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Rehabilitation in Autism. Pilot Project on the Health Centre-Based Primary Care Model within the National Health Plan Implementation Projects

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Open Journal of Psychiatry 2018年第2期8卷 182-197页

作者： Stefano Marini Tatiana D’Ambrogio Marco Esposito maria rita sergi Germana Sorge Il Cireneo Foundation for Autism Vasto Italy (Stefano Marini Germana Sorge) National Health System Child Neuro-Psychiatry Territorial Service L’Aquila-Avezzano-Sulmona Italy (Tatiana D’Ambrogio) Fondazione Istituto Ospedaliero Sospiro Cremona Italy (Marco Esposito) Psychological Sciences Humanities and Territory Psychometric Laboratory G. d’Annunzio University Chieti Italy (Maria Rita Sergi)

Background: In Italy, there is a lack of reliable data on the epidemiology of Autism Spectrum Disorder (ASD) on a national scale. The exact etiopathogenesis of ASDs is still largely unknown, with autism representing the final common pathway of different pathological conditions. Aim of the Study: Assessment of the effects produced by the individualised, intensive and holistic rehabilitation programme used by the Il Cireneo Foundation on the daily living skills of people diagnosed with ASD. Materials and Methods: Out of the eighty-seven (n = 87) enrolees, seventy-nine (n = 79), of whom 19 were females (24.1%) and 60 were males (75.9%), with a mean age of 13.41 years (SD = 6.93 years;range = 2 - 33 years) terminated the three-year study. The enrolees were evaluated two times: at the beginning of the rehabilitation programme and at the end of the three-year goal-oriented project. Results: Statistically significant results between T0 and T1 were recorded for CARS (t-4.221;p Conclusions: People diagnosed with autism can be helped to become more autonomous and independent in carrying out activities of daily living thanks to an intensive psycho-educational and cognitive-behavioural rehabilitation programme, of which the Il Cireneo Foundation is the only expression in the Abruzzo region.

关键词： Autism Spectrum Disorder Rehabilitation TEACCH

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Motivations for and barriers to innovation in non-profit organizations: The case of nursing homes in Northern Portugal

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International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： Ana rita Gonçalves Lopes Aldina Isabel de Azevedo Correia Alexandra maria da Silva Braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern *** enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business ***,it is important to support the innovation decisionmaking process in similar non-profit *** this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the *** sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern *** study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit *** results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： Determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

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Transcriptomic responses to drought stress in the Patagonian southern beech Nothofagus alpina

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Ecological Processes 2024年第2期13卷 192-203页

作者： rita maria Lopez Laphitz María Verónica Arana Santiago Agustín Varela Leandro Aníbal Becker Carolina Soliani María Marta Azpilicueta Paula Marchelli Nicolás Bellora Instituto de Diversidad y Evolución Austral (CENPAT CONICET ) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB INTA CONICET ) Instituto de Tecnologías Nucleares para la Salud (CONICET )

Background Deciphering the genetic architecture of drought tolerance could allow the candidate genes identification responding to water stress. In the Andean Patagonian forest, the genus Nothofagus represents an ecologically relevant species to be included in different genomic studies. These studies are scarce in South American ecosystems however represent an important source of genomic data in order to interpret future climate-change environment scenarios of these emblematic forests. Here, we achieved the assemblage of the transcriptome of N. alpina while searching for key genes of activated or suppressed metabolic pathways in response to drought *** De novo transcriptome assembly resulted in 104,030 transcripts. Following confirmation of drought conditions, based on reduction of leaf water potential and stomatal conductance, a differential gene expression analysis resulted in 2720 significantly expressed genes(1601 up-regulated and 1119 down-regulated). Enrichment analysis(over-representation analysis and gene set enrichment analysis) resulted in more than one hundred stress-responsive term ontologies(i.e. biological processes) and pathways. Terms such as response to abscisic acid and pathways such as plant hormone signal transduction or starch and sucrose metabolism were over-represented. Protein–protein interaction assessment resulted in networks with significantly expressed top common hub gene clusters(e.g. planttype cell wall biogenesis among down-regulated or ABA-signalling among up-regulated). These networks evidenced important regulators at gene expression such as transcriptional *** Responses of N. alpina seedlings to drought stress were evidenced by the activation of several genes linked to GO biological processes and KEGG pathways, which were mainly based on over-expression of specific protein kinases, phosphatases, synthases and transcription factors. This suggests an up-regulation of signalling pathways, triggered through pla

关键词： Climate change Differential gene expression Hub genes Patagonia Temperate forest

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Liquid crystal immunosensors for the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO C.OLIVEIRA maria S.SOARES BÁRBARA V.GONÇALVES ANDREIA C.M.RODRIGUES AMADEU M.V.M.SOARES rita G.SOBRAL NUNO F.SANTOS JAN NEDOMA PEDRO L.ALMEIDA CARLOS MARQUES CICECO-Aveiro Institute of Materials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESAM-Centre for Environmental and Marine Studies and Department of Biology University of Aveiro3810-193 AveiroPortugal Department of Telecommunications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious illnesses,and traditional methods to detect Escherichia coli are still associated with long waiting times and high costs given the necessity to transport samples to specialized *** is a need to develop new technologies that allow cheap,fast,and direct monitoring at the site of ***,in this work,we developed optical immunosensors for the selective detection of ***,based on liquid crystal technology,whose molecules can align in different manners depending on the boundary conditions (such as substrates) as well as the environment that they *** glass substrate was functionalized with *** antibody using cysteamine as an intermediate,and a vertical alignment was imposed on the liquid crystal molecules by using DMOAP during *** presence of bacteria disrupts the alignment of the liquid crystal molecules,changing the intensity of light emerging between cross polarizers,measured using a polarized optical microscope and a *** was possible to detect *** in suspensions in the concentration range from 2.8 cells/mL to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contaminated water samples.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instruments.

关键词： crystal alignment analysis

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Insular mammalian fauna dynamics and paleogeography:A lesson from the Western Mediterranean islands

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Integrative Zoology 2018年第1期13卷 2-20页

作者： maria rita PALOMBO Department of Earth Science Sapienza University of RomeRomaItaly CNR-IGAG Monterotondo(Roma)Italy

Since the time of Darwin(1859)and Wallace(1869),islands have been regarded by scientists as a prime target for scrutinizing the forces that may influence evolution and diversification and important elements in biogeographic *** research aims to scrutinize whether and to what extent the composition and structure of past mammal insular faunas and their changes through time may provide sound clues for inferring the paleogeographical evolution of a *** a case study,I critically analyzed the dynamics shown by the Plio-Pleistocene mammalian fauna of 3 Western Mediterranean insular districts,the Balearic Islands,Sardinia and Sicily,each characterized by its own peculiar paleobiogeographical evolutionary *** revision of faunas and the critical analysis of the dispersal ability of the ancestors of island settlers have allowed hypothesizing on the time and mode of island *** results obtained confirm that the early isolation of the Balearic Islands from the mainland led to the establishment of an endemic fauna since the pre-Messinian Miocene(?Astaracian European Land Mammal Age,MN7/8),and that Sardinia has definitely been isolated since the Pliocene,although dispersal events led to some faunal turnovers during the *** addition,the results suggest for Sicily a complex,still imperfectly disentangled history of alternate phases of complete separation and sporadic,more or less difficult connections with southern Italy.

关键词： dispersal islands mammal Plio–Pleistocene Western Mediterranean

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Lights and shadows in the evolutionary patterns of insular bovids

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Integrative Zoology 2014年第2期9卷 213-228页

作者： Roberto ROZZI maria rita PALOMBO Department of Earth Sciences SapienzaUniversity of RomeRomeItaly Consiglio Nazionale delle Ricerche-Istituto di Geologia Ambientale e Geoingegneria(DNR-IGAG) RomeItaly

Endemic bovids are intriguing elements of insular *** living species include the Japanese serow(Cap-ricornis crispus)and the Formosan serow(***),the tamaraw from Mindoro,Philippines,(Bubalus min-dorensis)and the anoas(*** and ***),2 species of dwarf buffalos endemic to Sulawesi,*** endemic bovids are only recorded in some Asian,North American and Western Mediterranean *** we present a comprehensive overview of the changes in body size and evolutionary patterns ex-hibited by both extant and extinct insular *** appraisal indicates that each insular representative of Bo-vidae shows its own peculiar evolutionary model,albeit some parallel trends exist(*** in body size,allometric changes in limb bones,alteration of the life history traits).Some changes in morphology(*** simplification of horn cores,the increase in hypsodonty,the acquisition of a‘low-gear’locomotion),for in-stance,appear as common,albeit not general,patterns triggered by a combination of selective *** size patterns support the‘generality of the island rule’and suggest that biotic interaction had/have a major role in in-fluencing body size evolution in these species,although in different ways on different *** things consid-ered,available evidence suggest that a major role in the evolution of insular bovids is played by the structure of the insular community,the nature of available niches and by the dynamics of ecological interactions.

关键词： evolutionary island shadow

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The intriguing giant deer from the Bate cave (Crete): could paleohistological evidence question its taxonomy and nomenclature?

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Integrative Zoology 2022年第1期17卷 54-77页

作者： maria rita PALOMBO Marco ZEDDA CNR-IGAG c/o Department of Earth Sciences Sapienza UniversityRomaItaly Department of Veterinary Medicine University of SassariItaly

The research describes for the first time a possible case of pituitary gigantism in fossil mammals,precisely in *** pathology was detected in 2 long bones(tibia and metatarsus)belonging to an individual of an unusual large size found at the Bate cave(Rethymnon,Northern Crete).It formed the basis of Candiacervus major,the largest among the endemic deer species recorded in the Pleistocene-Early Holocene of *** and histomorphological examinations highlighted a reduction in cortical bone thickness and the presence of wide lacunae inside of the bone *** pathological conditions suggest a pituitary gigantism diagnosis also supported by some morphological evidence,such as the extremely elongated distal part of the metatarsal diaphysis,the proportionally small proximal epiphysis,and some bone *** diagnosis of a case of pituitary gigantism as presumed responsible for the extraordinary elongation of the tibia and the metatarsal bone is intriguing as they are,respectively,the paratype and the holotype of the *** species represents a case of a deviation from the“island rule”in Pleistocene large *** new evidence recommends a taxonomic and nomenclatural revision of this *** main outcomes of this research are as follows:(i)a case of pituitary gigantism is described for the first time in an extinct mammal;(ii)it is underlined that paleohistology may provide interesting clues for disentangling taxonomic and nomenclatural issues;(iii)one of the very few cases of gigantism in insular mammals is being questioned.

关键词： Candiacervus major Cretan deer island rule paleohistology pituitary gigantism

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Do methods for predicting paleohabitats apply for mountain and insular fossil bovids?

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Integrative Zoology 2013年第3期8卷 244-259页

作者： Roberto ROZZI maria rita PALOMBO Department of Earth Sciences SapienzaDepartment of Earth SciencesUniversity of Rome Consiglio Nazionale delle Ricerche–Istituto di Geologia Ambientale e Geoingegneria(CNR-IGAG) RomeItaly

A variety of methods have been developed to use bovid postcranial elements in the functional morphology approach to paleohabitat *** study represents a first attempt at testing morphometric methods based on astragalus and phalanges on extant mountain-dwelling bovids and insular fossil bovids from Sardinia assigned to the so-called‘Nesogoral group’,already regarded as close to the Caprini *** intended to answer the questions whether a classic four-habitats model could be successfully applied to extant mountain-dwelling bovids,and whether results obtained could support the hypothesis of a radiative evolution for the Sardinian *** obtained,on the one hand,highlighted some inadequacies of the method if not applied to African bovids;on the other hand,they stressed the difficulties of discriminating habitat preferences of Sardinian taxa only based on biometry of astragalus and ***,statistical habitat predictions suggest the contemporaneous presence in Sardinia of bovids having about the same size,but inhabiting different environments,giving support to the hypothesis that Sardinian representatives of the genus Nesogoral originated from a still unknown ancestor by an adaptive radiation evolutionary process.

关键词： Bovidae ecological morphology paleoecology Pleistocene Sardinia

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Paleontology and evolution-part I

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Integrative Zoology 2014年第2期9卷 107-110页

作者： maria rita Palombo Dipartimento di Scienze della Terra Sapienza Universitàdi Roma Rome Italy

Evolution is one of the central unifying concepts of natural history and modern *** it is well documented by many lines of evidence from a number of scientific disciplines(***,molecular biolo-gy,comparative anatomy,biogeography),its major sup-port indeed comes from the fossil record,where the his-tory of life can be seen unravelling through geological deep *** have modified their characteris-tics over time,and new taxa have incessantly *** mechanisms and causal factors have been shap-ing this multifaceted evolutionary history?

关键词： anatomy evolution record

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Paleontology and evolution-part II

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Integrative Zoology 2014年第4期9卷 379-382页

作者： maria rita PALOMBO Department of Earth Sciences Sapienza University of Rome Rome Italy

Explaining the history of life through geological deep time is undoubtedly a fascinating and challenging task that intrigued scientists even before the inception of Darwin’s *** fossil record,bearing witness to the changing of life and the continuous origination of new organisms in the course of time,on one hand represents the primary evidence for evolution,and on the other provides hints for deciphering dynamic processes and factors shaping the long,multifaceted evolutionary history of the *** at the past,therefore,is of crucial importance in the never-ending cognitive process of deciphering the way we came to be here.

关键词： doubt plain Biosphere

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