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Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region,Italy

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Neural Regeneration Research 2018年第9期13卷 1619-1621页

作者： Damiana Scuteri maria Roberta Garreffa Stefania Esposito Giacinto Bagetta maria Diana Naturale maria tiziana corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and NutritionUniversity of Calabria Pharmacy Unit "Mater Domini" University Hospital Department of Health Sciences University "Magna Graecia" of Catanzaro

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 *** gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been *** latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine *** results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

关键词： Alzheimer's disease dementia neuropsychiatric symptoms pain appropriate prescriptions aromatherapy opioids α2δ-1 ligands

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Diabetic retinopathy and age-related macular degeneration: a survey of pharmacoutilization and cost in Calabria, Italy

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Neural Regeneration Research 2019年第8期14卷 1445-1448页

作者： Damiana Scuteri Ada Vero mariacristina Zito maria Diana Naturale Giacinto Bagetta Carlo Nucci Paolo Tonin maria tiziana corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and Nutrition University of Calabria Rende (Cosenza) Italy Pharmacy Unit "Mater Dominf* University Hospital Catanzaro Italy Department of Health Sciences University "Magna Graecia" of Catanzaro Catanzaro Italy Ophtalmology Unit Department of Experimental Medicine Univers 让 y of Rome "Tor Vergata" Rome Italy S. Anna Institute Regional Center for Serious Brain Injuries Crotone Italy

The aged population is constantly growing, thus fostering an increase in age-dependent diseases. Among these, diabetic retinopathy (DR) along with age-related macular degeneration entails progressive vision loss. Since such conditions are associated with the proliferation of novel vessels, their pharmacotherapeutic management consists of the intravitreal injection of anti-vascular endothelial growth factor drugs, able to hinder the driving of vascular proliferation prompted by vascular endothelial growth factor. The humanized anti-vascular endothelial growth factor monoclonal antibody ranibizumab provided evidence for efficacy in several trials, hence earning approval by the US Food and Drug Administration for therapeutic use in all the stages of DR. Due to the lack of epidemiologic and pharmacoeconomic evaluation in the local Calabria Region context, the present retrospective observational study focused on prevalence of DR and age-related macular degeneration, treatment and cost of therapy with ranibizumab in 870 patients arriving to clinical observation at the "Mater Domini” University Hospital in Calabria, Italy from January 2014 to June 2017. Data were extracted from the database of ophthalmology ward and subjected to statistical analysis. The results suggest that the most frequent retinal diseases are age-related macular degeneration and DR and that the use of ranibizumab has been decreasing over the 4-year study period together with the associated cost per patient which was similar for both disorders. Therefore, appropriateness of treatment with drugs other than ranibizumab needs to be assessed in this setting and deep monitoring of pharmacologic treatment for retinal diseases is necessary to prevent or delay visual acuity decrease and complete vision loss. Study procedures were performed in accordance with the "Mater Domini” University Hospital ethical standards of the responsible committee on human experimentation.

关键词： age-related macular degeneration diabetic retinopathy pharmacovigilance ranibizumab anti-VEGFs retrospective study

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Pattern of triptans use: a retrospective prescription study in Calabria, Italy

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Neural Regeneration Research 2020年第7期15卷 1340-1343页

作者： Damiana Scuteri Annagrazia Adornetto Laura Rombolà maria Diana Naturale Adele Emanuela De Francesco Stefania Esposito mariacristina Zito Luigi Antonio Morrone Giacinto Bagetta Paolo Tonin maria tiziana corasaniti Preclinical and Translational Pharmacology Department of PharmacyHealth Science and NutritionUniversity of CalabriaCosenzaItaly School of Hospital Pharmacy University"Magna Graecia"of CatanzaroCatanzaroItaly Pharmacy Unit "Mater Domini"University HospitalCatanzaroItaly Regional Center for Serious Brain Injuries S.Anna InstituteCatanzaroItaly Department of Health Sciences University"Magna Graecia"of CatanzaroCatanzaroItaly

Triptans are 5-hydroxytryptamine 1 B/1 D receptor agonists used in moderate to severe migraine attacks as first line when non-specific,symptomatic,nonsteroidal anti-inflammatory drugs are not *** gain insight in the treatment of migraine in the regional context,this retrospective(from January to August of the years 2017 and 2018)study aimed at monitoring the use of triptans approved by the regional health authority in *** data demonstrate that the overall treatment of migraine with triptans in the different provinces of Calabria falls in the average regional prescription/***,Crotone showed a trend to an increased amount of defined daily dose/1000 inhabitants per *** present analysis might stand for homogeneity of treatment of migraineurs in Calabria and highlights the need for better understanding the apparent differences in the local pattern of almotriptan use to improve the appropriateness.

关键词： 5-HT 1B/1D receptor agonists almotriptan Calabria DDD/1000 inhabitants per day migraine pharmacoepidemiology pharmacology of migraine prescriptions treatment triptans

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Local Peripheral Effects of <i>β</i>-Caryophyllene through CB<sub>2</sub>Receptors in Neuropathic Pain in Mice

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Pharmacology & Pharmacy 2012年第4期3卷 397-403页

作者： Hikari Kuwahata Soh Katsuyama Takaaki Komatsu Hitoshi Nakamura maria tiziana corasaniti Giacinto Bagetta Shinobu Sakurada Tsukasa Sakurada Kazuo Takahama Department of Clinical Pharmaceutics Tohoku Pharmaceutical University Sendai Japan Department of Environmental and Molecular Health and Sciences Graduated School of Pharmaceutical Sciences Kumamoto University Kumamoto Japan Department of Pharmacobiological Sciences University of Magna Gracia of Catanzaro Catanzaro Italy Department of Pharmacobiology and University Consortium for Adaptive Disorders and Headach (UCADH) Section of Neuropharmacology of Normal and Pathological Neuronal Plasticity University of Calabria Arcavacata di Rende Italy Department of Pharmacology Daiichi College of Pharmaceutical Sciences Fukuoka Japan Department of Physiology and Anatomy Tohoku Pharmaceutical University Sendai Japan.

β-Caryophyllene (BCP) is known as a common constitute of the essential oils of numerous food plants and primary component in Cannabis. In this study, we investigated the effect of local intraplantar (***.) injection of BCP on mechanical hypersensitivity induced by partial sciatic nerve ligation (PSNL) in mice. Relative to sham operation controls, mice with the PSNL displayed a maximum level of hyperresponsiveness to von Frey metallic filament on post-operative day 7. PSNL-induced allodynia was seen in the ipsilateral side of nerve ligation, but not in the contralateral side. The ***. injection of BCP into the ipsilateral hindpaw to PSNL attenuated mechanical allodynia in a dose-dependent manner. BCP injection into the contralateral hindpaw did not produce anti-allodynic effects, suggesting a local peripheral anti-allodynic effect of BCP. Anti-allodynic effects induced by ***. injection of BCP were prevented by pretreatment with the cannabinoid (CB2) receptor antagonist AM630, but not by the CB1 receptor antagonist AM251. These data suggest that ***. injection of BCP could produce anti-allodynia by activating peripheral CB2 receptors, but not CB1 receptors in a mouse model of neuropathic pain. Taken together, these results suggest that peripheral CB2 receptors may contribute to the effectiveness of BCP in the treatment of neuropathic pain disorders.

关键词： β-Caryophyllene (BCP) Neuropathic Pain Partial Sciatic Nerve Ligation (PSNL) Peripheral Cannabinoid (CB) Receptor

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