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Cadaveric bone marrow mesenchymal stem cells:first experience treating a patient with large severe burns

Burns & Trauma 2015年第2期3卷 74-82页

作者： Eduardo Mansilla Gustavo H.Marín Mirta Berges Silvia Scafatti Jaime Rivas Andrea Núñez Martin Menvielle Roberto Lamonega Cecilia Gardiner Hugo Drago Flavio Sturla Mercedes Portas Silvia Bossi maria victoria castuma Sandra Peña Luengas Gustavo Roque Karina Martire Jose maria Tau Gabriel Orlandi Adrian Tarditti Tissue Engineering Regenerative Medicine and Cell Therapies LaboratoryCUCAIBAProvince of Buenos Aires Ministry of HealthTransplantation ProgramLa PlataProvince of Buenos AiresArgentina Burns and Plastic Surgery Department San Martín HospitalProvince of Buenos Aires Ministry of HealthLa PlataProvince of Buenos AiresArgentina Burns Hospital Buenos Aires CityArgentina Department of Chemistry Mayaguez CampusUniversity of Puerto RicoMayaguezPuerto RicoUSA.

Background:In January 2005,Rasulov et *** published"First experience in the use of bone marrow mesenchymal stem cells(MSCs)for the treatment of a patient with deep skin burns".Here,we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells(CMSCs)in the history of ***:A young man,who severely burned 60%of his total body surface with 30%of full-thickness burns while working with a grass trimmer that exploded,was involved in the *** were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA,the Province of Buenos Aires,Argentina,Ministry of Health,Transplantation Agency,cultured,expanded,and applied on the burned surfaces using a fibrin spray after early ***:So far,our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of ***:Based on al this,we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the *** will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.

关键词： Burns Cadaveric Transplantation Skin regeneration Mesenchymal stem cells

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Co-Optimization of Behind-the-Meter and Front-of-Meter Value Streams in Community Batteries

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 334-345页

作者： Carmen Bas Domenech Antonella maria De Corato Pierluigi Mancarella University of Melbourne Parkville 2010VictoriaAustralia Department of Electrical and Electronic Engineering The University of ManchesterManchesterU.K. IEEE

Community batteries(CBs)are emerging to support and even enable energy communities and generally help consumers,especially space-constrained ones,to access potential techno-economic benefits from storage and support local grid ***,the economic viability of CB projects is often *** this regard,typical feasibility studies assess CB value for behind-the-meter(BTM)operation or whole-sale market participation,i.e.,front-of-meter(FOM).This work proposes a novel techno-economic operational framework that allows systematic assessment of the different options and introduces a two-meter architecture that co-optimizes both BTM and FOM benefits.A real CB project application in Australia is used to demonstrate the significant two-meter co-optimization opportunities that could enhance the business case of CB and energy communities by multi-service provision and value stacking.

关键词： Behind-the-meter community battery distributed energy resource(DER) energy community front-of-meter value stacking

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Comparison between Care Strategies for Patients with Osteoarthritis of the Hands Based on the Use of Joint Protection, Assistive Technology and Exercises

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Open Journal of Orthopedics 2024年第7期14卷 295-311页

作者： Daniele dos Santos Scarcella Talita Dias da Silva victoria Yanara Hernandes da Silva maria Cândida de Miranda Luzo Selma Lancman Marcia Uchoa de Rezende Carlos Bandeira de Mello Monteiro Instituto de Ortopedia e Traumatologia Hospital das Clnicas HCFMUSP Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Programa de Ps-Graduao em Cincias da Reabilitao Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Escola de Artes Cincias e Humanidades Universidade de So Paulo So Paulo Brazil

Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. Purpose: To assess whether a group of people with hand osteoarthritis (hOA) who received different types of treatment improved their function after two years of follow-up. Method: The entire sample (n = 97) underwent three follow-up assessments regarding anthropometric parameters of the upper limbs and ability to perform functional activities. Subsequently, the sample was divided into two groups for the intervention periods, called the First Period (n = 73) and the Second Period (n = 24);the First Period kept the same protocol with orientations, and the Second Period went to an intervention with orientation strength exercises and use of orthosis. Findings: In the separate analysis of the three questions of the DASH pain module, no differences were found between the assessment moments for groups of guidelines, treatment, or symptoms. Significant effects were observed for F(2, 162) = 3.5, p = 0.033, η2 = 0.04, and interaction for moments and intervention F(2, 162) = 4.3, p = 0.016, η2 = 0.05. Implications: It can be concluded that only guidance treatment does not benefit patients with hand osteoarthritis. In contrast, guidance, exercise, and orthosis treatment can significantly improve the disease.

关键词： Hand Osteoarthritis Hand Deformities Occupational Therapy

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Investigation of electrophysical, photo- and gas-sensitive properties of ZnO–SnO_(2) sol–gel fflms

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Journal of Advanced Dielectrics 2024年第1期14卷 42-50页

作者： Irina A.Gulyaeva Alexandra P.Ivanisheva maria G.Volkova victoria Yu.Storozhenko Soslan A.Khubezhov Ekaterina M.Bayan Victor V.Petrov Research and Education Centre“Microsystem Technics and Multisensory Monitoring Systems”Southern Federal University Russia Department of Chemistry Southern Federal UniversityRussia Department of Physics North-Ossetian State University362025 VladikavkazRussia Department of Physics and Engineering ITMO University191002 PetersburgRussia

Thin nanocomposite fflms based on tin dioxide with a low content of zinc oxide(0.5–5 mol.%)were obtained by the sol–gel *** synthesized fflms are 300–600 nm thick and contains pore sizes of 19–29 *** resulting ZnO–SnO_(2) fflms were comprehensively studied by atomic force and Kelvin probe force microscopy,X-ray diffraction,scanning electron microscopy,and high-resolution X-ray photoelectron spectroscopy *** photoconductivity parameters on exposure to light with a wavelength of 470 nm were also *** study of the photosensitivity kinetics of ZnO–SnO_(2) fflms showed that the fflm with the Zn:Sn ratio equal to 0.5:99.5 has the minimum value of the charge carrier generation time *** of the activation energy of the conductivity,potential barrier,and surface potential of ZnO–SnO_(2) fflms showed that these parameters have maxima at ZnO concentrations of 0.5 mol.%and 1 mol.%.Films with 1 mol.%ZnO exhibit high response values when exposed to 5–50 ppm of nitrogen dioxide at operating temperatures of 200℃ and 250℃.

关键词： Sol–gel method,ZnO–SnO_(2) films gas-sensitive properties surface potential potential barrier conduction activation energy

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Recent progress on bimetallic NiCo and CoFe based electrocatalysts for alkaline oxygen evolution reaction: A review

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Journal of Energy Chemistry 2022年第4期31卷 101-137页

作者： Gebrehiwet Abrham Gebreslase maria victoria Martínez-Huerta maria Jesus Lázaro Instituto de Carboquímica CSIC.Miguel LuesmaCastán 450018ZaragozaSpain Instituto de Catálisis y Petroleoquímica CSIC.Marie Curie 228049MadridSpain

The deployment of hydrogen as an energy carrier is found to be a vital alternative fuel for the future. It is expected that water electrolysis, powered by renewable energy sources, be able to scale-up hydrogen production. However, the reaction kinetic of oxygen evolution reaction(OER) is a sluggish process, which predominantly limits the efficiency of water electrolysis. This review recapitulates the recent progress and efforts made in the design and development of two selected earth-abundant bimetallic electrocatalysts(Ni Co and Co Fe) for alkaline OER. Each bimetal electrocatalyst is thoroughly outlined and discussed in five sub-sections, including bimetal(oxy) hydroxides, Layered double hydroxides(LDHs) structures,oxides, composites, alloy and nanostructured electrocatalysts, and assembled with ***, a brief introduction to an in situ/operando characterization techniques and advantages for monitoring the structure of the electrocatalysts is provided. Finally, a summary outlining the challenges and conceivable approaches to advance OER performance is highlighted and discussed.

关键词： Water electrolysis Oxygen evolution reaction Bimetallic electrocatalyst Nickel Cobalt and iron

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Redox regulation of the immune response

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Cellular & Molecular Immunology 2022年第10期19卷 1079-1101页

作者： Gerwyn Morris maria Gevezova victoria Sarafian Michael Maes Deakin University IMPACT-the Institute for Mental and Physical Health and Clinical TranslationSchool of MedicineBarwon HealthGeelongVICAustralia Department of Medical Biology Medical University-PlovdivPlovdivBulgaria Research Institute at Medical University-Plovdiv PlovdivBulgaria Department of Psychiatry Faculty of MedicineKing Chulalongkorn Memorial HospitalBangkokThailand Department of Psychiatry Medical University of PlovdivPlovdivBulgaria

The immune-inflammatory response is associated with increased nitro-oxidative *** aim of this mechanistic review is to examine:(a)the role of redox-sensitive transcription factors and enzymes,ROS/RNS production,and the activity of cellular antioxidants in the activation and performance of macrophages,dendritic cells,neutrophils,T-cells,B-cells,and natural killer cells;(b)the involvement of high-density lipoprotein(HDL),apolipoprotein A1(ApoA1),paraoxonase-1(PON1),and oxidized phospholipids in regulating the immune response;and(c)the detrimental effects of hypernitrosylation and chronic nitro-oxidative stress on the immune *** redox changes during immune-inflammatory responses are orchestrated by the actions of nuclear factor-κB,HIF1α,the mechanistic target of rapamycin,the phosphatidylinositol 3-kinase/protein kinase B signaling pathway,mitogen-activated protein kinases,5'AMP-activated protein kinase,and peroxisome proliferator-activated *** performance and survival of individual immune cells is under redox control and depends on intracellular and extracellular levels of ROS/*** are heavily influenced by cellular antioxidants including the glutathione and thioredoxin systems,nuclear factor erythroid 2-related factor 2,and the HDL/ApoA1/PON1 *** nitro-oxidative stress and hypernitrosylation inhibit the activity of those antioxidant systems,the tricarboxylic acid cycle,mitochondrial functions,and the metabolism of immune *** conclusion,redox-associated mechanisms modulate metabolic reprogramming of immune cells,macrophage and T helper cell polarization,phagocytosis,production of pro-versus anti-inflammatory cytokines,immune training and tolerance,chemotaxis,pathogen sensing,antiviral and antibacterial effects,Toll-like receptor activity,and endotoxin tolerance.

关键词： Oxidative and nitrosative stress Immune response Inflammation Antioxidants Physiological stres

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Modelling in vitro gametogenesis using induced pluripotent stem cells:a review

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Cell Regeneration 2023年第1期12卷 53-66页

作者： maria victoria Romualdez‑Tan Present Address:Repro Optima Center for Reproductive Health Inc.Ground Floor JRDC Bldg.Osmena Blvd.Capitol SiteCebu City 6000Philippines Cebu Doctors University Hospital Cebu CityPhilippines

In vitro gametogenesis(IVG)has been a topic of great interest in recent years not only because it allows for further exploration of mechanisms of germ cell development,but also because of its prospect for innovative medical applications especially for the treatment of *** of the mechanisms underlying gamete development in vivo has inspired scientists to attempt to recapitulate the entire process of gametogenesis in *** earlier studies have established IVG methods largely using pluripotent stem cells of embryonic origin,the scarcity of sources for these cells and the ethical issues involved in their use are serious limitations to the progress of IVG research especially in ***,with the emergence of induced pluripotent stem cells(iPSCs)due to the revolutionary discovery of dedifferentiation and reprogramming factors,IVG research has progressed remarkably in the last *** paper extensively reviews developments in IVG using ***,the paper presents key concepts from groundwork studies on IVG including earlier researches demonstrating that IVG methods using embryonic stem cells(ESCs)also apply when using *** for the derivation of iPSCs are briefly discussed,highlighting the importance of generating transgene-free iPSCs with a high capacity for germline transmission to improve efficacy when used for *** main part of the paper discusses recent advances in IVG research using iPSCs in various stages of *** addition,current clinical applications of IVG are presented,and potential future applications are *** IVG is still faced with many challenges in terms of technical issues,as well as efficacy and safety,novel IVG methodologies are emerging,and IVG using iPSCs may usher in the next era of reproductive medicine sooner than *** raises both ethical and social concerns and calls for the scientific community to cautiously develop IVG technology to ensure it is not only effica

关键词： In-vitro gametogenesis Artificial gametes Germ cell derivation Primordial germ cell-like cells Induced pluripotent stem cells

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Phenotype analysis and rescue on female FVB.129-Fmr1 knockout mice

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Frontiers in Biology 2016年第1期11卷 43-52页

作者： Stacy Nguy maria victoria Tejada-Simor~ Department of Pharmacological and Pharmaceutical Sciences University of Houston Houston TX 77204 USA Department of Biology University of Houston Houston TX 73204 USA Department of Psychology University of Houston Houston TX 77204 USA Biology of Behavior Institute (BoBI) University of Houston Houston TX 77204 USA

Fragile X syndrome （FXS） is the most common monogenic cause of intellectual disability and a cause for autism. FXS females report milder phenotypes and a lower rate of cognitive problems compared to males. This is most likely because most females are heterozygous, while males are hemizygous for the disease. Thus, most preclinical studies have been completed in males. As there is major interest in testing experimental drugs for FXS, it is imperative to determine whether females in animal models used for research, present behavioral alterations that might translate to humans in order to confirm that experimental drugs have an effect on both genders. In our study we describe behavioral phenotypes in homozygous FXS female mice developed on the FVB.129 background. We focused on detection of hippocampal-mediated cognitive abilities and other behaviors described for FXS. Our research shows that, while female FVB.129-Fmrl knockout mice present normal learning, they have impaired memory, as well as susceptibility to audiogenic seizures. In agreement with previous reports in rodents and humans, significant levels of the small GTPase Racl were found in FXS female mice. Because Racl is involved in neuronal development, plasticity and behavior, we additionally aimed to pharmacologically inhibit Racl and determine whether observed phenotypes are rescued. Treatment of female FVB.129-Fmrl knockout with a Racl inhibitor abolished behavioral deficits, bringing phenotypes to control levels. Our results suggest that female FVB.129-Fmrl knockout mice display behavioral impairments that resemble FXS in humans. Moreover, those behavioral shortfalls might be associated with alteration of plasticity involving excessive Racl function, since pharmacological reduction of Racl normalizes previously altered phenotypes to control levels.

关键词： autism small GTPases behavior Fragile X syndrome animal models

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Diagnostic endoscopic ultrasonography:Assessment of safety and prevention of complications

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World Journal of Gastroenterology 2012年第34期18卷 4659-4676页

作者： Christian Jenssen maria victoria Alvarez-Sánchez Bertrand Napoléon Siegbert Faiss Department of Internal Medicine Krankenhaus M rkisch-Oderland GmbHD15344 StrausbergGermany Department of Gastroenterology and Hepatology Hopital Privé Jean MermozF69008 LyonFrance Department of Gastroenterology and Hepatology Asklepios Klinik BarmbekD22291 HamburgGermany

Endoscopic ultrasonography (EUS) has gained wide acceptance as an important, minimally invasive diagnostic tool in gastroenterology, pulmonology, visceral surgery and oncology. This review focuses on data regarding risks and complications of non-interventional diagnostic EUS and EUS-guided fine-needle biopsy (EUS-FNB). Measures to improve the safety of EUS und EUS-FNB will be discussed. Due to the specific mechanical properties of echoendoscopes in EUS, there is a low but noteworthy risk of perforation. To minimize this risk, endoscopists should be familiar with the specific features of their equipment and their patients' specific anatomical situations (e.g., tumor stenosis, diverticula). Most diagnostic EUS complications occur during EUS-FNB. Pain, acute pancreatitis, infection and bleeding are the primary adverse effects, occurring in 1% to 2% ofpatients. Only a few cases of needle tract seeding and peritoneal dissemination have been reported. The mortality associated with EUS and EUS-FNB is 0.02%. The risks associated with EUS-FNB are affected by endoscopist experience and target lesion. EUS-FNB of cystic lesions is associated with an increased risk of infection and hemorrhage. Peri-interventional antibiotics are recommended to prevent cyst infection. Adequate education and training, as well consideration of contraindications, are essential to minimize the risks of EUS and EUS-FNB. Restricting EUS-FNB only to patients in whom the cytopathological results may be expected to change the course of management is the best way of reducing the number of complications.

关键词： Endoscopic ultrasonography Endoscopic ul-trasonography-guided fine-needle biopsy Complications Contraindications Risk Safety Perforation Bleeding Infection Acute pancreatitis

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Gender Media Representation in Uruguay：An Analysis of TV Ciudad，El País，and Del Sol FM.

Gender Media Representation in Uruguay：An Analysis of TV Ci...

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作者： maria victoria Techera 中国传媒大学

学位级别：硕士

这项研究探讨乌拉圭媒体中的性别表现,具体聚焦于电视台Ciudad、报纸El País和广播Del Sol FM,分别代表该国的三大主要媒体,并涵盖其三个政治派别.通过采用内容分析、调查和访谈等混合方法,本研究调查了影响乌拉圭媒体性别表现的因素... 详细信息

这项研究探讨乌拉圭媒体中的性别表现,具体聚焦于电视台Ciudad、报纸El País和广播Del Sol FM,分别代表该国的三大主要媒体,并涵盖其三个政治派别.通过采用内容分析、调查和访谈等混合方法,本研究调查了影响乌拉圭媒体性别表现的因素、女性在媒体内容创作中的角色以及三个媒体机构之间的性别表现差异.本文运用内容分析方法分析了一部分新闻文章、电视节目和广播节目,旨在识别普遍存在的性别刻板印象、女性在领导岗位上的存在程度以及对女性在传统性别角色中的描绘.研究结果显示,在媒体中,女性经常被低估和边缘化,男性更有可能担任领导职位并获得新闻报道.此外,女性往往被描绘成传统的性别角色。研究还强调了媒体素养教育的重要性,作为使个人能够批判性地分析和评估媒体表现的手段,使他们能够识别和挑战媒体内容中的性别刻板印象和偏见.这些发现突显了乌拉圭媒体行业迫切需要加强性别平等和多样性的需求。解决这种差距的潜在策略包括设定女性在领导职位中的代表目标,促进多元化和赋权的女性形象在媒体内容中的呈现,以及解决媒体机构内的性别薪酬差距.通过采取这些措施,旨在为乌拉圭和其他地区创造一个更具包容性和公平性的媒体行业.

关键词： GenderMedia representation Uruguay Media Literacy Critical Media

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