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H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease

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World Journal of Gastroenterology 2006年第48期12卷 7815-7820页

作者： Cristina Lenzi Alberto Palazzuoli Nicola Giordano Giuliano Alegente Catia Gonnelli maria stella campagna Annalisa Santucci Michele Sozzi Panagiotis Papakostas Fabio Rollo Ranuccio Nuti Natale Figura Department of In-ternal Medicine Endocrine-Metabolic Sciences and Biochemistry University of Siena Siena Italy Unit of Microbiology General Hospital Siena Italy Department of Molecular Biology University of Siena Siena Italy Unit of Gastroenterology and Digestive Endos-copy General Hospital Trieste Italy

AIM: To determine the overall prevalence of H pylori and CagA positive H pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (CHD), and the potential role of anti-heat-shock protein 60 (Hsp60) anti- body response to these proteins in increasing the risk of CHD development. METHODS: Eighty patients with CHD and 160 controls were employed. We also compared the levels of anti- heat-shock protein 60 (Hsp60) antibodies in the two groups. The H pylori infection and the CagA status were determined serologically, using commercially available enzyme-linked immunosorbent assays (ELISA), and a Western blotting method developed in our laboratory. Systemic antibodies to Hsp60 were determined by a sandwich ELISA, using a polyclonal antibody to Hsp60 to sensitise polystyrene plates and a commercially available human Hsp60 as an antigen. RESULTS: The overall prevalence of H pylori infec- tion was 78.7% (n = 63) in patients and 76.2% (n = 122) in controls (P = 0.07). Patients infected by CagA- positive (CagA+) H pylori strains were 71.4% (n = 45) vs 52.4% of infected controls (P = 0.030, OR = 2.27). Sys-temic levels of IgG to Hsp60 were increased in H pylori- negative patients compared with uninfected controls (P < 0.001) and CagA-positive infected patients compared with CagA-positive infected controls (P = 0.007). CONCLUSION: CagA positive H pylori infection may concur to the development of CHD; high levels of anti- Hsp60 antibodies may constitute a marker and/or a con- comitant pathogenic factor of the disease.

关键词： H pylori Coronary heart disease CagA protein Heat shock protein 60 Antibody response

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