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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander v.Romashchenko Dmitrii v.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.Illarionova maria v.zhukova Elena v.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Exploring Nanoscale Perovskite Materials for Next‑Generation Photodetectors:A Comprehensive Review and Future Directions

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Nano-Micro Letters 2025年第2期17卷 46-108页

作者： Xin Li Sikandar Aftab maria Mukhtar Fahmid Kabir Muhammad Farooq Khan Hosameldin Helmy Hegazy Erdi Akman State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037AnhuiPeople’s Republic of China Anhui Laboratory of Advanced Laser Technology Hefei 230037AnhuiPeople’s Republic of China Nanhu Laser Laboratory Changsha 410015HunanPeople’s Republic of China Department of Semiconductor Systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea Department of Artificial Intelligence and Robotics Sejong UniversitySeoul 05006Republic of Korea School of Engineering Science Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Electrical Engineering Sejong UniversitySeoul 05006South Korea Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Central Labs King Khalid UniversityAlQura’aP.O.Box 96061413 AbhaSaudi Arabia Scientific and Technological Research and Application Center Karamanoglu Mehmetbey University70100 KaramanTurkey

The rapid advancement of nanotechnology has sparked much interest in applying nanoscale perovskite materials for photodetection *** materials are promising candidates for next-generation photodetectors(PDs)due to their unique optoelectronic properties and flexible synthesis *** review explores the approaches used in the development and use of optoelectronic devices made of different nanoscale perovskite architectures,including quantum dots,nanosheets,nanorods,nanowires,and *** a thorough analysis of recent literature,the review also addresses common issues like the mechanisms underlying the degradation of perovskite PDs and offers perspectives on potential solutions to improve stability and scalability that impede widespread *** addition,it highlights that photodetection encompasses the detection of light fields in dimensions other than light intensity and suggests potential avenues for future research to overcome these obstacles and fully realize the potential of nanoscale perovskite materials in state-of-the-art photodetection *** review provides a comprehensive overview of nanoscale perovskite PDs and guides future research efforts towards improved performance and wider applicability,making it a valuable resource for researchers.

关键词： Nanoscale perovskites Photodetectors Nanosheets Nanorods Nanowires Quantum dots Nanocrystals

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Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 v,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

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Investigating the light stability of solid-solution-based AgCl-AgBr and AgBr-T1I crystals

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Chinese Optics Letters 2016年第2期14卷 16-18页

作者： Alexandr S.Korsakov Alexandr E.Lvov Dmitry S.vrublevsky Liya v.zhukova Department of Physical Chemistry and Chemistry of Colloids Ural Federal University Named After the First President of Russia B.N.Yeltsin

For the development of mid-infrared fiber-optical elements, one needs tight-stable, flexible materials that are transparent within this spectral band. Solid solutions of silver and monadic thallium halides prove to be the most suitable crystalline media for these needs. We study the light stability variation of high-purity AgCl1-xBrx （0 ≤ x ≤ 1） and Ag1-xTlxBr1-xIx （0 ≤ x ≤ 0.05） crystals by measuring the optical transmission change as func- tions of the composition and Uv exposure time. The former is executed in a broad spectral range from 6500 - 350 cm^-1, within which we choose three wavelengths to trace the transmission change. For thallimn- monoiodide-containing samples, an effect is observed that we assumed to be translucence.

关键词： AgBr AgCl

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia Cisneros maria Jose Garcia Larrosa maria del Mar Callejon Gil Ignacio Garcia Delgado maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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AC-current-induced magnetization switching in amorphous microwires

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Frontiers of physics 2018年第2期13卷 213-223页

作者： v. zhukova J. M. Blanco A. Chizhik M. Ipatov A. Zhukov Dpto. Fisica Aplicada I EUPDS UPV/EHU Plaza Europa 1 San Sebastidn 20018 Spain Dpto. Fisica de Materiales Facultad de Qulmica UPV/EHU 1072 20080 San Sebastidn Spain IKERBASQUE Basque Foundation for Science 58011 Bilbao Spain

We studied the influence of AC current flowing through microwires, on magnetization dynamics. We used a previously developed Sixtus-Tonks modified setup to evaluate the domain wall （DW） velocity within the microwire. However, instead of a magnetizing solenoid, we used a current flowing through the microwire. We observed that the AC current flowing through the annealed Co-rich microwire leads to remagnetization by fast domain wall propagation. The estimated DW velocity was approximately 4.5 km/s, which is similar to and even higher than that reported for the magnetic-field-driven domain wall propagation in Fe- and Co-rich microwires. We measured the DW velocity under tensile stress, and found that the DW velocity decreases under applied stress. An observed DW propagation induced by the current flowing through the microwire is explained considering the influence of an Oersted magnetic field on the outer domain shell. This field has a circular easy magnetization direction and magnetostatic interaction between the outer circumferentially magnetized shell and the inner axially magnetized core.

关键词： domain wall propagation magnetic microwire amorphous material magnetoelasticanisotropy

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Calcareous nannoplankton dating of the Late Quaternary deposits in Greece and the eastern Mediterranean: Case studies from terrestrial and marine sites

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Journal of Palaeogeography 2015年第4期4卷 349-358页

作者： maria v.Triantaphyllou Faculty of Geology and Geoenvironment University of Athens

The distribution and abundance of Emiliania huxleyi（E. huxleyi） assemblages in the marine sediments of the Aravonitsa Plateau, Greece, and from the eastern Mediterranean are used（1） to evaluate the calcareous nannoplankton NN21 a and NN21 b biozones and the NN21a/NN21 b boundary, and（2） to analyze the palaeoenvironmental and palaeoclimatic conditions prevailing in this interval. The sediment succession displays varied E. huxleyi assemblages and these are interpreted as reflecting climatic variability during marine isotope stages MIS 1-8.

关键词： Emiliania huxleyi biostratigraphy palaeoclimatic conditions Greece eastern Mediterranean

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Highly transparent ceramics for the spectral range from 1.0 to 60.0μm based on solid solutions of the system AgBr-AgI-TlI-TlBr

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Chinese Optics Letters 2021年第2期19卷 51-56页

作者： L.v.zhukova D.D.Salimgareev A.E.Lvov A.A.Yuzhakova A.S.Korsakov D.A.Belousov K.v.Lipustin v.M.Kondrashin Ural Federal University named after the first President of Russia B.N.Yeltsin Ekaterinburg 620002Russia

The article is devoted to the technology for obtaining optical ceramics of Ag Br-Tl I and Ag Br-Tl Br_(0.46)I_(0.54) systems and manufacturing samples with different *** new heterophase crystal ceramics are transparent without absorption windows in the spectral range from 1.0 to 60.0μ*** the ceramics’transparency spectra based on the Ag Br-Tl I and Ag Br-Tl Br_(0.46)I_(0.54) systems fusibility diagrams,with an increase in the thallium halides mass fraction,as well as the replacement of the bromine ion with iodine,the maximum transparency shifts to a long infrared region.

关键词： solid solution silver halides monovalent thallium

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Real time monitoring for analysis of dam stability:Potential of nonlinear elasticity and nonlinear dynamics approaches

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Frontiers of Structural and Civil Engineering 2013年第2期7卷 188-205页

作者： T.CHELIDZE T.MATCHARASHvILI v.ABASHIDZE M.KALABEGISHvILI N.zhukova M.Nodia Institute of Geophysics Ivane Javakhishvili Tbilisi State UniversityTbilisi 0218Georgia European Centre on Geodynamical Hazards of High Dams 1 Alexidze str.Tbilisi 0171Georgia Georgian Technical University Tbilisi 0171Georgia

Large dams are complex structures with nonlinear dynamic *** often are forced to assess dam safety based on the available incomplete data,which is extremely *** important problem can be solved with the modern theory of complex *** is possible to derive characteristics of the whole unknown dynamics of a structure using few data sets of certain carefully selected representative parameter(s).By means of high quality continuous records of some geotechnical characteristic(s)of a dam and modern methods of time series linear/nonlinear analysis the main dynamical features of the entire,unknown process(here—dam deformation)can be *** created the cost-effective Monitoring Telemetric System for Dam Diagnostics(DAMWATCH),which consists of sensors(tiltmeters),terminal and central controllers connected by the GSM/GPRS Modem to the diagnostic *** tilt data recorded for varying reservoir level are compared with static design model of dam deformations computed by a finite element method(FEM)for the dam-reservoir-foundation ***,recently developed linear/nonlinear data analysis and prediction schemes may help to quantify fine dynamical features of the dam *** software package DAMTOOL has been developed for this *** differences between measured and theoretically predicted response parameters of the dam may signal abnormal behavior of the *** data obtained already by testing of the DAMWATCH/DAMTOOL system during operation of the high Enguri arc dam and reservoir(Georgia)show interesting long-term and short-term patterns of tilts in the dam body,which can be used for dam *** proposed real-time telemetric monitoring(DAMWATCH)complex and linear/nonlinear dynamical analysis system(DAMTOOL)are unique.

关键词： real time monitoring telemetry dam tilts diagnostic tools hysteresis nonlinear dynamics

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