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Robotic assisted radical prostatectomy accelerates postoperative stress recovery: Final results of a contemporary prospective study assessing pathophysiology of cortisol peri-operative kinetics in prostate cancer surgery

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Asian Journal of Urology 2016年第2期3卷 88-95页

作者： Antonio B.Porcaro Nicolo`de Luyk Paolo Corsi Marco Sebben Alessandro Tafuri Davide Inverardi Davide De Marchi Irene Tamanini Matteo Brunelli maria angela Cerruto Gian Luca Salvagno Gian Cesare Guidi Walter Artibani Urologic Clinic University HospitalOspedale PoliclinicoAzienda Ospedaliera Universitaria IntegrataVeronaItaly Department of Pathology University HospitalOspedale PoliclinicoAzienda Ospedaliera Universitaria IntegrataVeronaItaly Department of Laboratory Medicine University HospitalOspedale PoliclinicoAzienda Ospedaliera Universitaria IntegrataVeronaItaly

Objective:To investigate the effects of prostate cancer(PCa)surgery on the stress system and to identify potential independent factors associating with stress ***:The design of the study was prospective and PCa surgery included robot assisted radical prostatectomy(RARP)or retropubic radical prostatectomy(RRP).Between February 2013 to December 2014,315 consecutive patients were *** effects of PCa surgery on the stress system were measured by cortisol serum levels before and after surgery on postoperative day(POD)0,1,3,5 and *** variations in the population and subpopulation(RARP ***)of patients were investigated by statistical *** associating with stress recovery were assessed by simple linear regression(SLR)and multiple linear regression(MLR)***:RARP was performed in 75.9%of *** the patient population,there were wide serum cortisol perioperative *** surgery triggered the stress system which immediately(POD 0)responded by cortisol overproduction which induced the negative feedback mechanism that started on POD 1,continued on POD 3,was still ongoing on POD 5 and completely settled on POD 45(stress recovery).In the subpopulation of patients,significantly lower cortisol serum levels were detected on POD 3e5 in RARP cases inwhomcortisol levels were close to preoperative levels(stress recovery)on POD *** predictive factors of serum cortisol on POD 5(stress recovery)were preoperative cortisol(p Z 0.02),cortisol levels on POD 3(p<0.0001)and RARP(p Z 0.03)in which the association was negative(stress recovery faster than RRP).Conclusion:Our study shows that PCa surgery immediately(POD 0)triggers the stress system which respond by overproduction of cortisol which induces the negative feedback mechanism that starts on POD 1,is still ongoing on POD 5,but is completely settled on POD ***,after surgical trauma,our study gives evidence that the RARP procedure associates with stress recovery

关键词： Prostate cancer Robot assisted radical prostatectomy Retropubic radical prostatectomy Stress system

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Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report

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World Journal of Gastrointestinal Oncology 2020年第12期12卷 1456-1463页

作者： mariacristina Di Marco Riccardo Carloni Stefania De Lorenzo Cristina Mosconi Andrea Palloni Elisa Grassi Daria maria Filippini angela Dalia Ricci Alessandro Rizzo Alessandro Di Federico Donatella Santini Daniela Turchetti Claudio Ricci Carlo Ingaldi Laura Alberici Francesco Minni Rita Golfieri Giovanni Brandi Riccardo Casadei Department of Experimental Diagnosticand Specialty Medicine-DIMESSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Division of Oncology Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Radiology Unit Department of Diagnostic Medicine and PreventionSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Medical Oncology Ospedale Degli InfermiFaenza 48018Italy Pathology Unit Sant'Orsola-Malpighi HospitalBologna 40138Italy Unit of Medical Genetics Sant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Division of Pancreatic Surgery Azienda Ospedaliero-Universitaria Di BolognaBologna 40138Italy Department of Internal Medicine and Surgery Alma Mater StudiorumUniversity of BolognaBologna 40138Italy

BACKGROUND Pancreatic mucinous cystadenocarcinoma(MCAC)is a rare malignancy with a poor prognosis when it presents metastases at *** to its very low incidence,there are no clear recommendations for the treatment of advanced ***(an oral PARP inhibitor)has been approved for the maintenance treatment of patients with metastatic pancreatic adenocarcinoma harbouring germline BRCA1/2 ***,we report the first case of a germline BRCA1 mutated unresectable MCAC which was effectively treated with *** SUMMARY A 41-year-old woman,without personal or family history of cancer,was diagnosed with ovarian and peritoneal metastases of *** underwent 12 cycles of gemcitabine plus oxaliplatin(GEMOX)obtaining a partial response and allowing radical *** year later,local recurrence was documented,and other 12 cycles of GEMOX were administered obtaining a complete *** years later,another local recurrence,not amenable to surgical resection,was *** started FOLFIRINOX(oxaliplatin,irinotecan,leucovorin and fluorouracil),obtaining a partial response after 8 *** the excellent response to platinum-based chemotherapy,BRCA testing was performed,and a BRCA1 germline mutation was *** was switched to maintenance olaparib due to chemotherapy-related toxicities and achieved an almost complete metabolic response,with a reduction in the diameter of the lesion,after three months of *** The current case suggests the beneficial effect of olaparib in BRCA mutated ***,further studies are required.

关键词： Mucinous cystadenocarcinoma Pancreatic cancer BRCA1 gene Olaparib Case report

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RNAi technology targeting PbGP43 and PbP27 in Paracoccidioides brasiliensis

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Open Journal of Genetics 2013年第2期3卷 1-8页

作者： Isaura Torres Gomez Orville Hernandez Ruiz Jose F.Munoz Ana maria Garcia angela Restrepo Juan G.McEwen Unidad de Biologia Celular y Molecular Corporacion para Investigaciones Biologicas(CIB)MedellinColombia Instituto de Biologia Universidad de AntioquiaMedellinColombia Grupo de Investigacion en Biociencias Facultad de Ciencias de la SaludInstitucion Universitaria Colegio Mayor de AntioquiaMedellinColombia Facultad de Medicina Universidad de AntioquiaMedellinColombia

Efficient technologies for gene silencing would be important to carry out functional analysis with P. brasiliensis genes, as well as for a better understanding of the biology and pathogenesis of this pathogenic fungus. Due to the fact that homologous recombination is unusual in P. brasiliensis, the development of knockout isolates is currently non-feasible. The goal of this work was to assess RNA interference (RNAi) technology as an alternative tool for gene silencing previously employed successfully in H. capsulatum. For this purpose, we built different inverted repeat transgenic hairpin constructs to down-regulate the PbGP43 and PbP27 genes known to codify for two fungal immunogenic proteins that elicit a strong immune response during experimental paracoccidioidomycosis. Using the RNAi strategy, a reduction in the mRNA levels of the PbGP43 and PbP27 genes was observed during the first 20 days after selection;however, in the transformed yeast cells, the gene silencing status proved non-stable through the assay. We demonstrated that electrotransformation was suitable to transform P. brasiliensis yeast cells and integrate the hairpin constructions;nonetheless, gene silencing was not stable along the experimental time. A detailed analysis of the underlying molecular RNAi machinery may provide further insights into the intracellular mechanism that governs this reverse genetic tool.

关键词： Paracoccidioides brasiliensis Interference RNA Gene Silencing PbGP43 PbP27 Gene Expression

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Prognostic Value of Cardiopulmonary Exercise Test in Elderly Women with Heart Failure and Reduced or Preserved Ejection Fraction

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World Journal of Cardiovascular Diseases 2014年第7期4卷 341-349页

作者： angela Beatrice Scardovi Renata De maria Alessandro Ferraironi Marco Renzi Franco Turi Marina Parolini Tiziana Di Giacomo Roberto Ricci Cardiology Department S. Spirito Hospital Rome Italy CNR Clinical Physiology Institute Cardio Thoracic and Vascular Department Niguarda Hospital Milan Italy

The prognostic role of cardiopulmonary exercise test (CPET) in elderly women with chronic heart failure (HF) has not yet been clarified. We assessed the incremental value of CPET variables for risk stratification in female HF patients with preserved or reduced left ventricular ejection fraction (LVEF). We prospectively followed up 131 female HF outpatients aged 72 [interquartile range 62 - 77] years after a symptom limited CPET. 34% had ischemic heart disease and 14% permanent atrial fibrillation, 24% were in NYHA class III. LVEF was 50% [interquartile range 36 - 62], peak oxygen consumption was 11.3 [interquartile range 9.2 - 13.5] ml/kg/min;the slope of the regression line relating ventilation to CO2 output was 33.9 [interquartile range 30.3 - 44.9];40% of patients showed exercise oscillatory breathing during CPET. During a median follow-up of 18 months [interquartile range 8 - 54], overall 39 patients (29.7%) met the combined end-point of cardiovascular mortality or HF admission using a time-to-first event approach. Moderate to severe mitral regurgitation, slope, exercise oscillatory breathing were independently associated to cardiovascular mortality or HF admission. When CPET ventilatory variables were added to clinical and echocardiographic parameters, prediction of the combined point improved significantly (AUC 0.755 (95% CI 0.662 to 0.832) vs 0.634 (95% CI 0.536 to 0.725), p = 0.016). In conclusion, among elderly female HF patients the CPET derived parameters EOB and VE/VCO2 slope emerged as strong prognostic markers, with additive predictive value to clinical and echocardiographic parameters in patients with both reduced and preserved LVEF.

关键词： Women Heart Failure Cardiopulmonary Exercise Test Ventilatory Inefficiency

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Intrauterine Exposure to Chronic 22 kHz Sound Affects Inhibitory Avoidance and Serotonergic Parameters in Forebrain Areas of Dams and Rat Offspring

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Journal of Behavioral and Brain Science 2015年第2期5卷 25-39页

作者： Patrícia da Silva Oliveira Ariomester Nascimento Daniel Polliana Toledo Nunes Karina Abdo Costa Hani Camille Yehia angela maria Ribeiro Programa de Pós-Graduaç ã o em Neurociências Laboratório de Neurociências Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Engenharia Eletrô nica Escola de Engenharia Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Bioquímica e Imunologia ICB and Departamento de Psicologia FaFiCH Laboratório de Neurociências Comportamental e Molecular LaNeC Universidade Federal de Minas Gerais Belo Horizonte Brazil

In the present study we evaluated the effects of chronic exposure to sounds at 22 kHz during pregnancy on the central serotonergic and behavioral parameters in Wistar rat dams after the suckling period and on their male rat offspring. In addition, we also assessed the effects of an acute 22 kHz sound, associated with the chronic intrauterine exposure, on the emotional responses of adult offspring. The primary hypothesis was that experiencing 22 kHz stimuli during an early stage of development would interfere with brain serotonergic parameters and, later, with the adult rat’s defensive responses. The corollary question was whether a 22 kHz sound exposure would differentially affect inhibitory avoidance and escape responses and central serotonergic parameters. Female rats were divided into four groups: non-pregnant control;non-pregnant chronic exposure;pregnant control;and pregnant chronic exposure. Male offspring were divided into four groups: chronic intrauterine sound exposure;acute sound exposure in adulthood;chronic intrauterine exposure with acute exposure in adulthood;and no exposure. Chronic sound exposure affected inhibitory avoidance and serotonergic parameters in female rats. For offspring, there was an interaction between chronic and acute sound exposure effects on inhibitory avoidance response but not on escape response. There were significant effects of chronic intrauterine exposure on serotonin turnover in the hippocampus and PFC of females. For offspring, the turnover was increased by chronic exposure only in PFC, and in amygdala it was increased by acute exposure. These results illuminate the potential of an early acoustic sound exposure for causing central serotonergic and emotional behavioral changes that can persist into later periods of life.

关键词： Intrauterine 22 kHz Sound Exposure Defensive Responses Serotonergic Parameters Adult Offspring

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Mandibular cementoblastoma:Case report

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Open Journal of Stomatology 2012年第1期2卷 50-53页

作者： Cintia Mussi Milani César Augusto Thomé Rosangela Sayuri Saga Kamikawa mariana Daniel da Silva maria angela Naval Machado Universidade Tuiuti do Paraná CuritibaBrazil Center for Health and Biological Sciences Pontifícia Universidade Católica do ParanáCuritibaBrazil Associacao Brasileira de Odontologia-Secao Paraná CuritibaBrazil Private Practice CuritibaBrazil Universidade Federal do Paraná CuritibaBrazil

Cementoblastoma is a rare benign lesion that represents less than 1% of all odontogenic tumours. It’s characterized by proliferation of cementum-like tissue and in almost all cases tends to be associated with an erupted permanent tooth, most often the first mo- lar. We present an unusual case of a large cemento-blastoma that affected the right mandibular body, extending from the first premolar to the second molar, of a 19-years-old male. In this case an initial surgery was attempted under local anaesthesia, resulting in incomplete tumor removal. A second surgical procedure was performed under general anaesthesia, ensuring the complete excision of the lesion. The patient was monitored for 1 year after surgery and did not show any signs of recurrence.

关键词： Odontogenic Tumor Cementoblasts Oral Surgery

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Relationship of MTHFR gene polymorphisms with renal and cardiac disease

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World Journal of Nephrology 2015年第1期4卷 127-137页

作者： Francesca M Trovato Daniela Catalano angela Ragusa G Fabio Martines Clara Pirri maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato Department of Internal Medicine University of Catania95100 CataniaItaly AOU Prenatal Diagnosis and Medical Genetics University of Catania95100 CataniaItaly Internal and Emergency Medicine Department University of Catania95100 CataniaItaly

AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are ***: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism.

关键词： Homocysteine Glomerular filtration rate Renal function Mediterranean diet Genetic Methyle-netetrahydrofolate reductase polymorphism Insulinresistance Obesity Left ventricular hypertrophy Echo-cardiography

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Effect of dietary supplementation with insect fats on growth performance,digestive efficiency and health of rabbits

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Journal of Animal Science and Biotechnology 2019年第2期10卷 501-509页

作者： Laura Gasco Sihem Dabbou angela Trocino Gerolamo Xiccato maria Teresa Capucchio Ilaria Biasato Daniela Dezzutto Marco Birolo Marco Meneguz Achille Schiavone Francesco Gai Largo Paolo Braccini 2 10095 GrugliascoTurinItaly Department of Veterinary Science University of TurinLargo Paolo Braccini 210095 GrugliascoTurinItaly Department of Comparative Biomedicine and Food Science University of PadovaViale dell’Università1635020 LegnaroPadovaItaly Department of Agronomy Food Natural Resources Animal and Environment University of PadovaViale dell’Università1635020 LegnaroPadovaItaly Veterinary Medical Research Institute for Piemonte Liguria and Valle d’AostaVia Bologna 14810154 TurinItaly Institute of Science of Food Production National Research CouncilLargo Paolo Braccini 210095 GrugliascoTurinItaly Institute of Interdisciplinary Research on Sustainability University of TurinVia Accademia Albertina 1310100 TurinItaly.

Background: The present work aimed at evaluating the effect of the dietary replacement of soybean oil(S) by two types of insect fats extracted from black soldier fly larvae(H, Hermetia il ucens L.) and yel ow mealworm larvae(T, Tenebrio molitor L.) on growth performance, nutrient digestibility, blood parameters, intestinal morphology and health of growing ***: At weaning, 200 crossbred rabbits(36 days old) were allotted to five dietary treatments(40 rabbits/group): a control diet(C) containing 1.5% of soybean oil and four experimental diets where soybean oil was partially(50%) or totally(100%) substituted by H(H50 and H100) or T(T50 and T100) fats. Total tract digestibility was evaluated on 12 rabbits per treatment. The growth trial lasted 41 d and, at slaughtering(78 days old), blood samples were collected from 15 rabbits per treatment, morphometric analyses were performed on duodenum, jejunum and ileum mucosa,and samples of liver, spleen and kidney were submitted to histological ***: No difference was observed between the control and the experimental groups fed insect fats in terms of performance, morbidity, mortality and blood variables. The addition of H and T fats did not influence apparent digestibility coefficients of dry matter, protein, ether extract, fibre fractions and gross energy. Gut morphometric indices and organ histopathology were not affected by dietary inclusion of H and T ***: H and T fats are suitable sources of lipid in rabbit diets to replace soybean oil without any detrimental effect on growth performance, apparent digestibility, gut mucosa traits and health.

关键词： Blood Digestibility Growing rabbit Gut health Insect fats Performances

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Effects of Pilocarpine Hydrochloride on the Hyposalivation Induced by Psychotropic Drugs

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Journal of Life Sciences 2013年第12期7卷 1236-1242页

作者： Juia Ribas C6sar Durscki Aline Cristina Batista Johann Antonio Adilson Soares Lima[ maria angela Naval Machado Luciana Reis Azevedo Edvaldo Antonio Ribeiro Rosa Ana maria Trindade Gregio School of Dentistry The Pontifical Catholic University of Paran6 Curitiba Paran6 80215-901 Brazil Laboratory of Pathology Faculty of Dentistry Federal University of Paran6 Curitiba Parandt 80215-901 Brazil

The aim was to study the secretagogue action of pilocarpine on the murine parotid glands submitted to chronic treatment with psychotropic drugs by salivary flow rate determinations and histological alterations. Fifty four male Wistar rats were equally divided in three groups： C group （control） received saline solution for 30 days; AD group （n = 18） received AmitriptylineR and DiazepamR for 30 days, and ADP group （n = 18） received Amitriptyline R and DiazepamR for 30 days and AmitriptylineR, DiazepamR and pilocarpine for further 30 days, resulting in 60 days of treatment. Saliva samples were collected 30 h after the end of treatment. Parotids were removed and processed for hematoxylin-eosin histological analysis. Dedicated software for image processing allowed the determination of cell number and volume. Significant differences between paired-groups C-AD （P 〈 0.01） and AD-ADP （P 〈 0.01） were observed for glands size and weight. The volume of serous cells was greater in AD, suggesting a hypertrophy of the salivary glands. For salivary flow rate, C group showed the highest average. The number of serous cells was similar between groups ADP and C, with the lowest average being found in AD group （P 〈 0.05）.

关键词： Salivary glands pilocarpine psychotropic drugs hyposalivation.

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Plasma betatrophin levels in patients with liver cirrhosis

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World Journal of Gastroenterology 2015年第37期21卷 10662-10668页

作者： maria Teresa Arias-Loste maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega Gastroenterology and Hepatology Unit Marqués de Valdecilla University HospitalInstituto de Investigación Sanitaria ValdecillaAvenida Valdecilla s/n 39008 Santander Cantabria Spain Endocrinology Unit Marqués de Valdecilla University HospitalInstituto de Investigación Sanitaria Valdecilla Avenida Valdecilla s/n 39008 Santander Cantabria Spain

AIM: To investigate the plasma levels of betatrophin in patients with ***: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were *** severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched *** blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, ***: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin

关键词： Liver cirrhosis Betatrophin Insulin resistance Bet

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