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Immune response to hepatitis B virus vaccine in celiac subjects at diagnosis

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World Journal of Hepatology 2016年第26期8卷 1105-1109页

作者： Martina Filippelli maria teresa garozzo Antonino Capizzi Massimo Spina Sara Manti Lucia Tardino Carmelo Salpietro Salvatore Leonardi Depart-ment of Medical and Pediatric Sciences University of Catania Department of Pediatric Sciences University of Messina

AIM To evaluate hepatitis B virus(HBV) vaccine response and correlation with human leukocyte antigens(HLA) and/or gluten intake in celiac patients at *** Fifty-one patients affected by celiac disease, diagnosed at the Department of Pediatrics of the University of Catania(Italy), were recruited. All patients were tested at admission for immunization against HBV, according to findings from analysis of quantitative HBV surface antibody(anti-HBs). The anti-HBs titer was measured by enzyme-linked immunosorbent assay. Following the international standards, subjects with antibody titer 0.05). With regard to the HLA haplotype, comparison of the distribution of vaccination response showed no statistically significant difference between the different genotypes(homozygosity for the HLADQ2 haplotype compared with HLADQ2/DQ8 heterozygosity or other haplotypes; P > 0.05). Moreover, distribution of the responders according to clinical features of celiac disease showed no statistically significant differences(P > 0.05).CONCLUSION This prospective study confirmed the lower percentage of response to HBV vaccine in celiac subjects. However, the underlying mechanism remains unclear and further studies are needed.

关键词： Celiac disease Hepatitis B virus vaccination Human leukocyte antigens Gluten Poor response

The cross-talk between family and pediatrician: The case of bronchial asthma

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Health 2013年第2期5卷 307-312页

作者： Salvatore Leonardi Rossella Pecoraro maria teresa garozzo Alfina Coco Mario La Rosa Department of Pediatrics Bronchopneumoallergology and Cystic Fibrosis Unit University of Catania Catania Italy

Today the most important challenge facing the pediatrician is the increasing prevalence of chronic diseases. With this regard, pediatricians play a key role in the management of these conditions. The closeness with the family, the knowledge of the clinical case and the care continuity allow the pediatrician to acquire a position of director of every case. When pathological events have a chronic feature, suddenly the quality of life of the whole family changes. For this reason the first communication of chronic disease is very important and the task of the pediatrician should be to provide a positive message to help the family in facing the difficulty of this new challenge. The bronchial asthma is the most common chronic disease worldwide. The incidence, the prevalence, and the mortality of the disease have increased in children over the past decades. These trends are particularly marked above all in preschool children. The success reached by Pediatricians is closely related to the compliance and the implementation of the therapy followed by the little patient and his family. With this regard authors, in this review, focus on the illustration of several strategies, based on the pediatrician’ skills and medicine documents, that can be used for the improvement of communication among pedia- trician-family and child, never forgetting the hu- man aspect of the same doctor, that should con- ciliate with the scientific knowledge in the taking care of a specific chronic disease.

关键词： Cross-Talk Bronchial Asthma Children

The plasticity of plasticity:lesson from remote microglia induced by focal central nervous system injury

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Neural Regeneration Research 2020年第1期15卷 57-58页

作者： maria teresa Viscomi Institute of Histology and Embriology Università Cattolica del S.Cuore

The last decades have represented an important season in the re-conceptualization of brain plasticity,especially in extending the concept at events occurring beyond the developmental stage and in demonstrating the profound impact of these changes on so-called spontaneous recovery after central nervous system(CNS)*** study of the cellular,molecular,functional and structural mechanisms involved in brain plasticity has clearly emphasized the multitude of players engaged in this phenomenon,leading to the conceptualization that non-neuronal cells and non-neuronal mechanisms intervene in these changes and orchestrate some of the responses observed(Werner and Stevens,2015).Among the different non-neuronal cells and non-neuronal substrates of injury-induced plasticity is becoming increasingly recognized that microglia drive a series of intrinsic CNS responses after damage(Sandvig et al.,2018;Bisicchia et al.,2019).

关键词： plasticity system injuries

Estrogen/Huntingtin:a novel pathway involved in neuroprotection

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Neural Regeneration Research 2016年第3期11卷 402-403页

作者： maria teresa Nuzzo maria Marino Department of Science-Division of Biomedical Sciences and Technologies University Roma Tre

Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive *** pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or *** most cases,

关键词： programmed mitochondrial pathogenesis progressively aggregation oxidative abnormal neuronal caspase physiological

Early life stress-induced neuroinflammation and neurological disorders: a novel perspective for research

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Neural Regeneration Research 2022年第9期17卷 1971-1972页

作者： Clarissa Catale Valeria Carola maria teresa Viscomi Division of Experimental Neuroscience IRCCS Santa Lucia FoundationRomeItaly Department of Dynamic and Clinical Psychology and Health StudiesSapienza University of RomeRomeItaly Department of Life Science and Public Health Section of Histology and EmbryologyUniversitàCattolica del S.CuoreRomeItaly

Childhood maltreatment(CM)has been consistently linked with numerous detrimental outcomes concerning physical and psychological ***,few studies have explored vulnerability to neurological disorders after *** life adversity,in the form of poverty,stress and abuse,has been associated with decline in cognitive function and dementia later in life(Short and Baram,2019).Robust preclinical data suggest that early life stress(ELS)may increase the risk and worsen the course of neurological disorders such as Alzheimer’s(AD)and Parkinson’s(PD)diseases,and traumatic brain injury(TBI)(Lesuis et al.,2018;Short and Baram,2019;He et al.,2020;Catale et al.,2021;Sanchez et al.,2021).

关键词： neurological disorders inflammation

Setting a highway for converting skin into neurons

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Journal of Molecular Cell Biology 2011年第6期3卷 322-323页

作者： Vania Broccoli Massimiliano Caiazzo maria teresa Dell’Anno San Raffaele Scientific Institute Via Olgettina 58Milan 20132Italy

Direct conversion of human skin fibroblasts into induced neuronal(iN)cells has been recently achieved by using different combi-nations of transcription factors eventually associated with *** findings lay the ground for a straightforward and effi-cient generation of human neurons in vitro with elaborated functional properties instrumental for disease modeling and cell-based approaches of brain repair.

关键词： eventually straight finding

Reviewing the discoverability and accessibility to data and information products linked to Essential Climate Variables

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International Journal of Digital Earth 2020年第2期13卷 236-252页

作者： maria teresa Miranda Espinosa Gregory Giuliani Nicolas Ray Institute for Environmental Sciences enviroSPACE labUniversity of GenevaGenevaSwitzerland Institute for Environmental Sciences GRID-GenevaUniversity of GenevaGenevaSwitzerland GeoHealth Group Institute of Global HealthFaculty of MedicineUniversity of GenevaGenevaSwitzerland'

Essential Climate Variables(ECVs)are geophysical records generated from systematic Earth Observations associated with climate variations,changes,and *** products support the data and information needs of international frameworks and policies such as the work of the United Nations Framework Convention on Climate Change(UNFCCC)and the Intergovernmental Panel on Climate Change(IPCC).We map the main networks and initiatives publishing ECVs,by presenting an overview of existing satellite-based ECVs,their general data creation characteristics,discoverability and accessibility methods from an end-user *** investigate key initiatives providing or coordinating access to ECV data records,such as the Global Climate Observing System(GCOS),the Committee on Earth Observation Satellites(CEOS),the Coordination Group for Meteorological Satellites(CGMS),Joint Working Group on Climate(WGClimate),the Remote Sensing Systems(REMSS),and the European Space Agency Climate Change Initiative(ESA CCI).We find that ECV data discovery and access is difficult and time consuming due to the lack of common data and metadata *** addition,the selection of fit-for-purpose data records by end-users requires the implementation of interoperable standards and scalable data infrastructures to allow the generation of tailored applications and datadriven information products in support of decision-making processes.

关键词： Essential Climate Variables Climate services discoverability accessibility usability

Nilotinib:from animal-based studies to clinical investigation in Alzheimer's disease patients

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Neural Regeneration Research 2023年第4期18卷 803-804页

作者： Annalisa Nobili Marcello D’Amelio maria teresa Viscomi Department of Medicine and Surgery University Campus Bio-MedicoDepartment of Experimental NeuroscienceIRCCS Santa Lucia FoundationRomeItaly Department of Life Science and Public Health Section of Histology and Embryology UniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario“A.Gemelli”IRCCSRomeItaly

Since their first description in the brains of patients suffering from Alzheimer ’s disease(AD), more than 100 years ago, extracellular amyloid-β(Aβ) plaques and intracellular neurofibrillary tangles have been the principal focus of AD research. However, this focus has led to the failure of several long and promising clinical trials, and the efficacy of new Aβ-targeting drugs to slow down the disease progression is still controversial despite being successful in reducing the Aβ load.

关键词： Alzheimer Aβ drugs

Non-celiac gluten sensitivity:Time for sifting the grain

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World Journal of Gastroenterology 2015年第27期21卷 8221-8226页

作者： Luca Elli Leda Roncoroni maria teresa Bardella Center for Prevention and Diagnosis of Celiac Disease Gastroenterology and Endoscopy Unit Department of Pathophysiology and Transplantation Università degli Studi di Milano. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

In the last few years, a new nomenclature has been proposed for the disease induced by the ingestion of gluten, a protein present in wheat, rice, barley and oats. Besides celiac disease and wheat allergy, the most studied forms of gluten-related disorders characterized by an evident immune mechanism(autoimmune in celiac disease and Ig E-mediated in wheat allergy), a new entity has been included, apparently not driven by an aberrant immune response: the non-celiac gluten sensitivity(NCGS). NCGS is characterized by a heterogeneous clinical picture with intestinal and extraintestinal symptoms arising after gluten ingestion and rapidly improving after its withdrawal from the diet. The pathogenesis of NCGS is largely unknown, but a mixture of factors such as the stimulation of the innate immune system, the direct cytotoxic effects of gluten, and probably the synergy with other wheat molecules, are clues for the complicated puzzle. In addition, the diagnostic procedures still remain problematic due to the absence of efficient diagnostic markers; thus, diagnosis is based upon the symptomatic response to a gluten-free diet and the recurrence of symptoms after gluten reintroduction with the possibility of an important involvement of a placebo effect. The temporary withdrawal of gluten seems a reasonable therapy, but the timing of gluten reintroduction and the correct patient management approach are have not yet been determined.

关键词： Celiac disease Gluten Gluten-relateddisorders Gluten sensitivity Non-celiac gluten sensitivity