎并不优于6个周期的相对短期治疗。在淋巴结和雌激素受体阴性的研究中,平均随访20年后,静脉使用CMF能显著降低疾病复发的相对危险度(0.65,0.47～0.90,P=0.009)以及死亡的相对危险度(0.65,0.470.92,P=0.01)。结论如应用适当,CMF方案能使具有远处复发风险的患者获益,没有证据显示它对任何研究亚组有不良影响。

关键词：队列研究随访随机研究辅助化疗手术相对危险度雌激素受体阴性复发风险 1980年乳腺癌患者意大利米兰多变量分析 CMF方案观察研究随机试验环磷酰胺辅助治疗氟尿嘧啶甲氨蝶呤结局指标可信区间短期治疗

Precision health: A nursing perspective

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International Journal of Nursing Sciences 2020年第1期7卷 5-12页

作者： Mei R.Fu Emma Kurnat-Thoma angela Starkweather Wendy A.Henderson Ann K.Cashion Janet K.Williams maria C.Katapodi Karin Reuter-Rice Kathleen T.Hickey Veronica Barcelona de Mendoza Kathleen Calzone Yvette P.Conley Cindy M.Anderson Debra E.Lyon Michael T.Weaver Pamela K.Shiao Rose E.Constantino Shu-Fen Wung Marilyn J.Hammer Joachim G.Voss Bernice Coleman William F.Connell School of Nursing Boston CollegeChestnut HillMAUSA National Institute of Nursing Research National Institutes of HealthBethesdaMDUSA School of Nursing and Health Studies Georgetown UniversityWashingtonDCUSA School of Nursing University of ConnecticutStorrsCTUSA School of Nursing The University of IowaIowa CityIAUSA Nursing Science University of BaselBaselSwitzerland School of Nursing Duke UniversityDurhamNCUSA School of Nursing Columbia UniversityNew YorkNYUSA School of Nursing Yale UniversityOrangeCTUSA National Cancer Institute Center for Cancer ResearchGenetic BranchBethesdaMDUSA School of Nursing University of PittsburghPittsburghPAUSA College of Nursing The Ohio State UniversityOHUSA University of Florida Gainesville FLUSA Center for Biotechnology and Genomic Medicine Medical College of GeorgiaAugusta UniversityAugustaGAUSA College of Nursing The University of Arizona TucsonAZUSA Dana-Farber Cancer Institute 450 Brookline AvenueLW523BostonMAUSA Frances Payne Bolton School of Nursing Case Western Reserve UniversityClevelandOHUSA Nursing Research and Development Cedars-Sinai Medical CenterLos AngelesUSA

Precision health refers to personalized healthcare based on a person's unique genetic,genomic,or omic composition within the context of lifestyle,social,economic,cultural and environmental influences to help individuals achieve well-being and optimal *** health utilizes big data sets that combine omics(*** sequence,protein,metabolite,and microbiome information)with clinical information and health outcomes to optimize disease diagnosis,treatment and prevention specific to each *** implementation of precision health requires interprofessional collaboration,community outreach efforts,and coordination of care,a mission that nurses are well-positioned to *** the surge of interest and attention to precision health,most nurses are not well-versed in precision health or its implications for the nursing *** on a critical analysis of literature and expert opinions,this paper provides an overview of precision health and the importance of engaging the nursing profession for its *** topics reviewed in this paper include big data and omics,information science,integration of family health history in precision health,and nursing omics research in symptom *** paper concludes with recommendations for nurse leaders in research,education,clinical practice,nursing administration and policy settings for which to develop strategic plans to implement precision health.

关键词： Nurses Genomics Omics Precision medicine Precision health

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

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Frontiers of Medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen maria Teresa Landi Mattias Johansson angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of Medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health Sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical Biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster Salzburg at PLUS Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of Medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of Medicine Carmel Medical CenterHaifa 3448516Israel Markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of Molecular and Clinical Cancer Medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

Surgical pitfalls with custom-made porous hydroxyapatite cranial implants

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Plastic and Aesthetic Research 2015年第1期2卷 7-11页

作者： Bruno Zanotti angela Verlicchi Roberto Stefini Attilio Carlo Salgarelli Nicola Zingaretti Pier Camillo Parodi Casadei Matteo Massimo Robiony Department of Neurosurgery University Hospital S.Maria della Misericordia33100 UdineItaly Neurology Unit Free University of Neuroscience“Anemos”42124 Reggio EmiliaItaly Department of Neuroscience Neurosurgery UnitUniversity of Brescia25123 BresciaItaly Department of Head and Neck Surgery Unit of Maxillofacial SurgeryModena and Reggio Emilia University41124 ModenaItaly Department of Plastic and Reconstructive Surgery University Hospital S.Maria della Misericordia33100 UdineItaly Department of Maxillo-Facial Surgery University Hospital S.Maria della Misericordia33100 UdineItaly

Aim:Cranioplasty implants are used primarily in cases of surgical cranial decompression following pathological elevations of intracranial *** bone substitutes include porous hydroxyapatite(HA)and *** material is used,however,prosthetic cranial implants are susceptible to intra-and postsurgical complications and even *** aim of this study was to investigate such occurrences in HA cranioplasty implants,seeking not only to determine the likely causes(whether correlated or not with the device itself)but also,where possible,to suggest ***:We analyzed information regarding failures or complications reported in postmarketing surveillance and clinical studies of patients treated worldwide with custom-made HA cranial implants(Custom Bone Service Fin-Ceramica Faenza,Italy)in the period ***:The two most common complications were implant fractures(84 cases,2.9%of the total fitted)and infections(51 cases,1.77%).Conclusion:Although cranioplasties are superficial and not difficult types of surgery,and use of custom-made implants are often considered the“easy”option from a surgical perspective,these procedures are nonetheless plagued by potential *** performed well they yield more than satisfactory results from the points of view of both the patient and surgeon,but lack of appropriate care can open the door to numerous potential sources of failure,which can compromise-even irreparably-the ability to heal.

关键词： Cranial cranioplasty custom-made hydroxyapatite implants

Retrospective Cohort Study on Acute Care in Obstetrics and Gynecology: Analogies and Differences When Compared to Emergency Medicine

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Open Journal of Obstetrics and Gynecology 2017年第4期7卷 473-485页

作者： Giuseppe Chiossi Stefano Palomba Sara Balduzzi Maged M. Costantine angela I. Falbo Anna M. Ferrari Giovanni B. La Sala Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX USA Department of Obstetrics and Gynecology Arcispedale Santa Maria Nuova IRCCS Reggio Emilia Italy Statistics Unit Department of Oncology Hematology and Respiratory Diseases University of Modena and Reggio Emilia Modena Italy Department of Emergency Medicine Arcispedale Santa Maria Nuova IRCCS Reggio Emilia Italy University of Modena and Reggio Emilia via Università 4 Modena Italy

Introduction: the demand for urgent obstetric and gynecology care has progressively increased: in the United States approximately 1.4 million gynecologic visits are made to the emergency department (ED) annually, while almost 75% of women make at least 1 unscheduled visit during pregnancy. Moreover, research has recently focused on setting standards in unscheduled care, and developing quality indicators to improve patients’ health. Therefore, we investigated the characteristics of women with acute gynecological or pregnancy complaints using quality indicators developed for emergency medicine, to better define the needs of this population and improve care. Methods: Retrospective cohort study on ED, and Obstetrics and Gynecology (ObGyn) triage visits, at a tertiary care hospital in Italy, during 2012. Data were analyzed with population-averaged logistic regression and Poisson regression. Results: When compared to the 33,557 ED visits, the 9245 ObGyntriage referrals were more frequently associated with pregnancy (≤12 weeks’ gestation, OR: 30.7, 95%CI;24.5 - 38.4;>12 weeks’ gestation, OR 81.2, 95%CI;64.8 - 101.4), vaginal bleeding (OR 156.6, 95%CI;82.7 - 294.4), diurnal (night access OR 0.87, 95% CI;0.78 - 0.96) and weekday access (holiday access OR 0.87, 95%CI;0.78 - 0.95), frequent users (recurrent ED visits IRR 0.87, 95%CI;0.83 - 0.9) and lower hospital admissions (ED admission OR 1.6, 95%CI;1.4 - 1.8). Conclusion: ObGyn triage patients differed from ED users, and were at higher risk of “crowding”. Such diversities should be considered to improve female healthcare services and allocate resources more efficiently.

关键词： Acute Care Obstetric Urgencies Gynecologic Urgencies Obstetrics and Gynecology Triage Emergency Department

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好朋友？

空中英语教室（初级版．大家说英语） 2018年第8期 40-41,55页

作者： Ruth Devlin maria Chen

凯伦与安琪拉是好朋友，她们在学校是同班同学。她们一起读书，一起逛购物中心．一起看电影，也会到彼此的家里去。有一天，凯伦看到了安琪拉。

关键词：朋友购物中心安琪